Cited by 147Metabolism, Diabetes, and CancerCancer, Hypoxia, and MetabolismT-cell and B-cell Immunology

Signaling Takes a Breath – New Quantitative Perspectives on Bioenergetics and Signal Transduction

Open access
Krauss, Stefan, Brand, Martin D, Buttgereit, Frank·2001·Immunity

Abstract

Immune cells are in constant need of energy for both basic housekeeping and specific immune functions. Increased energy demand during lymphocyte stimulation is coordinated by signal transduction pathways. This review explores the interface between lymphocyte signaling and energy metabolism. In particular, it discusses recent work that allows weighing signaling routes with respect to their role in the regulation of energy metabolism during lymphocyte activation.

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Crossref · 10.1016/s1074-7613(01)00205-9

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  • Uptake of Ca2+ by mitochondria stimulates Ca2+-dependent dehydrogenases of the TCA cycle, driving mitochondrial NADH production and ATP production by OXPHOS during early T cell activation.

    “Uptake of Ca2+ by mitochondria stimulates Ca2+-dependent dehydrogenases of the TCA cycle, driving mitochondrial NADH production and ATP production by OXPHOS during early T cell activation (32).”

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Authors
Krauss, S., Brand, M. D., & Buttgereit, F.
Affiliations
  • Beth Israel Deaconess Medical Center (US)
  • MRC Mitochondrial Biology Unit (GB)
  • Humboldt-Universität zu Berlin (DE)
Corresponding author
Krauss, Stefan
Venue
Immunity
Publisher
Elsevier BV
Published
2001-10
Volume
15
Issue
4
Pages
497-502
ISSN
1074-7613 (ISSN-L)
OpenAlex
W2058005998
Cited by
147
References
20
Citations by year
2026: 3 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 9 · 2015: 5 · 2014: 7 · 2013: 9 · 2012: 9
FWCI
1.74
Type
journal article
Language
en
Open access
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
lymphocyte signaling, energy metabolism, bioenergetics, signal transduction, lymphocyte activation
MeSH terms
Adenosine Triphosphate, Animals, Energy Metabolism, Humans, Lymphocyte Activation, Protein Kinase C, T-Lymphocytes, Signal Transduction, Models, Immunological, Calcineurin, Calcium Signaling, MAP Kinase Signaling System, Rats

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