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In vitro selection of RNA molecules that bind specific ligands

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Aptamers as targeted therapeutics: current potential and challenges

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Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

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Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

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Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo

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Aptamers evolved from live cells as effective molecular probes for cancer study

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Emerging landscape of oncogenic signatures across human cancers

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Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

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Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras

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Nanoparticle-Aptamer Bioconjugates

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Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

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2′-Fluoropyrimidine RNA-based Aptamers to the 165-Amino Acid Form of Vascular Endothelial Growth Factor (VEGF165)

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Synthetic genetic polymers capable of heredity and evolution

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Antibody against poly(ethylene glycol) adversely affects PEG-asparaginase therapy in acute lymphoblastic leukemia patients

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Aptamers as Therapeutics

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Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy

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Recent advances in biosensor development for the detection of cancer biomarkers

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A tenascin-C aptamer identified by tumor cell SELEX: Systematic evolution of ligands by exponential enrichment

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Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen.

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Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy

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Selection of DNA Aptamers against Epithelial Cell Adhesion Molecule for Cancer Cell Imaging and Circulating Tumor Cell Capture

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RNA aptamers as reversible antagonists of coagulation factor IXa

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The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells

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Discovery and development of anticancer aptamers

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A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma

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DNA Aptamers That Bind to MUC1 Tumour Marker: Design and Characterization of MUC1-Binding Single-Stranded DNA Aptamers

Ferreira, C. S. M., Matthews, C. S., & Missailidis, S. (2006) · Tumor Biology · doi:10.1159/000096085 · Cited by 411

Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase

Ganson, N. J., Kelly, S. J., Scarlett, E., Sundy, J. S., & Hershfield, M. S. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1861 · Cited by 350

G-quadruplex oligonucleotide AS1411 as a cancer-targeting agent: Uses and mechanisms

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Direct In Vitro Selection of a 2′-O-Methyl Aptamer to VEGF

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Aptamer Selection Technology and Recent Advances

Blind, M., & Blank, M. (2015) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2014.74 · Cited by 325

A Highlight of Recent Advances in Aptamer Technology and Its Application

Sun, H., & Zu, Y. (2015) · Molecules · doi:10.3390/molecules200711959 · Cited by 317

Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells

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Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice

McNamara, J. O., Kolonias, D. S., Pastor, F., Mittler, R. S., Chen, L., Giangrande, P. H., Sullenger, B. A., & Gilboa, E. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33365 · Cited by 311

Pharmacokinetics and Biodistribution of Novel Aptamer Compositions

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SELEX with modified nucleotides

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Antibodies against Polyethylene Glycol Produced in Animals by Immunization with Monomethoxy Polyethylene Glycol Modified Proteins

Richter, A. W., & Akerblom, E. B. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000233309 · Cited by 282

RNA-binding protein nucleolin in disease

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Biomarker detection technologies and future directions

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Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer

Ganson, N. J., Povsic, T. J., Sullenger, B. A., Alexander, J. H., Zelenkofske, S. L., Sailstad, J. M., Rusconi, C. P., & Hershfield, M. S. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.10.034 · Cited by 275

In vivo selection of tumor-targeting RNA motifs

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Aptamer Directly Evolved from Live Cells Recognizes Membrane Bound Immunoglobin Heavy Mu Chain in Burkitt's Lymphoma Cells

Mallikaratchy, P. R., Tang, Z., Sefah, K., Meng, L. H., Shangguan, D., & Tan, W. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700026-mcp200 · Cited by 267

Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients

Hershfield, M. S., Ganson, N. J., Kelly, S. J., Scarlett, E., Jaggers, D. A., & Sundy, J. S. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4500 · Cited by 265

Development of an aptasensor for electrochemical detection of exosomes

Zhou, Q., Rahimian, A., Son, K., Shin, D., Patel, T. C., & Revzin, A. (2015) · Methods · doi:10.1016/j.ymeth.2015.10.012 · Cited by 264

Aptamer Nanomedicine for Cancer Therapeutics: Barriers and Potential for Translation

Lao, Y., Phua, K. K. L., & Leong, K. W. (2015) · ACS Nano · doi:10.1021/nn507494p · Cited by 261

Aptamers: Active Targeting Ligands for Cancer Diagnosis and Therapy

Wu, X., Chen, J., Wu, M., & Zhao, J. X. (2015) · Theranostics · doi:10.7150/thno.10257 · Cited by 260

Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer® therapeutics

Vater, A., & Klußmann, S. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.09.004 · Cited by 251

Nucleic Acid Aptamers: An Emerging Tool for Biotechnology and Biomedical Sensing

Ku, T., Zhang, T., Luo, H., Yen, T., Chen, P., Han, Y., & Lo, Y. (2015) · Sensors · doi:10.3390/s150716281 · Cited by 250

Molecular Recognition of Small‐Cell Lung Cancer Cells Using Aptamers

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Cell‐Specific Internalization Study of an Aptamer from Whole Cell Selection

Xiao, Z., Shangguan, D., Cao, Z. C., Fang, X., & Tan, W. (2007) · Chemistry - A European Journal · doi:10.1002/chem.200701330 · Cited by 246

Plasma Membrane Nucleolin Is a Receptor for the Anticancer Aptamer AS1411 in MV4-11 Leukemia Cells

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The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization

Hoellenriegel, J., Zboralski, D., Maasch, C., Rosin, N. Y., Wierda, W. G., Keating, M. J., Kruschinski, A., & Burger, J. A. (2013) · Blood · doi:10.1182/blood-2013-03-493924 · Cited by 241

RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule

Shigdar, S. L., Lin, J., Yu, Y., Pastuovic, M., Wei, M. Q., & Duan, W. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.01897.x · Cited by 240

Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures

Mayer, G., Ahmed, M.-S. L., Dolf, A., Endl, E., Knolle, P. A., & Famulok, M. (2010) · Nature Protocols · doi:10.1038/nprot.2010.163 · Cited by 229

Aptamer–Drug Conjugates

Zhu, G., Niu, G., & Chen, X. S. (2015) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5b00291 · Cited by 227

Molecular recognition of acute myeloid leukemia using aptamers

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Nucleic Acid Aptamer-Guided Cancer Therapeutics and Diagnostics: the Next Generation of Cancer Medicine

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In vivo SELEX for Identification of Brain-penetrating Aptamers

Cheng, C., Chen, Y. H., Lennox, K. A., Behlke, M. A., & Davidson, B. L. (2013) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2012.59 · Cited by 215

Superior Performance of Aptamer in Tumor Penetration over Antibody: Implication of Aptamer-Based Theranostics in Solid Tumors

Xiang, D., Zheng, C., Zhou, S., Qiao, S., Tran, P. H. L., Pu, C., Li, Y., Kong, L., Kouzani, A. Z., Lin, J., et al. (2015) · Theranostics · doi:10.7150/thno.11711 · Cited by 215

Inhibition of Cell Proliferation by an Anti-EGFR Aptamer

Li, N., Nguyen, H. H., Byrom, M., & Ellington, A. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020299 · Cited by 206

Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers

Thiel, K. W., Hernandez, L. I., Dassie, J. P., Thiel, W. H., Liu, X., Stockdale, K. R., Rothman, A. M., Hernández, F. J., McNamara, J. O., & Giangrande, P. H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks294 · Cited by 202

Aptamer-Facilitated Biomarker Discovery (AptaBiD)

Berezovski, M. V., Lechmann, M., Musheev, M. U., Mak, T. W., & Krylov, S. N. (2008) · Journal of the American Chemical Society · doi:10.1021/ja801951p · Cited by 198

Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer

Povsic, T. J., Lawrence, M. G., Lincoff, A. M., Mehran, R., Rusconi, C. P., Zelenkofske, S. L., Huang, Z., Sailstad, J. M., Armstrong, P. W., Steg, P. G., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.04.058 · Cited by 198

Novel HER2 Aptamer Selectively Delivers Cytotoxic Drug to HER2-positive Breast Cancer Cells in Vitro

Liu, Z., Duan, J., Song, Y., Ma, J., Wang, F., Lu, X., & Yang, X. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-148 · Cited by 194

Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3

Chen, C. B., Chernis, G. A., Hoang, V. Q., & Landgraf, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332660100 · Cited by 190

Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity.

Santulli-Marotto, S., Nair, S. K., Rusconi, C. P., Sullenger, B. A., & Gilboa, E. (2003) · PubMed · Cited by 188

Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer

Dollins, C. M., Nair, S. K., Boczkowski, D., Lee, J., Layzer, J. M., Gilboa, E., & Sullenger, B. A. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.05.016 · Cited by 183

A Neutralizing RNA Aptamer against EGFR Causes Selective Apoptotic Cell Death

Esposito, C. L., Passaro, D., Longobardo, I., Condorelli, G., Marotta, P., Affuso, A., de Franciscis, V., & Cerchia, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024071 · Cited by 182

RNA aptamers targeting cancer stem cell marker CD133

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Liposome-Anchored Vascular Endothelial Growth Factor Aptamers

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Spiegelmers: Biostable Aptamers

Eulberg, D., & Klußmann, S. (2003) · ChemBioChem · doi:10.1002/cbic.200300663 · Cited by 182

Applications of Aptasensors in Clinical Diagnostics

Hong, P., Li, W., & Li, J. (2012) · Sensors · doi:10.3390/s120201181 · Cited by 179

Recognition of subtype non-small cell lung cancer by DNA aptamers selected from living cells

Zhao, Z., Xu, L., Shi, X., Tan, W., Fang, X., & Shangguan, D. (2009) · The Analyst · doi:10.1039/b904476k · Cited by 178

Enrichment of Cell‐Targeting and Population‐Specific Aptamers by Fluorescence‐Activated Cell Sorting

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Aptamer-Mediated Blockade of IL4Rα Triggers Apoptosis of MDSCs and Limits Tumor Progression

Roth, F., Fuente, A. C. D. L., Vella, J. L., Zoso, A., Inverardi, L., & Serafini, P. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2772 · Cited by 173

Aptamer to ErbB-2/HER2 enhances degradation of the target and inhibits tumorigenic growth

Mahlknecht, G., Maron, R., Mancini, M., Schechter, B., Sela, M., & Yarden, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302594110 · Cited by 169

Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2

White, R. R., Shan, S., Rusconi, C. P., Shetty, G. A., Dewhirst, M. W., Kontos, C. D., & Sullenger, B. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831159100 · Cited by 169

DNA aptamers against the MUC1 tumour marker: design of aptamer–antibody sandwich ELISA for the early diagnosis of epithelial tumours

Ferreira, C. S. M., Papamichael, K., Guilbault, G. G., Schwarzacher, T., Gariépy, J., & Missailidis, S. (2007) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-007-1470-1 · Cited by 167

Inhibition of DNA Replication and Induction of S Phase Cell Cycle Arrest by G-rich Oligonucleotides

Xu, X., Hamhouyia, F., Thomas, S. D., Burke, T. J., Girvan, A. C., McGregor, W. G., Trent, J. O., Miller, D. M., & Bates, P. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104446200 · Cited by 167

Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial

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Bi-specific Aptamers Mediating Tumor Cell Lysis

Boltz, A., Piater, B., Toleikis, L., Guenther, R., Kolmar, H., & Hock, B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.238261 · Cited by 166

The structural diversity of artificial genetic polymers

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Identification of an aptamer targeting hnRNP A1 by tissue slide‐based SELEX

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Efficient synthesis of nucleic acids heavily modified with non- canonical ribose 2'-groups using a mutantT7 RNA polymerase (RNAP)

Padilla, R. M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.6.1561 · Cited by 154

Targeting Axl With an High-affinity Inhibitory Aptamer

Cerchia, L., Esposito, C. L., Camorani, S., Rienzo, A., Stasio, L., Insabato, L., Affuso, A., & de Franciscis, V. (2012) · Molecular Therapy · doi:10.1038/mt.2012.163 · Cited by 153

Tumor Receptor Imaging

Mankoff, D. A., Link, J. M., Linden, H. M., Sundararajan, L., & Krohn, K. A. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.045963 · Cited by 152

RNA aptamer-conjugated liposome as an efficient anticancer drug delivery vehicle targeting cancer cells in vivo

Baek, S. E., Lee, K. H., Park, Y. S., Oh, D., Oh, S., Kim, K., & Kim, D. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.10.018 · Cited by 148

Liposome-Anchored Vascular Endothelial Growth Factor Aptamers

Willis, M. C., Collins, B. T., Zhang, T., Green, L. S., Sebesta, D. P., Bell, C. J., Kellogg, E. A., Gill, S. C., Magallanez, A., Knauer, S., et al. (1998) · Bioconjugate Chemistry · doi:10.1021/bc980200o · Cited by 146

Aptamers: A promising chemical antibody for cancer therapy

Zhou, G., Wilson, G., Hebbard, L., Duan, W., Liddle, C., George, J., & Qiao, L. (2016) · Oncotarget · doi:10.18632/oncotarget.7178 · Cited by 143

Current Progress of RNA Aptamer-Based Therapeutics

Zhou, J., Bobbin, M. L., Burnett, J., & Rossi, J. J. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00234 · Cited by 140

Inhibition of Receptor Signaling and of Glioblastoma-derived Tumor Growth by a Novel PDGFRβ Aptamer

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An RNA Alternative to Human Transferrin: A New Tool for Targeting Human Cells

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Towards XNA nanotechnology: new materials from synthetic genetic polymers

Pinheiro, V. B., & Holliger, P. (2014) · Trends in biotechnology · doi:10.1016/j.tibtech.2014.03.010 · Cited by 134

Aptamer Functionalization of Nanosystems for Glioblastoma Targeting through the Blood–Brain Barrier

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Upgrading SELEX Technology by Using Lambda Exonuclease Digestion for Single-Stranded DNA Generation

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DNA Aptamer Selected against Pancreatic Ductal Adenocarcinoma for in vivo Imaging and Clinical Tissue Recognition

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DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice.

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Aptamer-Mediated Targeted Delivery of Therapeutics: An Update

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Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation

Shigdar, S. L., MacDonald, J. P., O'Connor, M., Wang, T., Xiang, D., Shamaileh, H. A., Qiao, L., Wei, M. Q., Zhou, S., Zhu, Y., et al. (2013) · Sensors · doi:10.3390/s131013624 · Cited by 128

Selection of RNA aptamers against recombinant transforming growth factor-β type III receptor displayed on cell surface

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CD28 Aptamers as Powerful Immune Response Modulators

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Directed evolution of gold nanoparticle delivery to cells

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Targeted chemoimmunotherapy using drug-loaded aptamer–dendrimer bioconjugates

Lee, I., An, S., Yu, M. K., Kwon, H., Im, S., & Jon, S. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.05.025 · Cited by 126

Nucleic acid aptamers targeting cell-surface proteins

Dua, P., Kim, S., & Lee, D.-K. (2011) · Methods · doi:10.1016/j.ymeth.2011.02.002 · Cited by 122

Development of Cell-SELEX Technology and Its Application in Cancer Diagnosis and Therapy

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Aptamers: versatile molecular recognition probes for cancer detection

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Rapid Identification of Cell-Specific, Internalizing RNA Aptamers with Bioinformatics Analyses of a Cell-Based Aptamer Selection

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Aptamers in Therapeutics

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Calcium-dependent oligonucleotide antagonists specific for L-selectin.

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DNA Aptamers as Molecular Probes for Colorectal Cancer Study

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A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial

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The joys of in vitro selection: chemically dressing oligonucleotides to satiate protein targets

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Combinatorial Selection of DNA Thioaptamers Targeted to the HA Binding Domain of Human CD44

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Aptamers Selected to Postoperative Lung Adenocarcinoma Detect Circulating Tumor Cells in Human Blood

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Aptamer base: a collaborative knowledge base to describe aptamers and SELEX experiments

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Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats

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A Novel Aptamer Developed for Breast Cancer Cell Internalization

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Selection of DNA aptamers recognizing small cell lung cancer using living cell-SELEX

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Selection of DNA aptamers against epidermal growth factor receptor with high affinity and specificity

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Aptamers selected against the unglycosylated EGFRvIII ectodomain and delivered intracellularly reduce membrane-bound EGFRvIII and induce apoptosis

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Aptamer-mediated impairment of EGFR-integrin αvβ3 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers

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Alkaline Phosphatase ALPPL-2 Is a Novel Pancreatic Carcinoma-Associated Protein

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In Vitro Selection of RNA Aptamer and Specific Targeting of ErbB2 in Breast Cancer Cells

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Electrochemical, Electrochemiluminescence, and Photoelectrochemical Aptamer-Based Nanostructured Sensors for Biomarker Analysis

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Tumor‐targeted nanotherapeutics: overcoming treatment barriers for glioblastoma

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Hematopoietic Stem and Progenitor Cell Mobilization in Mice and Humans by a First-in-Class Mirror-Image Oligonucleotide Inhibitor of CXCL12

Vater, A., Sahlmann, J., Kröger, N., Zöllner, S. K., Lioznov, M. V., Maasch, C., Buchner, K., Vossmeyer, D., Schwoebel, F., Purschke, W. G., et al. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2013.58 · Cited by 84

Progress in Aptamer-Mediated Drug Delivery Vehicles for Cancer Targeting and Its Implications in Addressing Chemotherapeutic Challenges

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Immunotherapy of CD30-expressing lymphoma using a highly stable ssDNA aptamer

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PEGylated Anti‐MUC1 Aptamer‐Doxorubicin Complex for Targeted Drug Delivery to MCF7 Breast Cancer Cells

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Olaptesed pegol, an anti-CXCL12/SDF-1 Spiegelmer, alone and with bortezomib–dexamethasone in relapsed/refractory multiple myeloma: a Phase IIa Study

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Evolution of Complex Target SELEX to Identify Aptamers against Mammalian Cell-Surface Antigens

Mallikaratchy, P. R. (2017) · Molecules · doi:10.3390/molecules22020215 · Cited by 80

Cell-SELEX Aptamer for Highly Specific Radionuclide Molecular Imaging of Glioblastoma In Vivo

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Combinatorial Screening of DNA Aptamers for Molecular Imaging of HER2 in Cancer

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Streptavidin-Coated Magnetic Beads for DNA Strand Separation Implicate a Multitude of Problems During Cell-SELEX

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In Vitro Selection of Modified RNA Aptamers Against CD44 Cancer Stem Cell Marker

Ababneh, N. A., Alshaer, W., Al‐Louzi, O., Mahafzah, A. M., El-Khateeb, M. S., Hillaireau, H., Noiray, M., Fattal, E., & Ismail, S. I. (2013) · Nucleic Acid Therapeutics · doi:10.1089/nat.2013.0423 · Cited by 76

Nucleic Acid Aptamer‐Mediated Drug Delivery for Targeted Cancer Therapy

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Aptamer-Mediated Delivery of Chemotherapy to Pancreatic Cancer Cells

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Dual functional BAFF receptor aptamers inhibit ligand-induced proliferation and deliver siRNAs to NHL cells

Zhou, J., Tiemann, K., Chomchan, P., Alluin, J. V., Swiderski, P. M., Burnett, J., Zhang, X., Forman, S. J., Chen, R., & Rossi, J. J. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt125 · Cited by 75

Boron-containing aptamers to ATP

Lato, S. M. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.6.1401 · Cited by 75

Targeted inhibition of αvβ3 integrin with an RNA aptamer impairs endothelial cell growth and survival

Mi, J., Zhang, X., Giangrande, P. H., McNamara, J. O., Nimjee, S. M., Sarraf‐Yazdi, S., Sullenger, B. A., & Clary, B. M. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.043 · Cited by 74

RNA aptamers selected against the receptor activator of NF- B acquire general affinity to proteins of the tumor necrosis factor receptor family

Mori, T. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh949 · Cited by 74

Applications of Aptamers in Targeted Imaging: State of the Art

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3D Cell-SELEX: Development of RNA aptamers as molecular probes for PC-3 tumor cell line

de Souza, A. G., Marangoni, K., Fujimura, P. T., Alves, P. T., da Silva, M. J., Bastos, V. A. F., Goulart, L. R., & Alonso‐Goulart, V. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.01.015 · Cited by 72

Using Aptamers for Cancer Biomarker Discovery

Chang, Y. M., Donovan, M. J., & Tan, W. (2013) · Journal of Nucleic Acids · doi:10.1155/2013/817350 · Cited by 69

Selection Strategy to Generate Aptamer Pairs that Bind to Distinct Sites on Protein Targets

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Comparison of Different Strategies to Select Aptamers Against a Transmembrane Protein Target

Pestourie, C., Cerchia, L., Gombert, K., Aissouni, Y., Boulay, J., de Franciscis, V., Libri, D., Tavitian, B., & Ducongè, F. (2006) · Oligonucleotides · doi:10.1089/oli.2006.16.323 · Cited by 68

Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells

Camorani, S., Crescenzi, E., Colecchia, D., Carpentieri, A., Amoresano, A., Fedele, M., Chiariello, M., & Cerchia, L. (2015) · Oncotarget · doi:10.18632/oncotarget.6066 · Cited by 68

MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells

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Identification and Characterization of an Agonistic Aptamer Against the T Cell Costimulatory Receptor, OX40

Pratico, E. D., Sullenger, B. A., & Nair, S. K. (2012) · Nucleic Acid Therapeutics · doi:10.1089/nat.2012.0388 · Cited by 67

An RNA Aptamer That Binds Carcinoembryonic Antigen Inhibits Hepatic Metastasis of Colon Cancer Cells in Mice

Lee, Y. J., Han, S. R., Kim, N. Y., Lee, S., Jeong, J., & Lee, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.03.039 · Cited by 67

In vitro selection of BNA (LNA) aptamers

Kuwahara, M., & Obika, S. (2013) · Artificial DNA PNA & XNA · doi:10.4161/adna.25786 · Cited by 67

Oligonucleotide aptamers: A next-generation technology for the capture and detection of circulating tumor cells

Dickey, D. D., & Giangrande, P. H. (2015) · Methods · doi:10.1016/j.ymeth.2015.11.020 · Cited by 66

Methods To Identify Aptamers against Cell Surface Biomarkers

Cibiel, A., Dupont, D. M., & Ducongè, F. (2011) · Pharmaceuticals · doi:10.3390/ph4091216 · Cited by 65

Aptamer Identification of Brain Tumor–Initiating Cells

Kim, Y., Wu, Q., Hamerlik, P., Hitomi, M., Sloan, A. E., Barnett, G. H., Weil, R. J., Leahy, P. S., Hjelmeland, A. B., & Rich, J. N. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4556 · Cited by 60

Biomedical Applications of DNA‐Conjugated Gold Nanoparticles

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Ligand-Guided Selection of Target-Specific Aptamers: A Screening Technology for Identifying Specific Aptamers Against Cell-Surface Proteins

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Isolation of RNA Aptamers Targeting HER-2-overexpressing Breast Cancer Cells Using Cell-SELEX

Kang, H.-S. H. (2009) · Bulletin of the Korean Chemical Society · doi:10.5012/bkcs.2009.30.8.1827 · Cited by 60

Locked nucleic acid nucleoside triphosphates and polymerases: on the way towards evolution of LNAaptamers

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Identification and characterization of oligonucleotides that inhibit Toll‐like receptor 2‐associated immune responses

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Overcoming Key Technological Challenges in Using Mass Spectrometry for Mapping Cell Surfaces in Tissues

Griffin, N. M., & Schnitzer, J. E. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r110.000935 · Cited by 58

Therapeutic aptamers: developmental potential as anticancer drugs

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DNA aptamers that target human glioblastoma multiforme cells overexpressing epidermal growth factor receptor variant III in vitro

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Modulation of the Coagulation Cascade Using Aptamers

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Cancer biomarker discovery using DNA aptamers

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Identification of DNA Aptamers toward Epithelial Cell Adhesion Molecule via Cell-SELEX

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Identification of an aptamer through whole cell-SELEX for targeting high metastatic liver cancers

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Facile Discovery of Cell-Surface Protein Targets of Cancer Cell Aptamers

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Cell‐based selection provides novel molecular probes for cancer stem cells

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Cancer immunotherapy via nucleic acid aptamers

Khedri, M., Rafatpanah, H., Abnous, K., Ramezani, P., & Ramezani, M. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.10.013 · Cited by 52

Aptamer for imaging and therapeutic targeting of brain tumor glioblastoma

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2′,4′-BNA/LNA aptamers: CE-SELEX using a DNA-based library of full-length 2′-O,4′-C-methylene-bridged/linked bicyclic ribonucleotides

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Aptamers: Molecular Tools for Medical Diagnosis

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Towards the selection of phosphorothioate aptamers

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Randomized phase II trial of the nucleolin targeting aptamer AS1411 combined with high-dose cytarabine in relapsed/refractory acute myeloid leukemia (AML)

Stuart, R. K., Stockerl-Goldstein, K. E., Cooper, M., Devetten, M. P., Herzig, R. H., Medeiros, B. C., Schiller, G. J., Wei, A. H., Acton, G. D., & Rizzieri, D. A. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.15_suppl.7019 · Cited by 50

Knocking down nucleolin expression in gliomas inhibits tumor growth and induces cell cycle arrest

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Selection of Aptamers Against Whole Living Cells: From Cell-SELEX to Identification of Biomarkers

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Pitfalls of Cell-Systematic Evolution of Ligands by Exponential Enrichment (SELEX): Existing Dead Cells During In Vitro Selection Anticipate the Enrichment of Specific Aptamers

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Aptamers Selected by Cell-SELEX for Theranostics

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From Ugly Duckling to Swan: Unexpected Identification from Cell-SELEX of an Anti-Annexin A2 Aptamer Targeting Tumors

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RNA Aptamer-Based Functional Ligands of the Neurotrophin Receptor, TrkB

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Generation of an enriched pool of DNA aptamers for an HER2‐overexpressing cell line selected by Cell SELEX

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Cell-targeting aptamers act as intracellular delivery vehicles

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