The DOI matches its Crossref record; 230 of the 233 references it cites were found in a registry or an index.
Selection of Nucleic Acid Aptamers Targeting Tumor Cell-Surface Protein Biomarkers
Open accessAbstract
Aptamers are nucleic acids referred to as chemical antibodies as they bind to their specific targets with high affinity and selectivity. They are selected via an iterative process known as ‘selective evolution of ligands by exponential enrichment’ (SELEX). Aptamers have been developed against numerous cancer targets and among them, many tumor cell-membrane protein biomarkers. The identification of aptamers targeting cell-surface proteins has mainly been performed by two different strategies: protein- and cell-based SELEX, when the targets used for selection were proteins and cells, respectively. This review aims to update the literature on aptamers targeting tumor cell surface protein biomarkers, highlighting potentials, pitfalls of protein- and cell-based selection processes and applications of such selected molecules. Aptamers as promising agents for diagnosis and therapeutic approaches in oncology are documented, as well as aptamers in clinical development.
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“Nucleic acid aptamers are single-stranded oligonucleotides (ssDNA or ssRNA), which can be folded into a unique tertiary structure to identify its target.237”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [237]
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“In addition, surface modification enables ligand, antibodies, or aptamer active targeting of specific cancer cell markers, which further improves selectivity [32].”
From Advances in green-synthesized magnetic nanoparticles for targeted cancer therapy: mechanisms, applications, and future perspectives (2026) · cites this paper as [32]
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Items 201–230 of 230
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Flagged first, then by citations
3 of the 233 references couldn’t be matched to a known paper.
Cited by
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Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073
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Perspective on the Future Role of Aptamers in Analytical Chemistry
Wu, Y., Belmonte, I., Sykes, K. S., Xiao, Y., & White, R. J. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03853 · Cited by 173
Metadata
- Authors
- Mercier, M.-C., Dontenwill, M., & Choulier, L.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Choulier, Laurence
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2017-06-21
- Volume
- 9
- Issue
- 6
- Pages
- 69
- ISSN
- 2072-6694 (ISSN-L)
- PMC
- PMC5483888
- OpenAlex
- W2721117256
- Cited by
- 113
- References
- 233
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 8 · 2023: 17 · 2022: 7 · 2021: 11 · 2020: 15 · 2019: 15 · 2018: 20 · 2017: 5
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cancers (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Agence Nationale de la Recherche (ANR-10-SATT-0001)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- aptamers, SELEX, cancer diagnosis, cancer therapeutics
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