The DOI matches its Crossref record; 246 of the 248 references it cites were found in a registry or an index.
Neuron-Astrocyte Interactions in Parkinson’s Disease
Open accessAbstract
Parkinson’s disease (PD) is the second most common neurodegenerative disease. PD patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural instability due to a loss of nigrostriatal dopaminergic neurons. Although the pathogenesis in sporadic PD remains unknown, there is a consensus on the involvement of non-neuronal cells in the progression of PD pathology. Astrocytes are the most numerous glial cells in the central nervous system. Normally, astrocytes protect neurons by releasing neurotrophic factors, producing antioxidants, and disposing of neuronal waste products. However, in pathological situations, astrocytes are known to produce inflammatory cytokines. In addition, various studies have reported that astrocyte dysfunction also leads to neurodegeneration in PD. In this article, we summarize the interaction of astrocytes and dopaminergic neurons, review the pathogenic role of astrocytes in PD, and discuss therapeutic strategies for the prevention of dopaminergic neurodegeneration. This review highlights neuron-astrocyte interaction as a target for the development of disease-modifying drugs for PD in the future.
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“The release of pro-inflammatory factors and neurotoxins by activated glial cells leads to neuroinflammation, neuronal damage, and neurodegeneration [73].”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [73]
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Metadata
- Authors
- Miyazaki, I., & Asanuma, M.
- Affiliations
- Okayama University (JP)
- Corresponding author
- Miyazaki, Ikuko
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2020-12-07
- Volume
- 9
- Issue
- 12
- Pages
- 2623
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC7762285
- OpenAlex
- W3111143057
- Cited by
- 186
- References
- 248
- Citations by year
- 2026: 37 · 2025: 36 · 2024: 34 · 2023: 35 · 2022: 31 · 2021: 13
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by)
- Okayama University Scientific Achievement Repository (Okayama University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (JP25461279, JP16K09673, JP19K07993)
- Okayama Medical Foundation (2014)
- All Japan Coffee Association (2016, 2018)
- Japanese Society of Eucommia (2018)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, astrocyte-neuron interaction, astrocytes, dopaminergic neurons, neurodegeneration, neuroinflammation, inflammatory cytokines, glial cells, disease-modifying therapy, neuroprotection
- MeSH terms
- Neuroprotection, Animals, Antioxidants, Astrocytes, Dopamine, Humans, Inflammation, Mitochondria, Nerve Degeneration, Neuroglia, Neurons, Parkinson Disease, Signal Transduction, Oxidative Stress, Disease Progression, alpha-Synuclein, Dopaminergic Neurons
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