SERPINA3: Stimulator or Inhibitor of Pathological Changes
Open accessAbstract
SERPINA3, also called α-1-antichymotrypsin (AACT, ACT), is one of the inhibitors of serine proteases, one of which is cathepsin G. As an acute-phase protein secreted into the plasma by liver cells, it plays an important role in the anti-inflammatory response and antiviral response. Elevated levels of SERPINA3 have been observed in heart failure and neurological diseases such as Alzheimer’s disease or Creutzfeldt–Jakob disease. Many studies have shown increased expression levels of the SERPINA3 gene in various types of cancer, such as glioblastoma, colorectal cancer, endometrial cancer, breast cancer, or melanoma. In this case, the SERPINA3 protein is associated with an antiapoptotic function implemented by adjusting the PI3K/AKT or MAPK/ERK 1/2 signal pathways. However, the functions of the SERPINA3 protein are still only partially understood, mainly in the context of cancerogenesis, so it seems necessary to summarize the available information and describe its mechanism of action. In particular, we sought to amass the existing body of research focusing on the description of the underlying mechanisms of various diseases not related to cancer. Our goal was to present an overview of the correct function of SERPINA3 as part of the defense system, which unfortunately easily becomes the “Fifth Column” and begins to support processes of destruction.
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SERPINA3 is an inhibitor of cathepsin G, another protease important in neutrophil related immune responses and implicated in inflammation related tissue damage.
“SERPINA3 is an inhibitor of cathepsin G, another protease important in neutrophil related immune responses and implicated in inflammation related tissue damage23.”
From A deep-learning framework reveals whole-body perturbations at cell level (2026) · cites this paper as [23]
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A deep-learning framework reveals whole-body perturbations at cell level
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- Authors
- de Mezer, M., Rogaliński, J., Przewoźny, S., Chojnicki, M., Niepolski, L., Sobieska, M., & Przystańska, A.
- Affiliations
- Department of Immunobiology, Poznan University of Medical Sciences, Rokietnicka 8, 60-806 Poznan, Poland
- Poznan University of Medical Sciences (PL)
- ORCID
- Venue
- Biomedicines
- Publisher
- MDPI AG
- Published
- 2023-01-07
- Volume
- 11
- Issue
- 1
- Pages
- 156
- ISSN
- 2227-9059 (ISSN-L)
- PMC
- PMC9856089
- OpenAlex
- W4313826313
- Cited by
- 103
- References
- 97
- Citations by year
- 2026: 30 · 2025: 32 · 2024: 32 · 2023: 9
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- alpha-1-antichymotrypsin, serine protease inhibitors, cathepsin G, acute phase proteins, anti-inflammatory response, antiviral response, heart failure, Alzheimer's disease, Creutzfeldt-Jakob disease, cancer, antiapoptotic function, PI3K/Akt signaling, MAPK/ERK1/2 signaling, cancerogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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