The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Biological Activities of Reactive Oxygen and Nitrogen Species: Oxidative Stress versus Signal Transduction
Open accessAbstract
In the past, reactive oxygen and nitrogen species (RONS) were shown to cause oxidative damage to biomolecules, contributing to the development of a variety of diseases. However, recent evidence has suggested that intracellular RONS are an important component of intracellular signaling cascades. The aim of this review was to consolidate old and new ideas on the chemical, physiological and pathological role of RONS for a better understanding of their properties and specific activities. Critical consideration of the literature reveals that deleterious effects do not appear if only one primary species (superoxide radical, nitric oxide) is present in a biological system, even at high concentrations. The prerequisite of deleterious effects is the formation of highly reactive secondary species (hydroxyl radical, peroxynitrite), emerging exclusively upon reaction with another primary species or a transition metal. The secondary species are toxic, not well controlled, causing irreversible damage to all classes of biomolecules. In contrast, primary RONS are well controlled (superoxide dismutase, catalase), and their reactions with biomolecules are reversible, making them ideal for physiological/pathophysiological intracellular signaling. We assume that whether RONS have a signal transducing or damaging effect is primarily defined by their quality, being primary or secondary RONS, and only secondly by their quantity.
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Cites
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Mitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions
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Wilson, C., & González-Billault, C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00381 · Cited by 238
Oxidative Stress and Huntington’s Disease: The Good, the Bad, and the Ugly
Kumar, A., & Ratan, R. R. (2016) · Journal of Huntington s Disease · doi:10.3233/jhd-160205 · Cited by 236
Mitochondria: Are they causal players in cellular senescence?
Correia-Melo, C., & Passos, J. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.017 · Cited by 160
Metadata
- Authors
- Weidinger, A., & Kozlov, A.
- Venue
- Biomolecules
- Publisher
- MDPI AG
- Published
- 2015-04-15
- Volume
- 5
- Issue
- 2
- Pages
- 472-484
- ISSN
- 2218-273X (ISSN-L)
- OpenAlex
- W1999713485
- Cited by
- 646
- References
- 15
- FWCI
- 18.14
- Type
- journal article
- Language
- en
- Open access
- gold
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