The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease
Open accessAbstract
Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The role of AQP4 has been studied in health and in a range of pathological conditions. Interest in AQP4 has increased since it was discovered to be the target antigen in the inflammatory autoimmune disease neuromyelitis optica spectrum disorder (NMOSD). Emerging data suggest that AQP4 may also be implicated in the glymphatic system and may be involved in the clearance of beta-amyloid in Alzheimer’s disease (AD). In this review, we will describe the role of AQP4 in the adult and developing brain as well as its implication for disease.
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Cites
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International consensus diagnostic criteria for neuromyelitis optica spectrum disorders
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A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
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IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
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“Accumulation of beta-amyloid is a hallmark of AD and can begin years before disease onset [95].”
BackgroundThe glymphatic system: a beginner's guide
Jessen, N. A., Munk, A. S. F., Lundgaard, I., & Nedergaard, M. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1581-6 · Cited by 2,075
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The glymphatic pathway in neurological disorders.
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Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke
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Cited by
Więckowska-Gacek, A., Mietelska-Porowska, A., Wydrych, M., & Wojda, U. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101397 · Cited by 343
Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis
Salman, M. M., Kitchen, P., Halsey, A., Wang, M. X., Törnroth-Horsefield, S., Conner, A. C., Badaut, J., Iliff, J. J., & Bill, R. M. (2022) · Brain · doi:10.1093/brain/awab311 · Cited by 303
Xin, W., Pan, Y., Wei, W., Tatenhorst, L., Graf, I., Popa-Wagner, A., Gerner, S. T., Huber, S., Kilic, E., Hermann, D. M., et al. (2023) · Theranostics · doi:10.7150/thno.84059 · Cited by 77
Aquaporin-4 and Cognitive Disorders
Wang, Y., Huang, C., Guo, Q., & Chu, H. (2022) · Aging and disease · doi:10.14336/ad.2021.0731 · Cited by 55
LncRNA NEAT1/miR-128-3p/AQP4 axis regulating spinal cord injury-induced neuropathic pain progression
Xian, S., Ding, R., Li, M., & Chen, F. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577457 · Cited by 44
Metadata
- Authors
- Mader, S., & Brimberg, L.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2019-01-27
- Volume
- 8
- Issue
- 2
- Pages
- 90
- ISSN
- 2073-4409 (ISSN-L)
- OpenAlex
- W2912421167
- Cited by
- 293
- References
- 116
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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