The DOI matches its Crossref record; 267 of the 267 references it cites were found in a registry or an index.
Telomeres and Telomere Length: A General Overview
Open accessAbstract
Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity. Due to the inherent limitations of DNA replication and telomerase suppression in most somatic cells, telomeres undergo age-dependent incremental attrition. Short or dysfunctional telomeres are recognized as DNA double-stranded breaks, triggering cells to undergo replicative senescence. Telomere shortening, therefore, acts as a counting mechanism that drives replicative senescence by limiting the mitotic potential of cells. Telomere length, a complex hereditary trait, is associated with aging and age-related diseases. Epidemiological data, in general, support an association with varying magnitudes between constitutive telomere length and several disorders, including cancers. Telomere attrition is also influenced by oxidative damage and replicative stress caused by genetic, epigenetic, and environmental factors. Several single nucleotide polymorphisms at different loci, identified through genome-wide association studies, influence inter-individual variation in telomere length. In addition to genetic factors, environmental factors also influence telomere length during growth and development. Telomeres hold potential as biomarkers that reflect the genetic predisposition together with the impact of environmental conditions and as targets for anti-cancer therapies.
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Citations
Cites
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Self-citationBlackburn, E. H., Epel, E. S., & Lin, J. (2015) · Science · doi:10.1126/science.aab3389 · Cited by 1,596
G-quadruplexes and their regulatory roles in biology
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Cited by
Vaiserman, A., & Krasnienkov, D. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.630186 · Cited by 454
Crosstalk between G-quadruplex and ROS
Wu, S., Jiang, L., Lei, L., Fu, C., Huang, J., Hu, Y., Dong, Y., Chen, J., & Zeng, Q. (2023) · Cell Death & Disease · doi:10.1038/s41419-023-05562-0 · Cited by 69
The dynamics of telomere length in primary and metastatic colorectal cancer lesions
Kroupa, M., Kubecek, O., Tomasova, K., Hanak, P., Krupova, M., Cervena, K., Siskova, A., Rosendorf, J., Hosek, P., Vodickova, L., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-35835-9 · Cited by 10
Metadata
- Authors
- Srinivas, N., Rachakonda, S., & Kumar, R.
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2020-02-28
- Volume
- 12
- Issue
- 3
- Pages
- 558
- ISSN
- 2072-6694 (ISSN-L)
- OpenAlex
- W3009359263
- Cited by
- 304
- References
- 267
- FWCI
- 19.36
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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