Hair-Growth-Promoting Effects of Fermented Red Ginseng Marc and Traditional Polyherb Formula in C57BL/6 Mice
Open accessAbstract
An abnormal hair-growth cycle induces hair loss, which affects psychological distress and impairs life quality. Red ginseng marc (RGM) is usually discarded as a byproduct after extracting red ginseng, but several studies have shown that the RGM still has bioactive components including ginsenosides. Therefore, the hair-growth effects of fermented RGM (fRGM) and traditional polyherb formula (PH) were examined in C57BL/6 mice. The dorsal hairs of mice were depilated, and they were topically treated with fRGM or PH at 400, 200 and 100 mg/kg or the combination of both middle doses (combi) once a day for two weeks. The hair-covering regions were significantly increased with higher doses of fRGM and PH and in combi groups, compared with the control treated with distilled water. Hair length, thickness and weight also increased in the treatment groups. In particular, the fRGM and PH increased the anagen-phased hair follicles, the follicular diameters and the dermal thickness. Immunostains for Ki-67 showed the anagen-phased cell division in the treatment groups. The beneficial effects were greater in the high doses of fRGM and PH and the combi groups. These suggest hair-growth-promoting effects of fRGM, PH and the combination by enhancing the hair-growth cycle.
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Fermented red ginseng marc with Lactobacillus casei, Saccharomyces cerevisiae, and Rhodobacter capsulatus has promoting effects on the hair growth cycle.
“Red ginseng marc Lactobacillus casei, Saccharomyces cerevisiae, Rhodobacter capsulatus Promoting effects on the hair growth cycle [163]”
From Use of Waste from the Food Industry and Applications of the Fermentation Process to Create Sustainable Cosmetic Products: A Review (2024) · cites this paper as [163]
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- Authors
- Song, P. H., Park, G.-R., Kim, Y.-H., Jung, D. H., Ku, S.-K., & Song, C.-H.
- Affiliations
- Yeungnam University (KR)
- Daegu Haany University (KR)
- Pung-gi Ginseng Production Farming Cooperation, Yeongju 689-822, Korea
- Corresponding author
- Ku, Sae-Kwang
- Song, Chang-Hyun
- Venue
- Applied Sciences
- Publisher
- MDPI AG
- Published
- 2021-01-28
- Volume
- 11
- Issue
- 3
- Pages
- 1195
- ISSN
- 2076-3417 (ISSN-L)
- OpenAlex
- W3128384541
- Cited by
- 9
- References
- 50
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Applied Sciences (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of SMEs and Startups (C0237051)
- National Research Foundation of Korea (2018R1A5A2025272, 2017R1D1A3B03031498)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- hair growth, hair loss, ginsenosides, anagen phase, hair follicle, Ki-67, topical treatment, skin thickness, hair length
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