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Cited by 185

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Roles of Chemokines and Chemokine Receptors in Obesity-Associated Insulin Resistance and Nonalcoholic Fatty Liver Disease

Open access
Xu, Liang, Kitade, Hironori, Ni, Yinhua, Ota, Tsuguhito·2015·Biomolecules
DOI 10.3390/biom5031563
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Abstract

Abundant evidence has demonstrated that obesity is a state of low-grade chronic inflammation that triggers the release of lipids, aberrant adipokines, pro-inflammatory cytokines, and several chemokines from adipose tissue. This low-grade inflammation underlies the development of insulin resistance and associated metabolic comorbidities such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD). During this development, adipose tissue macrophages accumulate through chemokine (C-C motif) receptor 2 and the ligand for this receptor, monocyte chemoattractant protein-1 (MCP-1), is considered to be pivotal for the development of insulin resistance. To date, the chemokine system is known to be comprised of approximately 40 chemokines and 20 chemokine receptors that belong to the seven-transmembrane G protein-coupled receptor family and, as a result, chemokines appear to exhibit a high degree of functional redundancy. Over the past two decades, the physiological and pathological properties of many of these chemokines and their receptors have been elucidated. The present review highlights chemokines and chemokine receptors as key contributing factors that link obesity to insulin resistance, T2DM, and NAFLD.

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Metadata

Authors
Xu, L., Kitade, H., Ni, Y., & Ota, T.
Venue
Biomolecules
Publisher
MDPI AG
Published
2015-07-21
Volume
5
Issue
3
Pages
1563-1579
ISSN
2218-273X (ISSN-L)
DOI
10.3390/biom5031563
OpenAlex
W2123346621
Cited by
185
References
28
FWCI
14.91
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Roles of Chemokines and Chemokine Receptors in Obesity-Associated Insulin Resistance and Nonalcoholic Fatty Liver Disease. https://app.cochat.ai/papers/10.3390/biom5031563
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Xu, L., Kitade, H., Ni, Y., & Ota, T. (2015). Roles of Chemokines and Chemokine Receptors in Obesity-Associated Insulin Resistance and Nonalcoholic Fatty Liver Disease. Biomolecules. https://doi.org/10.3390/biom5031563

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.