The DOI matches its Crossref record; 104 of the 106 references it cites were found in a registry or an index.
The Influence of Adipokines on Radiographic Damage in Inflammatory Rheumatic Diseases
Open accessAbstract
Inflammatory rheumatic diseases (IRDs) are complex immune-mediated diseases that are characterized by chronic inflammation of the joints. Rheumatoid arthritis (RA) and spondyloarthritis (SpA), including axial SpA (ax SpA) and psoriatic arthritis (PsA), are the most common forms of IRD. Both RA and ax SpA are characterized by a chronic course with progressive structural modifications, namely, cartilage damage and bone erosions in RA and osteoproliferative changes with spinal ossifications in ax SpA. The adipose tissue is involved in the pathophysiology of IRDs via the release of several proteins, namely, adipokines. Several adipokines with pro-inflammatory effects have been identified, such as leptin, adiponectin, visfatin and resistin. In this review, we discuss the role that adipokines may play in the structural modifications of the peripheral joints and/or axial skeleton. In RA, the role of leptin in structural damage remains controversial, while adiponectin and its high-molecular-weight isoform are known to have an influence on the development of bone erosions and radiographic progression. Resistin also appears to be a potent detrimental adipokine for the joints in RA. In ax SpA, visfatin seems to be an attractive candidate for radiographic progression, while leptin and adiponectin have negative effects on radiographic progression.
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“Leptin derived from obesity or periarticular fat depots promotes synovial inflammation, cartilage catabolism, and pain, whereas adiponectin exerts context-dependent effects, including associations with radiographic progression and bone erosion in RA [124–126].”
From Interorgan Communications in Skeletal Pathophysiology: From Molecular Pathways to Multidisciplinary Therapies (2026) · cites this paper as [126]
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“Leptin derived from obesity or periarticular fat depots promotes synovial inflammation, cartilage catabolism, and pain, whereas adiponectin exerts context-dependent effects, including associations with radiographic progression and bone erosion in RA [124–126].”
From Interorgan Communications in Skeletal Pathophysiology: From Molecular Pathways to Multidisciplinary Therapies (2026) · cites this paper as [126]
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Cites
Smolen, J. S., Aletaha, D., & McInnes, I. B. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30173-8 · Cited by 5,165
Adipose tissue, adipokines, and inflammation
Fantuzzi, G. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.023 · Cited by 2,606
Leptin Inhibits Bone Formation through a Hypothalamic Relay
Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M., & Karsenty, G. (2000) · Cell · doi:10.1016/s0092-8674(00)81558-5 · Cited by 2,077
Management of Rheumatoid Arthritis: An Overview
Radu, A.-F., & Bungau, S. G. (2021) · Cells · doi:10.3390/cells10112857 · Cited by 1,089
Resistin, an Adipokine with Potent Proinflammatory Properties
Bokarewa, M. I., Nagaev, I., Dahlberg, L., Smith, U., & Tarkowski, A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5789 · Cited by 1,054
Adiponectin as an anti-inflammatory factor
Ouchi, N., & Walsh, K. X. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.01.026 · Cited by 910
The biology of leptin: a review.
Houseknecht, K. L., Baile, C. A., Matteri, R. L., & Spurlock, M. E. (1998) · Journal of Animal Science · doi:10.2527/1998.7651405x · Cited by 777
Otero, M., Lago, R., Gómez, R., Lago, F., Diéguez, C., Gómez-Reino, J. J., & Gualillo, O. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.046540 · Cited by 540
Adiponectin: a key adipocytokine in metabolic syndrome
Okamoto, Y., Kihara, S., Funahashi, T., Matsuzawa, Y., & Libby, P. (2006) · Clinical Science · doi:10.1042/cs20050182 · Cited by 445
Leptin Inhibits Osteoclast Generation
Holloway, W. R., Collier, F., Aitken, C. J., Myers, D. E., Hodge, J. M., Malakellis, M., Gough, T. J., Collier, G., & Nicholson, G. C. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.2.200 · Cited by 440
Cited by
Sorted by citations
Shi, Y., Guan, S., Liu, X., Zhai, H., Zhang, Y., Liu, J., Yang, W., & Wang, Z. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70329 · Cited by 9
Nesfatin-1 stimulates BMP5 expression and osteoclastogenesis in rheumatoid arthritis
Chang, J., Lin, Y., Tsai, C., Liu, S., He, X.-Y., Wu, Y., Huang, C., & Tang, C. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115687 · Cited by 8
Fioravanti, A., Cheleschi, S., Cavalier, E., Reginster, J., Alokail, M. S., Ladang, A., Tenti, S., & Bedogni, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104621 · Cited by 6
BORDEAN, L., Chiș, M., Cîmpean, A. M., Barb, A. C., Cosma, A. A., Fenesan, M. P., Cotoi, O. S., Nicolescu, L. C., NICOLESCU, C. M., & Avram, C. (2023) · In Vivo · doi:10.21873/invivo.13344 · Cited by 6
Yang, Y., Yichong, L., Shui, R., & Li, D. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1555135 · Cited by 4
Metadata
- Authors
- Toussirot, E.
- Affiliations
- INSERM CIC-1431, Centre d’Investigation Clinique Biothérapie, Pôle Recherche, CHU de Besançon, 25000 Besançon, France
- ORCID
- Toussirot, Eric
- Venue
- Biomedicines
- Publisher
- MDPI AG
- Published
- 2023-02-13
- Volume
- 11
- Issue
- 2
- Pages
- 536
- ISSN
- 2227-9059 (ISSN-L)
- PMC
- PMC9953013
- OpenAlex
- W4320497452
- Cited by
- 12
- References
- 106
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 1 · 2023: 3
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- CHU de Besancon (API/2013/37)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Keywords
- adipokines, inflammatory rheumatic diseases, radiographic damage, rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, leptin, adiponectin, visfatin, resistin, bone erosion, structural joint damage, adipose tissue, radiographic progression
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