Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications
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Over the last 30 years, optical biosensors based on nanostructured materials have obtained increasing interest since they allow the screening of a wide variety of biomolecules with high specificity, low limits of detection, and great sensitivity. Among them, flexible optical platforms have the advantage of adapting to non-planar surfaces, suitable for in vivo and real-time monitoring of diseases and assessment of food safety. In this review, we summarize the newest and most advanced platforms coupling optically active materials (noble metal nanoparticles) and flexible substrates giving rise to hybrid nanomaterials and/or nanocomposites, whose performances are comparable to the ones obtained with hard substrates (e.g., glass and semiconductors). We focus on localized surface plasmon resonance (LSPR)-based and surface-enhanced Raman spectroscopy (SERS)-based biosensors. We show that large-scale, cost-effective plasmonic platforms can be realized with the currently available techniques and we emphasize the open issues associated with this topic.
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Optical sensing platforms often employ nanomaterials, including silver and gold nanoparticles.
“Optical sensing platforms often employ nanomaterials, including silver and gold nanoparticles [175].”
From The emergence of AI-based wearable sensors for digital health technology: a review (2023) · cites this paper as [175]
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The emergence of AI-based wearable sensors for digital health technology: a review
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- Authors
- Miranda, B., Rea, I., Dardano, P., De Stefano, L., & Forestiere, C.
- Affiliations
- National Research Council (IT)
- Institute of Applied Sciences and Intelligent Systems, Unit of Naples, National Research Council, Via P. Castellino 111, 80131 Napoli, Italy
- University of Naples Federico II (IT)
- Venue
- Biosensors
- Publisher
- MDPI AG
- Published
- 2021-04-04
- Volume
- 11
- Issue
- 4
- Pages
- 107
- ISSN
- 2079-6374 (ISSN-L)
- PMC
- PMC8066870
- OpenAlex
- W3149528312
- Cited by
- 63
- References
- 133
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 15 · 2023: 13 · 2022: 14 · 2021: 2
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biosensors (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Plasmonic and Surface Plasmon Research
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Keywords
- plasmonic biosensors, localized surface plasmon resonance, surface-enhanced Raman spectroscopy, noble metal nanoparticles, flexible substrates, nanocomposites, hybrid nanostructures, in vivo monitoring, food safety, real-time disease monitoring
- MeSH terms
- Biological Science Disciplines, Spectrum Analysis, Raman, Biosensing Techniques, Surface Plasmon Resonance, Nanocomposites, Metal Nanoparticles
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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