p21 in Cancer Research

Genome engineering using the CRISPR-Cas9 system

Ran, F. A., Hsu, P. D., Wright, J., Agarwala, V., Scott, D. A., & Zhang, F. (2013) · Nature Protocols · doi:10.1038/nprot.2013.143 · Cited by 11,133

Comprehensive molecular characterization of human colon and rectal cancer

The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11252 · Cited by 8,499

WAF1, a potential mediator of p53 tumor suppression

El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651

TGFβ in Cancer

Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907

The emerging role of lncRNAs in cancer

Huarte, M. (2015) · Nature Medicine · doi:10.1038/nm.3981 · Cited by 2,712

p21 in cancer: Intricate networks and multiple activities

Abbas, T., & Dutta, A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2657 · Cited by 2,712

Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells

Ikeda, R., Che, X., Yamaguchi, T., Ushiyama, M., Zheng, C., Okumura, H., Takeda, Y., Shibayama, Y., Nakamura, K. T., Jeung, H., et al. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00057.x · Cited by 2,268

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

Huarte, M., Guttman, M., Feldser, D., Garber, M., Koziol, M. J., Kenzelmann-Broz, D., Khalil, A. M., Zuk, O., Amit, I., Rabani, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.040 · Cited by 2,053

Altering the Genome by Homologous Recombination

Capecchi, M. R. (1989) · Science · doi:10.1126/science.2660260 · Cited by 2,037

Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain.

Kim, Y. G., Cha, J., & Chandrasegaran, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1156 · Cited by 1,889

Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

Christian, M., Cermak, T., Doyle, E. L., Schmidt, C., Zhang, F., Hummel, A., Bogdanove, A. J., & Voytas, D. F. (2010) · Genetics · doi:10.1534/genetics.110.120717 · Cited by 1,869

Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1

Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

Zhou, B. P., Liao, Y., Xia, W., Spohn, B., Lee, M., & Hung, M. (2001) · Nature Cell Biology · doi:10.1038/35060032 · Cited by 1,148

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.Preprint

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The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.

Gartel, A. L., & Tyner, A. L. (2002) · PubMed · Cited by 918

Induction of WAF1/CIP1 by a p53-independent pathway.

Michieli, P., Chedid, M., Lin, D. P., Pierce, J. H., Mercer, W. E., & Givol, D. (1994) · PubMed · Cited by 768

Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy

Palmer, A. C., & Sorger, P. K. (2017) · Cell · doi:10.1016/j.cell.2017.11.009 · Cited by 642

Towards a complete map of the human long non-coding RNA transcriptome

Uszczyńska-Ratajczak, B., Lagarde, J., Frankish, A., Guigó, R., & Johnson, R. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0017-y · Cited by 637

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

Wang, T., Yu, H., Hughes, N. W., Liu, B., Kendirli, A., Klein, K., Chen, W. W., Lander, E. S., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.01.013 · Cited by 632

RNA-triggered gene silencing

Fire, A. Z. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01818-1 · Cited by 627

Viral Vectors for Gene Therapy

Robbins, P. D., & Ghivizzani, S. C. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00020-5 · Cited by 529

Reciprocal Regulation of HIF-1α and LincRNA-p21 Modulates the Warburg Effect

Yang, F., Zhang, H., Mei, Y., & Wu, M. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.11.004 · Cited by 514

p21: a two-faced genome guardian.

Georgakilas, A. G., Martin, O. A., & Bonner, W. M. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.02.001 · Cited by 489

LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity

Wu, G., Cai, J., Han, Y., Chen, J., Huang, Z., Chen, C., Cai, Y., Huang, H., Yang, Y., Liu, Y., et al. (2014) · Circulation · doi:10.1161/circulationaha.114.011675 · Cited by 486

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

Zeller, K. I., Jegga, A. G., Aronow, B. J., O’Donnell, K. A., & Dang, C. V. (2003) · Genome biology · doi:10.1186/gb-2003-4-10-r69 · Cited by 483

Examination of the expanding pathways for the regulation of p21 expression and activity

Jung, Y.-S., Qian, Y., & Chen, X. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.01.013 · Cited by 428

Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.

Martín‐Caballero, J., Flores, J. M., Garcı́a, P., & Serrano, M. (2001) · PubMed · Cited by 352

mdm-2 Inhibits the G1 Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein

Chen, J., Wu, X., Lin, J., & Levine, A. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2445 · Cited by 348

The p53-p21-DREAM-CDE/CHR pathway regulates G 2 /M cell cycle genes

Fischer, M., Quaas, M., Steiner, L., & Engeland, K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv927 · Cited by 339

Synthetic lethality: General principles, utility and detection using genetic screens in human cells

Nijman, S. M. B. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.11.024 · Cited by 334

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

Herreros‐Villanueva, M., Js, Z., König, A. O., Abel, E. V., Smyrk, T. C., Bamlet, W. R., de Narvajas, A. A.-M., Gomez, T. S., Simeone, D. M., Bujanda, L., et al. (2013) · Oncogenesis · doi:10.1038/oncsis.2013.23 · Cited by 331

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

Wu, S., Cetinkaya, C., Muñoz-Alonso, M. J., von der Lehr, N., Bahram, F., Beuger, V., Eilers, M., León, J., & Larsson, L. (2003) · Oncogene · doi:10.1038/sj.onc.1206145 · Cited by 322

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

Viale, A., Franco, F., Orleth, A., Cambiaghi, V., Giuliani, V., Bossi, D., Ronchini, C., Ronzoni, S., Muradore, I., Monestiroli, S., et al. (2008) · Nature · doi:10.1038/nature07618 · Cited by 314

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

Galanos, P., Vougas, K., Walter, D., Polyzos, A., Maya-Mendoza, A., Haagensen, E. J., Kokkalis, A., Roumelioti, F.-M., Gagos, S., Tzetis, M., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3378 · Cited by 308

p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cells

Gorospe, M., Cirielli, C., Wang, X., Seth, P. K., Capogrossi, M. C., & Holbrook, N. J. (1997) · Oncogene · doi:10.1038/sj.onc.1200897 · Cited by 294

Viral vectors for gene therapy

Robbins, P. D., Tahara, H., & Ghivizzani, S. C. (1998) · Trends in biotechnology · doi:10.1016/s0167-7799(97)01137-2 · Cited by 292

NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation

Qiu, L., Li, X., Tang, H., Jiang, B., Dou, Y., Gorospe, M., & Wang, W. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25957 · Cited by 284

p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation.

Zhang, W., Grasso, L., McClain, C. D., Gambel, A. M., Cha, Y., Travali, S., Deisseroth, A., & Mercer, W. E. (1995) · PubMed · Cited by 253

P21 activated kinase signaling in cancer

Rane, C. K., & Minden, A. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.01.006 · Cited by 247

The genetics of Pak

Hofmann, C., Shepelev, M. V., & Chernoff, J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01392 · Cited by 240

Potential Role of WAF1/Cip1/p21 as a Mediator of TGF-β Cytoinhibitory Effect

Li, C., Suardet, L., & Little, J. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.4971 · Cited by 239

P21 activated kinases

Rane, C. K., & Minden, A. (2014) · Small GTPases · doi:10.4161/sgtp.28003 · Cited by 232

Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer

Koster, R., di Pietro, A., Timmer‐Bosscha, H., Gibcus, J. H., van den Berg, A., Suurmeijer, A. J. H., Bischoff, R., Gietema, J. A., & de Jong, S. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41939 · Cited by 227

Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop

Zhang, J., Sun, Q., Zhang, Z., Ge, S., Han, Z.-G., & Chen, W.-T. (2012) · Oncogene · doi:10.1038/onc.2012.28 · Cited by 226

PAK signaling in cancer

Ye, D. Z., & Field, J. M. (2012) · Cellular Logistics · doi:10.4161/cl.21882 · Cited by 220

In vivo gene therapy with p53 or p21 adenovirus for prostate cancer.

Ja, E., Hall, S. J., Sehgal, I., Wang, J., Timme, T. L., Yang, G., Connell‐Crowley, L., Elledge, S. J., Ww, Z., & Harper, J. W. (1995) · PubMed · Cited by 219

Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit

Pavan Kumar, P., Desetty, R. D., Pineau, P., Marchio, A., Moon, A., Dejean, A., & Bischof, O. (2014) · Nature Communications · doi:10.1038/ncomms6323 · Cited by 205

The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters

Bao, X., Wu, H., Zhu, X., Guo, X., Hutchins, A. P., Luo, Z., Song, H., Chen, Y., Lai, K., Yin, M., et al. (2014) · Cell Research · doi:10.1038/cr.2014.165 · Cited by 189

Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals

Gawriluk, T. R., Simkin, J., Thompson, K. L., Biswas, S. K., Clare-Salzler, Z., Kimani, J. M., Kiama, S. G., Smith, J. J., Ezenwa, V. O., & Seifert, A. W. (2016) · Nature Communications · doi:10.1038/ncomms11164 · Cited by 167

Phosphorylation/Cytoplasmic Localization of p21Cip1/WAF1 Is Associated with HER2/ neu Overexpression and Provides a Novel Combination Predictor for Poor Prognosis in Breast Cancer Patients

Xia, W., Chen, J., Zhou, X. C., Sun, P.-R., Lee, D., Liao, Y., Zhou, B. P., & Hung, M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0527 · Cited by 167

Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses

Deng, T., Yan, G., Song, X., Xie, L. Y., Zhou, Y., Li, J., Hu, X., Li, Z., Hu, J., Zhang, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714938115 · Cited by 162

Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal.

Yang, W., Mathew, J., Velcich, A., Edelmann, W., Kucherlapati, R., Lipkin, M., Yang, K., & Augenlicht, L. H. (2001) · PubMed · Cited by 145

P21 RNA and protein expression in non-small cell lung carcinomas: Evidence of p53-independent expression and association with tumoral differentiation

Histology, M. I. P. A. (1996) · Lung Cancer · doi:10.1016/s0169-5002(97)89503-7 · Cited by 124

Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines

Baharuddin, P., Satar, N. A., Fakiruddin, K. S., Zakaria, N., Lim, M. N., Yusoff, N. M., Zakaria, Z., & Yahaya, B. H. (2015) · Oncology Reports · doi:10.3892/or.2015.4371 · Cited by 123

PAK family kinases

Zhao, Z.-S., & Manser, E. (2012) · Cellular Logistics · doi:10.4161/cl.21912 · Cited by 119

p21 Blocks Irradiation-Induced Apoptosis Downstream of Mitochondria by Inhibition of Cyclin-Dependent Kinase–Mediated Caspase-9 Activation

Sohn, D., Eßmann, F., Schulze‐Osthoff, K., & Jänicke, R. U. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1569 · Cited by 119

PSMD2 regulates breast cancer cell proliferation and cell cycle progression by modulating p21 and p27 proteasomal degradation

Li, Y., Huang, J., Zeng, B., Yang, D., Sun, J., Yin, X., Lu, M., Qiu, Z., Peng, W., Xiang, T., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.018 · Cited by 119

FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21

Zhang, L., Chen, J., Deng, N., Liu, Q., Wang, C., Zhang, Z., Chu, L., Yu, C., Liang, H., Zhang, B., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1058-6 · Cited by 112

Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer

Mousses, S., Özçelik, H., D.Lee, P., Malkin, D. M., Bull, S. B., & Andrulis, I. L. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.6.1089 · Cited by 109

PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion

Wells, C. M., Whale, A. D., Parsons, M., Masters, J. R., & Jones, G. E. (2010) · Journal of Cell Science · doi:10.1242/jcs.055707 · Cited by 107

Adenovirus-Mediated p21 (WAF1/SDII/CIP1) Gene Transfer Induces Apoptosis of Human Cervical Cancer Cell Lines

Tsao, Y., Huang, S.-J., Chang, J.-L., Hsieh, J., Pong, R.-C., & Chen, S. (1999) · Journal of Virology · doi:10.1128/jvi.73.6.4983-4990.1999 · Cited by 103

Defective G1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis.

Stewart, Z. A., Mays, D. J., & Pietenpol, J. A. (1999) · PubMed · Cited by 101

p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

Benson, E. K., Mungamuri, S. K., Attie, O., Kracikova, M., Sachidanandam, R., Manfredi, J. J., & Aaronson, S. A. (2013) · Oncogene · doi:10.1038/onc.2013.378 · Cited by 100

MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway

Chang, Y., Zhou, P.-J., Wei, L., Li, W., Ji, Z., Fang, Y., & Gao, W. (2015) · Oncotarget · doi:10.18632/oncotarget.4447 · Cited by 98

The Degree of Liver Injury Determines the Role of P21 in Liver Regeneration And Hepatocarcinogenesis in Mice

Buitrago‐Molina, L. E., Marhenke, S., Longerich, T., Sharma, A. D., Boukouris, A. E., Geffers, R., Guigas, B., Manns, M. P., & Vogel, A. (2013) · Hepatology · doi:10.1002/hep.26412 · Cited by 92

Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model

Adnane, J., Jackson, R. J., Nicosia, S. V., Cantor, A. B., Pledger, W. J., & Sebti, S. M. (2000) · Oncogene · doi:10.1038/sj.onc.1203956 · Cited by 91

LincRNa-p21: function and mechanism in cancer

Chen, S., Liang, H., Yang, H., Zhou, K., Xu, L., Liu, J., Lai, B., Li, S., Luo, H., Peng, J., et al. (2017) · Medical Oncology · doi:10.1007/s12032-017-0959-5 · Cited by 91

Oridonin‐induced mitochondria‐dependent apoptosis in esophageal cancer cells by inhibiting PI3K/AKT/mTOR and Ras/Raf pathways

Jiang, J., Pi, J., Jin, H., & Cai, J. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27654 · Cited by 91

Tumor suppressor functions for the Cdk inhibitor p21 in the mouse colon

Poole, A. J., Heap, D., Carroll, R. E., & Tyner, A. L. (2004) · Oncogene · doi:10.1038/sj.onc.1207994 · Cited by 90

PAKs in Human Cancer Progression

Kumar, R., & Li, D.-Q. (2016) · Advances in cancer research · doi:10.1016/bs.acr.2016.01.002 · Cited by 90

MiR-146b-5p overexpression attenuates stemness and radioresistance of glioma stem cells by targeting HuR/lincRNA-p21/β-catenin pathway

Yang, W., Yu, H., Shen, Y., Liu, Y., Yang, Z., & Sun, T. (2016) · Oncotarget · doi:10.18632/oncotarget.9214 · Cited by 87

Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53–MDM2 Inhibitor HDM201

Jeay, S., Ferretti, S., Holzer, P., Fuchs, J., Chapeau, E. A., Wartmann, M., Sterker, D., Romanet, V., Murakami, M., Kerr, G., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0338 · Cited by 87

Tumor suppression by p53: making cells senescent.

Qian, Y., & Chen, X. (2010) · PubMed · doi:10.14670/hh-25.515 · Cited by 85

RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC

Majumder, M., House, R. P., Palanisamy, N., Qie, S., Day, T. A., Neskey, D. M., Diehl, J. A., & Palanisamy, V. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006306 · Cited by 82

Oridonin inhibits oral cancer growth and PI3K/Akt signaling pathway

Yang, J., Ren, X., Zhang, L., Li, Y., Cheng, B., & Xia, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.011 · Cited by 82

Dual Role of p21 in the Progression of Cancer and Its Treatment

Parveen, A., Akash, M. S. H., Rehman, K., & Whang, W. K. (2016) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.v26.i1.60 · Cited by 81

Relationship between p21 expression and mutation of the p53 tumor suppressor gene in normal and malignant ovarian epithelial cells.

Elbendary, A., Cirisano, F. D., Evans, A. C., Davis, P. L., Iglehart, J. D., Marks, J. R., & Berchuck, A. (1996) · PubMed · Cited by 81

WAF1/Cip1 gene polymorphism and expression in carcinomas of the breast, ovary, and endometrium.

Lukas, J. L., Groshen, S. G., Saffari, B., Niu, N., Reles, A., Wen, W., Felix, J. C., Jones, L. A., Hall, F. L., & Press, M. F. (1997) · Europe PMC (PubMed Central) · Cited by 80

p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling

Tyagi, N., Marimuthu, S., Bhardwaj, A., Deshmukh, S. K., Srivastava, S. K., Singh, A. P., McClellan, S. B., Carter, J. E., & Singh, S. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.028 · Cited by 80

Induction of the WAF1/CIP1 protein and apoptosis in human T-cell leukemia virus type I-transformed lymphocytes after treatment with adriamycin by using a p53-independent pathway.

Gartenhaus, R. B., Wang, P., & Hoffmann, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.265 · Cited by 78

miRNA-regulated delivery of lincRNA-p21 suppresses β-catenin signaling and tumorigenicity of colorectal cancer stem cells

Wang, J., Lei, Z., Guo, Y., Wang, T., Qin, Z., Xiao, H., Fan, L., Chen, D., Bian, X., Liu, J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5635 · Cited by 78

Loss of the cell cycle inhibitors p21Cip1 and p27Kip1 enhances tumorigenesis in knockout mouse models

Jackson, R. J., Adnane, J., Coppola, D., Cantor, A. B., Sebti, S. M., & Pledger, W. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205946 · Cited by 77

Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells

Origanti, S., Cai, S.-R., Munir, A. Z., White, L. S., & Piwnica-Worms, H. (2013) · Oncogene · doi:10.1038/onc.2012.84 · Cited by 74

Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells

Wendt, J., Radetzki, S., von Haefen, C., Hemmati, P., Güner, D., Schulze‐Osthoff, K., Dörken, B., & Daniel, P. T. (2005) · Oncogene · doi:10.1038/sj.onc.1209031 · Cited by 71

Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex

Hussain, T., Saha, D., Purohit, G., Kar, A., Mukherjee, A. K., Sharma, S., Sengupta, S., Dhapola, P., Maji, B., Sreekanth, V., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-11177-1 · Cited by 70

p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis

Okuma, A., Hanyu, A., Watanabe, S., & Hara, E. (2017) · Nature Communications · doi:10.1038/s41467-017-02281-x · Cited by 69

A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression

Yamasaki, Y., Tazawa, H., Hashimoto, Y., Kojima, T., Kuroda, S., Yano, S., Yoshida, R., Uno, F., Mizuguchi, H., Ohtsuru, A., et al. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2011.12.020 · Cited by 67

The Dual Role Played by p21 May Influence the Apoptotic or Anti-Apoptotic Fate in Cancer

Piccolo, M. T., & Crispi, S. (2012) · Journal of cancer research updates · doi:10.6000/1929-2279.2012.01.02.5 · Cited by 65

Rbm24, an RNA-binding Protein and a Target of p53, Regulates p21 Expression via mRNA Stability

Jiang, Y., Zhang, M., Qian, Y., Xu, E., Zhang, J., & Chen, X. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.524413 · Cited by 65

LincRNA-p21: Implications in Human Diseases

Tang, S.-S., Zheng, B., & Xiong, X. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160818732 · Cited by 65

Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells

Stier, S., Cheng, T., Forkert, R., Lutz, C., Dombkowski, D., Zhang, J. L., & Scadden, D. T. (2003) · Blood · doi:10.1182/blood-2002-10-3053 · Cited by 65

FoxF1 and FoxF2 transcription factors synergistically promote rhabdomyosarcoma carcinogenesis by repressing transcription of p21Cip1 CDK inhibitor

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A Single Recombinant Adenovirus Expressing p53 and p21-targeting Artificial microRNAs Efficiently Induces Apoptosis in Human Cancer Cells

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