Depression and Cognitive Impairment—Extrahepatic Manifestations of NAFLD and NASH
Open accessAbstract
Non-alcoholic fatty liver disease (NAFLD) and its complication non-alcoholic steatohepatitis (NASH) are important causes of liver disease worldwide. Recently, a significant association between these hepatic diseases and different central nervous system (CNS) disorders has been observed in an increasing number of patients. NAFLD-related CNS dysfunctions include cognitive impairment, hippocampal-dependent memory impairment, and mood imbalances (in particular, depression and anxiety). This review aims at summarizing the main correlations observed between NAFLD development and these CNS dysfunctions, focusing on the studies investigating the mechanism(s) involved in this association. Growing evidences point at cerebrovascular alteration, neuroinflammation, and brain insulin resistance as NAFLD/NASH-related CNS manifestations. Since the pharmacological options available for the management of these conditions are still limited, further studies are needed to unravel the mechanism(s) of NAFLD/NASH and their central manifestations and identify effective pharmacological targets.
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One reason the onset of PD is higher in men than in women may be the effect of estrogen on dopaminergic neurons and pathways in the brain.
“One of the reasons why the onset of PD is higher in men than in women may be due to the effect of estrogen on dopaminergic neurons and pathways in the brain [75].”
From Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human (2020) · cites this paper as [75]
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Jee, H. J., Lee, S. G., Bormate, K. J., & Jung, Y.-S. (2020) · Nutrients · doi:10.3390/nu12103080 · Cited by 111 · see citing works
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BackgroundMASLD: Prevalence, Mechanisms, and Sex-Based Therapies in Postmenopausal Women
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- Authors
- Colognesi, M., Gabbia, D., & De Martin, S.
- Affiliations
- University of Padua (IT)
- Department of Pharmaceutical and Pharmacological Sciences, University of Padova, L.go Meneghetti 2, 35131 Padova, Italy
- Venue
- Biomedicines
- Publisher
- MDPI AG
- Published
- 2020-07-21
- Volume
- 8
- Issue
- 7
- Pages
- 229
- ISSN
- 2227-9059 (ISSN-L)
- PMC
- PMC7400092
- OpenAlex
- W3042750809
- Cited by
- 98
- References
- 81
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 16 · 2023: 18 · 2022: 24 · 2021: 10 · 2020: 5
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Università degli Studi di Padova (DEMA_SID19_01)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, depression, cognitive impairment, hippocampal-dependent memory, anxiety, cerebrovascular dysfunction, neuroinflammation, brain insulin resistance, central nervous system disorders
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