The DOI matches its Crossref record; 237 of the 237 references it cites were found in a registry or an index.
Examples of Inverse Comorbidity between Cancer and Neurodegenerative Diseases: A Possible Role for Noncoding RNA
Open accessAbstract
Cancer is one of the most common causes of death; in parallel, the incidence and prevalence of central nervous system diseases are equally high. Among neurodegenerative diseases, Alzheimer’s dementia is the most common, while Parkinson’s disease (PD) is the second most frequent neurodegenerative disease. There is a significant amount of evidence on the complex biological connection between cancer and neurodegeneration. Noncoding RNAs (ncRNAs) are defined as transcribed nucleotides that perform a variety of regulatory functions. The mechanisms by which ncRNAs exert their functions are numerous and involve every aspect of cellular life. The same ncRNA can act in multiple ways, leading to different outcomes; in fact, a single ncRNA can participate in the pathogenesis of more than one disease—even if these seem very different, as cancer and neurodegenerative disorders are. The ncRNA activates specific pathways leading to one or the other clinical phenotype, sometimes with obvious mechanisms of inverse comorbidity. We aimed to collect from the existing literature examples of inverse comorbidity in which ncRNAs seem to play a key role. We also investigated the example of mir-519a-3p, and one of its target genes Poly (ADP-ribose) polymerase 1, for the inverse comorbidity mechanism between some cancers and PD. We believe it is very important to study the inverse comorbidity relationship between cancer and neurodegenerative diseases because it will help us to better assess these two major areas of human disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“aberrant miRNA can contribute to cancers, cardiovascular diseases, metabolic diseases, immune-mediated disorders, and neurological disorders, etc.230,231”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [231]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
Items 201–237 of 237
Pathak, G. A., Zhou, Z., Silzer, T. K., Barber, R. C., & Phillips, N. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12003 · Cited by 33
Vallée, A., Lecarpentier, Y., Vallée, R., Guillevin, R., & Vallée, J.-N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030820 · Cited by 33
Fisicaro, F., Lanza, G., Pennisi, M., Vagli, C., Cantone, M., Pennisi, G., Ferri, R., & Bella, R. (2021) · Nutrients · doi:10.3390/nu13020536 · Cited by 33
Self-citationNutrigenetics and Nutrimiromics of the Circadian System: The Time for Human Health
Micó, V., Díez-Ricote, L., & Daimiel, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030299 · Cited by 30
Parkinson disease ( PARK ) genes are somatically mutated in cutaneous melanoma
Inzelberg, R., Samuels, Y., Azizi, E., Qutob, N., Inzelberg, L., Domany, E., Schechtman, E., & Friedman, E. (2016) · Neurology Genetics · doi:10.1212/nxg.0000000000000070 · Cited by 30
Yuan, Z., Yang, Z., Li, W., Wu, A., Su, Z., & Jiang, B. (2020) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2019.3499 · Cited by 30
Mahajan, M. R., & Sitasawad, S. L. (2021) · Cells · doi:10.3390/cells11010012 · Cited by 30
Fernández‐Santiago, R., Garrido, A., Infante, J., et al. (2018) · Movement Disorders · doi:10.1002/mds.27295 · Cited by 29
Linc00221 modulates cisplatin resistance in non-small-cell lung cancer via sponging miR-519a
Tang, H., Han, X., Li, M., et al. (2019) · Biochimie · doi:10.1016/j.biochi.2019.04.019 · Cited by 28
Daily variations in the expression of miR-16 and miR-181a in human leukocytes
de Siqueira Figueredo, D., Gitaí, D. L. G., & de Andrade, T. G. (2015) · Blood Cells, Molecules, and Diseases · doi:10.1016/j.bcmd.2015.01.004 · Cited by 27
Postoperative T-tube tract choledochoscopy
Hieken, T. J., & Birkett, D. H. (1992) · The American Journal of Surgery · doi:10.1016/0002-9610(92)90248-p · Cited by 26
Xiong, L., Tang, Y., Tang, J. P., et al. (2020) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2019.3017 · Cited by 26
Frequency and profile of Parkinson's disease prodromi in patients with malignant melanoma
Walter, U., Heilmann, E., Voss, J., et al. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-310239 · Cited by 23
Telomeric Repeat Containing RNA (TERRA): Aging and Cancer
Sinha, S., Shukla, S., Khan, S. U., Farhan, M., Kamal, M. A., & Meeran, S. M. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150317230124 · Cited by 23
BMAL1 associates with chromosome ends to control rhythms in TERRA and telomeric heterochromatin
Park, J., Zhu, Q., Mirek, E. T., Na, L., Raduwan, H., Anthony, T. G., & Belden, W. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223803 · Cited by 23
Kitson, R. R. A., & Moody, C. J. (2013) · Chemical Communications · doi:10.1039/c3cc43457e · Cited by 22
Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids
Kato, N. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i11.1718 · Cited by 22
Parkinson’s Disease Is Associated With Dysregulation of Circulatory Levels of lncRNAs
Tamizkar, K. H., Gorji, P., Gholipour, M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.763323 · Cited by 22
Motor activity and Becker’s muscular dystrophy: lights and shadows
Lanza, G., Pino, M., Fisicaro, F., Vagli, C., Cantone, M., Pennisi, M., Bella, R., & Bellomo, M. (2019) · The Physician and Sportsmedicine · doi:10.1080/00913847.2019.1684810 · Cited by 21
Self-citationFisicaro, F., Lanza, G., Pennisi, M., Vagli, C., Cantone, M., Falzone, L., Pennisi, G., Ferri, R., & Bella, R. (2022) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2022.2050999 · Cited by 21
Self-citationCho, H. R., Kumari, N., Thakur, N., Vu, H. T., Kim, H., & Choi, S. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-53147-9 · Cited by 20
Additional functions of selected proteins involved in DNA repair
Koliadenko, V., & Wilanowski, T. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.10.010 · Cited by 18
Tasker, R., Rowlands, J., Ahmed, Z., & Pietro, V. D. (2021) · Cells · doi:10.3390/cells10123479 · Cited by 18
The Influence of Radical Prostatectomy on the Expression of Cell-Free MiRNA
Konoshenko, M. Y., Bryzgunova, O. E., Lekchnov, E. A., et al. (2020) · Diagnostics · doi:10.3390/diagnostics10080600 · Cited by 17
MINCR: A long non-coding RNA shared between cancer and neurodegeneration
Pandini, C., Garofalo, M., Rey, F., et al. (2021) · Genomics · doi:10.1016/j.ygeno.2021.10.008 · Cited by 17
Mansueto, G., Lanza, G., Fisicaro, F., et al. (2022) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-022-01172-z · Cited by 17
Self-citationGujrati, H., Ha, S., Mohamed, A., & Wang, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23062926 · Cited by 17
Poly (ADP-ribose) polymerase 1 and Parkinson's disease: A study in post-mortem human brain
Salemi, M., Mazzetti, S., Leonardis, M. D., Giampietro, F., Medici, V., Poloni, T. E., Cannarella, R., Giaccone, G., Pezzoli, G., Cappelletti, G., et al. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.104978 · Cited by 16
Self-citationLiu, J., Yao, Y., Hu, Z.-Y., Zhou, H., & Zhong, M. (2019) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.994 · Cited by 15
Zhang, M., Zhang, Y., Wei, X., et al. (2019) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2019.1687183 · Cited by 15
Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases
Chinnapaiyan, S., Dutta, R. K., Devadoss, D., Chand, H. S., Rahman, I., & Unwalla, H. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21083013 · Cited by 15
Ray, I., & Goswami, S. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1928157 · Cited by 12
Identification of miRNA signatures and their therapeutic potentials in prostate cancer
Karadağ, A., Özen, A., Özkurt, M., et al. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06568-7 · Cited by 12
Chang, H., Zhang, X., Li, B., & Meng, X. (2021) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2020.4394 · Cited by 10
Role and Involvement of TENM4 and miR-708 in Breast Cancer Development and Therapy
Peppino, G., Riccardo, F., Arigoni, M., Bolli, E., Barutello, G., Cavallo, F., & Quaglino, E. (2022) · Cells · doi:10.3390/cells11010172 · Cited by 10
The Importance of Negative Comorbidity
Tabarés‐Seisdedos, R., Gómez-Beneyto, M., Haro, J. M., González-Pinto, A. M., & Vieta, E. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08lr04991 · Cited by 7
Pepe, P., Vatrano, S., Cannarella, R., et al. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06723-0 · Cited by 7
Flagged first, then by citations
Research works printed but not linked: 1
- Bella, 2017, Cell chemical biology, J. Int. Med. Res., 24, 725
Cited by
Sorted by citations
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246
“…miRNA can contribute to cancers, cardiovascular diseases, metabolic diseases, immune-mediated disorders, and neurological disorders, etc. 230,231 For example, miR-106b-5p is an oncogenic miRNA that appears to be upregulated in different cancers, such as hepatic cancer, 232 cervical cancer,…”
Background
Metadata
- Authors
- Salemi, M., Mogavero, M. P., Lanza, G., Mongioì, L. M., Calogero, A. E., & Ferri, R.
- Affiliations
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- University of Catania (IT)
- Corresponding author
- Salemi, Michele
- ORCID
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2022-06-15
- Volume
- 11
- Issue
- 12
- Pages
- 1930
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC9221903
- OpenAlex
- W4282972028
- Cited by
- 39
- References
- 237
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 7 · 2023: 15 · 2022: 1
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Italian Ministry of Health (2773804)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- cancer, neurodegenerative diseases, non-coding RNA, Alzheimer's disease, Parkinson's disease, PARP1
- MeSH terms
- Alzheimer Disease, Humans, Neoplasms, Parkinson Disease, Comorbidity, Neurodegenerative Diseases, RNA, Untranslated
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
