The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Voltage-Gated Ion Channels in Cancer Cell Proliferation
Open accessAbstract
Changes of the electrical charges across the surface cell membrane are absolutely necessary to maintain cellular homeostasis in physiological as well as in pathological conditions. The opening of ion channels alter the charge distribution across the surface membrane as they allow the diffusion of ions such as K+, Ca++, Cl−, Na+. Traditionally, voltage-gated ion channels (VGIC) are known to play fundamental roles in controlling rapid bioelectrical signaling including action potential and/or contraction. However, several investigations have revealed that these classes of proteins can also contribute significantly to cell mitotic biochemical signaling, cell cycle progression, as well as cell volume regulation. All these functions are critically important for cancer cell proliferation. Interestingly, a variety of distinct VGICs are expressed in different cancer cell types, including metastasis but not in the tissues from which these tumors were generated. Given the increasing evidence suggesting that VGIC play a major role in cancer cell biology, in this review we discuss the role of distinct VGIC in cancer cell proliferation and possible therapeutic potential of VIGC pharmacological manipulation.
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Citations
Cites
Overview of the voltage-gated sodium channel family
Yu (2003) · Genome biology · doi:10.1186/gb-2003-4-3-207 · Cited by 694
Membrane potential and cancer progression
Yang, M., & Brackenbury, W. J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00185 · Cited by 614
Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast Cancer Metastasis
Fraser, S. P., Diss, J. K. J., Chioni, A.-M., Mycielska, M. E., Pan, H., Yamaci, R. F., Pani, F., Siwy, Z., Krasowska, M., Grzywna, Z., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0327 · Cited by 481
Bioelectric controls of cell proliferation: Ion channels, membrane voltage and the cell cycle
Blackiston, D. J., McLaughlin, K. A., & Levin, M. (2009) · Cell Cycle · doi:10.4161/cc.8.21.9888 · Cited by 468
Potassium Channels, Proliferation and G1 Progression
Wonderlin, W. F., & Strobl, J. S. (1996) · Journal of Membrane Biology · doi:10.1007/s002329900135 · Cited by 402
Generation of resting membrane potential
Wright, S. H. (2004) · Advances in Physiology Education · doi:10.1152/advan.00029.2004 · Cited by 300 · cited 1×
“The cells are said to be depolarized (Figure 1) when the Vm is altered to relatively less negative state, whereas the cells are said to be hyperpolarized, when the membrane potential is moved to more negative values than the resting membrane potential [15].”
BackgroundAn Unexpected Role for Ion Channels in Brain Tumor Metastasis
Sontheimer, H. (2008) · Experimental Biology and Medicine · doi:10.3181/0711-mr-308 · Cited by 231
Induction of Mitosis in Mature Neurons in Central Nervous System by Sustained Depolarization
Cone, C. D., & Cone, C. M. (1976) · Science · doi:10.1126/science.56781 · Cited by 208
Brackenbury, W. J., Chioni, A.-M., Diss, J. K. J., & Djamgoz, M. B. A. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9281-1 · Cited by 175
Cone, C. D. (1969) · Transactions of the New York Academy of Sciences · doi:10.1111/j.2164-0947.1969.tb02926.x · Cited by 95
Cited by
Emerging Roles of the Membrane Potential: Action Beyond the Action Potential
Abdul Kadir, L., Stacey, M., & Barrett-Jolley, R. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01661 · Cited by 264
Burke, R. C., Bardet, S. M., Carr, L., Romanenko, S., Arnaud-Cormos, D., Leveque, P., & O'Connor, R. P. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.07.004 · Cited by 58
Levin, M. (2025) · BioEssays · doi:10.1002/bies.202400196 · Cited by 34
Duranti, C., Iorio, J., Manganelli, V., Bagni, G., Colasurdo, R., Lottini, T., Martinelli, M., Capitani, C., Boso, G., D’Alessandro, F. N., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02321-2 · Cited by 8
“The functional interaction between ion channels and the lipid component of the plasma membrane may offer a novel perspective in the comprehension of the pathophysiology of cancer [32, 33], where ion channel de-regulation represents one of the hallmarks [34].”
Metadata
- Authors
- Rao, V., Perez-Neut, M., Kaja, S., & Gentile, S.
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2015-05-22
- Volume
- 7
- Issue
- 2
- Pages
- 849-875
- ISSN
- 2072-6694 (ISSN-L)
- OpenAlex
- W1881061730
- Cited by
- 229
- References
- 10
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- gold
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- Rao, V., Perez-Neut, M., Kaja, S., & Gentile, S. (2015). Voltage-Gated Ion Channels in Cancer Cell Proliferation. Cancers. https://doi.org/10.3390/cancers7020813
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
