Establishment of a numerical model to design an electro-stimulating system for a porcine mandibular critical size defect
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Electrical stimulation is a promising therapeutic approach for the regeneration of large bone defects. Innovative electrically stimulating implants for critical size defects in the lower jaw are under development and need to be optimized in silico and tested in vivo prior to application. In this context, numerical modelling and simulation are useful tools in the design process. In this study, a numerical model of an electrically stimulated minipig mandible was established to find optimal stimulation parameters that allow for a maximum area of beneficially stimulated tissue. Finite-element simulations were performed to determine the stimulation impact of the proposed implant design and to optimize the electric field distribution resulting from sinusoidal low-frequency ( f = 20 Hz ) electric stimulation. Optimal stimulation parameters of the electrode length h el = 25 m m and the stimulation potential φ stim = 0.5 V were determined. These parameter sets shall be applied in future in vivo validation studies. Furthermore, our results suggest that changing tissue properties during the course of the healing process might make a feedback-controlled stimulation system necessary.
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Electromagnetic fields applied by implanted electrodes allow delivery of the electromagnetic field in a more optimized intensity range for the local tissue.
“Apart from noninvasive electromagnetic field application, electromagnetic fields can also be applied by implanted electrodes (58, 70, 71). This application mode allows the delivery of the electromagnetic field in a more optimized intensity range for the local tissue.”
From Methods to accelerate fracture healing – a narrative review from a clinical perspective (2024) · cites this paper as [71]
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Harshakumar, K., Kalyani, P., Shifa Balkhis, A., & Janardanan, K. (2022) · The Journal of Prosthetic and Implant Dentistry · doi:10.55231/jpid.2022.v06.i01.09
Lembcke, L., Bathel, H., Frerich, B., Dau, M., van Rienen, U., Kämmerer, P. W., & Engel, N. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1897534
Self-citationKaruppan, D., & Elsen, S. R. (2026) · Biophysics Reviews · doi:10.1063/5.0286124
- Authors
- Raben, H., Kämmerer, P. W., Bader, R., & van Rienen, U.
- Affiliations
- University of Rostock (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Universitätsmedizin Rostock (DE)
- Institute of General Electrical Engineering, University of Rostock, 18051 Rostock, Germany
- Corresponding author
- Raben, Hendrikje
- Venue
- Applied Sciences
- Publisher
- MDPI AG
- Published
- 2019-05-27
- Volume
- 9
- Issue
- 10
- Pages
- 2160
- ISSN
- 2076-3417 (ISSN-L)
- OpenAlex
- W3196923342
- Cited by
- 34
- References
- 73
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Applied Sciences (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deutsche Forschungsgemeinschaft (299150580)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
- Keywords
- electrical stimulation, bone regeneration, critical-size bone defect, mandible, finite element analysis, electric field distribution, stimulation parameter optimization, electrode length, minipigs, tissue repair
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