Cited by 98Liver Disease Diagnosis and TreatmentLiver Diseases and ImmunityAlcohol Consumption and Health Effects

Non‐alcoholic fatty liver disease comorbid with major depressive disorder: the pathological features and poor therapeutic efficacy

Tomeno, Wataru, Kawashima, Keigo, Yoneda, Masato, Saito, Satoru, Ogawa, Yuji, Honda, Yasushi, Kessoku, Takaomi, Imajo, Kento +5 more·2015·Journal of Gastroenterology and Hepatology

Abstract

BACKGROUND AND AIM: Major depressive disorder (MDD) is an important public health problem, and it is often comorbid with many chronic diseases. The purpose of this study was to identify the clinical features of non-alcoholic fatty liver disease (NAFLD) patients comorbid with MDD and to investigate the influence of MDD on the effect of treatment in patients with NAFLD. METHODS: A total of 258 patients with biopsy-proven NAFLD were included. MDD was diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision. The patients were followed up for 48 weeks under standard care for NAFLD, which consisted mainly of lifestyle modification. RESULTS: There were 32 patients comorbid with MDD. They were characterized by more severe histological steatosis and higher NAFLD activity score, and also significantly higher levels of serum aminotransferase, γ-glutamyl transpeptidase and ferritin, than age-and-sex-matched NAFLD patients without MDD. Moreover, NAFLD patients with MDD showed poor response to the standard care for NAFLD, in body weight loss and in other parameters. Particularly, NAFLD patients with unstable MDD (not in full/partial remission) showed severe resistance to the treatment. CONCLUSION: This is the first study to demonstrate the clinical features and response to therapy of NAFLD patients comorbid with MDD. The comorbid state of MDD was associated with more severe histological liver steatosis and worse treatment outcomes in patients with NAFLD. Further investigations are required to develop new lifestyle modification programs that enable NAFLD patients with MDD to achieve the treatment goal.

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Crossref · 10.1111/jgh.12897

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Authors
Tomeno, W., Kawashima, K., Yoneda, M., Saito, S., Ogawa, Y., Honda, Y., Kessoku, T., Imajo, K., Mawatari, H., Fujita, K., Saito, S., Hirayasu, Y., & Nakajima, A.
Affiliations
  • Yokohama City University (JP)
  • Nagoya City University (JP)
  • University of Miami (US)
Corresponding author
Nakajima, Atsushi
Venue
Journal of Gastroenterology and Hepatology
Publisher
Wiley
Published
2015-04-27
Volume
30
Issue
6
Pages
1009-1014
ISSN
  • 0815-9319 (ISSN-L)
  • 1440-1746
OpenAlex
W1567967478
Cited by
98
References
28
Citations by year
2026: 4 · 2025: 11 · 2024: 17 · 2023: 10 · 2022: 17 · 2021: 12 · 2020: 9 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 2
FWCI
2.87
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Gastroenterology and Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Young Scientists
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
non-alcoholic fatty liver disease, major depressive disorder, comorbidities, hepatic steatosis, NAFLD activity score, transaminases, ferritin, gamma-glutamyl transferase, lifestyle modification, treatment response, weight loss, depression remission
MeSH terms
Adult, Aged, Depressive Disorder, Female, Follow-Up Studies, Humans, Male, Middle Aged, Severity of Illness Index, Time Factors, Comorbidity, Treatment Outcome, Risk Reduction Behavior, Non-alcoholic Fatty Liver Disease

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