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Cited by 39Skin Protection and AgingSeaweed-derived Bioactive CompoundsMarine and coastal plant biology

UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium

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Prasedya, Eka Sunarwidhi, Syafitri, Sundari Maulinda, Geraldine, Brigitta A. F. D., Hamdin, Candra Dwipayana, Frediansyah, Andri, Miyake, Masao, Kobayashi, Daisuke, Hazama, Akihiro +1 more·2019·Biomedicines
DOI 10.3390/biomedicines7040077PMC PMC6966596
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Abstract

Sunscreens today contain several synthetic UV (Ultraviolet) filter molecules to protect the skin epidermis from UV radiation damage. However, these molecules may create several negative effects on human skin. Due to this condition, there is an increase in the development of natural products to replace uses of these synthetic chemicals. Brown macroalgae Sargassum has been recently studied for its photoprotective activities. The purpose of this study is to investigate photoprotective activity of one of most abundant Sargassum species in Lombok coast; Sargassum cristaefolium. Spectrophotometry analysis with UV-VIS revealed the UV spectra absorbing capability of Sargassum cristaefolium (SC) in the UVA spectrum range (314–400 nm). Furthermore, spectrometry analyses with LC-MS revealed the existence of UV absorbing compound MAA-palythene. In correlation, SC ethanol extracts also demonstrate that it could protect DNA from UVA irradiation as analyzed in vitro in HeLa cell model. The effects of SC on UVA exposed-dorsal mice skin have also shown interesting results, as mice pretreated with SC before UVA exposure showed protective activity on the epidermal integrity similar as positive control. Whereas, UV exposed mice without SC or commercial products resulted in increased epidermal thickness, which is the common parameter of skin photoaging. In addition, pretreated mice with SC also show protective effects in the formation of collagen connective tissues. Overall, current results show promising photoprotective activity of SC against UV radiation. More advanced investigations of SC as a potential photoprotective agent would be reasonable for development of macroalgae-based natural skin protection products.

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  • Palythine (41) was found in an ethanolic extract of brown macroalgae Sargassum cristafolium.

    “These MAAs were also found in an ethanolic extract of brown macroalgae Sargassum cristafolium, namely, palythine (41) [120].”

    From UV Filters: Challenges and Prospects (2022) · cites this paper as [120]

    Section 3.3 identifies the compound detected in the S. cristaefolium ethanol extract as palythene, not palythine. The Discussion likewise says the extract potentially contains palythene; it mentions palythine only as an MAA found in various seaweeds. (LLM, conf=0.90)

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  • The MAAs most reported for protective potential against UVR are palythine (41), asterina-330 (42), shinorine (43), and porphyra-334 (45).

    “but the most reported for their protective potential against UVR are palythine (41) [119], asterina-330 (42) [119,120], shinorine (43) [118,119], and porphyra-334 (45) [118].”

    From UV Filters: Challenges and Prospects (2022) · cites this paper as [120]

    The Discussion (section 4; page not provided) names palythine, shinorine, and Porphyra-334 as MAAs found in seaweeds and discusses MAAs’ protection against UV radiation. It does not name asterina-330 or establish that the listed MAAs are the most reported for protective potential; the study’s own conclusion concerns palythene. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Ethanolic extract of brown macroalgae Sargassum cristafolium contains palythine (41) and has photoprotective activity with λc = 370 nm.

    “| Ethanolic extract of brown macroalgae Sargassum cristafolium | Palythine (41) | Photoprotective | λc = 370 nm | [120] |”

    From UV Filters: Challenges and Prospects (2022) · cites this paper as [120]

    The Results (§3.2) report UVA absorption by the Sargassum cristaefolium ethanol extract, supporting its photoprotective activity. But the LC-MS result (§3.3) identifies palythene, not palythine, and the copy does not report a critical wavelength (λc) of 370 nm. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Authors
Prasedya, E. S., Syafitri, S. M., Geraldine, B. A. F. D., Hamdin, C. D., Frediansyah, A., Miyake, M., Kobayashi, D., Hazama, A., & Sunarpi, H.
Affiliations
  • University of Mataram (ID)
  • Indonesian Institute of Sciences (ID)
  • Fukushima Medical University (JP)
Corresponding author
Sunarpi, Haji
ORCID
Venue
Biomedicines
Publisher
MDPI AG
Published
2019-09-27
Volume
7
Issue
4
Pages
77
ISSN
2227-9059 (ISSN-L)
DOI
10.3390/biomedicines7040077
PMC
PMC6966596
OpenAlex
W2975228248
Cited by
39
References
32
Citations by year
2026: 1 · 2025: 7 · 2024: 4 · 2023: 9 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 1
FWCI
4.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomedicines (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Kementerian Riset Teknologi Dan Pendidikan Tinggi Republik Indonesia (LN.18/2019)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
Keywords
Sargassum cristaefolium, brown macroalgae, photoprotection, UVA, UV-absorbing compounds, DNA protection, epidermal integrity, photoaging, collagen synthesis, natural sunscreen

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