NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors
Open accessAbstract
The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) is a growing concern for the high incidence rate of hepatocellular carcinoma (HCC) globally. The progression of NAFLD to HCC is heterogeneous and non-linear, involving intermediate stages of non-alcoholic steatohepatitis (NASH), liver fibrosis, and cirrhosis. There is a high unmet clinical need for appropriate diagnostic, prognostic, and therapeutic options to tackle this emerging epidemic. Unfortunately, at present, there is no validated marker to identify the risk of developing HCC in patients suffering from NAFLD or NASH. Additionally, the current treatment protocols for HCC don't differentiate between viral infection or NAFLD-specific etiology of the HCC and have a limited success rate. The mammalian target of rapamycin complex 1 (mTORc1) is an important protein involved in many vital cellular processes like lipid metabolism, glucose homeostasis, and inflammation. These cellular processes are highly implicated in NAFLD and its progression to severe liver manifestations. Additionally, hyperactivation of mTORc1 is known to promote cell proliferation, which can contribute to the genesis and progression of tumors. Many mTORc1 inhibitors are being evaluated for different types of cancers under various phases of clinical trials. This paper deliberates on the strong pathological implication of the mTORc1 signaling pathway in NAFLD and its progression to NASH and HCC and advocates for a systematic investigation of known mTORc1 inhibitors in suitable pre-clinical models of HCC having NAFLD/NASH-specific etiology.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several pharmacological agents show potential for synergistic combination with MSC-based anti-fibrotic therapy.
“Beyond these drugs, several pharmacological agents show potential for synergistic combination with MSC-based anti-fibrotic therapy [386–388].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [388]
mTORc1 inhibitors such as rapamycin have demonstrated anti-fibrotic and pro-autophagic effects in NAFLD models.
“mTORc1 inhibitors, such as rapamycin, have demonstrated anti-fibrotic and pro-autophagic effects in NAFLD models [388].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [388]
Cites
mTOR Signaling in Growth, Metabolism, and Disease
Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555 · see citing works
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · see citing works
Inflammatory responses and inflammation-associated diseases in organs
Chen, L., Deng, H., Cui, H., Fang, J. S., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L. (2017) · Oncotarget · doi:10.18632/oncotarget.23208 · Cited by 5,280 · see citing works
Drug repurposing: progress, challenges and recommendations
Pushpakom, S., Iorio, F., Eyers, P. A., Escott, K. J., Hopper, S., Wells, A., Doig, A., Guilliams, T., Latimer, J., McNamee, C., et al. (2019) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.168 · Cited by 4,718 · see citing works
Eslam, M., Newsome, P. N., Sarin, S. K., Anstee, Q. M., Targher, G., Romero-Gomez, M., Zelber-Sagi, S., Wai-Sun Wong, V., Dufour, J.-F., Schattenberg, J. M., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.03.039 · Cited by 4,472 · see citing works
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941 · see citing works
Younossi, Z. M., Golabi, P., Paik, J. M., Henry, A., Van Dongen, C., & Henry, L. (2023) · Hepatology · doi:10.1097/hep.0000000000000004 · Cited by 3,383 · see citing works
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works
Mechanisms for Insulin Resistance: Common Threads and Missing Links
Samuel, V. T., & Shulman, G. I. (2012) · Cell · doi:10.1016/j.cell.2012.02.017 · Cited by 2,294 · see citing works
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications
Fabbrini, E., Sullivan, S., & Klein, S. (2010) · Hepatology · doi:10.1002/hep.23280 · Cited by 2,100 · see citing works
A phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis
Harrison, S. A., Bedossa, P., Guy, C. D., Schattenberg, J. M., Loomba, R., Taub, R., Labriola, D., Moussa, S. E., Neff, G. W., Rinella, M. E., et al. (2024) · New England Journal of Medicine · doi:10.1056/nejmoa2309000 · Cited by 2,084 · see citing works
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Jung, C. H., Jun, C. B., Ro, S.-H., Kim, Y.-M., Otto, N. M., Cao, J., Kundu, M., & Kim, D.-H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1249 · Cited by 2,025 · see citing works
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020 · see citing works
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677 · see citing works
The PI3K/AKT Pathway in Obesity and Type 2 Diabetes
Huang, X., Liu, G., Guo, J., & Su, Z. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.27173 · Cited by 1,673 · see citing works
ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
Ganley, I. G., Lam, D., Wang, J., Ding, X., Chen, S., & Jiang, X. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900573200 · Cited by 1,559 · see citing works
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y.-L., & Schulze, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.007 · Cited by 1,413 · see citing works
Rapamycin: one drug, many effects
Li, J., Kim, S. G., & Blenis, J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.001 · Cited by 1,287 · see citing works
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
Peterson, T. R., Sengupta, S., Harris, T. E., Carmack, A. E., Kang, S. A. W., Balderas, E., Guertin, D. A., Madden, K. L., Carpenter, A. E., Finck, B. N., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.034 · Cited by 1,233 · see citing works
Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
Lamming, D. W., Ye, L., Katajisto, P., Goncalves, M. D., Saitoh, M., Stevens, D. M., Davis, J. G., Salmon, A. B., Richardson, A., Ahima, R. S., et al. (2012) · Science · doi:10.1126/science.1215135 · Cited by 1,199 · see citing works
Liver immunology and its role in inflammation and homeostasis
Robinson, M. W., Harmon, C., & O’Farrelly, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2016.3 · Cited by 1,151 · see citing works
Inflammasome activation and regulation: toward a better understanding of complex mechanisms
Zheng, D., Liwinski, T., & Elinav, E. (2020) · Cell Discovery · doi:10.1038/s41421-020-0167-x · Cited by 1,042 · see citing works
Regulation and function of mTOR signalling in T cell fate decisions
Chi, H. (2012) · Nature Reviews Immunology · doi:10.1038/nri3198 · Cited by 1,035 · see citing works
TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop
Settembre, C., De Cegli, R., Mansueto, G., Saha, P. K., Vetrini, F., Visvikis, O., Huynh, T., Carissimo, A., Palmer, D., Jürgen Klisch, T., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2718 · Cited by 1,022 · see citing works
Signaling and Function of Interleukin-2 in T Lymphocytes
Ross, S. H., & Cantrell, D. A. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053352 · Cited by 969 · see citing works
Pouwels, S., Sakran, N., Graham, Y. N. H., Leal, A., Pintar, T., Yang, W., Kassir, R., Singhal, R., Mahawar, K. K., & Ramnarain, D. (2022) · BMC Endocrine Disorders · doi:10.1186/s12902-022-00980-1 · Cited by 912 · see citing works
Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification
Reghupaty, S. C., Fisher, P. B., & Sarkar, D. (2020) · Advances in cancer research · doi:10.1016/bs.acr.2020.10.001 · Cited by 865 · see citing works
The complex link between NAFLD and type 2 diabetes mellitus - mechanisms and treatments
Targher, G., Corey, K. E., Byrne, C. D., & Roden, M. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00448-y · Cited by 850 · see citing works
A multisociety Delphi consensus statement on new fatty liver disease nomenclature
Rinella, M. E., Lazarus, J. V., Ratziu, V., Francque, S. M., Sanyal, A. J., Kanwal, F., Romero, D., Abdelmalek, M. F., Anstee, Q. M., Arab, J. P., et al. (2024) · Annals of Hepatology · doi:10.1016/j.aohep.2023.101133 · Cited by 844 · see citing works
Regulation of Immune Responses by mTOR
Powell, J. D., Pollizzi, K. N., Heikamp, E. B., & Horton, M. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075024 · Cited by 836 · see citing works
Current status and future trends of the global burden of MASLD
Miao, L., Targher, G., Byrne, C. D., Cao, Y.-Y., & Zheng, M.-H. (2024) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2024.02.007 · Cited by 781 · see citing works
Management of Hepatocellular Carcinoma
Brown, Z. J., Tsilimigras, D. I., Ruff, S. M., Mohseni, A., Kamel, I. R., Cloyd, J. M., & Pawlik, T. M. (2023) · JAMA Surgery · doi:10.1001/jamasurg.2022.7989 · Cited by 779 · see citing works
Targeting mTOR for cancer therapy
Hua, H., Kong, Q.-B., Zhang, H., Wang, J., Luo, T., & Jiang, Y.-F. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0754-1 · Cited by 772 · see citing works
Regulation and metabolic functions of mTORC1 and mTORC2.
Szwed, A., Kim, E., & Jacinto, E. (2021) · Physiological Reviews · doi:10.1152/physrev.00026.2020 · Cited by 723 · see citing works
Metformin in non-alcoholic steatohepatitis.
Marchesini, G., Bianchi, G., Tomassetti, S., Zoli, M., & Melchionda, N. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06042-1 · Cited by 682 · see citing works
Wolf, M. J., Adili, A., Piotrowitz, K., Abdullah, Z., Boege, Y., Stemmer, K., Ringelhan, M., Simonavicius, N., Egger, M., Wohlleber, D., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.003 · Cited by 678 · see citing works
Yecies, J. L., Zhang, H., Menon, S., Liu, S., Yecies, D. W., Lipovsky, A. I., Görgün, C. Z., Kwiatkowski, D. J., Hotamışlıgil, G. S., Lee, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.002 · Cited by 655 · see citing works
Insulin regulation of gluconeogenesis
Hatting, M., Tavares, C. D. J., Sharabi, K., Rines, A. K., & Puigserver, P. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13435 · Cited by 589 · see citing works
Younossi, Z. M., Stepanova, M., Ong, J. P., Trimble, G., Alqahtani, S. A., Younossi, I. M., Ahmed, A., Racila, A., & Henry, L. L. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.05.064 · Cited by 587 · see citing works
Tsuchida, T., Lee, Y. A., Fujiwara, N., Ybanez, M., Allen, B., Martins, S., Fiel, M. I., Goossens, N., Chou, H.-I., Hoshida, Y., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.011 · Cited by 583 · see citing works
Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
Hagiwara, A., Cornu, M., Cybulski, N., Polak, P., Betz, C., Trapani, F., Terracciano, L., Heim, M. H., Rüegg, M. A., & Hall, M. N. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.015 · Cited by 551 · see citing works
A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer
Asgharpour, A., Cazanave, S. C., Pacana, T., Seneshaw, M., Vincent, R., Banini, B. A., Kumar, D. P., Daita, K., Min, H.-K., Mirshahi, F., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.005 · Cited by 538 · see citing works
Obesity: A Chronic Low-Grade Inflammation and Its Markers
Khanna, D., Khanna, S., Khanna, P., Kahar, P., & Patel, B. M. (2022) · Cureus · doi:10.7759/cureus.22711 · Cited by 531 · see citing works
Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
Polak, P., Cybulski, N., Feige, J. N., Auwerx, J., Rüegg, M. A., & Hall, M. N. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.003 · Cited by 480 · see citing works
He, G., Dhar, D., Nakagawa, H., Font-Burgada, J., Ogata, H., Jiang, Y., Shalapour, S., Seki, E., Yost, S. E., Jepsen, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.031 · Cited by 469 · see citing works
Histopathology of nonalcoholic fatty liver disease
Brunt, E. M. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i42.5286 · Cited by 448 · see citing works
mTORC1 and mTORC2 in cancer and the tumor microenvironment
Kim, L. C., Cook, R. S., & Chen, J. (2016) · Oncogene · doi:10.1038/onc.2016.363 · Cited by 443 · see citing works
Mitochondrial alterations in fatty liver diseases
Fromenty, B., & Roden, M. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.09.020 · Cited by 430 · see citing works
Pathogenesis of Nonalcoholic Steatohepatitis: An Overview
Parthasarathy, G., Revelo, X. S., & Malhi, H. (2020) · Hepatology Communications · doi:10.1002/hep4.1479 · Cited by 420 · see citing works
mTORC2 Promotes Tumorigenesis via Lipid Synthesis
Guri, Y., Colombi, M., Dazert, E., Hindupur, S. K., Roszik, J., Moes, S., Jenoe, P., Heim, M. H., Riezman, I., Riezman, H., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.11.011 · Cited by 410 · see citing works
Gawrieh, S., Noureddin, M., Loo, N., Mohseni, R., Awasty, V., Cusi, K., Kowdley, K. V., Lai, M., Schiff, E., Parmar, D., et al. (2021) · Hepatology · doi:10.1002/hep.31843 · Cited by 379 · see citing works
Targeting the biology of aging with mTOR inhibitors
Mannick, J. B., & Lamming, D. W. (2023) · Nature Aging · doi:10.1038/s43587-023-00416-y · Cited by 372 · see citing works
Xu, X., Poulsen, K. L., Wu, L., Liu, S., Miyata, T., Song, Q., Wei, Q., Zhao, C., Lin, C., & Yang, J. B. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01119-3 · Cited by 370 · see citing works
Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment
Llovet, J. M., Willoughby, C. E., Singal, A. G., Greten, T. F., Heikenwälder, M., El-Serag, H. B., Finn, R. S., & Friedman, S. L. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00754-7 · Cited by 354 · see citing works
Pathogenesis and Prevention of Hepatic Steatosis.
Nassir, F., Rector, R. S., Hammoud, G. M., & Ibdah, J. A. (2015) · PubMed Central · Cited by 321 · see citing works
Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis
Guo, J., & Friedman, S. L. (2010) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-3-21 · Cited by 315 · see citing works
Role of nonresolving inflammation in hepatocellular carcinoma development and progression
Yu, L., Yan, L., & Wang, H. (2018) · npj Precision Oncology · doi:10.1038/s41698-018-0048-z · Cited by 302 · see citing works
The role of mammalian target of rapamycin (mTOR) in insulin signaling
Yoon, M.-S. (2017) · Nutrients · doi:10.3390/nu9111176 · Cited by 300 · see citing works
The multifaceted role of mTORC1 in the control of lipid metabolism
Ricoult, S. J. H., & Manning, B. D. (2013) · EMBO Reports · doi:10.1038/embor.2013.5 · Cited by 287 · see citing works
Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma
Sun, E. J., Wankell, M., Palamuthusingam, P., McFarlane, C., & Hebbard, L. (2021) · Biomedicines · doi:10.3390/biomedicines9111639 · Cited by 287 · see citing works
Connecting mTORC1 signaling to SREBP-1 activation
Bakan, I., & Laplante, M. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328352dd03 · Cited by 283 · see citing works
NAFLD-driven HCC: Safety and efficacy of current and emerging treatment options.
Foerster, F., Gairing, S., Müller, L., & Galle, P. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.09.007 · Cited by 265 · see citing works
Kumar, A. T., Lawrence, J. C., Jung, D. Y., Ko, H. J., Keller, S. R., Kim, J. K., Magnuson, M. A., & Harris, T. E. (2010) · Diabetes · doi:10.2337/db09-1061 · Cited by 250 · see citing works
Self-citationThe Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis
Herman, M. A., & Samuel, V. T. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.06.005 · Cited by 249 · see citing works
Pipitone, R. M., Ciccioli, C., Infantino, G., Mantia, C. L., Parisi, S., Tulone, A., Pennisi, G., Grimaudo, S., & Petta, S. (2023) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188221145549 · Cited by 239 · see citing works
Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus
Dharmalingam, M., & Yamasandhi, P. (2018) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_585_17 · Cited by 239 · see citing works
Nonalcoholic Fatty Liver Disease: Focus on Lipoprotein and Lipid Deregulation
Tacer, K. F., & Rozman, D. (2011) · Journal of Lipids · doi:10.1155/2011/783976 · Cited by 232 · see citing works
NAFLD‐related hepatocellular carcinoma: The growing challenge
Shah, P. A., Patil, R., & Harrison, S. A. (2022) · Hepatology · doi:10.1002/hep.32542 · Cited by 232 · see citing works
Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments
Peng, C. Y., Stewart, A. G., Woodman, O. L., Ritchie, R. H., & Qin, C. X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.603926 · Cited by 230 · see citing works
Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease
Ma, Y., Lee, G., Heo, S.-Y., & Roh, Y. (2021) · Antioxidants · doi:10.3390/antiox11010091 · Cited by 227 · see citing works
Targeting mTOR and Metabolism in Cancer: Lessons and Innovations
Magaway, C., Kim, E., & Jacinto, E. (2019) · Cells · doi:10.3390/cells8121584 · Cited by 225 · see citing works
Bray, G. A. (2013) · Advances in Nutrition · doi:10.3945/an.112.002816 · Cited by 222 · see citing works
Epidemiology of non-alcoholic fatty liver disease and hepatocellular carcinoma
Younossi, Z. M., & Henry, L. L. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100305 · Cited by 218 · see citing works
NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer
Karki, R., Man, S. M., Malireddi, R. K. S., Kesavardhana, S., Zhu, Q., Burton, A. R., Sharma, B. R., Qi, X., Pelletier, S. W., Vogel, P., et al. (2016) · Nature · doi:10.1038/nature20597 · Cited by 215 · see citing works
Role of Cholesterol‐Associated Steatohepatitis in the Development of NASH
Horn, C. L., Morales, A. L., Savard, C. E., Farrell, G. C., & Ioannou, G. N. (2021) · Hepatology Communications · doi:10.1002/hep4.1801 · Cited by 215 · see citing works
Recent advances and limitations of mTOR inhibitors in the treatment of cancer
Ali, E. S., Mitra, K., Akter, S., Ramproshad, S., Mondal, B., Khan, I. N., Islam, M. T., Sharifi‐Rad, J., Călina, D. C., & Cho, W. C. S. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02706-8 · Cited by 213 · see citing works
mTOR-Dependent Cell Survival MechanismsPreprint
Hung, C., García-Haro, L., Sparks, C. A., & Guertin, D. A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008771 · Cited by 206 · see citing works
How big a problem is non-alcoholic fatty liver disease?
Anstee, Q. M., McPherson, S., & Day, C. (2011) · BMJ · doi:10.1136/bmj.d3897 · Cited by 200 · see citing works
Im, Y. R., Hunter, H., de Gracia Hahn, D., Duret, A., Cheah, Q., Dong, J., Fairey, M., Hjalmarsson, C., Li, A., Lim, H. K., et al. (2021) · Hepatology · doi:10.1002/hep.31897 · Cited by 195 · see citing works
Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition
Umemura, A., Park, E. J., Taniguchi, K., Lee, J. H., Shalapour, S., Valasek, M. A., Aghajan, M., Nakagawa, H., Seki, E., Hall, M. N., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.001 · Cited by 183 · see citing works
Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice
Menon, S., Yecies, J. L., Zhang, H., Howell, J. J., Nicholatos, J. W., Harputlugil, E., Bronson, R. T., Kwiatkowski, D. J., & Manning, B. D. (2012) · Science Signaling · doi:10.1126/scisignal.2002739 · Cited by 183 · see citing works
PPARα and PPARγ dual agonists for the treatment of type 2 diabetes and the metabolic syndrome
Fiévet, C., Fruchart, J., & Staels, B. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.06.009 · Cited by 182 · see citing works
Muscle and adipose tissue insulin resistance: malady without mechanism?
Fazakerley, D. J., Krycer, J. R., Kearney, A. L., HOCKING, S. L., & James, D. E. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r087510 · Cited by 181 · see citing works
Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease
Ramanathan, R., Ali, A. H., & Ibdah, J. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137280 · Cited by 179 · see citing works
Schreiber, K. H., Ortiz, D., Academia, E. C., Anies, A. C., Liao, C., & Kennedy, B. K. (2015) · Aging Cell · doi:10.1111/acel.12313 · Cited by 177 · see citing works
Natural History of NAFLD: Remarkably Benign in the Absence of Cirrhosis
Day, C. P. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.041 · Cited by 176 · see citing works
mTORC1 signaling in hepatic lipid metabolism
Han, J., & Wang, Y. (2017) · Protein & Cell · doi:10.1007/s13238-017-0409-3 · Cited by 168 · see citing works
Ducreux, M. P., Abou‐Alfa, G. K., Bekaii‐Saab, T., Berlin, J. D., Cervantes, A. M. R., de Baère, T., Eng, C., Galle, P. R., Gill, S., Gruenberger, T., et al. (2023) · ESMO Open · doi:10.1016/j.esmoop.2023.101567 · Cited by 167 · see citing works
Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis
Hansen, H. H., Ægidius, H. M., Oró, D., Evers, S. S., Heebøll, S., Eriksen, P. L., Thomsen, K. L., Bengtsson, A., Veidal, S. S., Feigh, M., et al. (2020) · BMC Gastroenterology · doi:10.1186/s12876-020-01356-2 · Cited by 157 · see citing works
Quan, H. Y., Kim, D. Y., Kim, S. J., Jo, H. K., Kim, G. W., & Chung, S. H. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.02.007 · Cited by 155 · see citing works
Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1
Gosis, B. S., Wada, S., Thorsheim, C. L., Li, K., Jung, S., Rhoades, J. H., Yang, Y., Brandimarto, J., Li, L., Uehara, K., et al. (2022) · Science · doi:10.1126/science.abf8271 · Cited by 155 · see citing works
Eckard, C. S., Cole, R. E., Lockwood, J., Torres, D. M., Williams, C. D., Shaw, J. C., & Harrison, S. A. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x13484078 · Cited by 155 · see citing works
The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes
Brown, N. F., Stefanović-Račić, M., SIPULA, I. J., & Perdomo, G. (2007) · Metabolism · doi:10.1016/j.metabol.2007.06.016 · Cited by 152 · see citing works
Simon, T. G., Roelstraete, B., Hartjes, K. T., Shah, U. S., Khalili, H., Arnell, H., & Ludvigsson, J. F. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.06.034 · Cited by 151 · see citing works
Lonardo, A., Mantovani, A., Lugari, S., & Targher, G. (2020) · Annals of Hepatology · doi:10.1016/j.aohep.2020.03.001 · Cited by 150 · see citing works
De Munck, T. J. I., Xu, P., Verwijs, H. J. A., Masclee, A. A. M., Jonkers, D., Verbeek, J., & Koek, G. H. (2020) · Liver International · doi:10.1111/liv.14696 · Cited by 145 · see citing works
Prevention of NAFLD-associated HCC: Role of lifestyle and chemoprevention
Lange, N. F., Radu, P., & Dufour, J. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.07.025 · Cited by 137 · see citing works
Activation of mTOR Signaling Pathway in Hepatocellular Carcinoma
Ferrín, G., Misas, M. G., Amado, V., Rodríguez‐Perálvarez, M., & de la Mata, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041266 · Cited by 137 · see citing works
Zhang, X., Wu, M., Liu, Z., Yuan, H., Wu, X., Shi, T., Chen, X., & Zhang, T. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-042843 · Cited by 131 · see citing works
Evolving Role for Pharmacotherapy in NAFLD/NASH
Attia, S. L., Softic, S., & Mouzaki, M. (2020) · Clinical and Translational Science · doi:10.1111/cts.12839 · Cited by 130 · see citing works
Blanchard, P.-G., Festuccia, W. T., Houde, V. P., St‐Pierre, P., Brûlé, S., Turcotte, V., Côté, M., Bellmann, K., Marette, A., & Deshaies, Y. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m021485 · Cited by 129 · see citing works
Inflammatory Reaction in Neurological Diseases
Wang, H., Lu, C., Cheng, K., & Chiang, J. (2014) · BioMed Research International · doi:10.1155/2014/408514 · Cited by 122 · see citing works
Recent Epidemiology of Nonalcoholic Fatty Liver Disease
Murag, S., Ahmed, A., & Kim, D. (2020) · Gut and Liver · doi:10.5009/gnl20127 · Cited by 121 · see citing works
Toward More Accurate Nomenclature for Fatty Liver Diseases
Eslam, M., Sanyal, A. J., & George, J. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.05.064 · Cited by 115 · see citing works
Role of vitamin E in nonalcoholic fatty liver disease
Nagashimada, M., & Ota, T. (2018) · IUBMB Life · doi:10.1002/iub.1991 · Cited by 113 · see citing works
Tokuhara, D. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.700058 · Cited by 104 · see citing works
Ikawa‐Yoshida, A., Matsuo, S., Kato, A., Ohmori, Y., Higashida, A., Kaneko, E., & Matsumoto, M. (2017) · International Journal of Experimental Pathology · doi:10.1111/iep.12240 · Cited by 98 · see citing works
The integral role of mTOR in lipid metabolism
Soliman, G. A. (2011) · Cell Cycle · doi:10.4161/cc.10.6.14930 · Cited by 96 · see citing works
Role of S6K1 in regulation of SREBP1c expression in the liver.
Li, S., Ogawa, W., Emi, A., Hayashi, K., Senga, Y., Nomura, K., Hara, K., Yu, D., & Kasuga, M. (2011) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2011.07.038 · Cited by 87 · see citing works
Zhou, W. P., & Ye, S. (2018) · Cell Biology International · doi:10.1002/cbin.11015 · Cited by 87 · see citing works
mTOR signalling and metabolic regulation of T cell differentiation
Peter, C., Waldmann, H., & Cobbold, S. P. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.08.010 · Cited by 85 · see citing works
Pinyopornpanish, K., Leerapun, A., Pinyopornpanish, K., & Chattipakorn, N. (2021) · Gut and Liver · doi:10.5009/gnl20367 · Cited by 81 · see citing works
NASH drug treatment development: challenges and lessons
Tilg, H., Byrne, C. D., & Targher, G. (2023) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(23)00159-0 · Cited by 81 · see citing works
S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy
Espeillac, C., Mitchell, C., Celton‐Morizur, S., Chauvin, C., Koka, V., Gillet, C., Albrecht, J. H., Desdouets, C., & Pende, M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44203 · Cited by 80 · see citing works
Dagorn, P. G., Foretz, M., Steinberg, G. R., Batchuluun, B., Zawistowska‐Deniziak, A., Lambooij, J. M., Guigas, B., Carling, D., Monternier, P., Moller, D. E., et al. (2021) · Hepatology Communications · doi:10.1002/hep4.1799 · Cited by 78 · see citing works
Bae, E., Xu, J., Oh, D., Bandyopadhyay, G., Lagakos, W., Keshwani, M. M., & Olefsky, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.365544 · Cited by 75 · see citing works
Weighing In on mTOR Complex 2 Signaling: The Expanding Role in Cell Metabolism
Luo, Y., Xu, W., Li, G., & Cui, W. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7838647 · Cited by 74 · see citing works
mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease
Feng, J., Qiu, S., Zhou, S., Tan, Y., Bai, Y., Cao, H., Guo, J., & Su, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169196 · Cited by 74 · see citing works
Race and Ethnicity in Non-Alcoholic Fatty Liver Disease (NAFLD): A Narrative Review
Riazi, K., Swain, M. G., Congly, S. E., Kaplan, G. G., & Shaheen, A. A. (2022) · Nutrients · doi:10.3390/nu14214556 · Cited by 71 · see citing works
Insulin Regulates Hepatic Triglyceride Secretion and Lipid Content via Signaling in the Brain
Scherer, T., Lindtner, C., O’Hare, J., Hackl, M. T., Zieliński, E., Freudenthaler, A., Baumgartner-Parzer, S. M., Tödter, K., Heeren, J., Krššák, M., et al. (2016) · Diabetes · doi:10.2337/db15-1552 · Cited by 68 · see citing works
Wong, S., Ting, Y., & Chan, W. (2018) · JGH Open · doi:10.1002/jgh3.12070 · Cited by 68 · see citing works
Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease
Kim, K., & Lee, B. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0137 · Cited by 68 · see citing works
Targeting mTOR as a Cancer Therapy: Recent Advances in Natural Bioactive Compounds and Immunotherapy
Bouyahya, A., Allam, A. E., Aboulaghras, S., Bakrim, S., Menyiy, N. E., Alshahrani, M. M., Awadh, A. A. A., Benali, T., Lee, L., Omari, N. E., et al. (2022) · Cancers · doi:10.3390/cancers14225520 · Cited by 66 · see citing works
Chen, Y.-S., Wang, W., Morgan, M., Robson, T., & Annett, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1148934 · Cited by 63 · see citing works
TFEB is a central regulator of the aging process and age-related diseases
Abokyi, S., Ghartey‐Kwansah, G., & Tse, D. Y. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101985 · Cited by 59 · see citing works
Fouqueray, P., Bolze, S., Dubourg, J., Hallakou‐Bozec, S., Theurey, P., Grouin, J., Chevalier, C., Dagorn, P. G., Moller, D. E., & Cusi, K. J. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100474 · Cited by 52 · see citing works
Uehara, K., Sostre‐Colón, J., Gavin, M. J., Santoleri, D., Leonard, K., Jacobs, R. L., & Titchenell, P. M. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.02.015 · Cited by 51 · see citing works
Chen, B. W., Chen, W., Liang, H., Liu, H., Liang, C., Zhi, X., Hu, L.-Q., Yu, X.-Z., Wei, T., Ma, T., et al. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0029 · Cited by 50 · see citing works
Insulin Regulation of Hepatic Lipid Homeostasis
Uehara, K., Santoleri, D., Whitlock, A. E. G., & Titchenell, P. M. (2023) · Comprehensive Physiology · doi:10.1002/cphy.c220015 · Cited by 49 · see citing works
Depletion of Gut Microbiota Inhibits Hepatic Lipid Accumulation in High-Fat Diet-Fed Mice
Han, H. L., Wang, M., Zhong, R., Yi, B., Schroyen, M., & Zhang, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169350 · Cited by 49 · see citing works
mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars
Sangüesa, G., Roglans, N., Baena, M., Velázquez, A. M., Laguna, J. C., & Alegret, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051117 · Cited by 48 · see citing works
Alkhouri, N., Almomani, A., Le, P., Payne, J. Y., Asaad, I., Sakkal, C., Vos, M. B., Noureddin, M., & Kumar, P. N. (2022) · BMC Gastroenterology · doi:10.1186/s12876-022-02430-7 · Cited by 48 · see citing works
Chen, H. (2020) · Liver Research · doi:10.1016/j.livres.2020.02.004 · Cited by 47 · see citing works
Non-alcoholic fatty liver disease-related hepatocellular carcinoma
Daher, D., Dahan, K. S. E., & Singal, A. G. (2023) · Journal of Liver Cancer · doi:10.17998/jlc.2022.12.30 · Cited by 43 · see citing works
Trust is good, control is better: technical considerations in blood microbiome analysis
Schierwagen, R., Silva, M. C. A., Servant, F., Trebicka, J., Lelouvier, B., & Arumugam, M. (2019) · Gut · doi:10.1136/gutjnl-2019-319123 · Cited by 39 · see citing works
Wang, W., Tan, J., Liu, X., Guo, W., Li, M., Liu, X., Liu, Y., Dai, W., Hu, L., Wang, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41757-x · Cited by 37 · see citing works
Hansen, H. H., Pors, S. E., Andersen, M. W., Vyberg, M., Nøhr-Meldgaard, J., Nielsen, M. H., Oró, D., Madsen, M. R., Lewińska, M., Møllerhøj, M. B., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-50328-5 · Cited by 37 · see citing works
Zhang, S., Mao, Y., & Fan, X. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s158985 · Cited by 36 · see citing works
Liu, F., Li, H., Chang, H., Wang, J., & Lu, J. (2015) · Tumori Journal · doi:10.5301/tj.5000241 · Cited by 34 · see citing works
Tessitore, A., Mastroiaco, V., Vetuschi, A., Sferra, R., Pompili, S., Cicciarelli, G., Barnabei, R., Capece, D., Zazzeroni, F., Capalbo, C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18585 · Cited by 32 · see citing works
TFEB: A Emerging Regulator in Lipid Homeostasis for Atherosclerosis
Li, M., Wang, Z., Wang, P., Li, H., & Yang, L. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.639920 · Cited by 32 · see citing works
Paklar, N., Mijić, M., & Filipec-Kanižaj, T. (2023) · Biomedicines · doi:10.3390/biomedicines11113096 · Cited by 31 · see citing works
mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia
Paolella, L. M., Mukherjee, S., Tran, C. M., Bellaver, B., Hugo, M., Luongo, T. S., Shewale, S. V., Lu, W., Chellappa, K., & Baur, J. A. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.12.003 · Cited by 30 · see citing works
Up-to-date global epidemiology of nonalcoholic fatty liver disease
Manikat, R., Ahmed, A., & Kim, D. (2023) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn-23-548 · Cited by 30 · see citing works
Márquez-Quiroga, L. V., Arellanes‐Robledo, J., Vásquez-Garzón, V. R., Villa‐Treviño, S., & Muriel, P. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114845 · Cited by 29 · see citing works
Inflammatory processes involved in NASH-related hepatocellular carcinoma
Cannito, S., Dianzani, U., Parola, M., Albano, E., & Sutti, S. (2023) · Bioscience Reports · doi:10.1042/bsr20221271 · Cited by 28 · see citing works
Chaudhary, S. P., Reyes, S., Chase, M. L., Govindan, A., Zhao, L., Luther, J., Bhan, I., Bethea, E., Franses, J., Walsh, E. P., et al. (2023) · The Oncologist · doi:10.1093/oncolo/oyac251 · Cited by 24 · see citing works
Allen, A. M., Pose, E., Reddy, K. R., Russo, M. W., & Kamath, P. S. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.11.007 · Cited by 22 · see citing works
Zhao, Y. M., Zhao, W., Ma, J., Toshiyoshi, M., & Zhao, Y. (2023) · Medicine · doi:10.1097/md.0000000000033110 · Cited by 20 · see citing works
Inhibitory effects of rapamycin on the different stages of hepatic fibrosis
Kim, Y. J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i23.7452 · Cited by 19 · see citing works
Okuno, T., Kakehashi, A., Ishii, N., Fujioka, M., Gi, M., & Wanibuchi, H. (2018) · Cancers · doi:10.3390/cancers10120465 · Cited by 19 · see citing works
Chan, W., Hilmi, I. N., Cheah, P., & Goh, K. (2014) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12175 · Cited by 17 · see citing works
Role of mechanistic target of rapamycin in autophagy and alcohol-associated liver disease
Chao, X., Williams, S. N., & Ding, W. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00281.2022 · Cited by 17 · see citing works
Ge, C., Ma, C., Cui, J., Dong, X., Sun, L., Li, Y., & Yu, A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281888 · Cited by 14 · see citing works
Type 2 diabetes originated from non-alcoholic fatty liver disease
Xiong, X., & Li, X. (2023) · Life Metabolism · doi:10.1093/lifemeta/load007 · Cited by 11 · see citing works
General Overview About the Current Management of Nonalcoholic Fatty Liver Disease
Ampuero, J. (2022) · Clinical Drug Investigation · doi:10.1007/s40261-022-01142-w · Cited by 10 · see citing works
Pharmacological effects of mTORC1/C2 inhibitor in a preclinical model of NASH progression
Arora, M., Pavlíková, Z., Kučera, T., Kozlík, P., Šopin, T., Vacı́k, T., Ľupták, M., Duda, M., Slanař, O., & Canová, N. K. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115447 · Cited by 9 · see citing works
Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC
Kroh, A., Walter, J., Fragoulis, A., Möckel, D., Lammers, T., Kiessling, F. M., Andruszkow, J., Preisinger, C., Egbert, M., Jiao, L. R., et al. (2023) · Neoplasia · doi:10.1016/j.neo.2023.100945 · Cited by 8 · see citing works
Preclinical models of non-alcoholic steatohepatitis leading to hepatocellular carcinoma
Green, C. D., & Spiegel, S. (2022) · Advances in Biological Regulation · doi:10.1016/j.jbior.2022.100925 · Cited by 3 · see citing works
Flagged first, then by citations
3 of the 162 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Ge, G., Jiang, X., Tian, X., Zhou, Y., & Cao, G. (2025) · Current Pharmaceutical Analysis · doi:10.1016/j.cpan.2025.04.001 · Cited by 15 · see citing works
Jin, X., Song, S. J., Lai, J. C., Wong, G. L., Kong, A. P. S., Peng, N., Xiao, X., Wong, V. W., & Yip, T. C. (2025) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2025.0860 · Cited by 5 · see citing works
Soudah, N., Baskin, A., Darash‐Yahana, M., Darlyuk‐Saadon, I., Smorodinsky-Atias, K., Shalit, T., Yu, W., Savidor, A., Pikarsky, E., & Engelberg, D. (2025) · Oncogene · doi:10.1038/s41388-025-03437-6 · Cited by 4 · see citing works
Liang, Q., Li, A., He, L., Li, W., & Wang, J.-L. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1681880 · Cited by 4 · see citing works
Lisco, G., Guido, D., Cerabino, N., Chito, M. D., Donvito, R., Bonfiglio, C., Shahini, E., Zappimbulso, M., Randazzo, C., Barletta, D., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06464-9 · Cited by 4 · see citing works
Liman, U. U., Hawage, A. S., Silva, S. D., Samarasinghe, S. M., Tennekoon, K. H., Siriwardana, R. C., & Niriella, M. A. (2025) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-025-00738-z · Cited by 3 · see citing works
Pan, X., Gao, T., & Wang, B. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01520-9 · Cited by 2 · see citing works
“Beyond these drugs, several pharmacological agents show potential for synergistic combination with MSC-based anti-fibrotic therapy [386–388]. mTORc1 inhibitors, such as rapamycin, have demonstrated anti-fibrotic and pro-autophagic effects in NAFLD models [388].”
Oh, K., Kwon, G.-H., Lee, K. J., Eom, J. A., Kim, D. J., & Suk, K. T. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102618 · Cited by 2 · see citing works
Shi, J., Wu, X., Yu, J., & Zhou, Q. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1651357 · Cited by 1 · see citing works
Liver injury in a preclinical model of short bowel syndrome is associated with impaired autophagy
Alligood, D. M., Park, A. J., Swanson, K. A., Pyarali, N., Mayse, E., Alvarado, D. M., Liu, X., Kim, J.-S., Davidson, N. O., Rubin, D. C., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-30243-7
Xu, L., Zhang, X., Zhu, H., Niu, D., Zhu, X., & Jin, C. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl45415
The Diverse Landscape of Cancer Genomics in Africa
Karla, C. S. S., Chiara, L. M. F., Wium, M., Maria, S. Z., Stefano, C., Lara, D., & Zerbini, L. F. (2026) · Nature anthropology · doi:10.70322/natanthropol.2026.10008
Sun, Y., Chen, T., Zhang, L., Duan, J., Xue, J., Huang, W., Di, J.-Z., & Zhang, Y. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.08.003
Fan, W.-J., Wu, Y.-M., Liu, X.-Y., Zhang, C.-A., Hu, C., Wang, B.-B., & Ding, H. (2026) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2026.08.008
- Authors
- Sharma, N., Singh, L., Sharma, A., Kumar, A., & Mahajan, D.
- Affiliations
- Translational Health Science and Technology Institute (IN)
- Corresponding author
- Mahajan, Dinesh
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2024-10
- Volume
- 208
- Pages
- 107375
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W4402059392
- Cited by
- 16
- References
- 162
- Citations by year
- 2026: 5 · 2025: 11
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Pharmacological Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Science and Engineering Research Board (TAR/2021/000189)
- Department of Science and Technology, Ministry of Science and Technology, India
- Department of Biotechnology
- Biotechnology Industry Research Assistance Council (BT/AIR01362/PACE-22/20)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- non-alcoholic fatty liver disease, hepatocellular carcinoma, mTORC1 inhibitors, nonalcoholic steatohepatitis, liver fibrosis, liver cirrhosis, mTOR signaling, drug repurposing, tumor progression
- MeSH terms
- Mechanistic Target of Rapamycin Complex 1, MTOR Inhibitors, Animals, Antineoplastic Agents, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Signal Transduction, Drug Repositioning, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review