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Cited by 40Mitochondrial Function and PathologyMetabolism, Diabetes, and CancerBiochemical Acid Research Studies

Mitochondrial pyruvate carrier function in health and disease across the lifespan

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Buchanan, Jane, Taylor, Eric·2020·Biomolecules
DOI 10.3390/biom10081162PMC PMC7464753
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Abstract

As a nodal mediator of pyruvate metabolism, the mitochondrial pyruvate carrier (MPC) plays a pivotal role in many physiological and pathological processes across the human lifespan, from embryonic development to aging-associated neurodegeneration. Emerging research highlights the importance of the MPC in diverse conditions, such as immune cell activation, cancer cell stemness, and dopamine production in Parkinson’s disease models. Whether MPC function ameliorates or contributes to disease is highly specific to tissue and cell type. Cell- and tissue-specific differences in MPC content and activity suggest that MPC function is tightly regulated as a mechanism of metabolic, cellular, and organismal control. Accordingly, recent studies on cancer and diabetes have identified protein–protein interactions, post-translational processes, and transcriptional factors that modulate MPC function. This growing body of literature demonstrates that the MPC and other mitochondrial carriers comprise a versatile and dynamic network undergirding the metabolism of health and disease.

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  1. [2]Herzig S. Raemy E. Montessuit S. Veuthey J.L. Zamboni N. Westermann B. Kunji E.R. Martinou J.C. Identification and functional expression of the mitochondrial pyruvate carrier Science 2012 337 93 96 10.1126/science.1218530 22628554 · DOI · Paper page
  2. [3]Papa S. Francavilla A. Paradies G. Meduri B. The transport of pyruvate in rat liver mitochondria FEBS Lett. 1971 12 285 288 10.1016/0014-5793(71)80200-4 11945601 · DOI · Paper page
  3. [4]Halestrap A.P. Denton R.M. Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate Biochem. J. 1974 138 313 316 10.1042/bj1380313 4822737 PMC1166210 · DOI
  4. [5]Halestrap A.P. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors Biochem. J. 1975 148 85 96 10.1042/bj1480085 1156402 PMC1165509 · DOI · Paper page
  5. [6]Gray L.R. Tompkins S.C. Taylor E.B. Regulation of pyruvate metabolism and human disease Cell. Mol. Life Sci. 2014 71 2577 2604 10.1007/s00018-013-1539-2 24363178 PMC4059968 · DOI
  6. [7]Pithukpakorn M. Disorders of pyruvate metabolism and the tricarboxylic acid cycle Mol. Genet. Metab. 2005 85 243 246 10.1016/j.ymgme.2005.06.006 16156009 · DOI
  7. [8]Marin-Valencia I. Roe C.R. Pascual J.M. Pyruvate carboxylase deficiency: Mechanisms, mimics and anaplerosis Mol. Genet. Metab. 2010 101 9 17 10.1016/j.ymgme.2010.05.004 20598931 · DOI
  8. [9]Oonthonpan L. Rauckhorst A.J. Gray L.R. Boutron A.C. Taylor E.B. Two human patient mitochondrial pyruvate carrier mutations reveal distinct molecular mechanisms of dysfunction JCI Insight 2019 5 10.1172/jci.insight.126132 PMC6629238 31145700 · DOI
  9. [10]Brivet M. Garcia-Cazorla A. Lyonnet S. Dumez Y. Nassogne M.C. Slama A. Boutron A. Touati G. Legrand A. Saudubray J.M. Impaired mitochondrial pyruvate importation in a patient and a fetus at risk Mol. Genet. Metab. 2003 78 186 192 10.1016/S1096-7192(03)00016-7 12649063 · DOI
  10. [11]Vigueira P.A. McCommis K.S. Schweitzer G.G. Remedi M.S. Chambers K.T. Fu X. McDonald W.G. Cole S.L. Colca J.R. Kletzien R.F. Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion Cell Rep. 2014 7 2042 2053 10.1016/j.celrep.2014.05.017 24910426 PMC4074444 · DOI
  11. [12]Vanderperre B. Herzig S. Krznar P. Horl M. Ammar Z. Montessuit S. Pierredon S. Zamboni N. Martinou J.C. Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet PLoS Genet. 2016 12 e1006056 10.1371/journal.pgen.1006056 27176894 PMC4866774 · DOI
  12. [13]Bowman C.E. Zhao L. Hartung T. Wolfgang M.J. Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series Mol. Cell. Biol. 2016 36 2089 2104 10.1128/MCB.00166-16 27215380 PMC4946427 · DOI
  13. [14]Xie H.L. Zhu S. Zhang J. Wen J. Yuan H.J. Pan L.Z. Luo M.J. Tan J.H. Glucose metabolism during in vitro maturation of mouse oocytes: An study using RNA interference J. Cell. Physiol. 2018 233 6952 6964 10.1002/jcp.26484 29336483 PMC13482445 · DOI
  14. [15]Bowman C.E. Selen Alpergin E.S. Cavagnini K. Smith D.M. Scafidi S. Wolfgang M.J. Maternal Lipid Metabolism Directs Fetal Liver Programming following Nutrient Stress Cell Rep. 2019 29 1299.e1293 1310.e1293 10.1016/j.celrep.2019.09.053 31665641 PMC6896898 · DOI
  15. [17]Schultz M.B. Sinclair D.A. When stem cells grow old: Phenotypes and mechanisms of stem cell aging Development 2016 143 3 14 10.1242/dev.130633 26732838 PMC4725211 · DOI
  16. [18]Tsogtbaatar E. Landin C. Minter-Dykhouse K. Folmes C.D.L. Energy Metabolism Regulates Stem Cell Pluripotency Front. Cell Dev. Biol. 2020 8 87 10.3389/fcell.2020.00087 32181250 PMC7059177 · DOI
  17. [19]Wisidagama D.R. Thummel C.S. Regulation of Drosophila Intestinal Stem Cell Proliferation by Enterocyte Mitochondrial Pyruvate Metabolism G3 (Bethesda) 2019 9 3623 3630 10.1534/g3.119.400633 31488514 PMC6829144 · DOI
  18. [20]Schell J.C. Wisidagama D.R. Bensard C. Zhao H. Wei P. Tanner J. Flores A. Mohlman J. Sorensen L.K. Earl C.S. Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism Nat. Cell Biol. 2017 19 1027 1036 10.1038/ncb3593 28812582 PMC6137334 · DOI · Paper page
  19. [21]Flores A. Schell J. Krall A.S. Jelinek D. Miranda M. Grigorian M. Braas D. White A.C. Zhou J.L. Graham N.A. Lactate dehydrogenase activity drives hair follicle stem cell activation Nat. Cell Biol. 2017 19 1017 1026 10.1038/ncb3575 28812580 PMC5657543 · DOI · Paper page
  20. [23]Sandoval I.T. Delacruz R.G. Miller B.N. Hill S. Olson K.A. Gabriel A.E. Boyd K. Satterfield C. Van Remmen H. Rutter J. A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC) Elife 2017 6 10.7554/eLife.22706 28397687 PMC5388534 · DOI
  21. [24]Vander Heiden M.G. Cantley L.C. Thompson C.B. Understanding the Warburg effect: The metabolic requirements of cell proliferation Science 2009 324 1029 1033 10.1126/science.1160809 19460998 PMC2849637 · DOI · Paper page
  22. [25]Takaoka Y. Konno M. Koseki J. Colvin H. Asai A. Tamari K. Satoh T. Mori M. Doki Y. Ogawa K. Mitochondrial pyruvate carrier 1 expression controls cancer epithelial-mesenchymal transition and radioresistance Cancer Sci. 2019 110 1331 1339 10.1111/cas.13980 30801869 PMC6447954 · DOI
  23. [26]Tai Y. Cao F. Li M. Li P. Xu T. Wang X. Yu Y. Gu B. Yu X. Cai X. Enhanced mitochondrial pyruvate transport elicits a robust ROS production to sensitize the antitumor efficacy of interferon-gamma in colon cancer Redox Biol. 2019 20 451 457 10.1016/j.redox.2018.10.024 30439686 PMC6232645 · DOI
  24. [27]He S. Nakada D. Morrison S.J. Mechanisms of stem cell self-renewal Annu. Rev. Cell Dev. Biol. 2009 25 377 406 10.1146/annurev.cellbio.042308.113248 19575646 · DOI
  25. [28]Bensard C.L. Wisidagama D.R. Olson K.A. Berg J.A. Krah N.M. Schell J.C. Nowinski S.M. Fogarty S. Bott A.J. Wei P. Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier Cell Metab. 2020 31 284.e287 300.e287 10.1016/j.cmet.2019.11.002 31813825 PMC7004878 · DOI
  26. [29]Li X. Han G. Li X. Kan Q. Fan Z. Li Y. Ji Y. Zhao J. Zhang M. Grigalavicius M. Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells Oncotarget 2017 8 46363 46380 10.18632/oncotarget.18199 28624784 PMC5542273 · DOI
  27. [30]Zhong Y. Li X. Yu D. Li X. Li Y. Long Y. Yuan Y. Ji Z. Zhang M. Wen J.G. Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro Oncotarget 2015 6 37758 37769 10.18632/oncotarget.5386 26413751 PMC4741963 · DOI
  28. [31]Li X. Ji Y. Han G. Li X. Fan Z. Li Y. Zhong Y. Cao J. Zhao J. Zhang M. MPC1 and MPC2 expressions are associated with favorable clinical outcomes in prostate cancer BMC Cancer 2016 16 894 10.1186/s12885-016-2941-6 27852261 PMC5112705 · DOI
  29. [32]Wang L. Xu M. Qin J. Lin S.C. Lee H.J. Tsai S.Y. Tsai M.J. MPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancer Oncotarget 2016 7 14673 14683 10.18632/oncotarget.7405 26895100 PMC4924743 · DOI
  30. [33]Chai Y. Wang C. Liu W. Fan Y. Zhang Y. MPC1 deletion is associated with poor prognosis and temozolomide resistance in glioblastoma J. Neurooncol. 2019 144 293 301 10.1007/s11060-019-03226-8 31236818 · DOI
  31. [34]Karsy M. Guan J. Huang L.E. Prognostic role of mitochondrial pyruvate carrier in isocitrate dehydrogenase-mutant glioma J. Neurosurg. 2018 130 56 66 10.3171/2017.9.JNS172036 29547090 · DOI
  32. [35]Xiao B. Fan Y. Ye M. Lv S. Xu B. Chai Y. Wu M. Zhu X. Downregulation of COUP-TFII inhibits glioblastoma growth via targeting MPC1 Oncol. Lett. 2018 15 9697 9702 10.3892/ol.2018.8601 29928345 PMC6004717 · DOI
  33. [36]Marin-Valencia I. Yang C. Mashimo T. Cho S. Baek H. Yang X.L. Rajagopalan K.N. Maddie M. Vemireddy V. Zhao Z. Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo Cell Metab. 2012 15 827 837 10.1016/j.cmet.2012.05.001 22682223 PMC3372870 · DOI · Paper page
  34. [38]Seyfried T.N. Shelton L. Arismendi-Morillo G. Kalamian M. Elsakka A. Maroon J. Mukherjee P. Provocative Question: Should Ketogenic Metabolic Therapy Become the Standard of Care for Glioblastoma? Neurochem. Res. 2019 44 2392 2404 10.1007/s11064-019-02795-4 31025151 · DOI
  35. [39]Koh E. Kim Y.K. Shin D. Kim K.S. MPC1 is essential for PGC-1alpha-induced mitochondrial respiration and biogenesis Biochem. J. 2018 475 1687 1699 10.1042/BCJ20170967 29669911 · DOI
  36. [40]Tang X.P. Chen Q. Li Y. Wang Y. Zou H.B. Fu W.J. Niu Q. Pan Q.G. Jiang P. Xu X.S. Mitochondrial pyruvate carrier 1 functions as a tumor suppressor and predicts the prognosis of human renal cell carcinoma Lab. Investig. 2019 99 191 199 10.1038/s41374-018-0138-0 30291323 · DOI
  37. [41]Li Y. Li X. Kan Q. Zhang M. Li X. Xu R. Wang J. Yu D. Goscinski M.A. Wen J.G. Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas Oncotarget 2017 8 1058 1073 10.18632/oncotarget.13717 27911865 PMC5352034 · DOI
  38. [42]Zou H. Chen Q. Zhang A. Wang S. Wu H. Yuan Y. Wang S. Yu J. Luo M. Wen X. MPC1 deficiency accelerates lung adenocarcinoma progression through the STAT3 pathway Cell Death Dis. 2019 10 148 10.1038/s41419-019-1324-8 30770798 PMC6377639 · DOI
  39. [43]Hensley C.T. Faubert B. Yuan Q. Lev-Cohain N. Jin E. Kim J. Jiang L. Ko B. Skelton R. Loudat L. Metabolic Heterogeneity in Human Lung Tumors Cell 2016 164 681 694 10.1016/j.cell.2015.12.034 26853473 PMC4752889 · DOI · Paper page
  40. [44]Hui S. Ghergurovich J.M. Morscher R.J. Jang C. Teng X. Lu W. Esparza L.A. Reya T. Le Z. Yanxiang Guo J. Glucose feeds the TCA cycle via circulating lactate Nature 2017 551 115 118 10.1038/nature24057 29045397 PMC5898814 · DOI · Paper page
  41. [45]Chen Y.J. Mahieu N.G. Huang X. Singh M. Crawford P.A. Johnson S.L. Gross R.W. Schaefer J. Patti G.J. Lactate metabolism is associated with mammalian mitochondria Nat. Chem. Biol. 2016 12 937 943 10.1038/nchembio.2172 27618187 PMC5069139 · DOI · Paper page
  42. [46]Valenti D. de Bari L. Atlante A. Passarella S. L-Lactate transport into rat heart mitochondria and reconstruction of the L-lactate/pyruvate shuttle Biochem. J. 2002 364 101 104 10.1042/bj3640101 11988081 PMC1222550 · DOI
  43. [47]Passarella S. de Bari L. Valenti D. Pizzuto R. Paventi G. Atlante A. Mitochondria and L-lactate metabolism FEBS Lett. 2008 582 3569 3576 10.1016/j.febslet.2008.09.042 18831974 · DOI
  44. [48]Passarella S. Schurr A. l-Lactate Transport and Metabolism in Mitochondria of Hep G2 Cells-The Cori Cycle Revisited Front. Oncol. 2018 8 120 10.3389/fonc.2018.00120 29740537 PMC5924780 · DOI
  45. [49]Bader D.A. Hartig S.M. Putluri V. Foley C. Hamilton M.P. Smith E.A. Saha P.K. Panigrahi A. Walker C. Zong L. Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer Nat. Metab. 2019 1 70 85 10.1038/s42255-018-0002-y 31198906 PMC6563330 · DOI
  46. [51]Kim J. Yu L. Chen W. Xu Y. Wu M. Todorova D. Tang Q. Feng B. Jiang L. He J. Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation Cancer Cell 2019 35 191.e198 203.e198 10.1016/j.ccell.2018.12.012 30712844 · DOI
  47. [52]Jung K.H. Lee J.H. Park J.W. Moon S.H. Cho Y.S. Lee K.H. Troglitazone exerts metabolic and antitumor effects on T47D breast cancer cells by suppressing mitochondrial pyruvate availability Oncol. Rep. 2020 43 711 717 10.3892/or.2019.7436 31894283 · DOI
  48. [53]Park S. Safi R. Liu X. Baldi R. Liu W. Liu J. Locasale J.W. Chang C.Y. McDonnell D.P. Inhibition of ERRalpha Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer Cell Rep. 2019 27 3587.e3584 3601.e3584 10.1016/j.celrep.2019.05.066 31216477 PMC6604861 · DOI
  49. [54]Dan L. Wang C. Ma P. Yu Q. Gu M. Dong L. Jiang W. Pan S. Xie C. Han J. PGC1alpha promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect Cell Death Dis. 2018 9 466 10.1038/s41419-018-0494-0 29700317 PMC5919932 · DOI
  50. [55]Corbet C. Bastien E. Draoui N. Doix B. Mignion L. Jordan B.F. Marchand A. Vanherck J.C. Chaltin P. Schakman O. Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects Nat. Commun. 2018 9 1208 10.1038/s41467-018-03525-0 29572438 PMC5865202 · DOI
  51. [57]Sharma A. Oonthonpan L. Sheldon R.D. Rauckhorst A.J. Zhu Z. Tompkins S.C. Cho K. Grzesik W.J. Gray L.R. Scerbo D.A. Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness Elife 2019 8 10.7554/eLife.45873 PMC6684275 31305240 · DOI
  52. [58]Lou M.D. Li J. Cheng Y. Xiao N. Ma G. Li P. Liu B. Liu Q. Qi L.W. Glucagon up-regulates hepatic mitochondrial pyruvate carrier 1 through cAMP-responsive element-binding protein; inhibition of hepatic gluconeogenesis by ginsenoside Rb1 Br. J. Pharmacol. 2019 176 2962 2976 10.1111/bph.14758 31166615 PMC6637041 · DOI
  53. [59]Rauckhorst A.J. Gray L.R. Sheldon R.D. Fu X. Pewa A.D. Feddersen C.R. Dupuy A.J. Gibson-Corley K.N. Cox J.E. Burgess S.C. The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity Mol. Metab. 2017 6 1468 1479 10.1016/j.molmet.2017.09.002 29107293 PMC5681281 · DOI
  54. [60]McCommis K.S. Chen Z. Fu X. McDonald W.G. Colca J.R. Kletzien R.F. Burgess S.C. Finck B.N. Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling Cell Metab. 2015 22 682 694 10.1016/j.cmet.2015.07.028 26344101 PMC4598280 · DOI
  55. [61]Gray L.R. Sultana M.R. Rauckhorst A.J. Oonthonpan L. Tompkins S.C. Sharma A. Fu X. Miao R. Pewa A.D. Brown K.S. Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis Cell Metab. 2015 22 669 681 10.1016/j.cmet.2015.07.027 26344103 PMC4754674 · DOI
  56. [62]Li A. Liu Q. Li Q. Liu B. Yang Y. Zhang N. Berberine Reduces Pyruvate-driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1 EBioMedicine 2018 34 243 255 10.1016/j.ebiom.2018.07.039 30093307 PMC6117739 · DOI
  57. [63]Vigueira P.A. McCommis K.S. Hodges W.T. Schweitzer G.G. Cole S.L. Oonthonpan L. Taylor E.B. McDonald W.G. Kletzien R.F. Colca J.R. The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism Exp. Physiol. 2017 102 985 999 10.1113/EP086380 28597936 PMC5667918 · DOI
  58. [64]McCommis K.S. Hodges W.T. Brunt E.M. Nalbantoglu I. McDonald W.G. Holley C. Fujiwara H. Schaffer J.E. Colca J.R. Finck B.N. Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis Hepatology 2017 65 1543 1556 10.1002/hep.29025 28027586 PMC5397348 · DOI
  59. [65]Zou S. Lang T. Zhang B. Huang K. Gong L. Luo H. Xu W. He X. Fatty acid oxidation alleviates the energy deficiency caused by the loss of MPC1 in MPC1(+/-) mice Biochem. Biophys. Res. Commun. 2018 495 1008 1013 10.1016/j.bbrc.2017.11.134 29175325 · DOI
  60. [66]Li X. Li Y. Han G. Li X. Ji Y. Fan Z. Zhong Y. Cao J. Zhao J. Mariusz G. Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses Oncotarget 2016 7 79981 79994 10.18632/oncotarget.13210 27835892 PMC5346765 · DOI
  61. [67]Feng J. Ma Y. Chen Z. Hu J. Yang Q. Ding G. Mitochondrial pyruvate carrier 2 mediates mitochondrial dysfunction and apoptosis in high glucose-treated podocytes Life Sci. 2019 237 116941 10.1016/j.lfs.2019.116941 31606382 · DOI
  62. [68]Han P. Wang Y. Zhan H. Weng W. Yu X. Ge N. Wang W. Song G. Yi T. Li S. Artemether ameliorates type 2 diabetic kidney disease by increasing mitochondrial pyruvate carrier content in db/db mice Am. J. Transl. Res. 2019 11 1389 1402 30972169 PMC6456515
  63. [69]Zhu H. Wan H. Wu L. Li Q. Liu S. Duan S. Huang Z. Zhang C. Zhang B. Xing C. Mitochondrial pyruvate carrier: A potential target for diabetic nephropathy BMC Nephrol. 2020 21 274 10.1186/s12882-020-01931-5 32664896 PMC7362444 · DOI
  64. [70]McCommis K.S. Hodges W.T. Bricker D.K. Wisidagama D.R. Compan V. Remedi M.S. Thummel C.S. Finck B.N. An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion Mol. Metab. 2016 5 602 614 10.1016/j.molmet.2016.06.016 27656398 PMC5021712 · DOI
  65. [72]Vadvalkar S.S. Matsuzaki S. Eyster C.A. Giorgione J.R. Bockus L.B. Kinter C.S. Kinter M. Humphries K.M. Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart: ROLE OF MITOCHONDRIAL PYRUVATE CARRIER 2 (MPC2) ACETYLATION J. Biol. Chem. 2017 292 4423 4433 10.1074/jbc.M116.753509 28154187 PMC5377762 · DOI
  66. [73]Divakaruni A.S. Wallace M. Buren C. Martyniuk K. Andreyev A.Y. Li E. Fields J.A. Cordes T. Reynolds I.J. Bloodgood B.L. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death J. Cell Biol. 2017 216 1091 1105 10.1083/jcb.201612067 28254829 PMC5379957 · DOI
  67. [75]Rossi A. Rigotto G. Valente G. Giorgio V. Basso E. Filadi R. Pizzo P. Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer’s Disease-Related Models Cell Rep. 2020 30 2332.e2310 2348.e2310 10.1016/j.celrep.2020.01.060 32075767 · DOI · Paper page
  68. [76]Ghosh A. Tyson T. George S. Hildebrandt E.N. Steiner J.A. Madaj Z. Schulz E. Machiela E. McDonald W.G. Escobar Galvis M.L. Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson’s disease Sci. Transl. Med. 2016 8 368ra174 10.1126/scitranslmed.aag2210 27928028 · DOI
  69. [77]Yang Y. Wang L. Li L. Li W. Zhang Y. Chang H. Xiao X. Li M. Lv L. Genetic association and meta-analysis of a schizophrenia GWAS variant rs10489202 in East Asian populations Transl. Psychiatry 2018 8 144 10.1038/s41398-018-0211-x 30087317 PMC6081446 · DOI
  70. [78]Jin C. Zhang Y. Wang J. Zhou Z. Sha W. Wang M. Zhang F. Li J. Li J. Yu S. Lack of association between MPC2 variants and schizophrenia in a replication study of Han Chinese Neurosci. Lett. 2013 552 120 123 10.1016/j.neulet.2013.07.051 23933155 · DOI
  71. [79]Krauss S. Brand M.D. Buttgereit F. Signaling takes a breath--new quantitative perspectives on bioenergetics and signal transduction Immunity 2001 15 497 502 10.1016/S1074-7613(01)00205-9 11672532 · DOI · Paper page
  72. [80]Rathmell J.C. Vander Heiden M.G. Harris M.H. Frauwirth K.A. Thompson C.B. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability Mol. Cell 2000 6 683 692 10.1016/S1097-2765(00)00066-6 11030347 · DOI · Paper page
  73. [81]Roos D. Loos J.A. Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. II. Relative importance of glycolysis and oxidative phosphorylation on phytohaemagglutinin stimulation Exp. Cell Res. 1973 77 127 135 10.1016/0014-4827(73)90561-2 4690164 · DOI
  74. [82]Ekiz H.A. Ramstead A.G. Lee S.H. Nelson M.C. Bauer K.M. Wallace J.A. Hu R. Round J.L. Rutter J. Drummond M.J. T Cell-Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation J. Immunol. 2020 204 2064 2075 10.4049/jimmunol.1901484 32161096 PMC7325601 · DOI
  75. [83]Ramstead A.G. Wallace J.A. Lee S.H. Bauer K.M. Tang W.W. Ekiz H.A. Lane T.E. Cluntun A.A. Bettini M.L. Round J.L. Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development Cell Rep. 2020 30 2889.e2886 2899.e2886 10.1016/j.celrep.2020.02.042 32130894 PMC7170217 · DOI
  76. [84]Lam W.Y. Becker A.M. Kennerly K.M. Wong R. Curtis J.D. Llufrio E.M. McCommis K.S. Fahrmann J. Pizzato H.A. Nunley R.M. Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells Immunity 2016 45 60 73 10.1016/j.immuni.2016.06.011 27396958 PMC4956536 · DOI
  77. [85]Sze D.M. Toellner K.M. Garcia de Vinuesa C. Taylor D.R. MacLennan I.C. Intrinsic constraint on plasmablast growth and extrinsic limits of plasma cell survival J. Exp. Med. 2000 192 813 821 10.1084/jem.192.6.813 10993912 PMC2193289 · DOI
  78. [86]Jacob J. Kassir R. Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations J. Exp. Med. 1991 173 1165 1175 10.1084/jem.173.5.1165 1902502 PMC2118845 · DOI
  79. [88]Zhan Y. Carrington E.M. Zhang Y. Heinzel S. Lew A.M. Life and Death of Activated T Cells: How Are They Different from Naive T Cells? Front. Immunol. 2017 8 1809 10.3389/fimmu.2017.01809 29326701 PMC5733345 · DOI
  80. [89]Du J. Cleghorn W. Contreras L. Linton J.D. Chan G.C. Chertov A.O. Saheki T. Govindaraju V. Sadilek M. Satrustegui J. Cytosolic reducing power preserves glutamate in retina Proc. Natl. Acad. Sci. USA 2013 110 18501 18506 10.1073/pnas.1311193110 24127593 PMC3831988 · DOI
  81. [90]Du J. Yanagida A. Knight K. Engel A.L. Vo A.H. Jankowski C. Sadilek M. Tran V.T. Manson M.A. Ramakrishnan A. Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium Proc. Natl. Acad. Sci. USA 2016 113 14710 14715 10.1073/pnas.1604572113 27911769 PMC5187684 · DOI
  82. [91]Xu R. Ritz B.K. Wang Y. Huang J. Zhao C. Gong K. Liu X. Du J. The retina and retinal pigment epithelium differ in nitrogen metabolism and are metabolically connected J. Biol. Chem. 2020 295 2324 2335 10.1074/jbc.RA119.011727 31953322 PMC7039560 · DOI
  83. [92]Grenell A. Wang Y. Yam M. Swarup A. Dilan T.L. Hauer A. Linton J.D. Philp N.J. Gregor E. Zhu S. Loss of MPC1 reprograms retinal metabolism to impair visual function Proc. Natl. Acad. Sci. USA 2019 116 3530 3535 10.1073/pnas.1812941116 30808746 PMC6397593 · DOI
  84. [93]Du J. Cleghorn W.M. Contreras L. Lindsay K. Rountree A.M. Chertov A.O. Turner S.J. Sahaboglu A. Linton J. Sadilek M. Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina J. Biol. Chem. 2013 288 36129 36140 10.1074/jbc.M113.507285 24187136 PMC3861660 · DOI
  85. [95]Kalavalapalli S. Bril F. Koelmel J.P. Abdo K. Guingab J. Andrews P. Li W.Y. Jose D. Yost R.A. Frye R.F. Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis Am. J. Physiol. Endocrinol. Metab. 2018 315 E163 E173 10.1152/ajpendo.00023.2018 29634314 PMC6139494 · DOI
  86. [96]Colca J.R. VanderLugt J.T. Adams W.J. Shashlo A. McDonald W.G. Liang J. Zhou R. Orloff D.G. Clinical proof-of-concept study with MSDC-0160, a prototype mTOT-modulating insulin sensitizer Clin. Pharmacol. Ther. 2013 93 352 359 10.1038/clpt.2013.10 23462886 PMC3604641 · DOI
  87. [97]Harrison S.A. Alkhouri N. Davison B.A. Sanyal A. Edwards C. Colca J.R. Lee B.H. Loomba R. Cusi K. Kolterman O. Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study J. Hepatol. 2020 72 613 626 10.1016/j.jhep.2019.10.023 31697972 · DOI · Paper page
  88. [98]Lacroix M. Rodier G. Kirsh O. Houles T. Delpech H. Seyran B. Gayte L. Casas F. Pessemesse L. Heuillet M. E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity Proc. Natl. Acad. Sci. USA 2016 113 10998 11003 10.1073/pnas.1602754113 27621446 PMC5047171 · DOI
  89. [99]Chen C.N. Lin S.Y. Liao Y.H. Li Z.J. Wong A.M. Late-onset caloric restriction alters skeletal muscle metabolism by modulating pyruvate metabolism Am. J. Physiol. Endocrinol. Metab. 2015 308 E942 E949 10.1152/ajpendo.00508.2014 26032513 · DOI · Paper page
  90. [100]Tornatore L. Thotakura A.K. Bennett J. Moretti M. Franzoso G. The nuclear factor kappa B signaling pathway: Integrating metabolism with inflammation Trends Cell Biol. 2012 22 557 566 10.1016/j.tcb.2012.08.001 22995730 · DOI
  91. [101]Liang L. Li Q. Huang L. Li D. Li X. Sirt3 binds to and deacetylates mitochondrial pyruvate carrier 1 to enhance its activity Biochem. Biophys. Res. Commun. 2015 468 807 812 10.1016/j.bbrc.2015.11.036 26577410 · DOI
  92. [102]Taylor E.B. Functional Properties of the Mitochondrial Carrier System Trends Cell Biol. 2017 27 633 644 10.1016/j.tcb.2017.04.004 28522206 PMC5773108 · DOI
  93. [103]Palmieri F. Monne M. Discoveries, metabolic roles and diseases of mitochondrial carriers: A review Biochim. Biophys. Acta 2016 1863 2362 2378 10.1016/j.bbamcr.2016.03.007 26968366 · DOI

Cited by

Sorted by citations

Authors
Buchanan, J., & Taylor, E.
Affiliations
University of Iowa (US)
Corresponding author
Taylor, Eric
ORCID
Venue
Biomolecules
Publisher
MDPI AG
Published
2020-08-08
Volume
10
Issue
8
Pages
1162
ISSN
2218-273X (ISSN-L)
DOI
10.3390/biom10081162
PMC
PMC7464753
OpenAlex
W3048285610
Cited by
40
References
10
Citations by year
2026: 4 · 2025: 12 · 2024: 10 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 2
FWCI
0.34
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomolecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (DK104998)
  • NIH Medical Scientist Training Program T32 grant (GM007337)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
Keywords
mitochondrial pyruvate carrier, pyruvate metabolism, mitochondrial carrier protein, embryonic development, immune cell activation, dopamine synthesis, Parkinson's disease, cancer metabolism, diabetes mellitus, post-translational regulation, transcriptional regulation, protein-protein interaction
MeSH terms
Aging, Animals, Diabetes Mellitus, Humans, Neoplasms, Pyruvic Acid, Neurodegenerative Diseases, Monocarboxylic Acid Transporters, Mitochondrial Membrane Transport Proteins

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