The DOI matches its Crossref record; 211 of the 211 references it cites were found in a registry or an index.
NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction
Open accessAbstract
Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation, and aging. Mechanical stress along with synovial inflammation promotes the degradation of the extracellular matrix in the cartilage, leading to the breakdown of joint cartilage. The nuclear factor-kappaB (NF-κB) transcription factor has long been recognized as a disease-contributing factor and, thus, has become a therapeutic target for OA. Because NF-κB is a versatile and multi-functional transcription factor involved in various biological processes, a comprehensive understanding of the functions or regulation of NF-κB in the OA pathology will aid in the development of targeted therapeutic strategies to protect the cartilage from OA damage and reduce the risk of potential side-effects. In this review, we discuss the roles of NF-κB in OA chondrocytes and related signaling pathways, including recent findings, to better understand pathological cartilage remodeling and provide potential therapeutic targets that can interfere with NF-κB signaling for OA treatment.
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Cites
2 retracted
Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro
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Shared Principles in NF-κB Signaling
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Remodelling the extracellular matrix in development and disease
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Cited by
Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis
Molnar, V., Matišić, V., Kodvanj, I., Bjelica, R., Jeleč, Ž., Hudetz, D., Rod, E., Čukelj, F., Vrdoljak, T., Vidović, D., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179208 · Cited by 615
Guo, Q., Chen, X., Chen, J., Zheng, G., Xie, C., Wu, H., Miao, Z., Lin, Y., Wang, X., Gao, W., et al. (2021) · Cell Death & Disease · doi:10.1038/s41419-020-03341-9 · Cited by 253
Kuppa, S. S., Kim, H.-K., Kang, J.-Y., Lee, S.-C., Yang, H.-Y., Sankaranarayanan, J., & Seon, J.-K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512282 · Cited by 36
Metadata
- Authors
- Choi, M.-C., Jo, J., Park, J., Kang, H. K., & Park, Y.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2019-07-17
- Volume
- 8
- Issue
- 7
- Pages
- 734
- ISSN
- 2073-4409 (ISSN-L)
- OpenAlex
- W2961082130
- Cited by
- 531
- References
- 211
- FWCI
- 35.05
- Type
- journal article
- Language
- en
- Open access
- gold
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- Choi, M.-C., Jo, J., Park, J., Kang, H. K., & Park, Y. (2019). NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction. Cells. https://doi.org/10.3390/cells8070734
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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