Cited by 302Alzheimer's disease research and treatmentsMemory and Neural MechanismsOlfactory and Sensory Function Studies

Intranasal Insulin Improves Memory in Humans: Superiority of Insulin Aspart

Benedict, Christian, Hallschmid, Manfred, Schmitz, Katrin, Schultes, Bernd, Ratter, Frank, Fehm, Horst L, Born, Jan, Kern, Werner·2007·Neuropsychopharmacology

Abstract

There is compelling evidence that intranasal administration of regular human insulin (RH-I) improves memory in humans. Owing to the reduced tendency of its molecules to form hexamers, the rapid-acting insulin analog insulin aspart (ASP-I) is more rapidly absorbed than RH-I after subcutaneous administration. Since after intranasal insulin administration, ASP-I may also be expected to access the brain, we examined whether intranasal ASP-I has stronger beneficial effects on declarative memory than RH-I in humans. Acute (40 IU) and long-term (4 x 40 IU/day over 8 weeks) effects of intranasally administered ASP-I, RH-I, and placebo on declarative memory (word lists) were assessed in 36 healthy men in a between-subject design. Plasma insulin and glucose levels were not affected. After 8 weeks of treatment, however, word list recall was improved compared to placebo in both the ASP-I (p<0.01) and the RH-I groups (p<0.05). ASP-I-treated subjects performed even better than those of the RH-I-treated group (p<0.05). Our results indicate that insulin-induced memory improvement can be enhanced by using ASP-I. This finding may be especially relevant for a potential clinical administration of intranasal insulin in the treatment of memory disorders like Alzheimer's disease.

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Crossref · 10.1038/sj.npp.1301193

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  • Administering the rapid-acting insulin analogue insulin aspart intensifies the improvement in declarative memory.

    “Administering the rapid-acting insulin analogue insulin aspart intensifies the improvement in declarative memory.40”

    From Intranasal insulin (2021) · cites this paper as [40]

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Authors
Benedict, C., Hallschmid, M., Schmitz, K., Schultes, B., Ratter, F., Fehm, H. L., Born, J., & Kern, W.
Affiliations
  • University of Lübeck (DE)
  • Kantonsspital St. Gallen (CH)
  • Novo Nordisk (Germany) (DE)
Corresponding author
Benedict, Christian
Venue
Neuropsychopharmacology
Published
2006-08-16
Volume
32
Issue
1
Pages
239-243
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
OpenAlex
W2156600347
Cited by
302
References
43
Citations by year
2026: 11 · 2025: 16 · 2024: 8 · 2023: 16 · 2022: 18 · 2021: 15 · 2020: 17 · 2019: 16 · 2018: 28 · 2017: 16 · 2016: 13 · 2015: 16 · 2014: 17 · 2013: 19 · 2012: 14
FWCI
7.73
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft (SFB654)
  • Novo Nordisk
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords
intranasal insulin, insulin aspart, regular insulin, declarative memory, memory enhancement, insulin analogues, word list recall, Alzheimer's disease, cognitive impairment treatment
MeSH terms
Administration, Intranasal, Adolescent, Adult, Analysis of Variance, Blood Glucose, Double-Blind Method, Drug Administration Schedule, Humans, Hypoglycemic Agents, Insulin, Male, Memory, Neuropsychological Tests, Insulin Aspart

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