The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Cell Death Pathways in Photodynamic Therapy of Cancer
Open accessAbstract
Photodynamic therapy (PDT) is an emerging cancer therapy that uses the combination of non-toxic dyes or photosensitizers (PS) and harmless visible light to produce reactive oxygen species and destroy tumors. The PS can be localized in various organelles such as mitochondria, lysosomes, endoplasmic reticulum, Golgi apparatus and plasma membranes and this sub-cellular location governs much of the signaling that occurs after PDT. There is an acute stress response that leads to changes in calcium and lipid metabolism and causes the production of cytokines and stress response mediators. Enzymes (particularly protein kinases) are activated and transcription factors are expressed. Many of the cellular responses center on mitochondria and frequently lead to induction of apoptosis by the mitochondrial pathway involving caspase activation and release of cytochrome c. Certain specific proteins (such as Bcl-2) are damaged by PDT-induced oxidation thereby increasing apoptosis, and a build-up of oxidized proteins leads to an ER-stress response that may be increased by proteasome inhibition. Autophagy plays a role in either inhibiting or enhancing cell death after PDT.
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Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Photodynamic Efficiency: From Molecular Photochemistry to Cell Death
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Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials
Hong, E. J., Choi, D. G., & Shim, M. S. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.01.007 · Cited by 361
He, L., Li, Y., Tan, C.-P., Ye, R.-R., Chen, M.-H., Cao, J.-J., Ji, L.-N., & Mao, Z.-W. (2015) · Chemical Science · doi:10.1039/c5sc01955a · Cited by 358
Upconversion-based photodynamic cancer therapy
Liu, Y., Meng, X., & Bu, W. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.09.006 · Cited by 319
Metadata
- Authors
- Mroz, P., Yaroslavsky, A., Kharkwal, G. B., & Hamblin, M. R.
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2011-06-03
- Volume
- 3
- Issue
- 2
- Pages
- 2516-2539
- ISSN
- 2072-6694 (ISSN-L)
- OpenAlex
- W2135025266
- Cited by
- 704
- References
- 10
- FWCI
- 14.85
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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