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Cited by 332

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Epstein-Barr Virus in Gastric Carcinoma

Open access
Nishikawa, Jun, Yoshiyama, Hironori, Iizasa, Hisashi, Kanehiro, Yuichi, Nakamura, Munetaka, Nishimura, Junichi, Saito, Mari, Okamoto, Takeshi, Sakai, Kouhei, Suehiro, Yutaka, Yamasaki, Takahiro, Oga, Atsunori, Yanai, Hideo, Sakaida, Isao·2014·Cancers
DOI 10.3390/cancers6042259
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Abstract

The Epstein-Barr virus (EBV) is detected in about 10% of gastric carcinoma cases throughout the world. In EBV-associated gastric carcinoma, all tumor cells harbor the clonal EBV genome. Gastric carcinoma associated with EBV has distinct clinicopathological features, occurs predominately in men and in younger-aged individuals, and presents a generally diffuse histological type. Most cases of EBV-associated gastric carcinoma exhibit a histology rich in lymphocyte infiltration. The immunological reactiveness in the host may represent a relatively preferable prognosis in EBV-positive cases. This fact highlights the important role of EBV in the development of EBV-associated gastric carcinoma. We have clearly proved direct infection of human gastric epithelialcells by EBV. The infection was achieved by using a recombinant EBV. Promotion of growth by EBV infection was observed in the cells. Considerable data suggest that EBV may directly contribute to the development of EBV-associated GC. This tumor-promoting effect seems to involve multiple mechanisms, because EBV affects several host proteins and pathways that normally promote apoptosis and regulate cell proliferation.

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Crossref · 10.3390/cancers6042259

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Metadata

Authors
Nishikawa, J., Yoshiyama, H., Iizasa, H., Kanehiro, Y., Nakamura, M., Nishimura, J., Saito, M., Okamoto, T., Sakai, K., Suehiro, Y., Yamasaki, T., Oga, A., Yanai, H., & Sakaida, I.
Venue
Cancers
Publisher
MDPI AG
Published
2014-11-07
Volume
6
Issue
4
Pages
2259-2274
ISSN
2072-6694 (ISSN-L)
DOI
10.3390/cancers6042259
OpenAlex
W1999596535
Cited by
332
References
57
FWCI
8.62
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Epstein-Barr Virus in Gastric Carcinoma. https://app.cochat.ai/papers/10.3390/cancers6042259
The paper
Nishikawa, J., Yoshiyama, H., Iizasa, H., Kanehiro, Y., Nakamura, M., Nishimura, J., Saito, M., Okamoto, T., Sakai, K., Suehiro, Y., Yamasaki, T., Oga, A., Yanai, H., & Sakaida, I. (2014). Epstein-Barr Virus in Gastric Carcinoma. Cancers. https://doi.org/10.3390/cancers6042259

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.