Lipid metabolism as a targetable metabolic vulnerability in colorectal cancer
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Colorectal cancer (CRC), the second leading cause of cancer-related deaths according to the World Health Organization, remains a substantial public health problem worldwide [...]
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Fatty acids acquired by cancer cells are rapidly incorporated into cellular triglycerides and stored in lipid droplets.
“FAs that are acquired by cancer cells are rapidly incorporated into cellular triglycerides (TGs) and stored in lipid droplets [26].”
From Inhibition of fatty acid synthase enhances therapeutic efficacy and delays acquired resistance to BRAF-targeted therapy in colorectal cancer (2026) · cites this paper as [26]
Dysregulation of lipid metabolic pathways, including de novo lipid synthesis and fatty acid oxidation, has been observed in colorectal cancer.
“Dysregulation of lipid metabolic pathways, including de novo lipid synthesis and fatty acid oxidation (FAO), have been observed in CRC [26].”
From Inhibition of fatty acid synthase enhances therapeutic efficacy and delays acquired resistance to BRAF-targeted therapy in colorectal cancer (2026) · cites this paper as [26]
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- Authors
- Zaytseva, Y.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Zaytseva, Yekaterina
- ORCID
- Zaytseva, Yekaterina
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2021-01-15
- Volume
- 13
- Issue
- 2
- Pages
- 301
- ISSN
- 2072-6694 (ISSN-L)
- PMC
- PMC7830794
- OpenAlex
- W3119173064
- Cited by
- 53
- References
- 56
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 11 · 2023: 11 · 2022: 9 · 2021: 9
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cancers (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UKnowledge (University of Kentucky) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Cancer Institute (R01CA208343, R01CA249734)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- colorectal cancer, lipid metabolism, metabolic vulnerability, therapeutic target, cancer metabolism
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