Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

Ferlay, J., Shin, H.-R., Bray, F., Forman, D., Mathers, C., & Parkin, D. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25516 · Cited by 22,207 · see citing works

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455 · see citing works

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

Estes, C., Razavi, H. A., Loomba, R. S., Younossi, Z. M., & Sanyal, A. J. (2017) · Hepatology · doi:10.1002/hep.29466 · Cited by 2,416 · see citing works

Understanding the Intersections between Metabolism and Cancer Biology

Heiden, M. G. V., & DeBerardinis, R. J. (2017) · Cell · doi:10.1016/j.cell.2016.12.039 · Cited by 2,316 · see citing works

From Krebs to clinic: glutamine metabolism to cancer therapy

Altman, B. J., Stine, Z. E., & Dang, C. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.71 · Cited by 2,119 · see citing works

Glutathione metabolism in cancer progression and treatment resistance

Bansal, A., & Simon, M. C. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201804161 · Cited by 1,234 · see citing works

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

Harris, I. S., Treloar, A. E., Inoue, S., Sasaki, M., Gorrini, C., Lee, K. C., Yung, K. Y., Brenner, D., Knobbe-Thomsen, C. B., Cox, M. A., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.11.019 · Cited by 993 · see citing works

Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace

Baffy, G., Brunt, E. M., & Caldwell, S. H. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.10.027 · Cited by 856 · see citing works

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, <i>Drosophila</i> , and Humans

Bricker, D. K., Taylor, E. B., Schell, J. C., Orsak, T., Boutron, A., Chen, Y.-C., Cox, J. E., Cardon, C. M., Van Vranken, J. G., Dephoure, N., et al. (2012) · Science · doi:10.1126/science.1218099 · Cited by 843 · see citing works

Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009

Younossi, Z. M., Otgonsuren, M., Henry, L., Venkatesan, C., Mishra, A., Erario, M., & Hunt, S. (2015) · Hepatology · doi:10.1002/hep.28123 · Cited by 802 · see citing works

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

Herzig, S., Raemy, E., Montessuit, S., Veuthey, J.-L., Zamboni, N., Westermann, B., Kunji, E. R. S., & Martinou, J.-C. (2012) · Science · doi:10.1126/science.1218530 · Cited by 747 · see citing works

Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport

Yang, C., Ko, B., Hensley, C. T., Jiang, L., Wasti, A. T., Kim, J., Sudderth, J., Calvaruso, M. A., Lumata, L., Mitsche, M., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.025 · Cited by 679 · see citing works

Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine

Zhang, J., Pavlova, N. N., & Thompson, C. B. (2017) · The EMBO Journal · doi:10.15252/embj.201696151 · Cited by 651 · see citing works

Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team

Dyson, J., Jaques, B., Chattopadyhay, D., Lochan, R., Graham, J., Das, D., Aslam, T., Patanwala, I., Gaggar, S., Cole, M., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.08.011 · Cited by 603 · cited 13× · see citing works

Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics

Huang, Q., Tan, Y., Yin, P., Ye, G., Gao, P., Lu, X., Wang, H., & Xu, G. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0308 · Cited by 415 · see citing works

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

Satapati, S., Sunny, N. E., Kucejova, B., Fu, X., He, T. T., Méndez-Lucas, A., Shelton, J. M., Perales, J. C., Browning, J. D., & Burgess, S. C. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m023382 · Cited by 407 · see citing works

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

Satapati, S., Kucejová, B., Duarte, J. A. G., Fletcher, J. A., Reynolds, L., Sunny, N. E., He, T., Nair, L. A., Livingston, K. A., Fu, X., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci82204 · Cited by 400 · see citing works

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

Schell, J. C., Wisidagama, D. R., Bensard, C., Zhao, H., Wei, P., Tanner, J., Flores, A., Mohlman, J., Sorensen, L. K., Earl, C. S., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3593 · Cited by 322 · see citing works

Lactate dehydrogenase activity drives hair follicle stem cell activation

Flores, A., Schell, J., Krall, A. S., Jelinek, D., Miranda, M., Grigorian, M., Braas, D., White, A. C., Zhou, J. L., Graham, N. A., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3575 · Cited by 301 · see citing works

Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier

Vacanti, N. M., Divakaruni, A. S., Green, C. R., Parker, S. J., Henry, R. R., Ciaraldi, T. P., Murphy, A. N., & Metallo, C. M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.024 · Cited by 277 · see citing works

The story of HCC in NAFLD : from epidemiology, across pathogenesis, to prevention and treatment

Margini, C., & Dufour, J. (2015) · Liver International · doi:10.1111/liv.13031 · Cited by 246 · see citing works

Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis

Gray, L. R., Sultana, M. R., Rauckhorst, A. J., Oonthonpan, L., Tompkins, S. C., Sharma, A., Fu, X., Miao, R., Pewa, A. D., Brown, K., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.027 · Cited by 217 · see citing works

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling

McCommis, K. S., Chen, Z., Fu, X., McDonald, W. G., Colca, J. R., Kletzien, R. F., Burgess, S. C., & Finck, B. N. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.028 · Cited by 210 · see citing works

Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer

Bader, D. A., Hartig, S. M., Putluri, V., Foley, C., Hamilton, M. P., Smith, E. A., Saha, P., Panigrahi, A., Walker, C. M., Zong, L., et al. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0002-y · Cited by 168 · see citing works

Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma

Ma, R., Zhang, W., Tang, K., Zhang, H., Zhang, Y., Li, D., Li, Y., Xu, P., Luo, S., Cai, W., et al. (2013) · Nature Communications · doi:10.1038/ncomms3508 · Cited by 163 · see citing works

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

Divakaruni, A. S., Wallace, M., Buren, C., Martyniuk, K. M., Andreyev, A. Y., Li, E., Fields, J. A., Cordes, T., Reynolds, I. J., Bloodgood, B. L., et al. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201612067 · Cited by 157 · see citing works

The DEN and CCl4‐Induced Mouse Model of Fibrosis and Inflammation‐Associated Hepatocellular Carcinoma

Uehara, T., Pogribny, I. P., & Rusyn, I. (2014) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph1430s66 · Cited by 156 · see citing works

Distinctive features of hepatocellular carcinoma in non-alcoholic fatty liver disease

Degasperi, E., & Colombo, M. (2016) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(16)30018-8 · Cited by 155 · see citing works

Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma

Hirata, H., Sugimachi, K., Komatsu, H., Ueda, M., Masuda, T., Uchi, R., Sakimura, S., Nambara, S., Saito, T., Shinden, Y., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2601 · Cited by 151 · see citing works

Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis

McCommis, K. S., Hodges, W. T., Brunt, E. M., Nalbantoglu, I., McDonald, W. G., Holley, C. L., Fujiwara, H., Schaffer, J. E., Colca, J. R., & Finck, B. N. (2016) · Hepatology · doi:10.1002/hep.29025 · Cited by 138 · see citing works

Multifaceted Roles of Glutathione and Glutathione-Based Systems in Carcinogenesis and Anticancer Drug Resistance

Hatem, E., Banna, N. E., & Huang, M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7134 · Cited by 126 · see citing works

Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma

Kutlu, Ö., Kaleli, H. N., & Ozer, E. (2018) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2018/8543763 · Cited by 102 · see citing works

New Serum Markers of Hepatocellular Carcinoma

Masuzaki, R., Karp, S. J., & Omata, M. (2012) · Seminars in Oncology · doi:10.1053/j.seminoncol.2012.05.009 · Cited by 101 · see citing works

Loss of MPC1 reprograms retinal metabolism to impair visual function

Grenell, A., Wang, Y., Yam, M., Swarup, A., Dilan, T. L., Hauer, A., Linton, J. D., Philp, N. J., Gregor, E., Zhu, S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812941116 · Cited by 101 · see citing works

Human thyroxine binding globulin (TBG) promoter directs efficient and sustaining transgene expression in liver-specific pattern

Yan, Z., Yan, H., & Ou, H. (2012) · Gene · doi:10.1016/j.gene.2012.07.009 · Cited by 87 · see citing works

Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats

Pound, A. W., & McGuire, L. J. (1978) · British Journal of Cancer · doi:10.1038/bjc.1978.88 · Cited by 85 · see citing works

The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

Rauckhorst, A. J., Gray, L. R., Sheldon, R. D., Fu, X., Pewa, A. D., Feddersen, C. R., Dupuy, A. J., Gibson-Corley, K. N., Cox, J. E., Burgess, S. C., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.09.002 · Cited by 74 · see citing works

The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state

Tavoulari, S., Thangaratnarajah, C., Mavridou, V., Harbour, M. E., Martinou, J., & Kunji, E. R. (2019) · The EMBO Journal · doi:10.15252/embj.2018100785 · Cited by 73 · see citing works

Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells

Li, X., Han, G., Li, X., Kan, Q., Fan, Z., Li, Y., Ji, Y., Zhao, J., Zhang, M., Grigalavicius, M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18199 · Cited by 71 · see citing works

mTORC2 controls cancer cell survival by modulating gluconeogenesis

Khan, M. W., Biswas, D., Ghosh, M., Mandloi, S., Chakrabarti, S., & Chakrabarti, P. (2015) · Cell Death Discovery · doi:10.1038/cddiscovery.2015.16 · Cited by 70 · see citing works

Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness

Sharma, A., Oonthonpan, L., Sheldon, R. D., Rauckhorst, A. J., Zhu, Z., Tompkins, S. C., Cho, K., Grzesik, W. J., Gray, L. R., Scerbo, D. A., et al. (2019) · eLife · doi:10.7554/elife.45873 · Cited by 67 · see citing works

p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis

Lam, H. C., Baglini, C. V., Lope, A. L., Parkhitko, A. A., Liu, H.-J., Alesi, N., Malinowska, I. A., Ebrahimi‐Fakhari, D., Saffari, A., Yu, J. J., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2458 · Cited by 61 · see citing works

Clinical applications of urinary organic acids. Part I: Detoxification markers.

Lord, R. S., & Bralley, J. A. (2008) · PubMed · Cited by 60 · see citing works

MSDC-0602K, a metabolic modulator directed at the core pathology of non-alcoholic steatohepatitis

Colca, J. R., McDonald, W. G., & Adams, W. J. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1494153 · Cited by 49 · see citing works

Mammalian Sulfur Amino Acid Metabolism: A Nexus Between Redox Regulation, Nutrition, Epigenetics, and Detoxification

Pajares, M. A., & Pérez‐Sala, D. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7237 · Cited by 48 · see citing works

Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas

Li, Y., Li, X., Kan, Q., Zhang, M., Li, X., Xu, R., Wang, J., Yu, D., Goscinski, M. A., Wen, J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13717 · Cited by 41 · see citing works

Glutathione metabolism modeling: A mechanism for liver drug-robustness and a new biomarker strategy

Geenen, S., du Preez, F. B., Snoep, J. L., Foster, A. J., Sarda, S., Kenna, J. G., Wilson, I. D., & Westerhoff, H. V. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.04.014 · Cited by 39 · see citing works

Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis

Orrù, C., Szydlowska, M., Taguchi, K., Zavattari, P., Perra, A., Yamamoto, M. P., & Columbano, A. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.05.010 · Cited by 38 · see citing works

A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)

Sandoval, I. T., Delacruz, R. G. C., Miller, B. N., Hill, S., Olson, K. A., Gabriel, A. E., Boyd, K. A., Satterfield, C., Remmen, H. V., Rutter, J. P., et al. (2017) · eLife · doi:10.7554/elife.22706 · Cited by 32 · see citing works

Two human patient mitochondrial pyruvate carrier mutations reveal distinct molecular mechanisms of dysfunction

Oonthonpan, L., Rauckhorst, A. J., Gray, L. R., Boutron, A., & Taylor, E. B. (2019) · JCI Insight · doi:10.1172/jci.insight.126132 · Cited by 31 · see citing works

The anti-angiogenic effect of dexamethasone in a murine hepatocellular carcinoma model by augmentation of gluconeogenesis pathway in malignant cells

Shang, F., Liu, M., Li, B., Zhang, X., Sheng, Y., Liu, S., Han, J., Li, H., & Xiu, R. (2016) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-016-3030-x · Cited by 29 · see citing works

Glutathione biosynthesis is upregulated at the initiation of MYCN‐driven neuroblastoma tumorigenesis

Carter, D. R., Sutton, S. K., Pajic, M., Murray, J. E., Sekyere, E. O., Fletcher, J. I., Beckers, A., Preter, K. D., Speleman, F., George, R. E., et al. (2016) · Molecular Oncology · doi:10.1016/j.molonc.2016.02.004 · Cited by 25 · see citing works

Prevention of Hepatocellular Carcinoma

Schütte, K., Balbisi, F., & Malfertheiner, P. (2016) · Gastrointestinal Tumors · doi:10.1159/000446680 · Cited by 22 · see citing works

Mitochondrial Signaling and Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Implications

Facciorusso, A., Villani, R., Bellanti, F., Mitarotonda, D., Vendemiale, G., & Serviddio, G. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160209153624 · Cited by 18 · see citing works

Meta-analysis of gene expression profiles identifies differential biomarkers for hepatocellular carcinoma and cholangiocarcinoma

Likhitrattanapisal, S., Tipanee, J., & Janvilisri, T. (2016) · Tumor Biology · doi:10.1007/s13277-016-5186-8 · Cited by 17 · see citing works

Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice

Marrone, A. K., Shpyleva, S., Chappell, G. A., Tryndyak, V., Uehara, T., Tsuchiya, M., Beland, F. A., Rusyn, I., & Pogribny, I. P. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22323 · Cited by 13 · see citing works

Characterization of copy number alterations in a mouse model of fibrosis‐associated hepatocellular carcinoma reveals concordance with human disease

Chappell, G. A., Silva, G. O., Uehara, T., Pogribny, I. P., & Rusyn, I. (2016) · Cancer Medicine · doi:10.1002/cam4.606 · Cited by 8 · see citing works

Glutamine reliance in cell metabolism

Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental &amp; Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021 · see citing works

Redox regulation of immunometabolism

Muri, J., & Köpf, M. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-00478-8 · Cited by 501 · see citing works

Changes in Glutathione Content in Liver Diseases: An Update

Vairetti, M., Pasqua, L. G. D., Cagna, M., Richelmi, P., Ferrigno, A., & Berardo, C. (2021) · Antioxidants · doi:10.3390/antiox10030364 · Cited by 323 · see citing works

The multifaceted pyruvate metabolism: role of the mitochondrial pyruvate carrier

Zangari, J., Petrelli, F., Maillot, B., & Martinou, J.-C. (2020) · Biomolecules · doi:10.3390/biom10071068 · Cited by 172 · see citing works

Tumour metabolism and its unique properties in prostate adenocarcinoma

Bader, D. A., & McGuire, S. E. (2020) · Nature Reviews Urology · doi:10.1038/s41585-020-0288-x · Cited by 154 · see citing works

Glutathione Metabolism and the Novel Role of Mitochondrial GSH in Retinal Degeneration

Sreekumar, P. G., Ferrington, D. A., & Kannan, R. (2021) · Antioxidants · doi:10.3390/antiox10050661 · Cited by 103 · see citing works

Mitochondrial pyruvate carrier 1 regulates ferroptosis in drug-tolerant persister head and neck cancer cells via epithelial-mesenchymal transition

You, J. H., Lee, J., & Roh, J. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.03.013 · Cited by 90 · see citing works

Advancing Cancer Treatment by Targeting Glutamine Metabolism—A Roadmap

Halama, A., & Suhre, K. (2022) · Cancers · doi:10.3390/cancers14030553 · Cited by 92 · see citing works

The mitochondrial pyruvate carrier (MPC) complex mediates one of three pyruvate-supplying pathways that sustain Arabidopsis respiratory metabolism

Le, X. H., Lee, C. P., & Millar, A. H. (2021) · The Plant Cell · doi:10.1093/plcell/koab148 · Cited by 83 · see citing works

The Importance of Mitochondrial Pyruvate Carrier in Cancer Cell Metabolism and Tumorigenesis

Ruiz-Iglesias, A., & Mañes, S. (2021) · Cancers · doi:10.3390/cancers13071488 · Cited by 76 · see citing works

Cancer cell metabolism: Rewiring the mitochondrial hub

Oliveira, G. L., Coelho, A. R., Marques, R., & Oliveira, P. J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.166016 · Cited by 62 · see citing works

Liver mitochondrial DNA damage and genetic variability of Cytochrome b – a key component of the respirasome – drive the severity of fatty liver disease

Pirola, C. J., Garaycoechea, M. E., Flichman, D. M., Castaño, G. O., & Sookoian, S. C. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13147 · Cited by 63 · see citing works

Remodeling of Mitochondrial Plasticity: The Key Switch from NAFLD/NASH to HCC

Longo, M., Paolini, E., Meroni, M., & Dongiovanni, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084173 · Cited by 61 · see citing works

Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling

Veliova, M., Ferreira, C. M., Benador, I. Y., Jones, A. E., Mahdaviani, K., Brownstein, A. J., Desousa, B. R., Acín‐Pérez, R., Petcherski, A., Assali, E. A., et al. (2020) · EMBO Reports · doi:10.15252/embr.201949634 · Cited by 51 · see citing works

Glutamine metabolic reprogramming in hepatocellular carcinoma

Ye, Y., Yu, B., Wang, H., & Yi, F. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1242059 · Cited by 47 · see citing works

The retina and retinal pigment epithelium differ in nitrogen metabolism and are metabolically connected

Xu, R., Ritz, B. K., Wang, Y., Huang, J., Zhao, C., Gong, K., Liu, X., & Du, J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011727 · Cited by 49 · see citing works

Protective effect of metformin on BPA-induced liver toxicity in rats through upregulation of cystathionine β synthase and cystathionine γ lyase expression

Sun, Y., Wang, X., Zhou, Y., Zhang, J., Cui, W., Wang, E., Du, J., Wei, B., & Xu, X. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.141685 · Cited by 49 · see citing works

Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer

Saggese, P., Sellitto, A., Martinez, C. A., Giurato, G., Nassa, G., Rizzo, F. M., Tarallo, R., & Scafoglio, C. (2020) · Cancers · doi:10.3390/cancers12123788 · Cited by 46 · see citing works

ASCT2 overexpression is associated with poor survival of OSCC patients and ASCT2 knockdown inhibited growth of glutamine‐addicted OSCC cells

Luo, Y., Li, W., Ling, Z., Hu, Q., Fan, Z., Cheng, B., & Tao, X. (2020) · Cancer Medicine · doi:10.1002/cam4.2965 · Cited by 46 · see citing works

20,000 picometers under the OMM: diving into the vastness of mitochondrial metabolite transport

Cunningham, C. N., & Rutter, J. P. (2020) · EMBO Reports · doi:10.15252/embr.202050071 · Cited by 44 · see citing works

Interrogating in vivo T-cell metabolism in mice using stable isotope labeling metabolomics and rapid cell sorting

Sheldon, R. D., Ma, E. H., DeCamp, L. M., Williams, K. S., & Jones, R. G. (2021) · Nature Protocols · doi:10.1038/s41596-021-00586-2 · Cited by 43 · see citing works

Fifty years of the mitochondrial pyruvate carrier: New insights into its structure, function, and inhibition

Tavoulari, S., Sichrovsky, M., & Kunji, E. R. S. (2023) · Acta Physiologica · doi:10.1111/apha.14016 · Cited by 43 · see citing works

Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis

Sharma, S., Agnihotri, N., & Kumar, S. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114943 · Cited by 42 · see citing works

Immunometabolism and oxidative stress: roles and therapeutic strategies in cancer and aging

Zhou, N.-J., Bao, W.-Q., Zhang, C., Jiang, M., Liang, T.-L., Ma, G.-Y., Liu, L., Pan, H., & Li, R.-Z. (2025) · npj Aging · doi:10.1038/s41514-025-00250-z · Cited by 44 · see citing works

Mitochondrial pyruvate carrier function in health and disease across the lifespan

Buchanan, J., & Taylor, E. (2020) · Biomolecules · doi:10.3390/biom10081162 · Cited by 40 · see citing works

Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2–dependent glutaminolysis pathway

Wei, P., Bott, A. J., Cluntun, A. A., Morgan, J. T., Cunningham, C. N., Schell, J. C., Ouyang, Y., Ficarro, S. B., Marto, J. A., Danial, N. N., et al. (2022) · Science Advances · doi:10.1126/sciadv.abq0117 · Cited by 38 · see citing works

Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment

Giafaglione, J. M., Crowell, P. D., Delcourt, A. M. L., Hashimoto, T., Ha, S. M., Atmakuri, A., Nunley, N. M., Dang, R. M. A., Tian, M., Diaz, J. A., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01274-x · Cited by 37 · see citing works

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer

Tavoulari, S., Schirris, T. J. J., Mavridou, V., Thangaratnarajah, C., King, M. S., Jones, D. T. D., Ding, S., Fearnley, I. M., & Kunji, E. R. S. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101469 · Cited by 38 · see citing works

Glutamine metabolism, a double agent combating or fuelling hepatocellular carcinoma

Ziki, R. A., & Colnot, S. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101077 · Cited by 35 · see citing works

HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia

Dong, Q.-Z., Xiu, Y., Wang, Y., Hodgson, C., Borcherding, N., Jordan, C., Buchanan, J. L., Taylor, E., Wagner, B., Leidinger, M. R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33861-1 · Cited by 31 · see citing works

Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult

Yiew, N. K. H., Vazquez, J. H., Martino, M. R., Kennon‐McGill, S., Price, J. R., Allard, F. D., Yee, E. U., Layman, A. J., James, L. P., McCommis, K. S., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101808 · Cited by 32 · see citing works

Atypical immunometabolism and metabolic reprogramming in liver cancer: Deciphering the role of gut microbiome.

Golonka, R., & Vijay-Kumar, M. (2021) · Advances in Cancer Research · doi:10.1016/bs.acr.2020.10.004 · Cited by 21 · see citing works

Alterations in glycolytic/cholesterogenic gene expression in hepatocellular carcinoma

Jiang, J., Zheng, Q., Zhu, W., Chen, X., Lu, H., Chen, D., Zhang, H., Shao, M., Zhou, L., & Zheng, S. (2020) · Aging · doi:10.18632/aging.103254 · Cited by 25 · see citing works

Monocarboxylate Transporter-1 (MCT1)-Mediated Lactate Uptake Protects Pancreatic Adenocarcinoma Cells from Oxidative Stress during Glutamine Scarcity Thereby Promoting Resistance against Inhibitors of Glutamine Metabolism

Ammar, N., Hildebrandt, M., Geismann, C., Röder, C., Gemoll, T., Sebens, S., Trauzold, A., & Schäfer, H. (2023) · Antioxidants · doi:10.3390/antiox12101818 · Cited by 27 · see citing works

The fuel and engine: The roles of reprogrammed metabolism in metastasis of primary liver cancer

Zhu, W., Lü, M., Wang, X., Xu, Z., Gao, C., & Qin, L. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.01.016 · Cited by 23 · see citing works

A novel cuproptosis-related prognostic gene signature and validation of differential expression in hepatocellular carcinoma

Li, Y., & Zeng, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1081952 · Cited by 22 · see citing works

Evidence-based pathogenesis and treatment of ulcerative colitis: A causal role for colonic epithelial hydrogen peroxide

Pravda, J. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i31.4263 · Cited by 23 · see citing works

Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier

Sichrovsky, M., Lacabanne, D., Ruprecht, J. J., Rana, J. J., Stanik, K., Dionysopoulou, M., Sowton, A. P., King, M. S., Jones, S. A., Cooper, L. R., et al. (2025) · Science Advances · doi:10.1126/sciadv.adw1489 · Cited by 21 · see citing works

Loss of muscle PDH induces lactic acidosis and adaptive anaplerotic compensation via pyruvate-alanine cycling and glutaminolysis

Gopal, K., Abdualkader, A. M., Li, X., Greenwell, A. A., Karwi, Q. G., Altamimi, T., Saed, C. T., Uddin, G. M., Darwesh, A. M., Jamieson, K. L., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105375 · Cited by 20 · see citing works

Prohibitin‐1 Is a Dynamically Regulated Blood Protein With Cardioprotective Effects in Sepsis

Mattox, T. A., Psaltis, C. E., Weihbrecht, K., Robidoux, J., Kilburg-Basnyat, B. J., Murphy, M. P., Gowdy, K. M., & Anderson, E. J. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.019877 · Cited by 16 · see citing works

Metabolism-Associated Epigenetic and Immunoepigenetic Reprogramming in Liver Cancer

Fan, C., Kam, S., & Ramadori, P. (2021) · Cancers · doi:10.3390/cancers13205250 · Cited by 17 · see citing works

Dysbiotic Microbiome–Metabolome Axis in Childhood Obesity and Metabolic Syndrome

Salman, U., Dabdoub, S. M., Reyes, A., Sidahmed, A., Weber‐Gasparoni, K., Brown, R., Evans, I. A., Taylor, E. B., Mangalam, A. K., Kanner, L. A., et al. (2025) · Journal of Dental Research · doi:10.1177/00220345251336129 · Cited by 16 · see citing works

Mitochondrial Pyruvate Carrier Subunits Are Essential for Pyruvate-Driven Respiration, Infectivity, and Intracellular Replication of Trypanosoma cruzi

Negreiros, R. S., Lander, N. M., Chiurillo, M. Á., Vercesi, A. E., & Docampo, R. (2021) · mBio · doi:10.1128/mbio.00540-21 · Cited by 15 · see citing works

Follicular Fluid Metabolite Changes in Dairy Cows with Inactive Ovary Identified Using Untargeted Metabolomics

Bai, Y., Zhang, F., Zhang, H., Xu, C., Wu, L., & Xia, C. (2020) · BioMed Research International · doi:10.1155/2020/9837543 · Cited by 16 · see citing works

Unraveling mitochondrial pyruvate dysfunction to mitigate hyperlactatemia and lethality in sepsis

Nuyttens, L., Heyerick, M., Heremans, G., Moens, E., Roes, M., Dender, C. V., Bus, L. D., Decruyenaere, J. M. A., Waele, J. J. D., Vandewalle, J., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116032 · Cited by 22 · see citing works

Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis

Ryuge, A., Kosugi, T., Maeda, K., Banno, R., Gou, Y., Zaitsu, K., Ito, T., Sato, Y., Hirayama, A., Tsubota, S., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.142464 · Cited by 15 · see citing works

Allopurinol Lowers Serum Urate but Does Not Reduce Oxidative Stress in CKD

Sun, M., Hines, N. G., Scerbo, D. A., Buchanan, J. L., Wu, C., Eyck, P. T., Zepeda‐Orozco, D., Taylor, E. B., & Jalal, D. I. (2022) · Antioxidants · doi:10.3390/antiox11071297 · Cited by 15 · see citing works

Disposition and Metabolomic Effects of 2,2’,5,5’-Tetrachlorobiphenyl in Female Rats Following Intraperitoneal Exposure

Bullert, A. J., Li, X., Chunyun, Z., Lee, K., Pulliam, C. F., Cagle, B. S., Doorn, J. A., Klingelhutz, A. J., Robertson, L. W., & Lehmler, H. (2023) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2023.104245 · Cited by 15 · see citing works

The Hepatic Mitochondrial Pyruvate Carrier as a Regulator of Systemic Metabolism and a Therapeutic Target for Treating Metabolic Disease

McCommis, K. S., & Finck, B. N. (2023) · Biomolecules · doi:10.3390/biom13020261 · Cited by 14 · see citing works

Insulin sensitizers in 2023: lessons learned and new avenues for investigation

Colca, J. R., Tanis, S. P., Kletzien, R. F., & Finck, B. N. (2023) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2023.2263369 · Cited by 13 · see citing works

The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma

Findlay, S., Nair, R., Merrill, R. A., Kaiser, Z., Cajelot, A., Aryanpour, Z., Heath, J., St‐Louis, C., Papadopoli, D. J., Topisirović, I., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2022008345 · Cited by 13 · see citing works

Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury

Rauckhorst, A. J., Vasquez-Martinez, G., Andrade, G. M., Wen, H., Kim, J., Simoni, A. A., Robles-Planells, C., Mapuskar, K. A., Rastogi, P., Steinbach, E. J., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101849 · Cited by 13 · see citing works

Inhibition of LDHB suppresses the metastatic potential of lung cancer by reducing mitochondrial GSH catabolism

Ge, H., Malsiu, F., Gao, Y., Losmanová, T., Blank, F., Ott, J. G., Medová, M., Peng, R., Deng, H., Dorn, P., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217353 · Cited by 11 · see citing works

UPLC-orbitrap-MS-based metabolic profiling of HaCaT cells exposed to withanolides extracted from Datura metel.L: Insights from an untargeted metabolomics

Li, T., Zheng, W., & Kuang, H. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.113979 · Cited by 11 · see citing works

Glutathione determines chronic myeloid leukemia vulnerability to an inhibitor of CMPK and TMPK

Huang, C.-Y., Chung, Y.-H., Wu, S.-Y., Wang, H.-Y., Lin, C.-Y., Yang, T.-J., Fang, J., Hu, C., & Chang, Z.-F. (2024) · Communications Biology · doi:10.1038/s42003-024-06547-1 · Cited by 10 · see citing works

Activation of the integrated stress response in human hair follicles

Pye, D., Scholey, R., Ung, S., Dawson, M., Shahmalak, A., & Purba, T. S. (2024) · PLoS ONE · doi:10.1371/journal.pone.0303742 · Cited by 9 · see citing works

Recent advancements in nanomedicine based lipid metabolism for tumour immunotherapy

Zhao, Y., Zhang, X., An, M., Zhang, J., & Liu, Y. (2023) · Journal of drug targeting · doi:10.1080/1061186x.2023.2283829 · Cited by 8 · see citing works

Senecavirus A- and Non-Infected Cells at Early Stage of Infection: Comparative Metabolomic Profiles

Liu, F., Ni, B., & Wei, R. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.736506 · Cited by 8 · see citing works

Kidney development at a glance: metabolic regulation of renal progenitor cells

Kurtzeborn, K., El-Dahr, S. S., Pakkasjärvi, N. A., Tortelote, G. G., & Kuure, S. (2024) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2024.11.009 · Cited by 7 · see citing works

Hesperetin Protects from Palmitic-Acid-Induced Lipotoxicity through the Inhibition of Glutaminolysis, mTORC1 Signaling, and Limited Apoptosis

Li, W., Cai, Z., Schindler, F., Brenner, M., Winter, C., Stiller, B., Heffeter, P., & Weckwerth, W. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c05570 · Cited by 7 · see citing works

Nutrition deprivation affects the cytotoxic effect of CD8 T cells in hepatocellular carcinoma

Zhang, C., Liu, S., & Yang, M. J. (2022) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v14.i9.1887 · Cited by 7 · see citing works

Structural transport and inhibition mechanism of the mitochondrial pyruvate carrier

Lacabanne, D., Ruprecht, J. J., Sichrovsky, M., Forrest, L. R., Leone, V., Tavoulari, S., & Kunji, E. R. S. (2025) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2025.11.002 · Cited by 4 · see citing works

Fluoride impairs vascular smooth muscle A7R5 cell lines via disrupting amino acids metabolism

Li, Y., Yang, R.-R., Li, X., Liu, W.-W., Zhao, Y., Zu, M.-M., Gao, Y.-H., Huo, M.-Q., Jiang, Y., & Li, B. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05350-0 · Cited by 4 · see citing works

Aberrant gene expression pattern in the glycolysis-cholesterol synthesis axis is linked with immune infiltration and prognosis in prostate cancer: A bioinformatics analysis

Yuan, Y., Song, J., & Wu, Q. (2022) · Medicine · doi:10.1097/md.0000000000031416 · Cited by 3 · see citing works

Targeting pyruvate metabolism generates distinct CD8+ T cell responses to gammaherpesvirus and B lymphoma

Kang, T., Usherwood, Y.-K., Reisz, J. A., Kamerkar, S. C., Culp‐Hill, R., Wilkins, O. M., Veríssimo, A. F., Kolling, F., Hung, A. M., Musial, S. C., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.187680 · Cited by 3 · see citing works

Loss of Skeletal Muscle Pyruvate Dehydrogenase Induces Lactic Acidosis and Adaptive Anaplerotic Compensation via Pyruvate-Alanine Cycling and GlutaminolysisPreprint

Gopal, K., Abdualkader, A. M., Li, X., Greenwell, A. A., Karwi, Q. G., Saed, C. T., Uddin, G. M., Darwesh, A. M., Jamieson, K. L., Altamimi, T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.10.540277 · Cited by 3 · see citing works

Targeting Reductive Metabolic Shifts by T315I Mutation in BCR-ABL Myeloid Leukemia for TherapyPreprint

Huang, C.-Y., Chung, Y.-H., Wu, S.-Y., Wang, H.-Y., Lin, Z., Yang, T.-J., Feng, J.-M., Hu, C., & Chang, Z.-F. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.22.485260 · Cited by 2 · see citing works

Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult in micePreprint

Yiew, N. K. H., Vazquez, J. H., Martino, M. R., Kennon‐McGill, S., Price, J. R., Allard, F. D., Yee, E. U., James, L. P., McCommis, K. S., Finck, B. N., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.14.495517 · Cited by 2 · see citing works

Fluoride impairs vascular smooth muscle cells via disrupting amino acids metabolismPreprint

Li, Y., Yang, R.-R., Li, X.-Y., Liu, W.-W., Zhao, Y., Zu, M.-M., Gao, Y.-H., Huo, M.-Q., Jiang, Y., & Li, B. (2024) · Research Square · doi:10.21203/rs.3.rs-4089224/v1 · Cited by 1 · see citing works

Mitochondrial pyruvate supports lymphoma proliferation by fueling a non-canonical glutamine metabolism pathwayPreprint

Wei, P., Bott, A. J., Cluntun, A. A., Morgan, J. T., Cunningham, C. N., Schell, J. C., Ouyang, Y., Ficarro, S. B., Marto, J. A., Danial, N. N., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.26.457847

A Non-Canonical Convergence of Carbohydrate and Glutamine Metabolism is Required After Metabolic Rewiring in a Solid EnvironmentPreprint

Wei, P., Bott, A. J., Cluntun, A. A., Morgan, J., Cunningham, C. N., Schell, J. C., Ouyang, Y., Ficarro, S. B., Marto, J. A., Danial, N. N., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3979182

Mitochondrial metabolism in progression of liver cancer

Bajpai, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-98806-3.00003-9

Nutrition deprivation affects the cytotoxic effect of CD8 T cells in hepatocellular carcinoma

Zhang, C., Liu, S., & Yang, M. J. (2022) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v14.i9.1886

Metabolomic profiling and stable isotope tracing of human schwannomas: A novel perspective on tumor biology and radiation response

Dougherty, M. C., Syed, H., Xu, L., Liu, S. J., Raleigh, D. R., Rauckhorst, A. J., Taylor, E. B., & Hansen, M. R. (2025) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdaf223

Olaparib targets Ubiquitin D to promote autophagy in hepatocellular carcinoma by regulating glutamine metabolism

Zhu, W., Zhang, F., Qu, H., Li, N., Chen, X., & Tu, W. (2025) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2025.2586736

Heat therapy attenuates hepatic lipid accumulation via CSAD-driven metabolic reprogramming of fatty acid oxidation

Li, A., Dai, Y., Luo, Y., Liang, G., Gui, L., Hu, X., Li, X., Zhang, D., Zheng, W., Zhang, L., et al. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2026.159722

Mechanistic target of rapamycin complex (mTORC)-glutamine axis in cancer: Mechanistic crosstalk, therapeutic resistance, and clinical opportunities

Das, S. R., Koman, I. E., & Nesher, E. (2026) · Cancer Pathogenesis and Therapy · doi:10.1016/j.cpt.2026.08.003

Glutamine metabolism in health and disease

Zhao, J., Lin, Y., Gao, R., Gao, H., & Li, L. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02981-1

Itaconate protects the blood-brain barrier by preserving microvascular bioenergetics after traumatic brain injury

Liu, N., Zhou, D., Shi, M., Xiu, Y., Jiang, Y., Wang, Y., Moyano, G. A., McGuire, J. L., Iskender, A., Kilgore, M. D., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104446

The role of the mitochondrial pyruvate carrier in the development of hepatocellullar carcinoma

Tompkins, S. C., Taylor, E. B., Geyer, P., Weeks, D. L., Brenner, C., Abel, E. D., & Bassuk, A. G. (2020) · doi:10.17077/etd.005293

LOSS OF MITOCHONDRIAL PYRUVATE CARRIER ACTIVITY SHORT CIRCUITS HEPATOCELLULAR TUMORIGENESIS

Taylor, E. B. (2018) · The FASEB Journal · doi:10.1096/fasebj.2018.32.1_supplement.125.1

Glutamine metabolism, a double agent combating or fuelling hepatocellular carcinoma

Ziki, R. A., & Colnot, S. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101077 · Cited by 35 · see citing works

Genome‐Wide CRISPR/Cas9 Library Screening Revealed Dietary Restriction of Glutamine in Combination with Inhibition of Pyruvate Metabolism as Effective Liver Cancer Treatment

Yang, C., Lee, D., Zhang, M. S., Tse, A. P., Wei, L., Bao, M. H., Wong, B. P., Chan, C. Y., Yuen, V. W., Chen, Y., et al. (2022) · Advanced Science · doi:10.1002/advs.202202104 · Cited by 33 · see citing works

Reprogramming of Glutamate Metabolism and Redox Homeostasis in De Novo MYC-Driven Liver Tumors

Anderton, B. N. (2015) · eScholarship (California Digital Library)