Cited by 16Rheumatoid Arthritis Research and TherapiesAdipokines, Inflammation, and Metabolic DiseasesSpondyloarthritis Studies and Treatments

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The Influence of Adipokines on Radiographic Damage in Inflammatory Rheumatic Diseases

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Toussirot, Eric·2023·Biomedicines

DOI 10.3390/biomedicines11020536PMC PMC9953013

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Abstract

Inflammatory rheumatic diseases (IRDs) are complex immune-mediated diseases that are characterized by chronic inflammation of the joints. Rheumatoid arthritis (RA) and spondyloarthritis (SpA), including axial SpA (ax SpA) and psoriatic arthritis (PsA), are the most common forms of IRD. Both RA and ax SpA are characterized by a chronic course with progressive structural modifications, namely, cartilage damage and bone erosions in RA and osteoproliferative changes with spinal ossifications in ax SpA. The adipose tissue is involved in the pathophysiology of IRDs via the release of several proteins, namely, adipokines. Several adipokines with pro-inflammatory effects have been identified, such as leptin, adiponectin, visfatin and resistin. In this review, we discuss the role that adipokines may play in the structural modifications of the peripheral joints and/or axial skeleton. In RA, the role of leptin in structural damage remains controversial, while adiponectin and its high-molecular-weight isoform are known to have an influence on the development of bone erosions and radiographic progression. Resistin also appears to be a potent detrimental adipokine for the joints in RA. In ax SpA, visfatin seems to be an attractive candidate for radiographic progression, while leptin and adiponectin have negative effects on radiographic progression.

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Figure 1 The contribution of adipokines to joint modification in inflammatory rheumatic diseases (IRDs). Several factors are produced by the adipose tissue, collectively called adipokines. Leptin, adiponectin, visfatin and resistin are all involved in inflammation of the joints/axial skeleton in rheumatoid arthritis and axial spondyloarthritis. By stimulating pro-inflammatory cytokine release from innate and adaptive immune cells, adipokines induce an inflammatory milieu. In turn, pro-inflammatory cytokines may promote the release of adipokines. Leptin, visfatin and resistin all have pro-inflammatory effects on the joints and/or axial skeleton, while the effects of adiponectin on the inflammatory process are variable and depend on its isoform, with the high-molecular-weight isoform driving a pro-inflammatory reaction. Due to the interplay that adipokines have with specific factors involved in cartilage and bone metabolism, they may contribute to cartilage degradation and bone erosions in RA or spinal ligamentous ossifications in ax SpA (RA: rheumatoid arthritis; ax SpA: axial spondyloarthritis; HMW: high molecular weight; MMP: metalloproteinases; RANKL: receptor activator of nuclear factor κB ligand; dashed arrow: inhibitory effect; lined arrow: stimulating effect).CC BY · PubMed Central

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Authors: Toussirot, E.
Affiliations: INSERM CIC-1431, Centre d’Investigation Clinique Biothérapie, Pôle Recherche, CHU de Besançon, 25000 Besançon, France
ORCID: Toussirot, Eric
Venue: Biomedicines
Publisher: MDPI AG
Published: 2023-02-13
Volume: 11
Issue: 2
Pages: 536
ISSN: 2227-9059 (ISSN-L)
DOI: 10.3390/biomedicines11020536
PMC: PMC9953013
OpenAlex: W4320497452
Cited by: 12
References: 106
Citations by year: 2026: 2 · 2025: 6 · 2024: 1 · 2023: 3
FWCI: 0.53
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Biomedicines (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: CHU de Besancon (API/2013/37)
Topics: Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
Keywords: adipokines, inflammatory rheumatic diseases, radiographic damage, rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, leptin, adiponectin, visfatin, resistin, bone erosion, structural joint damage, adipose tissue, radiographic progression

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The Influence of Adipokines on Radiographic Damage in Inflammatory Rheumatic Diseases

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