Assessment and impact of cognitive impairment in multiple sclerosis: An overview
Open accessAbstract
Cognitive impairment affects 40–60% of patients with multiple sclerosis. It may be present early in the course of the disease and has an impact on a patient’s employability, social interactions, and quality of life. In the last three decades, an increasing interest in diagnosis and management of cognitive impairment has arisen. Neuropsychological assessment and neuroimaging studies focusing on cognitive impairment are now being incorporated as primary outcomes in clinical trials. However, there are still key uncertainties concerning the underlying mechanisms of damage, neural basis, sensitivity and validity of neuropsychological tests, and efficacy of pharmacological and non-pharmacological interventions. The present article aimed to present an overview of the assessment, neural correlates, and impact of cognitive impairment in multiple sclerosis.
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- Authors
- Macías Islas, M. Á., & Ciampi, E.
- Affiliations
- Department of Neurosciences, CUCS. University of Guadalajara and Mexico, Guadalajara 44160, Mexico
- Pontificia Universidad Católica de Chile (CL)
- Venue
- Biomedicines
- Publisher
- MDPI AG
- Published
- 2019-03-19
- Volume
- 7
- Issue
- 1
- Pages
- 22
- ISSN
- 2227-9059 (ISSN-L)
- PMC
- PMC6466345
- OpenAlex
- W2921709315
- Cited by
- 144
- References
- 144
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 21 · 2023: 26 · 2022: 20 · 2021: 30 · 2020: 17 · 2019: 2
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- multiple sclerosis, cognitive impairment, neuropsychological assessment, neuroimaging, neural correlates, quality of life, employability, clinical trial results, pharmacological interventions, non-pharmacological treatment, neuropsychological test validity
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