The DOI matches its Crossref record; 164 of the 164 references it cites were found in a registry or an index.
Cancer Stem Cells and Radioresistance: DNA Repair and Beyond
Open accessAbstract
The current preclinical and clinical findings demonstrate that, in addition to the conventional clinical and pathological indicators that have a prognostic value in radiation oncology, the number of cancer stem cells (CSCs) and their inherent radioresistance are important parameters for local control after radiotherapy. In this review, we discuss the molecular mechanisms of CSC radioresistance attributable to DNA repair mechanisms and the development of CSC-targeted therapies for tumor radiosensitization. We also discuss the current challenges in preclinical and translational CSC research including the high inter- and intratumoral heterogeneity, plasticity of CSCs, and microenvironment-stimulated tumor cell reprogramming.
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Citations
Cites
1 retracted
Prostate Cancer Cell Lines under Hypoxia Exhibit Greater Stem-Like Properties
Ma, Y., Liang, D., Liu, J., Axcrona, K., Kvalheim, G., Stokke, T., Nesland, J. M., & Suo, Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029170 · Cited by 103
RetractedCancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M., Reinhard, F., Zhang, C. C., Shipitsin, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,672
Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods
Ferlay, J., Colombet, M., Soerjomataram, I., Mathers, C., Parkin, D. M., Piñeros, M., Znaor, A., & Bray, F. (2019) · International Journal of Cancer · doi:10.1002/ijc.31937 · Cited by 7,553
ROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Bao, S., Wu, Q., McLendon, R. E., Hao, Y., Shi, Q., Hjelmeland, A. B., Dewhirst, M. W., Bigner, D. D., & Rich, J. N. (2006) · Nature · doi:10.1038/nature05236 · Cited by 6,379
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
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The Global Burden of Cancer 2013
Fitzmaurice, C., Dicker, D., Pain, A., Hamavid, H., Moradi-Lakeh, M., MacIntyre, M. F., Allen, C., Hansen, G., Woodbrook, R., Wolfe, C., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.0735 · Cited by 2,707
Cited by
Stem cell programs in cancer initiation, progression, and therapy resistance
Huang, T., Song, X., Xu, D., Tiek, D., Goenka, A., Wu, B., Sastry, N., Hu, B., & Cheng, S.-Y. (2020) · Theranostics · doi:10.7150/thno.41648 · Cited by 524
Molecular mechanisms of tumor resistance to radiotherapy
Wu, Y., Song, Y., Wang, R., & Wang, T. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01801-2 · Cited by 527
Deng, S., Vlatkovic, T., Li, M., Zhan, T., Veldwijk, M. R., & Herskind, C. (2022) · Cancers · doi:10.3390/cancers14194874 · Cited by 62
Hypoxia-induced cancer cell reprogramming: a review on how cancer stem cells arise
Abd, G. M., Laird, M. C., Ku, J. C., & Li, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1227884 · Cited by 41
Wang, Y., Han, X., Zhang, S., Wang, L., Sun, S., Xue, C., & Yao, T. (2025) · Biopolymers · doi:10.1002/bip.70054 · Cited by 6
Metadata
- Authors
- Schulz, A., Meyer, F., Dubrovska, A., & Borgmann, K.
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2019-06-21
- Volume
- 11
- Issue
- 6
- Pages
- 862
- ISSN
- 2072-6694 (ISSN-L)
- OpenAlex
- W2952051913
- Cited by
- 303
- References
- 164
- FWCI
- 14.06
- Type
- journal article
- Language
- en
- Open access
- gold
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- Schulz, A., Meyer, F., Dubrovska, A., & Borgmann, K. (2019). Cancer Stem Cells and Radioresistance: DNA Repair and Beyond. Cancers. https://doi.org/10.3390/cancers11060862
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
