Curcumin Regulates Anti-inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells
Open accessAbstract
Microglia play important physiological roles in central nervous system (CNS) homeostasis and in the pathogenesis of inflammatory brain diseases. Inflammation stimulates microglia to secrete cytokines and chemokines that guide immune cells to sites of injury/inflammation. Neuroinflammation is also strongly implicated in the pathogenesis of a number of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, for which nutritional intervention could represent a benefit due to a lack of clinically efficacious drugs. To this end, the anti-inflammatory mechanisms of several phytochemicals, including curcumin, have been extensively studied. The present experiments show that the administration of curcumin is able to increase the production of the anti-inflammatory cytokines, IL-4 and IL-10, in murine BV-2 microglial cells treated with lipopolysaccharide (LPS). Consistent with these data, curcumin stimulation upregulates the expression of Suppressors of cytokine signaling (SOCS)-1, whereas phosphorylation of the JAK2 and STAT3 was reduced. Taken together, these results provide evidence that curcumin is able to regulate neuroinflammatory reactions by eliciting anti-inflammatory responses in microglia through JAK/STAT/SOCS signaling pathway modulation.
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Curcumin inhibits NF-κB and MAPK activation in LPS-stimulated microglia.
“curcumin has been demonstrated to inhibit NF-κB and MAPK activation in LPS-stimulated microglia (Porro et al., 2019; Zhang et al., 2019)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Porro et al., 2019
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ResultRegulation of JAK–STAT signalling in the immune system
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The Potential Role of Nutrition in Lung Cancer Establishment and Progression
Porro, C., Torre, M. E. L., Tartaglia, N., Tarek, B., Santini, M., Ambrosi, A., Messina, G., Cibelli, G., Fiorelli, A., Polito, R., et al. (2022) · Life · doi:10.3390/life12020270 · Cited by 23 · see citing works
Lagoa, R., Logesh, R., Violante, C., Babiaka, S. B., Marques‐da‐Silva, D., Kapoor, B., Reis, F., & Atanasov, A. G. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108568 · Cited by 24 · see citing works
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Hemshekhar, M., Anaparti, V., El-Gabalawy, H. S., & Mookherjee, N. (2021) · Arthritis Research & Therapy · doi:10.1186/s13075-021-02423-z · Cited by 22 · see citing works
Jithavech, P., Suwattananuruk, P., Hasriadi, H., Muangnoi, C., Thitikornpong, W., Towiwat, P., Vajragupta, O., & Rojsitthisak, P. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265689 · Cited by 20 · see citing works
Nawaz, A., Latif, M. S., Shah, M. K. A., Elsayed, T. M. A., Ahmad, S., & Khan, H. A. (2023) · Gels · doi:10.3390/gels9030201 · Cited by 20 · see citing works
Targeting the JAK/STAT3/SOCS signaling pathway in Alzheimer’s disease
Al-Kuraishy, H. M., Sulaiman, G. M., Mohammed, H. A., Saad, . M., Al-Gareeb, A. I., & Albuhadily, A. K. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01796-w · Cited by 20 · see citing works
Comparative Analysis of Multiple Neurodegenerative Diseases Based on Advanced Epigenetic Aging Brain
Shi, F., He, Y., Chen, Y., Yin, X., Sha, X., & Wang, Y. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.657636 · Cited by 19 · see citing works
Development of a Slow-Degrading Polymerized Curcumin Coating for Intracortical Microelectrodes
Ziemba, A. M., Woodson, M. C. C., Funnell, J. L., Wich, D. M., Balouch, B., Rende, D., Amato, D. N., Bao, J., Oprea, I., Cao, D., et al. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00969 · Cited by 19 · see citing works
IRF5 Signaling in Phagocytes Is Detrimental to Neonatal Hypoxic Ischemic Encephalopathy
Mamun, A. A., Yu, H., Sharmeen, R., McCullough, L. D., & Liu, F. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00832-x · Cited by 17 · see citing works
Domínguez-Avila, J. A., Salazar‐López, N. J., Montiel‐Herrera, M., Martı́nez-Martı́nez, A., Villegas‐Ochoa, M. A., & González-Aguilar, G. A. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14260 · Cited by 16 · see citing works
Gholami, A. A., Tahmasebi, F., Haghir, H., & Babaloo, H. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01884-x · Cited by 15 · see citing works
Wang, R., Yu, H., Chen, P., Yuan, T., & Zhang, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512479 · Cited by 15 · see citing works
Retinasamy, T., Lee, A. L. Y., Lee, H. S., Lee, V. L. L., Shaikh, M. F., & Yeong, K. Y. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00205 · Cited by 15 · see citing works
Park, J., Lee, C.-H., & Kim, Y. T. (2023) · Pharmaceuticals · doi:10.3390/ph16070941 · Cited by 14 · see citing works
Oxley, R. A., & Peart, D. J. (2023) · Nutrition and Health · doi:10.1177/02601060231186439 · Cited by 17 · see citing works
Yu, L., Zhang, C., Gu, L., Chen, H., Huo, Y., Wang, S., Tao, J., Xu, C. L., Zhang, Q., Ma, M., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03896-6 · Cited by 14 · see citing works
Neuroinflammation and Disease: Pathways and Opportunities
Hoffman, O., Varvel, N. H., Roopra, A., & Dingledine, R. J. (2025) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-062124-043519 · Cited by 14 · see citing works
Cross-kingdom regulation of ginseng miRNA156 on immunity and metabolism
Wang, J., Li, C., Ruan, J., Yang, C., Tian, Y., Lu, B., & Wang, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112577 · Cited by 12 · see citing works
Ortiz-Islas, E., Montes, P., Rodríguez-Pérez, C. E., Ruiz-Sánchez, E., Sánchez-Barbosa, T., Pichardo-Rojas, D., Zavala‐Tecuapetla, C., Carvajal, K., & Campos‐Peña, V. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17010128 · Cited by 12 · see citing works
Ji, X., Chai, J., Zhao, S., & Zhao, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1605027 · Cited by 14 · see citing works
Corneal Application of R9-SOCS1-KIR Peptide Alleviates Endotoxin-Induced Uveitis
Ahmed, C. M. I., Patel, A. P., Ildefonso, C. J., Johnson, H. M., & Lewin, A. S. (2021) · Translational Vision Science & Technology · doi:10.1167/tvst.10.3.25 · Cited by 12 · see citing works
Autophagy Modulation and Its Implications on Glioblastoma Treatment
Chen, J., Salinas, A., Morales, M. A., & Fang, X. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45110546 · Cited by 11 · see citing works
Li, Q., Ding, Y., Ou, Y., Li, M., Jithavech, P., Buranasudja, V., Sritularak, B., Xu, Y., Rojsitthisak, P., & Han, J. (2023) · Current Pharmaceutical Design · doi:10.2174/0113816128263974231029180947 · Cited by 11 · see citing works
Xian, L., Cheng, S., Chen, W., Zhong, C., Hu, Z., & Deng, X. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1320811 · Cited by 9 · see citing works
Gharat, S., Basudkar, V., & Momin, M. M. (2024) · Immunological Investigations · doi:10.1080/08820139.2024.2301997 · Cited by 9 · see citing works
Tylek, K., Trojan, E., Leśkiewicz, M., Francavilla, F., Lacivita, E., Leopoldo, M., & Basta‐Kaim, A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00525 · Cited by 8 · see citing works
The Anti-Vitiligo Effects of Feshurin In Vitro from Ferula samarcandica and the Mechanism of Action
Nueraihemaiti, M., Deng, Z., Kamoldinov, K., Niu, C., Habasi, M., & Aisa, H. A. (2024) · Pharmaceuticals · doi:10.3390/ph17091252 · Cited by 7 · see citing works
Barangi, S., Hosseinzadeh, P., Karimi, G., Najaran, Z. T., & Mehri, S. (2023) · PubMed Central · doi:10.22038/ijbms.2023.68292.14905 · Cited by 7 · see citing works
Covid-19 pandemic: What is the truth?
Blaylock, R. L. (2021) · Surgical Neurology International · doi:10.25259/sni_1008_2021 · Cited by 7 · see citing works
Su, A.-L., Zhao, S., Hong-Na, Z. H. U., Ying, Q. I. A. O., & Zhang, T. (2024) · Biomedical Research · doi:10.2220/biomedres.45.13 · Cited by 6 · see citing works
Wang, Y., Liu, J., Jiang, Q., Mi, Y., Meng, Q., Mu, D., & Hou, Y. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105418 · Cited by 6 · see citing works
Bioactive Natural Compounds for Therapeutic and Nutraceutical Applications in Neurodegeneration
Panaro, M. A., & Porro, C. (2022) · Nutrients · doi:10.3390/nu14112216 · Cited by 6 · see citing works
Astaneh, M. E., & Fereydouni, N. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.11.016 · Cited by 5 · see citing works
Gui, S., Ni, J., Mizutani, S., SHIGEMATSU, N., Nakanishi, H., Kashiwazaki, H., & Wu, Z. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4045 · Cited by 5 · see citing works
Curcumin for protecting mitochondria and downregulating inflammation
Salimi, A., Jamali, Z., & Shirmard, L. R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90256-4.00014-x · Cited by 5 · see citing works
Fang, F., Zhang, S., Chen, C., Wang, X., Luo, C., & Wei, Q. L. (2023) · Optical Materials · doi:10.1016/j.optmat.2023.113800 · Cited by 5 · see citing works
Probing curcumin reactive conformers in keto-enol tautomerization enhanced by clustering with t-SNE
Rusydi, F., Susanti, E. D., Puspitasari, I. P. I., Fadilla, R. N., Madinah, R., & Mark-Lee, W. F. (2026) · Journal of Molecular Modeling · doi:10.1007/s00894-025-06621-3 · Cited by 4 · see citing works
Exosomes and their Cargo as a New Avenue for Brain and Treatment of CNS-Related Diseases
Benameur, T., Panaro, M. A., & Porro, C. (2022) · The Open Neurology Journal · doi:10.2174/1874205x-v16-e2201190 · Cited by 4 · see citing works
Kuru, G., Üner, G., & Bedіr, E. (2022) · Phytochemistry Reviews · doi:10.1007/s11101-022-09829-w · Cited by 4 · see citing works
Ji, Q., Han, L., Zhang, T., Xia, X., & Xiang, X. (2023) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2023.104931 · Cited by 4 · see citing works
Opportunities and challenges of foodborne polyphenols applied to anti-aging health foods
Zhuang, H., Zhang, X., Wu, S., Pang, Y., & Yan, H. (2024) · Food Science and Biotechnology · doi:10.1007/s10068-024-01686-x · Cited by 4 · see citing works
- Authors
- Porro, C., Cianciulli, A., Trotta, T., Lofrumento, D. D., & Panaro, M. A.
- Affiliations
- University of Foggia (IT)
- University of Bari Aldo Moro (IT)
- University of Salento (IT)
- Corresponding author
- Panaro, Maria Antonietta
- ORCID
- Venue
- Biology
- Publisher
- MDPI AG
- Published
- 2019-06-27
- Volume
- 8
- Issue
- 3
- Pages
- 51
- ISSN
- 2079-7737 (ISSN-L)
- PMC
- PMC6784227
- OpenAlex
- W2953720445
- Cited by
- 124
- References
- 40
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 19 · 2023: 28 · 2022: 17 · 2021: 18 · 2020: 15 · 2019: 3
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, public-domain)
- AIRUS (submittedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, cc-by-nc-nd)
- Funders
- Università degli Studi di Foggia
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- curcumin, microglia, neuroinflammation, SOCS1, STAT3 phosphorylation, JAK2 phosphorylation, IL-4, IL-10, anti-inflammatory cytokines, lipopolysaccharide, BV-2 cells, neurodegenerative diseases, phytochemicals
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