Signaling Takes a Breath – New Quantitative Perspectives on Bioenergetics and Signal Transduction
Open accessAbstract
Immune cells are in constant need of energy for both basic housekeeping and specific immune functions. Increased energy demand during lymphocyte stimulation is coordinated by signal transduction pathways. This review explores the interface between lymphocyte signaling and energy metabolism. In particular, it discusses recent work that allows weighing signaling routes with respect to their role in the regulation of energy metabolism during lymphocyte activation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Uptake of Ca2+ by mitochondria stimulates Ca2+-dependent dehydrogenases of the TCA cycle, driving mitochondrial NADH production and ATP production by OXPHOS during early T cell activation.
“Uptake of Ca2+ by mitochondria stimulates Ca2+-dependent dehydrogenases of the TCA cycle, driving mitochondrial NADH production and ATP production by OXPHOS during early T cell activation (32).”
From Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013) · cites this paper as [32]
Cites
Role of calcium ions in regulation of mammalian intramitochondrial metabolism
McCormack, J. G., Halestrap, A. P., & Denton, R. M. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.391 · Cited by 1,398 · see citing works
Calcineurin: Form and Function
Rusnak, F. M., & Mertz, P. S. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1483 · Cited by 1,375 · see citing works
Understanding the control of metabolism
(1997) · Choice Reviews Online · doi:10.5860/choice.34-6252 · Cited by 1,230 · see citing works
Ultrasensitivity in the mitogen-activated protein kinase cascade.
Huang, C. Y., & Ferrell, J. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10078 · Cited by 1,186 · see citing works
Decoding of cytosolic calcium oscillations in the mitochondria
Hajnóczky, G., Gaspers, L. D., Seitz, M. B., & Thomas, A. P. (1995) · Cell · doi:10.1016/0092-8674(95)90430-1 · Cited by 1,110 · see citing works
A hierarchy of ATP-consuming processes in mammalian cells
Buttgereit, F., & Brand, M. D. (1995) · Biochemical Journal · doi:10.1042/bj3120163 · Cited by 929 · see citing works
Self-citationDuchen, M. R. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.001aa.x · Cited by 610 · see citing works
Rathmell, J. C., Heiden, M. G. V., Harris, M. H., Frauwirth, K. A., & Thompson, C. B. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00066-6 · Cited by 467 · see citing works
Brand, K. A., & Hermfisse, U. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.5.9141507 · Cited by 401 · see citing works
Bioenergetics of immune functions: fundamental and therapeutic aspects
Buttgereit, F., Burmester, G. R., & Brand, M. D. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01593-0 · Cited by 284 · see citing works
Self-citationHoth, M., Button, D. C., & Lewis, R. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180143997 · Cited by 269 · see citing works
The modulation of B7.2 and B7.1 on B cells by immunosuppressive agents
Jirapongsananuruk, O., & Leung, D. Y. M. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.01028.x · Cited by 266 · see citing works
Superoxide dismutase protects calcineurin from inactivation
Wang, X., Culotta, V., & Klee, C. B. (1996) · Nature · doi:10.1038/383434a0 · Cited by 266 · see citing works
A cellular calculus for signal integration by T cells
Gett, A. V., & Hodgkin, P. D. (2000) · Nature Immunology · doi:10.1038/79782 · Cited by 246 · see citing works
Calcineurin: Not Just a Simple Protein Phosphatase
Guerini, D. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6802 · Cited by 156 · see citing works
Calcium regulation of oxidative phosphorylation in rat skeletal muscle mitochondria
Kavanagh, N. I., Ainscow, E., & Brand, M. D. (2000) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00054-2 · Cited by 80 · see citing works
Self-citationRedox regulation of calcineurin in T-lymphocytes
Reiter, T. A., Abraham, R. T., Choi, M., et al. (1999) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s007750050387 · Cited by 44 · see citing works
Effects of the mitogen concanavalin A on pathways of thymocyte energy metabolism
Krauss, S. J. K., Buttgereit, F., & Brand, M. D. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00058-4 · Cited by 42 · see citing works
Self-citationMishra, N., Khan, I. U., Tsokos, G. C., & Kammer, G. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.5.2830 · Cited by 37 · see citing works
Quantitation of signal transduction
Krauss, S. J. K., & Brand, M. D. (2000) · The FASEB Journal · doi:10.1096/fj.00-0064com · Cited by 25 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · see citing works
“TCR- and costimulator-mediated signals drive T cell growth and clonal expansion, and coordinately reprogram metabolic cascades to fulfill the ensuing bioenergetic and biosynthetic demands (Fox et al., 2005; Krauss et al., 2001).”
BackgroundHIF-1α is essential for myeloid cell-mediated inflammation
Cramer, T., Yamanishi, Y., Clausen, B. E., Förster, I., Pawlinski, R., Mackman, N., Haase, V. H., Jaenisch, R., Corr, M., Nizet, V., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00154-5 · Cited by 2,046 · see citing works
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
van der Windt, G. J. W., Everts, B., Chang, C.-H., Curtis, J. D., Freitas, T. C., Amiel, E., Pearce, E. J., & Pearce, E. L. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.007 · Cited by 1,540 · see citing works
The CD28 Signaling Pathway Regulates Glucose Metabolism
Frauwirth, K. A., Riley, J. L., Harris, M. H., Parry, R. V., Rathmell, J. C., Plas, D. R., Elstrom, R. L., June, C. H., & Thompson, C. B. (2002) · Immunity · doi:10.1016/s1074-7613(02)00323-0 · Cited by 1,475 · see citing works
Fueling Immunity: Insights into Metabolism and Lymphocyte Function
Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363 · see citing works
Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C.-R., Schumacker, P. T., Licht, J. D., Perlman, H., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.020 · Cited by 1,338 · see citing works
Metabolic switching and fuel choice during T‐cell differentiation and memory development
van der Windt, G. J. W., & Pearce, E. L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01150.x · Cited by 563 · see citing works
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
van der Windt, G. J. W., O’Sullivan, D., Everts, B., Huang, S. C.-C., Buck, M. D., Curtis, J. D., Chang, C.-H., Smith, A. M., Ai, T., Faubert, B., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221740110 · Cited by 523 · see citing works
Regulation of immune cells by local-tissue oxygen tension: HIF1α and adenosine receptors
Sitkovsky, M., & Lukashev, D. (2005) · Nature Reviews Immunology · doi:10.1038/nri1685 · Cited by 518 · see citing works
Doughty, C. A., Bleiman, B. F., Wagner, D. J., Dufort, F. J., Mataraza, J. M., Roberts, M. F., & Chiles, T. C. (2006) · Blood · doi:10.1182/blood-2005-12-4788 · Cited by 369 · see citing works
Revving the Engine: Signal Transduction Fuels T Cell Activation
Jones, R. G., & Thompson, C. B. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.008 · Cited by 349 · see citing works
Metabolism in T cell activation and differentiation
Pearce, E. L. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.018 · Cited by 314 · see citing works
<scp>AMPK</scp> α1: A glucose sensor that controls <scp>CD</scp> 8 <scp>T</scp> ‐cell memory
Rolf, J., Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B., & Cantrell, D. A. (2013) · European Journal of Immunology · doi:10.1002/eji.201243008 · Cited by 245 · see citing works
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism
MacIver, N. J., Blagih, J., Saucillo, D. C., Tonelli, L., Griss, T., Rathmell, J. C., & Jones, R. G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100367 · Cited by 235 · see citing works
The brain and immune system prompt energy shortage in chronic inflammation and ageing
Straub, R. H. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.172 · Cited by 192 · see citing works
The metabolic life and times of a T‐cell
Michalek, R. D., & Rathmell, J. C. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00911.x · Cited by 186 · see citing works
“These physiologic processes have specific metabolic needs that are largely supplied by efficient generation of adenosine triphosphate (ATP) as an energy source and modest levels of biosynthetic precursors for cell maintenance (15).”
BackgroundGlucose-dependent de Novo Lipogenesis in B Lymphocytes
Dufort, F. J., Gumina, M. R., Ta, N. L., Tao, Y., Heyse, S. A., Scott, D. A., Richardson, A. D., Seyfried, T. N., & Chiles, T. C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.551051 · Cited by 160 · see citing works
Nakamura, H., Makino, Y., Okamoto, K., Poellinger, L., Ohnuma, K., Morimoto, C., & Tanaka, H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7592 · Cited by 158 · see citing works
Jones, R. G., Bui, T., White, C., Madesh, M., Krawczyk, C. M., Lindsten, T., Hawkins, B. J., Kubek, S., Frauwirth, K. A., Wang, Y. L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.023 · Cited by 109 · see citing works
Larbi, A., Zelba, H., Goldeck, D., & Pawelec, G. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0509304 · Cited by 58 · see citing works
- Authors
- Krauss, S., Brand, M. D., & Buttgereit, F.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- MRC Mitochondrial Biology Unit (GB)
- Humboldt-Universität zu Berlin (DE)
- Corresponding author
- Krauss, Stefan
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 15
- Issue
- 4
- Pages
- 497-502
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2058005998
- Cited by
- 147
- References
- 20
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 9 · 2015: 5 · 2014: 7 · 2013: 9 · 2012: 9
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- lymphocyte signaling, energy metabolism, bioenergetics, signal transduction, lymphocyte activation
- MeSH terms
- Adenosine Triphosphate, Animals, Energy Metabolism, Humans, Lymphocyte Activation, Protein Kinase C, T-Lymphocytes, Signal Transduction, Models, Immunological, Calcineurin, Calcium Signaling, MAP Kinase Signaling System, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review