Cited by 144Multiple Sclerosis Research StudiesCancer-related cognitive impairment studiesDementia and Cognitive Impairment Research

Assessment and impact of cognitive impairment in multiple sclerosis: An overview

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Macías Islas, Miguel Ángel, Ciampi, Ethel·2019·Biomedicines

Abstract

Cognitive impairment affects 40–60% of patients with multiple sclerosis. It may be present early in the course of the disease and has an impact on a patient’s employability, social interactions, and quality of life. In the last three decades, an increasing interest in diagnosis and management of cognitive impairment has arisen. Neuropsychological assessment and neuroimaging studies focusing on cognitive impairment are now being incorporated as primary outcomes in clinical trials. However, there are still key uncertainties concerning the underlying mechanisms of damage, neural basis, sensitivity and validity of neuropsychological tests, and efficacy of pharmacological and non-pharmacological interventions. The present article aimed to present an overview of the assessment, neural correlates, and impact of cognitive impairment in multiple sclerosis.

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Crossref · 10.3390/biomedicines7010022

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Research works printed but not linked: 3

  1. [39]Lezak M.D. Howieson D.B. Bigler E.D. Tranel D. Neuropsychological Assessment 5th ed. Oxford University Press New York, NY, USA 2012
  2. [64]Friesen W.V. Ekman P. Friesen Pictures of Facial Affect Consulting Psychologists Press Palo Alto, CA, USA 1976
  3. [78]Labbé T. Ciampi E. Cruz J.P. Zurita M. Uribe S. Cárcamo C. Functional magnetic resonance imaging in the study of multiple sclerosis Rev. Neurol. 2018 67 91 98 29999173

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Authors
Macías Islas, M. Á., & Ciampi, E.
Affiliations
  • Department of Neurosciences, CUCS. University of Guadalajara and Mexico, Guadalajara 44160, Mexico
  • Pontificia Universidad Católica de Chile (CL)
Venue
Biomedicines
Publisher
MDPI AG
Published
2019-03-19
Volume
7
Issue
1
Pages
22
ISSN
2227-9059 (ISSN-L)
OpenAlex
W2921709315
Cited by
144
References
144
Citations by year
2026: 12 · 2025: 16 · 2024: 21 · 2023: 26 · 2022: 20 · 2021: 30 · 2020: 17 · 2019: 2
FWCI
2.57
Type
journal article
Language
en
Open access
Locations
  • Biomedicines (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
multiple sclerosis, cognitive impairment, neuropsychological assessment, neuroimaging, neural correlates, quality of life, employability, clinical trial results, pharmacological interventions, non-pharmacological treatment, neuropsychological test validity

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