The Potential of Lonidamine in Combination with Chemotherapy and Physical Therapy in Cancer Treatment

Cisplatin in cancer therapy: Molecular mechanisms of action

Dasari, S., & Bernard Tchounwou, P. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.025 · Cited by 5,537

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

Johnstone, T. C., Suntharalingam, K., & Lippard, S. J. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00597 · Cited by 2,508

Photodynamic therapy – mechanisms, photosensitizers and combinations

Kwiatkowski, S., Knap, B., Przystupski, D., Saczko, J., Kędzierska, E., Knap-Czop, K., Kotlińska, J., Michel, O., Kotowski, K., & Kulbacka, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.049 · Cited by 2,173

Targeting cancer metabolism: a therapeutic window opens

Heiden, M. G. V. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3504 · Cited by 1,443

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

Octavia, Y., Tocchetti, C. G., Gabrielson, K. L., Janssens, S. P., Crijns, H. J. G. M., & Moens, A. L. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.03.006 · Cited by 1,425

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

DeBerardinis, R. J., & Cheng, T. (2010) · Oncogene · doi:10.1038/onc.2009.358 · Cited by 1,365

Mechanisms of action of arsenic trioxide.

Miller, W. H., Schipper, H. M., Lee, J. S., Singer, J. W., & Waxman, S. (2002) · PubMed · Cited by 941

Heat Shock Proteins: Endogenous Modulators of Apoptotic Cell Death

Garrido, C., Gurbuxani, S. K., Ravagnan, L., & Kroemer, G. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5427 · Cited by 790

A microenvironmental model of carcinogenesis

Gatenby, R. A., & Gillies, R. J. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2255 · Cited by 741

Metabolic targets for cancer therapy

Galluzzi, L., Kepp, O., Heiden, M. G. V., & Kroemer, G. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4145 · Cited by 731

Targeting monocarboxylate transporters (MCTs) in cancer: How close are we to the clinics?

Singh, M., Afonso, J., Sharma, D., Gupta, R., Kumar, V., Rani, R., Baltazar, F., & Kumar, V. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.01.007 · Cited by 194

Dysregulation of metabolic pathways in pulmonary fibrosis

Rajesh, R., Atallah, R., & Bärnthaler, T. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108436 · Cited by 132

The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells

Jaworska, M., Szczudło, J., Pietrzyk, A., Shah, J., Trojan, S., Ostrowska, B., & Kocemba‐Pilarczyk, K. A. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00504-1 · Cited by 128

Mitochondria-Targeted Multifunctional Nanoprodrugs by Inhibiting Metabolic Reprogramming for Combating Cisplatin-Resistant Lung Cancer

Lu, H., Tong, W., Jiang, M., Liu, H., Meng, C., Wang, K., & Mu, X. (2024) · ACS Nano · doi:10.1021/acsnano.4c04024 · Cited by 92

Nanomaterial-enabled metabolic reprogramming strategies for boosting antitumor immunity

Ma, M., Zhang, Y., Pu, K., & Tang, W. (2024) · Chemical Society Reviews · doi:10.1039/d4cs00679h · Cited by 100

GLUT and HK: Two primary and essential key players in tumor glycolysis

Yadav, D., Yadav, A., Bhattacharya, S., Dagar, A., Kumar, V., & Rani, R. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.03.001 · Cited by 87

Antibody-conjugated liposomes loaded with indocyanine green for oral targeted photoacoustic imaging-guided sonodynamic therapy of Helicobacter pylori infection

Wang, R., Song, C., Gao, A., Liu, Q., Guan, W., Mei, J., Ma, L., & Cui, D. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.02.031 · Cited by 78

Biomimetic nanoparticles for effective mild temperature photothermal therapy and multimodal imaging

Shu, X., Chen, Y., Yan, P., Xiang, Y., Shi, Q., Yin, T., Wang, P., Liu, L., & Shuai, X. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.010 · Cited by 69

Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer

Kooshki, L., Mahdavi, P., Fakhri, S., Akkol, E. K., & Khan, H. Z. (2021) · BioFactors · doi:10.1002/biof.1799 · Cited by 67

Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy

Kejík, Z., Hajduch, J., Abramenko, N., Vellieux, F. M. D., Veselá, K., Fialová, J. L., Petrláková, K., Kučnirová, K., Kaplánek, R., Tatar, A., et al. (2024) · Communications Chemistry · doi:10.1038/s42004-024-01256-6 · Cited by 69

Metabolic Intervention Liposome Boosted Lung Cancer Radio‐Immunotherapy via Hypoxia Amelioration and PD‐L1 Restraint

Wang, S., Zhou, Z., Hu, R., Dong, M., Zhou, X., Ren, S.-Y., Zhang, Y., Chen, C., Huang, R., Zhu, M., et al. (2023) · Advanced Science · doi:10.1002/advs.202207608 · Cited by 66

Linking Metabolic Reprogramming, Plasticity and Tumor Progression

Shuvalov, O., Daks, A., Fedorova, O., Petukhov, A., & Barlev, N. (2021) · Cancers · doi:10.3390/cancers13040762 · Cited by 63

The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism

Yiew, N. K. H., & Finck, B. N. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00074.2022 · Cited by 64

Contemporary Perspectives on the Warburg Effect Inhibition in Cancer Therapy

Kozal, K., Jóźwiak, P., & Krześlak, A. (2021) · Cancer Control · doi:10.1177/10732748211041243 · Cited by 65

Functions and mechanisms of lactylation in carcinogenesis and immunosuppression

Su, J., Zheng, Z., Bian, C., Chang, S., Bao, J., Yu, H., Xin, Y., & Jiang, X. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1253064 · Cited by 57

Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy

Ni, X., Lu, C., Xu, G.-Q., & Ma, J. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01264-1 · Cited by 56

Amplification of anticancer efficacy by co-delivery of doxorubicin and lonidamine with extracellular vesicles

Li, H., Xu, W., Li, F., Zeng, R., Zhang, X., Wang, X., Zhao, S., Weng, J., Zhu, L., & Sun, L. (2022) · Drug Delivery · doi:10.1080/10717544.2021.2023697 · Cited by 56

Therapeutic targeting of immunometabolism reveals a critical reliance on hexokinase 2 dosage for microglial activation and Alzheimer’s progression

Codocedo, J. F., Mera-Reina, C., Bor-Chian Lin, P., Fallen, P. B., Puntambekar, S. S., Casali, B. T., Jury-Garfe, N., Martinez, P., Lasagna-Reeves, C. A., & Landreth, G. E. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114488 · Cited by 52

Targeting cancer-specific metabolic pathways for developing novel cancer therapeutics

Pal, S., Sharma, A. K., Mathew, S. P., & Jaganathan, B. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.955476 · Cited by 50

Lactate-related metabolic reprogramming and immune regulation in colorectal cancer

Sun, Q., Wu, J., Zhu, G., Li, T., Zhu, X., Ni, B., Xu, B., Ma, X., & Li, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1089918 · Cited by 48

Fifty years of the mitochondrial pyruvate carrier: New insights into its structure, function, and inhibition

Tavoulari, S., Sichrovsky, M., & Kunji, E. R. S. (2023) · Acta Physiologica · doi:10.1111/apha.14016 · Cited by 45

Role of Glucose Metabolic Reprogramming in Breast Cancer Progression and Drug Resistance

Lei, P., Wang, W., Sheldon, M., Sun, Y., Yao, F., & Ma, L. (2023) · Cancers · doi:10.3390/cancers15133390 · Cited by 45

Endogenous Zinc‐Ion‐Triggered In Situ Gelation Enables Zn Capture to Reprogram Benign Hyperplastic Prostate Microenvironment and Shrink Prostate

Ge, J., Fang, C., Tan, H., Zhan, M., Gu, M., Ni, J., Yang, G., Zhang, H., Ni, J., Zhang, K., et al. (2023) · Advanced Materials · doi:10.1002/adma.202307796 · Cited by 39

Exploring the mystery of tumor metabolism: Warburg effect and mitochondrial metabolism fighting side by side

Yu, Y., Jiang, Y., Glandorff, C., & Sun, M. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111239 · Cited by 41

Innovations in Cancer Therapy: Endogenous Stimuli-Responsive Liposomes as Advanced Nanocarriers

Torres, J., Oses, J. K. V., Rabasco, A. M., González-Rodrı́guez, M. L., & García, M. C. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020245 · Cited by 40

Inhibiting Glycolysis and Disrupting the Mitochondrial HK2–VDAC1 Protein–Protein Interaction Using a Bifunctional Lonidamine-Conjugated Metal Probe for Combating Triple-Negative Breast Cancer

Wang, L., Kong, L., Zhang, D., Ye, L., Nao, S.-C., Chan, D. S., Li, X., Peng, Y., Yang, L., Wong, C.-Y., et al. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c04233 · Cited by 39

2-Deoxy-D-glucose increases the sensitivity of glioblastoma cells to BCNU through the regulation of glycolysis, ROS and ERS pathways: In vitro and in vivo validation

Sun, X., Fan, T., Sun, G., Zhou, Y., Huang, Y., Zhang, N., Zhao, L., Zhong, R., & Peng, Y. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115029 · Cited by 39

Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2

Zheng, Y., Zhan, Y., Zhang, Y., Zhang, Y., Liu, Y., Xie, Y., Sun, Y., Qian, J., Ding, Y., Ding, Y., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06009-2 · Cited by 40

Glutathione‐Sensitive Photosensitizer–Drug Conjugates Target the Mitochondria to Overcome Multi‐Drug Resistance in Cancer

Song, W., Yang, H., Wang, Y., Chen, S., Zhong, W., Wang, Q., Ding, W., Xu, G., Chen, M., Liang, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202307765 · Cited by 36

Active mitochondrial respiration in cancer: a target for the drug

Bedi, M., Ray, M., & Ghosh, A. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04281-4 · Cited by 34

Tumor energy metabolism: implications for therapeutic targets

Hu, Y., Liu, W., Fang, W., Dong, Y., Zhang, H., & Luo, Q. (2024) · Molecular Biomedicine · doi:10.1186/s43556-024-00229-4 · Cited by 32

The Molecular Mechanisms behind Advanced Breast Cancer Metabolism: Warburg Effect, OXPHOS, and Calcium

Mitaishvili, E., Feinsod, H., David, Z., Shpigel, J., Fernandez, C., Sauane, M., & de la Parra, C. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2903099 · Cited by 34

Multimodal representation learning for predicting molecule–disease relations

Wen, J., Zhang, X., Rush, E. N., Panickan, V. A., Li, X., Cai, T. A., Ho, Y.-L. A., Ho, Y.-L., Costa, L., Begoli, E., et al. (2023) · Bioinformatics · doi:10.1093/bioinformatics/btad085 · Cited by 27

Podophyllotoxin: Recent Advances in the Development of Hybridization Strategies to Enhance Its Antitumoral Profile

Miranda‐Vera, C., Hernández, Á., Garcı́a, P. G., David Diez, A., García, P. A., & Castro, M. A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15122728 · Cited by 27

Antineoplastic Properties by Proapoptotic Mechanisms Induction of Inula viscosa and Its Sesquiterpene Lactones Tomentosin and Inuviscolide

Migheli, R., Virdis, P., Galleri, G., Arru, C., Lostia, G., Coradduzza, D., Muroni, M. R., Pintore, G., Podda, L., Fozza, C., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10112739 · Cited by 25

Research progress of hyperthermia in tumor therapy by influencing metabolic reprogramming of tumor cells

Yang, Y., Huangfu, L., Li, H., & Yang, D. (2023) · International Journal of Hyperthermia · doi:10.1080/02656736.2023.2270654 · Cited by 24

Exploring monocarboxylate transporter inhibition for cancer treatment

Koltai, T., & Fliegel, L. (2024) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2024.00210 · Cited by 25

The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors

Liu, B., Lu, Y., Taledaohan, A., Qiao, S., Li, Q., & Wang, Y. (2023) · Molecules · doi:10.3390/molecules29010075 · Cited by 24

20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells

Shuvalov, O., Kirdeeva, Y., Fefilova, E., Netsvetay, S., Zorin, M., Vlasova, Y., Fedorova, O., Daks, A., Parfenyev, S., & Barlev, N. (2023) · Metabolites · doi:10.3390/metabo13050656 · Cited by 21

Co-delivery of mitochondrial targeted lonidamine and PIN1 inhibitor ATRA by nanoparticulate systems for synergistic metastasis suppression

Chen, C., Li, Q., Xing, L., Zhou, M., Luo, C., Li, S., Li, L., & Huang, Y. (2021) · Nano Research · doi:10.1007/s12274-021-3923-9 · Cited by 21

cRGD-modified nanoparticles of multi-bioactive agent conjugate with pH-sensitive linkers and PD-L1 antagonist for integrative collaborative treatment of breast cancer

Zou, C., Tang, Y., Zeng, P., Cui, D., Amili, M. A., Chang, Y. F., Zhu, J., Shen, Y., Tan, S., & Guo, S. (2023) · Nanoscale Horizons · doi:10.1039/d2nh00590e · Cited by 20

Role of monocarboxylate transporters in cancer immunology and their therapeutic potential

Faghihkhorasani, F., Moosavi, M., Abdulwahid, A. R. R., Kavei, M., Karimi, S., Karimi, M. S., Vezvaei, P., Varkiani, M. M., Aref, A. R., & Ebrahimi, N. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70110 · Cited by 24

Dendrimer-Entrapped CuPt Bimetallic Nanozymes for Tumor Microenvironment-Regulated Photothermal/Catalytic Therapy

Lu, S., Li, A., Huang, H., Ni, C., Cao, X., Shi, X., & Guo, R. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c05324 · Cited by 17

Mitochondrial Targeting and pH-Responsive Nanogels for Co-Delivery of Lonidamine and Paclitaxel to Conquer Drug Resistance

Chen, E., Wang, T., Zhang, J., Zhou, X. Y., Niu, Y., Liu, F., Zhong, Y., Huang, D., & Chen, W. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.787320 · Cited by 17

Salvia miltiorrhiza inhibited lung cancer through aerobic glycolysis suppression

Bai, J., Qin, Q., Li, S., Cui, X., Zhong, Y., Yang, L., An, L., Deng, D., Zhao, J., Zhang, R., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118281 · Cited by 17

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Zhang, Z., Huang, S., Wang, Y., Jiang, Z., Liu, Z., Wang, C., Ji, R., Yuan, Y., Mao, X., Yang, K., et al. (2025) · Advanced Science · doi:10.1002/advs.202513400 · Cited by 16

A mitochondria-targeting self-assembled carrier-free lonidamine nanodrug for redox-activated drug release to enhance cancer chemotherapy

Yang, T., Zhang, X., Yang, X., Li, Y., Xiang, J., Xiang, C., Liu, Z., Hai, L., Huang, S., Zhou, L., et al. (2023) · Journal of Materials Chemistry B · doi:10.1039/d2tb02728c · Cited by 16

Progress in the treatment of drug-loaded nanomaterials in renal cell carcinoma

Li, J., Wu, K.-Z., Zhang, J., Gao, H., & Xu, X. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115444 · Cited by 16

Aptamer‐modified tetrahedral DNA nanostructure‐immobilized liposome for specific gene delivery and potential cancer theragnostic

Lim, D. Y., & Hwang, B. H. (2023) · Biotechnology Journal · doi:10.1002/biot.202300156 · Cited by 16

[Role and Mechanism of Lactylation in Cancer].

Zhang, Q., Cao, L., & Xu, K. (2024) · PubMed Central · doi:10.3779/j.issn.1009-3419.2024.102.20 · Cited by 15

Photothermal therapy enhance the anti-mitochondrial metabolism effect of lonidamine to renal cell carcinoma in homologous-targeted nanosystem

Chen, J., Ren, F., Cao, W., Wu, Z., Ju, G., Xiao, C., Wu, W., Gao, S., Xu, C., & Gao, Y. (2021) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2021.102370 · Cited by 15

Energy Blocker Lonidamine Reverses Nimustine Resistance in Human Glioblastoma Cells through Energy Blockade, Redox Homeostasis Disruption, and O 6 -Methylguanine-DNA Methyltransferase Downregulation: In Vitro and In Vivo Validation

Huang, Y., Wang, P., Fan, T., Zhang, N., Zhao, L., Zhong, R., & Sun, G. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00085 · Cited by 14

Synthesis of Novel Hybrid Lonidamine-Coumarin Derivatives and Their Anticancer Activities

İpek, Ö. Ş., Sucu, B. O., Gül, Ş., Yolaçan, Ç., & Güzel, M. (2023) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2023.135114 · Cited by 14

Targeting lactate metabolism in the tumor microenvironment: Immunomodulation and prospects for antitumor therapy

Yan, J., Qi, Y., Liu, Y., Jiang, X., Li, Y., Song, Z., Zhang, L., & Zhang, Z. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115390 · Cited by 14

Targeted degradation of hexokinase 2 by a novel engineered bispecific chimeric liposome-based Nano-PROTACs for enhancing tumor chemotherapy

Gong, L., Li, S., Sun, J., Liu, R., Wang, J., Wang, S., Zhao, Y., Yan, L., Ji, M., Yang, D., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123651 · Cited by 12

Discovery of a novel Wnt inhibitor DK419: Reversing temozolomide resistance in glioblastoma by switching off Wnt/β-catenin signaling pathway to inhibit MGMT expression

Bai, P., Wang, P., Ren, T., Tang, Q., Zhang, N., Zhao, L., 钟儒刚, & Sun, G. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117411 · Cited by 12

Addressing artifacts of colorimetric anticancer assays for plant-based drug development

Batool, S., Javaid, S., Javed, H., Asim, L., Shahid, I., Khan, M., & Muhammad, A. (2022) · Medical Oncology · doi:10.1007/s12032-022-01791-z · Cited by 12

Metabolic Rewiring in Cancer: Small Molecule Inhibitors in Colorectal Cancer Therapy

Masci, D., Puxeddu, M., Silvestri, R., & Regina, G. L. (2024) · Molecules · doi:10.3390/molecules29092110 · Cited by 11

Protective Effect of Aquilaria crassna Leaf Extract against Benzo[a]pyrene-Induced Toxicity in Neuronal Cells and Caenorhabditis elegans: Possible Active Constituent Includes Clionasterol

Pattarachotanant, N., Rangsinth, P., Warayanon, W., Leung, G., Chuchawankul, S., Prasansuklab, A., & Tencomnao, T. (2023) · Nutrients · doi:10.3390/nu15183985 · Cited by 11

Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines

García‐Molina, P., Sola‐Leyva, A., Luque-Navarro, P. M., Laso, A., Ríos‐Marco, P., Ríos, A., Lanari, D., Torretta, A., Parisini, E., Lopez-Cara, L. C., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020426 · Cited by 11

New Organometallic Ru(II) Compounds with Lonidamine Motif as Antitumor Agents

Shutkov, I. A., Okulova, Y. N., Mazur, D. M., Melnichuk, N. A., Babkov, D. A., Sokolova, E. V., Спасов, А. А., Milaeva, E. R., & Nazarov, A. A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051366 · Cited by 10

Bioenergetic alteration in gastrointestinal cancers: The good, the bad and the ugly

Chu, Y., Chen, C.-W. D., Lai, M., Lim, S., & Lin, W.-R. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i29.4499 · Cited by 12

Advances in the Study of Liposomes Gel with Stimulus Responsiveness in Disease Treatment

Yang, Q., Luo, S., Tong, S., Zhao, H., Chen, R., Song, B., & Wu, J. (2023) · Journal of Cluster Science · doi:10.1007/s10876-023-02510-y · Cited by 9

RNA-Seq Technology Reveals the Mechanism of SDT Combined With Novel Nanobubbles Against HCC

Shang, H., Chen, Y., Wang, C., Zhang, S., Wu, B., Liang, X., Liu, Z., Wang, Q., & Cheng, W. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.791331 · Cited by 9

mTORC1/rpS6 and p-FAK-Y407 signaling regulate spermatogenesis: Insights from studies of the adjudin pharmaceutical/toxicant model

Wang, L., Li, L., Wu, X., Wong, C. K. C., Perrotta, A. M., Silvestrini, B., Sun, F., & Cheng, C. Y. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.03.024 · Cited by 9

Is antitumor Pt(IV) complex containing two axial lonidamine ligands a true dual- or multi-action prodrug?

Kašpárková, J., Kostrhunová, H., Novohradský, V., Ma, L., Zhu, G., Milaeva, E. R., Shtill, A. A., Vinck, R., Gasser, G., Brabec, V., et al. (2022) · Metallomics · doi:10.1093/mtomcs/mfac048 · Cited by 9

Tumoral oxygenation and biodistribution of Lonidamine oxygen microbubbles following localized ultrasound-triggered delivery

Lacerda, Q., Rochani, A., Oeffinger, B. E., Liu, J., Wessner, C. E., Tahmasebi, A., Falatah, H. A., Lee, P., Leeper, D. B., Forsberg, F., et al. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122072 · Cited by 9

Development of a Dual Drug-Loaded, Surfactant-Stabilized Contrast Agent Containing Oxygen

Patel, R. B., Lacerda, Q., Oeffinger, B. E., Eisenbrey, J. R., Rochani, A., Kaushal, G., Wessner, C. E., & Wheatley, M. A. (2022) · Polymers · doi:10.3390/polym14081568 · Cited by 9

Glucose metabolism reprogramming in gastric cancer: Implications for tumor

Li, X., Cao, X., Wang, Y., Deng, Y., Thomas, E. R., Xiao, W., Wang, W., Xu, L., & He, Q. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115630 · Cited by 7

Harnessing Drug Repurposing to Combat Breast Cancer by Targeting Altered Metabolism and Epithelial-to-Mesenchymal Transition Pathways

Kandasamy, T., Sarkar, S., & Ghosh, S. S. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00545 · Cited by 7

Strategies for the treatment of breast cancer: from classical drugs to mathematical models

Costa, A., & Vale, N. (2021) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2021316 · Cited by 7

Mito-LND and (E)-Akt inhibitor-IV: novel compounds inducing endoplasmic reticulum stress and ROS accumulation against hepatocellular carcinoma

Liao, S., Wang, Q., Chen, S., Huang, Q., Zhou, L., Liu, H., He, S., & Zhou, Z. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05545-5 · Cited by 8

Deciphering Medulloblastoma: Epigenetic and Metabolic Changes Driving Tumorigenesis and Treatment Outcomes

Bonifacio-Mundaca, J., Casavilca-Zambrano, S. A., Desterke, C., Casafont, Í., & Mata-Garrido, J. (2025) · Biomedicines · doi:10.3390/biomedicines13081898 · Cited by 6

Targeted nanomedicines for the treatment of Helicobacter pylori infection

Wang, S., Ding, H., Li, L., Zhao, R., & Chai, N. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101820 · Cited by 7

Chemotherapy Resistance in Cancer: Mechanism and Roadmap to Evade Exploring Apoptosis

Halder, K. (2024) · International Journal of Advancement in Life Sciences Research · doi:10.31632/ijalsr.2024.v07i02.003 · Cited by 6

Water soluble 1,2,3-triazole based metal-free, zinc(II) and indium(III) phthalocyanines: Synthesis, characterization, photochemical and photophysical properties

Ouis, T., Khezami, K., Durmuş, M., & Saïdi‐Besbes, S. (2025) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2025.116575 · Cited by 5

Co-delivery of copper chelators and glycolytic inhibitors to disrupt glucose metabolism and inhibit tumor metastasis

Lu, J., Feng, S., Liu, Z., Xiao, Y., Zhang, H., Wang, S., & Zhao, Q. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.165899 · Cited by 5

Therapeutic targeting of immunometabolism in Alzheimer’s disease reveals a critical reliance on Hexokinase 2 dosage on microglial activation and disease progressionPreprint

Codocedo, J. F., Mera-Reina, C., Lin, P. B., Puntambekar, S. S., Casali, B. T., Jury, N., Martínez, P., Lasagna‐Reeves, C. A., & Landreth, G. E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.11.566270 · Cited by 5

Efficient identification of new small molecules targeting succinate dehydrogenase in non-small cell lung cancer

Silva, L. F. O., Skiados, N. G., Murugavel, N., Cover, K., Luna, N., Gupta, M., Contreras, S. C., O’Brien, T. E., & Zhang, W. C. (2025) · Cancer Cell International · doi:10.1186/s12935-025-04002-7 · Cited by 6

Lonidamine-1,3,4-oxadiazole derivatives with antiproliferative effects on HCT116 colon cancer cell lines: biological evaluation, ADMET, and computational studies

Bhat, R. M., Priyadarshini, A. N., Srinivasa, S. M., Muddapur, G. V., Alhussieni, K., Raman Kumar, K., & Keri, R. S. (2026) · RSC Advances · doi:10.1039/d5ra07852k · Cited by 4

Lonidamine, a Novel Modulator for the BvgAS System of Bordetella Species

Ota, N., Nishida, T., Standley, D. M., Sherif, A., Iwano, S., Nugraha, D. K., Ueno, T., & Horiguchi, Y. (2024) · Microbiology and Immunology · doi:10.1111/1348-0421.13193 · Cited by 4

Leveraging selection for function in tumor evolution: System-level cancer therapies

Frédéric Thomas, A., Capp, J., Dujon, A. M., Marusyk, A., Asselin, K., Campone, M., Pujol, P., Alix‐Panabières, C., Roche, B., Újvári, B., et al. (2025) · Evolution Medicine and Public Health · doi:10.1093/emph/eoaf022 · Cited by 5

Strategies for Attenuating Chemotherapy Side Effects: A Review

Almukram, A. M. A., Al-Mamoori, F. F., Sameer, H. N., Farhan, D. M., Al-Shammari, A. H., Al-Hussaniy, H. A., & Oraibi, A. I. (2024) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2024.00857 · Cited by 4

Carbohydrate kinase inhibition: a promising strategy in cancer treatment

Jain, A., Das, R., Giri, M., Mane, P., & Shard, A. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104308 · Cited by 4

Study on the Mechanism of Action of the Pt(IV) Complex with Lonidamine Ligands by Ultrafast Chemical Proteomics

Imaikina, E. A., Fedorov, I. I., Emekeeva, D. D., Kazakova, E. M., Garibova, L. A., Ivanov, M. V., Shutkov, I. A., Nazarov, A. A., Gorshkov, M. V., & Tarasova, I. A. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00718 · Cited by 4

Inhibition of human maltase-glucoamylase, sucrase-isomaltase and α-amylases by gallotannins and ellagitannins

Farazi, M., Houghton, M. J., Murray, M., Cardoso, B. R., & Williamson, G. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144204 · Cited by 3

Lonidamine Increases the Cytotoxic Effect of 1-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl)-3-nitrosourea via Energy Inhibition, Disrupting Redox Homeostasis, and Downregulating MGMT Expression in Human Lung Cancer Cell Line

Fan, T., Shen, L., Huang, Y., Wang, X., Zhao, L., Zhong, R., Wang, P., & Sun, G. (2024) · ACS Omega · doi:10.1021/acsomega.4c00641 · Cited by 3

Design, Synthesis, and Biological Evaluation of Naphthoquinone Salts as Anticancer Agents

Cheng, Y., Yu, T. T., Olzomer, E. M., Hoehn, K. L., Byrne, F. L., Kumar, N., & Black, D. S. (2025) · Molecules · doi:10.3390/molecules30091938 · Cited by 3

Design and synthesis of multitarget triazinoindole derivatives with potent antiproliferative activity: Targeting EGFR, SIRT1, MDM2, Hsp90, PI3K, p53, and caspase-9

Badawi, W. A., Ezz-ElDien, E. S., El‐Atawy, M. A., Omar, A. Z., Hamed, E. A., Ahmed, H. A., Jaremko, M., Emwas, A.-H. M., Okda, T. M., El-Readi, M. Z., et al. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108943 · Cited by 4

Carrier-free prodrug nanoparticles based on lonidamine and cisplatin for synergistic treatment of breast cancer

Lü, Y., Li, J., Guan, Z., Zhang, J., Wang, X., & Tang, R. (2022) · Journal of Biomaterials Applications · doi:10.1177/08853282221107951 · Cited by 3

Targeting glycolytic enzymes to combat cancer metastasis: Strategies toward clinical translation

Zhang, D., He, Y., & He, Y. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117499 · Cited by 2

A targeted pyroptosis nanoamplifier for boosting αPD-1 neoadjuvant immunotherapy in colorectal cancer

Zhou, Y., Zhang, Z., Deng, W., Huang, J., Liu, W., Jin, C., Zhang, J., Chen, W., & Xu, C. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.173030 · Cited by 2

Lactate targeting: Regulatory networks and therapeutic potential in bone diseases

Zhang, X., Yan, X., Gao, W., Ma, J., Wu, Z., An, N., Qiu, L., & 郭佳杰 (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116376 · Cited by 2

Development of Potent ERα Inhibitors: Effectively Inhibit the Growth of Breast Cancer Cells

Yao, W., Wang, P., Yang, H., Pu, X., & Yang, J. (2022) · ChemistrySelect · doi:10.1002/slct.202201451 · Cited by 2

Ketogenic Diet Therapy for Glioma: Combined Effects

Qin, H., Zhang, F., & Gao, S. (2023) · Current Cancer Therapy Reviews · doi:10.2174/1573394719666230717160843 · Cited by 2

Targeting HK2 in Anticancer Therapy

Walczak, K. (2024) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2024.56.008847 · Cited by 1

Targeting Metabolic Reprogramming: A New Frontier in Cancer Therapy

Thakur, R. K., & Kumari, N. (2025) · Springer eBooks · doi:10.1007/978-981-96-7336-0_9 · Cited by 1

Deciphering enemy tactics – the narrow path to an optimal anti-cancer strategy targeting the Warburg effect

Kocemba‐Pilarczyk, K. A., Ostrowska, B., Trojan, S., & Dudzik, P. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00768-9 · Cited by 2

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Wu, X., Geng, S., & Yang, J. Y. (2025) · Advanced NanoBiomed Research · doi:10.1002/anbr.202500105 · Cited by 3

The Interventional Effects and Mechanisms of Lonidamine in Combination with Apigenin on Colorectal Cancer

Zhou, Y., Shi, J., Zhang, M., Yang, H., & Fei, J. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47100825 · Cited by 1

In vitro and in vivo potentiation by lonidamine of the antitumor effect of adriamycin.

Zupi, G., Greco, C., Laudonio, N., Benassi, M., Silvestrini, B., & Caputo, A. (1986) · PubMed · Cited by 48

Mechanism of antineoplastic activity of lonidamine

Nath, K., Guo, L., Nancolas, B., NELSON, D. S., Shestov, A. A., Lee, S., Roman, J., Zhou, R., Leeper, D. B., Halestrap, A. P., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.08.001 · Cited by 219

Potentiation of Antiproliferative Drug Activity by Lonidamine in Hepatocellular Carcinoma Cells

Ricotti, L., Tesei, A., Paola, F. D., Milandri, C., Amadori, D., Frassineti, G. L., Ulivi, P., & Zoli, W. (2003) · Journal of Chemotherapy · doi:10.1179/joc.2003.15.5.480 · Cited by 11

In vitro effect of lonidamine on the cytotoxicity of mitomycin C and BCNU in human colon adenocarcinoma cells

Villa, R., Zaffaroni, N., Orlandi, L., Bearzatto, A., da Costa, A. L. T., & Silvestrini, R. (1994) · European Journal of Cancer · doi:10.1016/0959-8049(94)e0162-w · Cited by 13

Lonidamine, a New Approach to Cancer Therapy

Caputo, A., & Silvestrini, B. (2009) · Oncology · doi:10.1159/000225878 · Cited by 27