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Cited by 622Cancer Risks and FactorsColorectal Cancer Screening and DetectionObesity, Physical Activity, Diet

Obesity and Risk of Colorectal Cancer: A Systematic Review of Prospective Studies

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Ma, Yanlei, Yang, Yongzhi, Wang, Feng, Zhang, Peng, Shi, Chenzhang, Zou, Yang, Qin, Huanlong·2013·PLoS ONE
DOI 10.1371/journal.pone.0053916PMC PMC3547959
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Abstract

BACKGROUND: Mounting evidence indicates that obesity may be associated with the risk of colorectal cancer (CRC). To conduct a systematic review of prospective studies assessing the association of obesity with the risk of CRC using meta-analysis. METHODOLOGY/PRINCIPAL FINDINGS: Relevant studies were identified by a search of MEDLINE and EMBASE databases before January 2012, with no restrictions. We also reviewed reference lists from retrieved articles. We included prospective studies that reported relative risk (RR) estimates with 95% confidence intervals (CIs) for the association between general obesity [measured using body mass index (BMI)] or central obesity [measured using waist circumference (WC)] and the risk of colorectal, colon, or rectal cancer. Approximately 9, 000, 000 participants from several countries were included in this analysis. 41 studies on general obesity and 13 studies on central obesity were included in the meta-analysis. The pooled RRs of CRC for the obese vs. normal category of BMI were 1.334 (95% CI, 1.253-1.420), and the highest vs. lowest category of WC were 1.455 (95% CI, 1.327-1.596). There was heterogeneity among studies of BMI (P<0.001) but not among studies of WC (P=0.323). CONCLUSIONS: Both of general and central obesity were positively associated with the risk of CRC in this meta-analysis.

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Cited by

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Authors
Ma, Y., Yang, Y., Wang, F., Zhang, P., Shi, C., Zou, Y., & Qin, H.
Affiliations
  • Tongji University (CN)
  • Shanghai Jiao Tong University (CN)
Corresponding author
  • Ma, Yanlei
  • Qin, Huanlong
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-01-17
Volume
8
Issue
1
Pages
e53916
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0053916
PMC
PMC3547959
OpenAlex
W1990436525
Cited by
622
References
5
Citations by year
2026: 25 · 2025: 35 · 2024: 45 · 2023: 55 · 2022: 68 · 2021: 55 · 2020: 64 · 2019: 62 · 2018: 49 · 2017: 37 · 2016: 35 · 2015: 34 · 2014: 37 · 2013: 20
FWCI
4.44
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
Funders
  • Shanghai Science and Technology Development Foundation (12140902300, 12410707400)
  • National Natural Science Foundation of China (81001069)
  • Shanghai Rising-Star Program (11QA1404800)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
obesity, colorectal cancer, body mass index, waist circumference, abdominal obesity, colon cancer, rectal cancer, cancer risk factors
MeSH terms
Humans, Obesity, Prospective Studies, Risk Factors, Colorectal Neoplasms, Body Mass Index, Risk Assessment, Waist Circumference

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