p21 in Cancer Research

Genome engineering using the CRISPR-Cas9 system

Ran, F. A., Hsu, P. D., Wright, J., Agarwala, V., Scott, D. A., & Zhang, F. (2013) · Nature Protocols · doi:10.1038/nprot.2013.143 · Cited by 11,133

Comprehensive molecular characterization of human colon and rectal cancer

The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11252 · Cited by 8,499

WAF1, a potential mediator of p53 tumor suppression

El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651

TGFβ in Cancer

Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907

The emerging role of lncRNAs in cancer

Huarte, M. (2015) · Nature Medicine · doi:10.1038/nm.3981 · Cited by 2,712

p21 in cancer: Intricate networks and multiple activities

Abbas, T., & Dutta, A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2657 · Cited by 2,712

Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells

Ikeda, R., Che, X., Yamaguchi, T., Ushiyama, M., Zheng, C., Okumura, H., Takeda, Y., Shibayama, Y., Nakamura, K. T., Jeung, H., et al. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00057.x · Cited by 2,268

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

Huarte, M., Guttman, M., Feldser, D., Garber, M., Koziol, M. J., Kenzelmann-Broz, D., Khalil, A. M., Zuk, O., Amit, I., Rabani, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.040 · Cited by 2,053

Cell cycle control in cancer

Matthews, H. K., Bertoli, C., & de Bruin, R. A. M. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00404-3 · Cited by 1,506

Senescence and cancer — role and therapeutic opportunities

Schmitt, C. A., Wang, B., & Demaria, M. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00668-4 · Cited by 794

Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial Treatments, and New Developments

Yip, H. Y. K., & Papa, A. (2021) · Cells · doi:10.3390/cells10030659 · Cited by 341

P16INK4A—More Than a Senescence Marker

Safwan‐Zaiter, H., Wagner, N., & Wagner, K. (2022) · Life · doi:10.3390/life12091332 · Cited by 204

TGF-β signaling: critical nexus of fibrogenesis and cancer

Giarratana, A. O., Prendergast, C. M., Salvatore, M. M., & Capaccione, K. M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05411-4 · Cited by 180

The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis

Wagner, K., & Wagner, N. (2022) · Cells · doi:10.3390/cells11121966 · Cited by 161

Circadian regulator BMAL1::CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle

Qu, M., Zhang, G., Qu, H., Vu, A., Wu, R. P., Tsukamoto, H., Jia, Z., Huang, W., Lenz, H., Rich, J. N., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2214829120 · Cited by 146

The role of key gut microbial metabolites in the development and treatment of cancer

Jaye, K. M., Li, C. G., Chang, D., & Bhuyan, D. J. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2038865 · Cited by 129

Empagliflozin and Doxorubicin Synergistically Inhibit the Survival of Triple-Negative Breast Cancer Cells via Interfering with the mTOR Pathway and Inhibition of Calmodulin: In Vitro and Molecular Docking Studies

Eliaa, S. G., Al-Karmalawy, A. A., Saleh, R. M., & Elshal, M. F. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00144 · Cited by 119

Overcoming anti-cancer drug resistance via restoration of tumor suppressor gene function

Gao, L., Wu, Z., Assaraf, Y. G., Chen, Z., & Wang, L. (2021) · Drug Resistance Updates · doi:10.1016/j.drup.2021.100770 · Cited by 119

Emerging role of aging in the progression of NAFLD to HCC

He, Y., Su, Y., Duan, C., Wang, S., He, W. G., Zhang, Y., An, X., & He, M. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101833 · Cited by 100

Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers

Zhang, L., Li, C., & Su, X. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01784-8 · Cited by 90

Understanding Failure and Improving Treatment Using HDAC Inhibitors for Prostate Cancer

Rana, Z., Diermeier, S. D., Hanif, M., & Rosengren, R. J. (2020) · Biomedicines · doi:10.3390/biomedicines8020022 · Cited by 84

The multifaceted mechanisms of Paeoniflorin in the treatment of tumors: State-of-the-Art.

Wang, X.-Z., Xia, L., Zhang, X.-Y., Chen, Q., Li, X., Mou, Y., Wang, T., & Zhang, Y.-N. (2022) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2022.112800 · Cited by 76

Critical signaling pathways governing hepatocellular carcinoma behavior; small molecule-based approaches

Farzaneh, Z., Vosough, M., Agarwal, T., & Farzaneh, M. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01924-w · Cited by 81

The 3-deoxysappanchalcone induces ROS-mediated apoptosis and cell cycle arrest via JNK/p38 MAPKs signaling pathway in human esophageal cancer cells

Kwak, A., Lee, M.-J., Lee, M.-H., Yoon, G., Cho, S., Chae, J., & Shim, J. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153564 · Cited by 70

Myeloid-like tumor hybrid cells in bone marrow promote progression of prostate cancer bone metastasis

Ye, X., Huang, X., Fu, X., Zhang, X., Lin, R., Zhang, W., Zhang, J., & Lü, Y. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01442-4 · Cited by 69

CDK regulators—Cell cycle progression or apoptosis—Scenarios in normal cells and cancerous cells

Nilmani, D'costa, M., Bothe, A., Das, S., Kumar, S. U., Ramanathan, G., & Doss, C. G. P. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2022.11.008 · Cited by 62

5-HT2B-mediated serotonin activation in enterocytes suppresses colitis-associated cancer initiation and promotes cancer progression

Mao, L., Xin, F., Ren, J., Xu, S., Huang, H., Zha, X., Wen, X., Gu, G., Yang, G., Cheng, Y., et al. (2022) · Theranostics · doi:10.7150/thno.70762 · Cited by 59

The emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment

Chen, X., Cao, M., Wang, P., Chu, S., Li, M., Hou, P., Zheng, J., Li, Z., & Bai, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.968755 · Cited by 52

Marine peptides in breast cancer: Therapeutic and mechanistic understanding

Ahmed, S., Mirzaei, H., Aschner, M., Khan, A., Al‐Harrasi, A., & Khan, H. Z. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112038 · Cited by 53

The Role of Cell Cycle Regulators in Cell Survival—Dual Functions of Cyclin-Dependent Kinase 20 and p21Cip1/Waf1

Lai, L., Shin, G. Y., & Qiu, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228504 · Cited by 53

A hybrid membrane coating nanodrug system against gastric cancer via the VEGFR2/STAT3 signaling pathway

Long, Y., Wang, Z., Fan, J., Yuan, L., Tong, C., Zhao, Y., & Liu, B. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00029b · Cited by 51

Palbociclib induces DNA damage and inhibits DNA repair to induce cellular senescence and apoptosis in oral squamous cell carcinoma

Wang, T.-H., Chen, C.-C., Leu, Y.-L., Lee, Y.-S., Lian, J.-H., Hsieh, H.-L., & Chen, C.-Y. (2021) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2020.12.009 · Cited by 49

Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo

Ling, Z., Guan, H., You, Z., Wang, C., Hu, L., Zhang, L., Wang, Y., Chen, S., Xu, B., & Chen, M. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s165262 · Cited by 48

Long non‑coding RNA nuclear paraspeckle assembly transcript 1 regulates ionizing radiation‑induced pyroptosis via microRNA‑448/gasdermin E in colorectal cancer cells

Su, F., Duan, J., Zhu, J., Fu, H., Zheng, X., & Ge, C. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5259 · Cited by 48

MDA-9/Syntenin/SDCBP: new insights into a unique multifunctional scaffold protein

Pradhan, A. K., Maji, S., Das, S. K., Emdad, L., Sarkar, D., & Fisher, P. B. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09886-7 · Cited by 44

LMNB2 promotes the progression of colorectal cancer by silencing p21 expression

Dong, C., Jiang, T., Yin, H., Hu, S., Zhang, Y., Geng, H., Shi, P.-C., Xu, Y., Gao, H., Liu, L., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03602-1 · Cited by 45

NEDD4L inhibits glycolysis and proliferation of cancer cells in oral squamous cell carcinoma by inducing ENO1 ubiquitination and degradation

Zhang, G., Zhao, X., & Liu, W. (2022) · Cancer Biology & Therapy · doi:10.1080/15384047.2022.2054244 · Cited by 44

Out of the cycle: Impact of cell cycle aberrations on cancer metabolism and metastasis

Cheung, A. H. K., Hui, C. H., Wong, K. Y., Liu, X., Chen, B., Kang, W., & To, K. F. (2022) · International Journal of Cancer · doi:10.1002/ijc.34288 · Cited by 47

Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis

Almalki, W. H., & Almujri, S. S. (2024) · Biogerontology · doi:10.1007/s10522-024-10153-3 · Cited by 45

TTK inhibitor promotes radiosensitivity of liver cancer cells through p21

Zhang, H., Yao, W., Zhang, M., Lu, Y., Tang, J., Jiang, M., Mou, X., You, G., & Liang, X. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.01.089 · Cited by 41

Loperamide potentiates doxorubicin sensitivity in triple‐negative breast cancer cells by targeting MDR1 and JNK and suppressing mTOR and Bcl‐2: In vitro and molecular docking study

Eliaa, S. G., Al-Karmalawy, A. A., Nasr, M., & Elshal, M. F. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22938 · Cited by 41

Isoliquiritigenin inhibits the proliferation, migration and metastasis of Hep3B cells via suppressing cyclin D1 and PI3K/AKT pathway

Huang, Y., Liu, C., Zeng, W.-C., Xu, G. G., Wu, J., Li, Z., Huang, X., Lin, R., & Shi, X. (2020) · Bioscience Reports · doi:10.1042/bsr20192727 · Cited by 39

Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer

Amani, J., Gorjizadeh, N., Younesi, S., Najafi, M., Ashrafi, A. M., Irian, S., Gorjizadeh, N., & Azizian, K. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103103 · Cited by 42

Immunohistochemical Profile of Parathyroid Tumours: A Comprehensive Review

Uljanovs, R., Sinkarevs, S., Štrumfs, B., Vīduša, L., Merkurjeva, K., & Štrumfa, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136981 · Cited by 38

To target cellular senescence in diabetic kidney disease: the known and the unknown

Wei, Y., Mou, S., Yang, Q., Liu, F., Cooper, M. E., & Chai, Z. (2024) · Clinical Science · doi:10.1042/cs20240717 · Cited by 41

Swertia chirayita suppresses the growth of non-small cell lung cancer A549 cells and concomitantly induces apoptosis via downregulation of JAK1/STAT3 pathway

Ahmad, A., Tiwari, R. K., Almeleebia, T. M., Fayi, M. S. A., Alshahrani, M. Y., Ahmad, I. S., Abohassan, M., Saeed, M., & Ansari, I. A. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.06.085 · Cited by 37

PI3K/Akt signaling in urological cancers: Tumorigenesis function, therapeutic potential, and therapy response regulation

Rezaei, S., Nikpanjeh, N., Rezaee, A., Gholami, S., Hashemipour, R., Biavarz, N., Yousefi, F., Tashakori, A., Salmani, F., Rajabi, R., et al. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175909 · Cited by 38

Smad4 and p53 synergize in suppressing autochthonous intestinal cancer

Park, J. W., Seo, M., Cho, K. S., Kook, M., Jeong, J. M., Roh, S., Cho, S. Y., Cheon, J. H., & Kim, H. K. (2022) · Cancer Medicine · doi:10.1002/cam4.4533 · Cited by 33

Nuclear receptor tyrosine kinase transport and functions in cancer

Chen, M., Hsu, J. L., & Hung, M. (2020) · Advances in cancer research · doi:10.1016/bs.acr.2020.04.010 · Cited by 33

The interaction between MALAT1 target, miR-143-3p, and RALGAPA2 is affected by functional SNP rs3827693 in breast cancer

Dolatabadi, N. F., Dehghani, A., Shahand, E., Yazdanshenas, M., Tabatabaeian, H., Zamani, A., Azadeh, M., & Ghaedi, K. (2020) · Human Cell · doi:10.1007/s13577-020-00422-x · Cited by 31

The Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer

Ziegler, D. V., Huber, K., & Fajas, L. (2021) · Cancers · doi:10.3390/cancers14010153 · Cited by 34

Rumex Vesicarius L. extract improves the efficacy of doxorubicin in triple-negative breast cancer through inhibiting Bcl2, mTOR, JNK1 and augmenting p21 expression

Ghanem, A., Al-Karmalawy, A. A., Maksoud, A. I. A. E., Hanafy, S. M., Emara, H. A., Saleh, R. M., & Elshal, M. F. (2022) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2022.100869 · Cited by 34

Synthesis, molecular docking, and in-vitro studies of pyrimidine-2-thione derivatives as antineoplastic agents via potential RAS/PI3K/Akt/JNK inhibition in breast carcinoma cells

Salem, M. M., Gerges, M. N., & Noser, A. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-26571-7 · Cited by 33

p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775

Hauge, S., Macurek, L., & Syljuåsen, R. G. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1593649 · Cited by 30

USP39 mediates p21‐dependent proliferation and neoplasia of colon cancer cells by regulating the p53/p21/CDC2/cyclin B1 axis

Yuan, J., Li, X., Zhang, G., Cheng, W., Wang, W., Lei, Y., Ma, Q., & Song, G. (2021) · Molecular Carcinogenesis · doi:10.1002/mc.23290 · Cited by 29

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

Moghadam, S. K., Bakhshinejad, B., Khalafizadeh, A., Hussen, B. M., & Babashah, S. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17126 · Cited by 31

Targeting the p53-p21 axis in liver cancer: Linking cellular senescence to tumor suppression and progression

Thangavelu, L. P., Altamimi, A. S., Ghaboura, N., Babu, M. A., Roopashree, R., Sharma, P., Pal, P., Choudhary, C., Prasad, G. V. S., Sinha, A., et al. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155652 · Cited by 30

Natural compound catechol induces DNA damage, apoptosis, and G1 cell cycle arrest in breast cancer cells

Vazhappilly, C. G., Hodeify, R. F., Siddiqui, S. S., Laham, A. J., Menon, V., El‐Awady, R., Matar, R., Merheb, M. M., Marton, J., Zouabi, H. A., et al. (2020) · Phytotherapy Research · doi:10.1002/ptr.6970 · Cited by 28

The Effect of Resveratrol or Curcumin on Head and Neck Cancer Cells Sensitivity to the Cytotoxic Effects of Cisplatin

Bostan, M., Petrică-Matei, G. G., Radu, N., Hainăroșie, R., Stefanescu, C. D., Diaconu, C. C., & Roman, V. (2020) · Nutrients · doi:10.3390/nu12092596 · Cited by 28

Magnesium in Combinatorial With Valproic Acid Suppressed the Proliferation and Migration of Human Bladder Cancer Cells

Li, T., Yu, Y., Shi, H., Cao, Y., Liu, X., Hao, Z., Ren, Y., Qin, G. W., Huang, Y., & Wang, B. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.589112 · Cited by 27

Activation of DNA damage response signaling in mammalian cells by ionizing radiation

Ghosh, S., & Ghosh, A. (2021) · Free Radical Research · doi:10.1080/10715762.2021.1876853 · Cited by 28

Knockdown of the prognostic cancer stem cell marker Musashi-1 decreases radio-resistance while enhancing apoptosis in hormone receptor-positive breast cancer cells via p21WAF1/CIP1

Troschel, F. M., Palenta, H., Borrmann, K., Heshe, K., Hua, S. H., Yip, G. W., Kiesel, L., Eich, H. T., Götte, M., & Greve, B. (2021) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-021-03743-y · Cited by 27

In vitro anticancer activity of ethanol extract of Adhatoda vasica Nees on human ovarian cancer cell lines

Nikhitha, J. N., Swathy, K. S., & Chandran, R. P. (2021) · Journal of Genetic Engineering and Biotechnology · doi:10.1186/s43141-021-00215-1 · Cited by 27

uL3 Mediated Nucleolar Stress Pathway as a New Mechanism of Action of Antiproliferative G-quadruplex TBA Derivatives in Colon Cancer Cells

Pecoraro, A., Virgilio, A., Esposito, V., Galeone, A., Russo, G., & Russo, A. (2020) · Biomolecules · doi:10.3390/biom10040583 · Cited by 26

SH3GL3 functions as a potent tumor suppressor in lung cancer in a SH3 domain dependent manner

Lin, Z., Liu, Z., Tan, X., & Li, C. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.10.107 · Cited by 24

Dynamic Spatiotemporal Expression Pattern of the Senescence-Associated Factor p16Ink4a in Development and Aging

Safwan‐Zaiter, H., Wagner, N., Michiels, J., & Wagner, K. (2022) · Cells · doi:10.3390/cells11030541 · Cited by 28

Critical roles of microRNA-141-3p and CHD8 in hypoxia/reoxygenation-induced cardiomyocyte apoptosis

Yao, B.-F., Wan, X., Zheng, X., Zhong, T., Hu, J., Zhou, Y., Qin, A., Ma, Y., & Yin, D. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00384-5 · Cited by 26

p21-Activated kinase 3 promotes cancer stem cell phenotypes through activating the Akt-GSK3β-β-catenin signaling pathway in pancreatic cancer cells

Wu, H.-Y., Yang, M.-C., Ding, L.-Y., Chen, C. S., & Chu, P. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.04.026 · Cited by 25

Do Bacteria Provide an Alternative to Cancer Treatment and What Role Does Lactic Acid Bacteria Play?

Dicks, L. M. T., & Vermeulen, W. (2022) · Microorganisms · doi:10.3390/microorganisms10091733 · Cited by 25

Carotenoid pigment of Halophilic archaeon Haloarcula sp. A15 induces apoptosis of breast cancer cells

Shahbazi, S., Zargar, M., Zolfaghari, M. R., & Amoozegar, M. A. (2023) · Cell Biochemistry and Function · doi:10.1002/cbf.3786 · Cited by 26

Ubiquitin-specific protease-44 inhibits the proliferation and migration of cells via inhibition of JNK pathway in clear cell renal cell carcinoma

Zhou, J., Wang, T., Qiu, T., Chen, Z., Ma, X., Zhang, L., & Zou, J. (2020) · BMC Cancer · doi:10.1186/s12885-020-6713-y · Cited by 23

DHMMF, a natural flavonoid from Resina Draconis, inhibits hepatocellular carcinoma progression via inducing apoptosis and G2/M phase arrest mediated by DNA damage-driven upregulation of p21

Tian, Y., Wang, L., Chen, X., Zhao, Y., Yang, A., Huang, H., Ouyang, L., Pang, D.-R., Xie, J., Liu, D., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115518 · Cited by 23

Paradigm shift: microRNAs interact with target gene promoters to cause transcriptional gene activation or silencing

Sarkar, N., & Kumar, A. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114372 · Cited by 25

Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats

Yakubu, O. F., Metibemu, D. S., Adelani, I. B., Adesina, G. O., Edokwe, C. B., Oseha, O. E., & Adebayo, A. H. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110786 · Cited by 22

Caprylic Acid (FFA C8:0) promotes the progression of prostate cancer by up-regulating G protein-coupled receptor 84/ Krüppel-like factor 7

Li, X., Yuan, C., Yang, B., Pang, H., Li, W., Li, M., Tang, Y., Ma, D., Xie, J., Wang, J., et al. (2023) · BMC Cancer · doi:10.1186/s12885-023-10841-2 · Cited by 21

Small nucleolar RNA 42 promotes the growth of hepatocellular carcinoma through the p53 signaling pathway

Wang, G., Li, J., Yao, Y., Liu, Y., Xia, P., Zhang, H., Yin, M., Qin, Z., Ma, W., & Yuan, Y. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00740-5 · Cited by 22

ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination

Geng, S., Peng, W., Wang, X., Hu, X., Liang, H., Hou, J., Wang, F., Zhao, G., Lü, M., & Cui, H. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04965-9 · Cited by 21

Milk-Derived miR-22-3p Promotes Proliferation of Human Intestinal Epithelial Cells (HIECs) by Regulating Gene Expression

Jiang, R., & Lönnerdal, B. L. (2022) · Nutrients · doi:10.3390/nu14224901 · Cited by 21

The Interplay between Noncoding RNAs and p21 Signaling in Gastrointestinal Cancer: From Tumorigenesis to Metastasis

Rahmani, F., Zandigohar, M., Safavi, P., Behzadi, M., Ghorbani, Z., Payazdan, M., Ferns, G. A., Hassanian, S. M., & Avan, A. (2023) · Current Pharmaceutical Design · doi:10.2174/1381612829666230306123455 · Cited by 21

Therapeutic strategies targeting cellular senescence for cancer and other diseases

Wang, X., Fukumoto, T., & Noma, K.-I. (2024) · The Journal of Biochemistry · doi:10.1093/jb/mvae015 · Cited by 23

FOXD1 promotes dedifferentiation and targeted therapy resistance in melanoma by regulating the expression of connective tissue growth factor

Sun, Q., Novak, D., Hüser, L., Poelchen, J., Wu, H., Granados, K., Federico, A., Liu, K., Steinfass, T., Vierthaler, M., et al. (2021) · International Journal of Cancer · doi:10.1002/ijc.33591 · Cited by 20

GATA6 Exerts Potent Lung Cancer Suppressive Function by Inducing Cell Senescence

Chen, W., Chen, Z., Zhang, M., Tian, Y., Liu, L., Lan, R., Zeng, G., Fu, X., Ru, G., Liu, W., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00824 · Cited by 22

The phytochemical brazilin suppress DNMT1 expression by recruiting p53 to its promoter resulting in the epigenetic restoration of p21 in MCF7cells

Chatterjee, B., Ghosh, K. K., Swain, A., Nalla, K., Ravula, H., Pan, A., & Kanade, S. R. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153885 · Cited by 20

Synthetic Design and Biological Evaluation of New p53-MDM2 Interaction Inhibitors Based on Imidazoline Core

Bazanov, D. R., Pervushin, N. V., Savin, E. V., Tsymliakov, M. D., Maksutova, A. I., Savitskaya, V. Y., Sosonyuk, S. E., Gracheva, Y. A., Seliverstov, M. Y., Lozinskaya, N. A., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15040444 · Cited by 21

Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC

Wang, K., Lu, H., Wang, X., Liu, Q., Hu, J., Liu, Y., Jin, M., & Kong, D. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1200538 · Cited by 20

Modulation of Apoptotic, Cell Cycle, DNA Repair, and Senescence Pathways by Marine Algae Peptides in Cancer Therapy

Visuddho, V., Halim, P., Helen, H., Muhar, A. M., Iqhrammullah, M., Mayulu, N., Surya, R., Tjandrawinata, R. R., Ribeiro, R. I. M. D. A., Tallei, T. E., et al. (2024) · Marine Drugs · doi:10.3390/md22080338 · Cited by 20

Glucosinolate-Degradation Products as Co-Adjuvant Therapy on Prostate Cancer in Vitro

Núñez-Iglesias, M. J., Novío, S., Garcı́a, C., Pérez-Muñuzuri, M. E., Soengas, P., Cartea, M. E., Velasco, P., & Freire‐Garabal, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20204977 · Cited by 21

ZFP36L1 plays an ambiguous role in the regulation of cell expansion and negatively regulates CDKN1A in chronic myeloid leukemia cells

Kaehler, M., Dworschak, M., Rodin, J. P., Ruemenapp, J., Vater, I., Penas, E. M. M., Liu, C., Cascorbi, I., & Nagel, I. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.05.006 · Cited by 21

Anticancer and Antibacterial Properties of Curcumin-Loaded Mannosylated Solid Lipid Nanoparticles for the Treatment of Lung Diseases

Chae, J., Choi, Y., Hong, J., Kim, N., Kim, J., Lee, H., & Choi, J. H. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c01145 · Cited by 22

LncRNA‐ZXF1 stabilizes P21 expression in endometrioid endometrial carcinoma by inhibiting ubiquitination‐mediated degradation and regulating the miR‐378a‐3p/PCDHA3 axis

Kong, D., Hou, Y., Li, W., Ma, X., & Jiang, J. (2021) · Molecular Oncology · doi:10.1002/1878-0261.12940 · Cited by 19

Integrated miRNA and mRNA omics reveal the anti-cancerous mechanism of Licochalcone B on Human Hepatoma Cell HepG2

Wang, J., & Wang, C. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112096 · Cited by 19

PSMC2 Regulates Cell Cycle Progression Through the p21/Cyclin D1 Pathway and Predicts a Poor Prognosis in Human Hepatocellular Carcinoma

Liu, Y., Chen, H., Li, X., Zhang, F., Kong, L., Wang, X., Bai, J., & Wu, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.607021 · Cited by 19

Oncogenic activity and cellular functionality of melanoma associated antigen A3

Schäfer, P., Paraschiakos, T., & Windhorst, S. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114700 · Cited by 20

Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) deubiquitinase module

Cornelio-Parra, D. V., Goswami, R., Costanzo, K. M., Morales‐Sosa, P., & Mohan, R. D. (2020) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2020.194630 · Cited by 20

Sulfonamide derivatives of cis-imidazolines as potent p53-MDM2/MDMX protein-protein interaction inhibitors

Bazanov, D. R., Pervushin, N. V., Savin, E. V., Tsymliakov, M. D., Maksutova, A. I., Sosonyuk, S. E., Kopeina, G. S., & Lozinskaya, N. A. (2021) · Medicinal Chemistry Research · doi:10.1007/s00044-021-02802-w · Cited by 18

Addiction of Merkel cell carcinoma to MUC1-C identifies a potential new target for treatment

Morimoto, Y., Fushimi, A., Yamashita, N., Hagiwara, M., Bhattacharya, A., Cheng, J., Frost, T. C., Ahmad, R., Daimon, T., Huang, L. H., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02361-3 · Cited by 18

Tumors driven by RAS signaling harbor a natural vulnerability to oncolytic virus M1

Cai, J., Lin, K., Cai, W., Lin, Y., Liu, X., Guo, L., Zhang, J., Xu, W., Lin, Z., Wong, C.-W., et al. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12820 · Cited by 17

Doxorubicin delivery by magnetic nanotheranostics enhances the cell death in chemoresistant colorectal cancer-derived cells

Martín, M. J., Azcona, P. L., Lassalle, V., & Gentili, C. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105681 · Cited by 17

Interplay Between Thiamine and p53/p21 Axes Affects Antiproliferative Action of Cisplatin in Lung Adenocarcinoma Cells by Changing Metabolism of 2-Oxoglutarate/Glutamate

Aleshin, V. A., Zhou, X., Krishnan, S., Karlsson, A., & Bunik, V. I. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.658446 · Cited by 17

Di-(2-ethylhexyl) phthalate triggers DNA methyltransferase 1 expression resulting in elevated CpG-methylation and enrichment of MECP2 in the p21 promoter in vitro

Ghosh, K. K., Chatterjee, B., Nalla, K., Behera, B., Mukherjee, A. K., & Kanade, S. R. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.133569 · Cited by 17

Characteristics of SOX9-positive progenitor-like cells during cholestatic liver regeneration in biliary atresia

Lin, Y., Zhang, F., Zhang, L., Chen, L., & Zheng, S. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02795-2 · Cited by 17

Poly(rC)-binding proteins as pleiotropic regulators in hematopoiesis and hematological malignancy

Zhao, H., Wei, Z., Shen, G., Chen, Y., Hao, X., Li, S., & Wang, R. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1045797 · Cited by 17

Traditional herbs: mechanisms to combat cellular senescence

Wang, L., Wang, J., Yang, Z., Wang, Y., Zhao, T., Luo, W., Liang, T., & Zheng, Y. (2023) · Aging · doi:10.18632/aging.205269 · Cited by 18

Linseed ameliorates renal apoptosis in rat fetuses induced by single or combined exposure to diesel nanoparticles or fenitrothion by inhibiting transcriptional activation of p21/p53 and caspase‐3/9 through pro‐oxidant stimulus

Ibrahim, K. A., Abdelgaid, H. A., El-Desouky, M. A., Fahmi, A. A., & Abdel‐Daim, M. M. (2021) · Environmental Toxicology · doi:10.1002/tox.23097 · Cited by 17

DNA Damage-Induced Ferroptosis: A Boolean Model Regulating p53 and Non-Coding RNAs in Drug Resistance

Gupta, S., Silveira, D. A., Mombach, J. C. M., & Hashimoto, R. F. (2025) · Proteomes · doi:10.3390/proteomes13010006 · Cited by 16

Lycorine hydrochloride inhibits melanoma cell proliferation, migration and invasion via down-regulating p21Cip1/WAF1.

Shi, S., Li, C., Zhang, Y., Deng, C., Tan, M., Pan, G., Du, J., Ji, Y., Li, Q., Liang, H., et al. (2021) · PubMed Central · Cited by 16

S100A6 promotes proliferation and migration of HepG2 cells via increased ubiquitin-dependent degradation of p53

Song, D., Xu, B., Shi, D.-M., Li, S., & Cai, Y. (2020) · Open Medicine · doi:10.1515/med-2020-0101 · Cited by 16

Key genes and drug delivery systems to improve the efficiency of chemotherapy

Torres‐Martínez, Z., Delgado, Y., Ferrer‐Acosta, Y., Suárez-Arroyo, I. J., Joaquín-Ovalle, F. M., Delinois, L. J., & Griebenow, K. H. (2020) · Cancer Drug Resistance · doi:10.20517/cdr.2020.64 · Cited by 16

The Dual Role Played by p21 May Influence the Apoptotic or Anti-Apoptotic Fate in Cancer

Piccolo, M. T., & Crispi, S. (2012) · Journal of cancer research updates · doi:10.6000/1929-2279.2012.01.02.5 · Cited by 65

The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics

Bitar, S. A., & Gali‐Muhtasib, H. U. (2019) · Cancers · doi:10.3390/cancers11101475 · Cited by 231

Dual Role of p21 in the Progression of Cancer and Its Treatment

Parveen, A., Akash, M. S. H., Rehman, K., & Whang, W. K. (2016) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.v26.i1.60 · Cited by 81

p21(WAF1) Mediates Cell-Cycle Inhibition, Relevant to Cancer Suppression and Therapy

El‐Deiry, W. S. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-2055 · Cited by 268

p21 in cancer: Intricate networks and multiple activities

Abbas, T., & Dutta, A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2657 · Cited by 2,712