Neuron-Astrocyte Interactions in Parkinson’s Disease

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971

Astrocyte-endothelial interactions at the blood-brain barrier

Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481

GDNF: a Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons

Lin, L.-F. H., Doherty, D. H., Lile, J. D., Bektesh, S. L., & Collins, F. (1993) · Science · doi:10.1126/science.8493557 · Cited by 3,206

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Lazarou, M., Sliter, D. A., Kane, L. A., Sarraf, S. A., Wang, C., Burman, J. L., Sideris, D. P., Fogel, A. I., & Youle, R. J. (2015) · Nature · doi:10.1038/nature14893 · Cited by 2,774

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

Sidransky, E., Nalls, M. A., Aasly, J. O., Aharon-Peretz, J., Annesi, G., Barbosa, E. R., Bar-Shira, A., Berg, D., Bras, J., Brice, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901281 · Cited by 2,135

Non-motor features of Parkinson disease

Schapira, A. H. V., Chaudhuri, K. R., & Jenner, P. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.62 · Cited by 2,053

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947

Tripartite synapses: astrocytes process and control synaptic information

Perea, G., Navarrete, M., & Araque, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.001 · Cited by 1,820

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

(1998) · Europe PMC (PubMed Central) · Cited by 1,594

β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression

Rothstein, J. D., Patel, S., Regan, M. R., Haenggeli, C., Huang, Y. H., Bergles, D. E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D. S., et al. (2005) · Nature · doi:10.1038/nature03180 · Cited by 1,518

Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

Braak, H., de Vos, R. A. I., Bohl, J., & Del Tredici, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.012 · Cited by 1,354

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

Blum, D. L., Torch, S., Lambeng, N., Nissou, M.-F., Benabid, A., Sadoul, R., & Verna, J. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00003-x · Cited by 1,269

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

Ramirez, A., Heimbach, A., Gründemann, J., Stiller, B., Hampshire, D., Cid, L. P., Goebel, I., Mubaidin, A. F., Wriekat, A.-L., Roeper, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1884 · Cited by 1,208

Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones

GRAHAM, D. G. (1978) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13535-9 · Cited by 1,126 · cited 1×

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Yun, S. P., Kam, T.-I., Panicker, N., Kim, S., Oh, Y., Park, J.-S., Kwon, S.-H., Park, Y. J., Karuppagounder, S. S., Park, H., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0051-5 · Cited by 1,123

Gastrointestinal Dysfunction in Parkinson’s Disease

Fasano, A., Visanji, N. P., Liu, L. W. C., Lang, A. E., & Pfeiffer, R. F. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00007-1 · Cited by 1,016

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M.-I., Kobayashi, A., Yamamoto, M., Kensler, T. W., & Talalay, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307301101 · Cited by 986 · cited 1×

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

Lee, H.-J., Suk, J.-E., Patrick, C., Bae, E.-J., Cho, J.-H., Rho, S., Hwang, D., Masliah, E., & Lee, S.-J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081125 · Cited by 877

Mechanisms of Disease: astrocytes in neurodegenerative disease

Maragakis, N. J., & Rothstein, J. D. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0355 · Cited by 836

DJ-1, a cancer- and Parkinson’s disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

Clements, C. M., McNally, R. S., Conti, B. J., Mak, T. W., & Ting, J. P.-Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607260103 · Cited by 818

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

Shih, A. Y., Johnson, D. A., Wong, G., Kraft, A. D., Jiang, L., Erb, H., Johnson, J. A., & Murphy, T. H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03394.2003 · Cited by 792

Glutathione metabolism in brain

Dringen, R., Gutterer, J. M., & Hirrlinger, J. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01597.x · Cited by 774

Dopamine covalently modifies and functionally inactivates parkin

LaVoie, M. J., Ostaszewski, B. L., Weihofen, A., Schlossmacher, M. G., & Selkoe, D. J. (2005) · Nature Medicine · doi:10.1038/nm1314 · Cited by 722

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

Sofroniew, M. V. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.004 · Cited by 721

Neuroinflammation as a common feature of neurodegenerative disorders

Guzman-Martinez, L., Maccioni, R. B., Andrade, V., Navarrete, L. P., Pastor, M. G., & Ramos-Escobar, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01008 · Cited by 702

Glial reactions in Parkinson's disease

McGeer, P. L., & McGeer, E. G. (2008) · Movement Disorders · doi:10.1002/mds.21751 · Cited by 701

Transcellular degradation of axonal mitochondria

Davis, C.-H. O., Kim, K.-Y., Bushong, E. A., Mills, E. A., Boassa, D., Shih, T., Kinebuchi, M., Phan, S., Zhou, Y., Bihlmeyer, N. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404651111 · Cited by 673

Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors

Klingelhoefer, L., & Reichmann, H. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.197 · Cited by 598

A timeline for Parkinson's disease

Hawkes, C. H., Del Tredici, K., & Braak, H. (2010) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2009.08.007 · Cited by 594

Synthesis of the Antioxidant Glutathione in Neurons: Supply by Astrocytes of CysGly as Precursor for Neuronal Glutathione

Dringen, R., Pfeiffer, B., & Hamprecht, B. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00562.1999 · Cited by 589

Inflammation, glutamate, and glia: a trio of trouble in mood disorders

Haroon, E., Miller, A. H., & Sanacora, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.199 · Cited by 584

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson’s disease: Critical role for the astrocyte

Chen, P.-C., Vargas, M. R., Pani, A. K., Smeyne, R. J., Johnson, D. A., Kan, Y. W., & Johnson, J. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813361106 · Cited by 579

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

Joshi, A. U., Minhas, P. S., Liddelow, S. A., Haileselassie, B., Andreasson, K. I., Dorn, G. W., & Mochly-Rosen, D. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0486-0 · Cited by 571

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

Choi, I., Zhang, Y., Seegobin, S. P., Pruvost, M., Wang, Q., Purtell, K., Zhang, B., & Yue, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-15119-w · Cited by 549

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

Kang, M.-I., Kobayashi, A., Wakabayashi, N., Kim, S.-G., & Yamamoto, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308347100 · Cited by 545

Zinc Metabolism in the Brain: Relevance to Human Neurodegenerative Disorders

Cuajungco, M. P., & Lees, G. J. (1997) · Neurobiology of Disease · doi:10.1006/nbdi.1997.0163 · Cited by 544

Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury

Yi, J., & Hazell, A. S. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.001 · Cited by 477

The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease

Bandopadhyay, R. (2004) · Brain · doi:10.1093/brain/awh054 · Cited by 475

Axonal -synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

Orimo, S., Uchihara, T., Nakamura, A., Mori, F., Kakita, A., Wakabayashi, K., & Takahashi, H. (2007) · Brain · doi:10.1093/brain/awm302 · Cited by 469

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

Craig, K. J. T., McCoy, M. K., Blackinton, J. G., Beilina, A. G., van der Brug, M., Matton, A., Miller, D. W., Maric, D., Cedazo-Mı́nguez, Á., & Cookson, M. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq430 · Cited by 467

NLRP3 inflammasome in neurological diseases, from functions to therapies

Song, L., Pei, L., Yao, S., Wu, Y., & Shang, Y. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00063 · Cited by 467

Glutathione peroxidase, glial cells and Parkinson's disease

Damier, P., Hirsch, É. C., Zhang, P., Agid, Y., & Javoy-Agid, F. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90175-f · Cited by 466

Development of α-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson’s disease

Braak, H., Sastre, M., & Del Tredici, K. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0244-3 · Cited by 462

Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles

Sulzer, D. L., Bogulavsky, J. J., Larsen, K. E., Behr, G. G., Karatekin, E., Kleinman, M. H., Turro, N. J., Krantz, D. E., Edwards, R. H., Greene, L. A., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.22.11869 · Cited by 460

NACP/α-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson’s disease brains

Wakabayashi, K., Hayashi, S., Yoshimoto, M., Kudo, H., & Takahashi, H. (2000) · Acta Neuropathologica · doi:10.1007/pl00007400 · Cited by 451

Neuropathology underlying clinical variability in patients with synucleinopathies

Halliday, G. M., Holton, J. L., Révész, T., & Dickson, D. W. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0852-9 · Cited by 447

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

Lindholm, P., Voutilainen, M. H., Laurén, J., Peränen, J., Leppänen, V., Andressoo, J., Lindahl, M., Janhunen, S. K., Kalkkinen, N., Timmusk, T., et al. (2007) · Nature · doi:10.1038/nature05957 · Cited by 444

DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism

Bonifati, V., Rizzu, P., Squitieri, F., Krieger, E., Vanacore, N., Swieten, J. C. V., Brice, A., van Duijn, C. M., Oostra, B. A., Meco, G., et al. (2003) · Neurological Sciences · doi:10.1007/s10072-003-0108-0 · Cited by 427

Potential oxidative pathways of brain catecholamines

Tse, D. C. S., McCreery, R. L., & Adams, R. N. (1976) · Journal of Medicinal Chemistry · doi:10.1021/jm00223a008 · Cited by 415 · cited 1×

TNFα potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NFκB inhibition

Zou, J., & Crews, F. T. (2005) · Brain Research · doi:10.1016/j.brainres.2004.11.014 · Cited by 410

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

Gray, M. T., & Woulfe, J. M. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.32 · Cited by 409

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

Xiong, H., Wang, D., Chen, L., Choo, Y. S., Ma, H., Tang, C., Xia, K., Jiang, W. B., Ronai, Z. A., Zhuang, X., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37617 · Cited by 406

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

Freeman, L., Guo, H., David, C. N., Brickey, W. J., Jha, S., & Ting, J. P.-Y. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20150237 · Cited by 397

Neuron‐to‐neuron transmission of α‐synuclein fibrils through axonal transport

Freundt, E. C., Maynard, N., Clancy, E. K., Roy, S., Bousset, L., Sourigues, Y., Covert, M. W., Melki, R., Kirkegaard, K., & Brahic, M. (2012) · Annals of Neurology · doi:10.1002/ana.23747 · Cited by 394

Lipopolysaccharide Intranigral Injection Induces Inflammatory Reaction and Damage in Nigrostriatal Dopaminergic System

Castaño, A., Herrera, A. J., Cano, J., & Machado, A. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70041584.x · Cited by 393

Neuroinflammation and regulation of glial glutamate uptake in neurological disorders

Tilleux, S., & Hermans, E. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21325 · Cited by 381

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

di Domenico, A., Carola, G., Calatayud, C., Pons-Espinal, M., Muñoz, J. P., Richaud-Patin, Y., Fernandez-Carasa, I., Gut, M., Faella, A., Parameswaran, J., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.12.011 · Cited by 372

MANF: A New Mesencephalic, Astrocyte-Derived Neurotrophic Factor with Selectivity for Dopaminergic Neurons

Petrova, P. S., Raibekas, A. A., Pevsner, J., Vigo, N. T., Anafi, M., Moore, M. K., Peaire, A. E., Shridhar, V., Smith, D. I., Kelly, J., et al. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:20:2:173 · Cited by 353

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

Gu, X., Long, C.-X., Sun, L., Xie, C., Lin, X. Z., & Cai, H. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-12 · Cited by 351

The Role of Inflammatory and Oxidative Stress Mechanisms in the Pathogenesis of Parkinson’s Disease: Focus on Astrocytes

Niranjan, R. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8483-x · Cited by 338

The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease

Mirza, B., Hadberg, H., Thomsen, P., & Moos, T. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00455-8 · Cited by 327

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

Kahle, P. J., Waak, J., & Gasser, T. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.08.003 · Cited by 324

Cystine/Glutamate Exchange Modulates Glutathione Supply for Neuroprotection from Oxidative Stress and Cell Proliferation

Shih, A. Y., Erb, H., Sun, X., Toda, S., Kalivas, P. W., & Murphy, T. H. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3178-06.2006 · Cited by 315

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

Collins, L. M., Toulouse, A., Connor, T. J., & Nolan, Y. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.028 · Cited by 306

The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia [published erratum appears in J Neurosci 1992 Mar;12(3):685]

Engele, J., & Bohn, M. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-10-03070.1991 · Cited by 303

The Nrf2–ARE cytoprotective pathway in astrocytes

Vargas, M. R., & Johnson, J. A. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409001094 · Cited by 295

Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Kohutnicka, M., Lewandowska, E., Kurkowska‐Jastrzębska, I., Członkowski, A., & Członkowska, A. (1998) · Immunopharmacology · doi:10.1016/s0162-3109(98)00022-8 · Cited by 283

Astrocytes Provide Cysteine to Neurons by Releasing Glutathione

Wang, X. F., & Cynader, M. S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741434.x · Cited by 281

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

Hao, L.-Y., Giasson, B. I., & Bonini, N. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911175107 · Cited by 270

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Neurorestorative in Rat Model of Parkinson's Disease

Voutilainen, M. H., Bäck, S., Pörsti, E., Toppinen, L., Lindgren, L., Lindholm, P., Peränen, J., Saarma, M., & Tuominen, R. K. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0833-09.2009 · Cited by 269

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

Lastres‐Becker, I., Ulusoy, A., Innamorato, N. G., Şahin, G., Rábano, A., Kirik, D., & Cuadrado, A. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds143 · Cited by 269

Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease

Dolgacheva, L. P., Berezhnov, A. V., Fedotova, E. I., Zinchenko, V. P., & Abramov, A. Y. (2019) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-019-09798-4 · Cited by 254

Degeneration in Different Parkinsonian Syndromes Relates to Astrocyte Type and Astrocyte Protein Expression

Song, Y. J. C., Halliday, G. M., Holton, J. L., Lashley, T., O’Sullivan, S. S., McCann, H., Lees, A. J., Ozawa, T., Williams, D. R., Lockhart, P. J., et al. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181b66f1b · Cited by 245

Copper pathology in vulnerable brain regions in Parkinson's disease

Davies, K. M., Bohic, S., Carmona, A., Ortega, R., Cottam, V., Hare, D. J., Finberg, J. P. M., Reyes, S., Halliday, G. M., Mercer, J. F. B., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.034 · Cited by 244

NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

Arima, K., Uéda, K., Sunohara, N., Arakawa, K., Hirai, S., Nakamura, M., Tonozuka-Uehara, H., & Kawai, M. (1998) · Acta Neuropathologica · doi:10.1007/s004010050917 · Cited by 239

Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

Henry, A. G., Aghamohammadzadeh, S., Samaroo, H., Chen, Y., Mou, K., Needle, E., & Hirst, W. D. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv314 · Cited by 235

Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2

Eggler, A. L., Gay, K. A., & Mesecar, A. D. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700249 · Cited by 234

RAISED CEREBROSPINAL-FLUID COPPER CONCENTRATION IN PARKINSON'S DISEASE

Pall, H., Blake, D. R., Gutteridge, J. M. C., Williams, A. C., Lunec, J., Hall, M., & Taylor, A. (1987) · The Lancet · doi:10.1016/s0140-6736(87)90827-0 · Cited by 230

Environmental Exposures and Parkinson’s Disease

Nandipati, S., & Litvan, I. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13090881 · Cited by 219

Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)

Ho, P. W., Leung, C.-T., Liu, H., Pang, S. Y.-Y., Lam, C. S.-C., Xian, J., Li, L., Kung, M. H.-W., Ramsden, D. B., & Ho, S. (2019) · Autophagy · doi:10.1080/15548627.2019.1603545 · Cited by 215

Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist

Iida, M., Miyazaki, I., Tanaka, K.-I., Kabuto, H., Iwata‐Ichikawa, E., & Ogawa, N. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01688-1 · Cited by 211

The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression

Shu, X., Sun, Y., Sun, X., Zhou, Y., Bian, Y., Shu, Z., Ding, J., Lu, M., & Hu, G. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1813-9 · Cited by 203

Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection

Yao, W., Lu, M., Mei, M., Wang, H., Han, Z., Chen, M., Yao, H. P., Song, N., Ding, X. L., Ding, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14788-x · Cited by 198

Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter

Whitehead, R. E., Ferrer, J. V., Javitch, J. A., & Justice, J. B. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00125.x · Cited by 194

Metal swap between Zn7-metallothionein-3 and amyloid-β–Cu protects against amyloid-β toxicity

Meloni, G., Sonois, V., Delaine, T., Guilloreau, L., Gillet, A., Teissié, J., Faller, P., & Vašák, M. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.89 · Cited by 190

Regulation of astrocyte inflammatory responses by the Parkinson's disease‐associated gene DJ–1

Waak, J., Weber, S. S., Waldenmaier, A., Görner, K., Alunni‐Fabbroni, M., Schell, H., Weisenhorn, D. M. V., Pham, T., Reumers, V., Baekelandt, V., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-125153 · Cited by 190

Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model

Gan, L., Vargas, M. R., Johnson, D. A., & Johnson, J. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3049-12.2012 · Cited by 189

Copper at synapse: Release, binding and modulation of neurotransmission

D’Ambrosi, N., & Rossi, L. C. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.07.006 · Cited by 187

Neuropathobiology of non-motor symptoms in Parkinson disease

Jellinger, K. A. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1405-5 · Cited by 186

LRRK2 at the interface of autophagosomes, endosomes and lysosomes

Roosen, D. A., & Cookson, M. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0140-1 · Cited by 186

Tyrosine Hydroxylase Is Inactivated by Catechol‐Quinones and Converted to a Redox‐Cycling Quinoprotein

Kuhn, D. M., Arthur, R. E., Thomas, D. M., & Elferink, L. A. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731309.x · Cited by 184

Regulation of PINK1-Parkin-mediated mitophagy

Springer, W., & Kahle, P. J. (2011) · Autophagy · doi:10.4161/auto.7.3.14348 · Cited by 184

Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation

Jo, M., Kim, J., Song, G. J., Seo, M., Hwang, E. M., & Suk, K. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2534-16.2017 · Cited by 184

LRRK2 Expression in Normal and Pathologic Human Brain and in Human Cell Lines

Judith Miklossy, A., Arai, T., Guo, J., Klegeris, A., Yu, S. Y., McGeer, E. G., & McGeer, P. L. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000235121.98052.54 · Cited by 183

How is alpha‐synuclein cleared from the cell?

Stefanis, L., Emmanouilidou, E., Pantazopoulou, M., Kirik, D., Vekrellis, K., & Tofaris, G. K. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14704 · Cited by 183

Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3

Zhu, J., Hu, Z., Han, X., Wang, D., Jiang, Q., Ding, J., Xiao, M., Wang, C., Lu, M., & Hu, G. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0127-2 · Cited by 179

L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

Takaki, J., Fujimori, K., Miura, M., Suzuki, T., Sekino, Y., & Sato, K. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-275 · Cited by 173

The mitochondrion: a central architect of copper homeostasis

Baker, Z. N., Cobine, P. A., & Leary, S. C. (2017) · Metallomics · doi:10.1039/c7mt00221a · Cited by 172

Dopaminergic neuron-specific oxidative stress caused by dopamine itself.

Miyazaki, I., & Asanuma, M. (2008) · PubMed · doi:10.18926/amo/30942 · Cited by 168

Cooperative action of glutamate transporters and cystine/glutamate antiporter system Xc– protects from oxidative glutamate toxicity

Lewerenz, J., Klein, M., & Methner, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03921.x · Cited by 164

Copper metallothioneins

Calvo, J. S., Jung, H., & Meloni, G. (2017) · IUBMB Life · doi:10.1002/iub.1618 · Cited by 164

The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress

Hirrlinger, J., König, J., Keppler, D., Lindenau, J., Schulz, J. B., & Dringen, R. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00101.x · Cited by 158

Redefining the Role of Metallothionein within the Injured Brain

Chung, R. S., Penkowa, M., Dittmann, J., King, C., Bartlett, C. A., Asmussen, J. W., Hidalgo, J., Carrasco, J., Leung, Y. K., Walker, A. K., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708446200 · Cited by 154

Glial phagocytic clearance in Parkinson’s disease

Tremblay, M.-E., Cookson, M. R., & Civiero, L. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0314-8 · Cited by 152

GDNF, A Neuron-Derived Factor Upregulated in Glial Cells during Disease

Azevedo, M. D., Sander, S., & Tenenbaum, L. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020456 · Cited by 146

Riluzole stimulates nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis in cultured mouse astrocytes

Mizuta, I., Ohta, M., Ohta, K., Nishimura, M., Mizuta, E., & Kuno, S. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02098-5 · Cited by 145

Characterization of the origins of astrocyte response to injury using the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

O'Callaghan, J. P., Miller, D. B., & Reinhard, J. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)91526-m · Cited by 145

Inducible Alterations of Glutathione Levels in Adult Dopaminergic Midbrain Neurons Result in Nigrostriatal Degeneration

Chinta, S. J., Kumar, M. J., Hsu, M., Rajagopalan, S., Kaur, D., Rane, A., Nicholls, D. G., Choi, J., & Andersen, J. K. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3885-07.2007 · Cited by 145

Different Susceptibility to the Parkinson's Toxin MPTP in Mice Lacking the Redox Master Regulator Nrf2 or Its Target Gene Heme Oxygenase-1

Innamorato, N. G., Jaźwa, A., Rojo, A. I., García, C., Fernández‐Ruíz, J., Grochot‐Przeczek, A., Stachurska, A., Józkowicz, A., Dulak, J., & Cuadrado, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011838 · Cited by 141

Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

Schapansky, J., Khasnavis, S., DeAndrade, M. P., Nardozzi, J. D., Falkson, S. R., Boyd, J. D., Sanderson, J. B., Bartels, T., Melrose, H. L., & LaVoie, M. J. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.12.005 · Cited by 137

Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones

Erlank, H., Elmann, A., Kohen, R., & Kanner, J. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.033 · Cited by 137

Astrocytes shed extracellular vesicles that contain fibroblast growth factor-2 and vascular endothelial growth factor

Proia, P., Schiera, G., Mineo, M., Ingrassia, A. M. R., Santoro, G., Savettieri, G., & Liegro, I. D. (2008) · International Journal of Molecular Medicine · doi:10.3892/ijmm.21.1.63 · Cited by 136

GDNF and Parkinson’s Disease: Where Next? A Summary from a Recent Workshop

Barker, R. A., Björklund, A., Gash, D. M., Whone, A. L., Laar, A. D. V., Kordower, J. H., Bankiewicz, K. S., Kieburtz, K. D., Saarma, M., Booms, S., et al. (2020) · Journal of Parkinson s Disease · doi:10.3233/jpd-202004 · Cited by 136

CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery after MPTP Treatment in Mice

Airavaara, M., Harvey, B. K., Voutilainen, M. H., Shen, H., Chou, J., Lindholm, P., Lindahl, M., Tuominen, R. K., Saarma, M., Hoffer, B. J., et al. (2011) · Cell Transplantation · doi:10.3727/096368911x600948 · Cited by 135

Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia

Miyazaki, I., Asanuma, M., Diaz-Corrales, F. J. J., Miyoshi, K., & Ogawa, N. (2004) · Brain Research · doi:10.1016/j.brainres.2004.09.014 · Cited by 134

Protective actions of human recombinant basic fibroblast growth factor on MPTP-lesioned nigrostriatal dopamine neurons after intraventricular infusion

Chadi, G., Er, A., Rosén, L., Janson, A. M., Agnati, L. A., Goldstein, M., Ögren, S. O., Pettersson, R. F., & Fuxé, K. (1993) · Experimental Brain Research · doi:10.1007/bf00228825 · Cited by 133

Metallothioneins are multipurpose neuroprotectants during brain pathology

Penkowa, M. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05207.x · Cited by 131

Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread

Kovács, G. G., Breydo, L., Green, R. J., Kis, V., Puska, G., Lőrincz, P., Perju‐Dumbrava, L., Giera, R., Pirker, W., Lutz, M. I., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.020 · Cited by 131

Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

Konno, M., Hasegawa, T., Baba, T., Miura, E., Sugeno, N., Kikuchi, A., Fiesel, F. C., Sasaki, T., Aoki, M., Itoyama, Y., et al. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-38 · Cited by 122

N‐Acetyl Cysteine Is Associated With Dopaminergic Improvement in Parkinson's Disease

Monti, D. A., Zabrecky, G., Kremens, D., Liang, T., Wintering, N. A., Bazzan, A. J., Zhong, L., Bowens, B. K., Chervoneva, I., Intenzo, C., et al. (2019) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1548 · Cited by 121

Glial Dysfunction in Parkin Null Mice: Effects of Aging

Solano, R. M., Casarejos, M. J., Menéndez-Cuervo, J., Rodríguez‐Navarro, J. A., de Yébenes, J. G., & Mena, M. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4609-07.2008 · Cited by 119

Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation

Tsunemi, T., Ishiguro, Y., Yoroisaka, A., Valdez, C., Miyamoto, K., Ishikawa, K., Saiki, S., Akamatsu, W., Hattori, N., & Krainc, D. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0954-20.2020 · Cited by 118

Riluzole elevates GLT-1 activity and levels in striatal astrocytes

Carbone, M., Duty, S., & Rattray, M. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.10.017 · Cited by 117

Neuroprotective effects of zonisamide target astrocyte

Asanuma, M., Miyazaki, I., Diaz-Corrales, F. J. J., Kimoto, N., Kikkawa, Y., Takeshima, M., Miyoshi, K., & Murata, M. (2009) · Annals of Neurology · doi:10.1002/ana.21885 · Cited by 117

Dopamine D3 receptor‐preferring agonists induce neurotrophic effects on mesencephalic dopamine neurons

Du, F., Li, R., Huang, Y., Li, X., & Le, W. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04438.x · Cited by 117

The Interplay between Alpha-Synuclein Clearance and Spreading

da Fonseca, T. L., Villar‐Piqué, A., & Outeiro, T. F. (2015) · Biomolecules · doi:10.3390/biom5020435 · Cited by 115

Aquaporin-4 mediates communication between astrocyte and microglia: Implications of neuroinflammation in experimental Parkinson’s disease

Sun, H., Liang, R., Yang, B., Zhou, Y., Liu, M., Fang, F., Ding, J., Fan, Y., & Hu, G. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.003 · Cited by 114

Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation

Tong, J., Ang, L.-C., Williams, B., Furukawa, Y., Fitzmaurice, P. S., Guttman, M., Boileau, I., Hornykiewicz, O., & Kish, S. J. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.06.010 · Cited by 112

Cinnamon Treatment Upregulates Neuroprotective Proteins Parkin and DJ-1 and Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease

Khasnavis, S., & Pahan, K. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9552-2 · Cited by 112

Lysosome and Inflammatory Defects in GBA1‐Mutant Astrocytes Are Normalized by LRRK2 Inhibition

Sanyal, A., DeAndrade, M. P., Novis, H. S., Lin, S. C., Chang, J., Lengacher, N. A., Tomlinson, J. J., Tansey, M. G., & LaVoie, M. J. (2020) · Movement Disorders · doi:10.1002/mds.27994 · Cited by 111

Different preferences in the utilization of amino acids for glutathione synthesis in cultured neurons and astroglial cells derived from rat brain

Kranich, O., Hamprecht, B., & Dringen, R. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13217-1 · Cited by 110

Astrocyte-Neuron Interaction at Tripartite Synapses

Pérez‐Alvarez, A., & Araque, A. (2013) · Current Drug Targets · doi:10.2174/13894501113149990203 · Cited by 108

Human iPSCs derived astrocytes rescue rotenone-induced mitochondrial dysfunction and dopaminergic neurodegeneration in vitro by donating functional mitochondria

Cheng, X.-Y., Biswas, S., Li, J., Mao, C.-J., Chechneva, O. V., Chen, J., Li, K., Li, J., Zhang, J.-R., Liu, C., et al. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00190-6 · Cited by 108

Basic fibroblast growth factor increases division and delays differentiation of dopamine precursors in vitro

Bouvier, M., & Mytilineou, C. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07141.1995 · Cited by 104

Aminopeptidase N mediates the utilization of the GSH precursor CysGly by cultured neurons

Dringen, R., Gutterer, J. M., Gros, C., & Hirrlinger, J. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10042 · Cited by 104

C dk5‐ D ependent A ctivation of N euronal I nflammasomes in P arkinson's D isease

Zhang, P., Shao, X., Qi, G., Chen, Q., Bu, L.-L., Chen, L., Shi, J., Ming, J., & Tian, B. (2016) · Movement Disorders · doi:10.1002/mds.26488 · Cited by 102

Chronic Systemic Exposure to Low-Dose Rotenone Induced Central and Peripheral Neuropathology and Motor Deficits in Mice: Reproducible Animal Model of Parkinson’s Disease

Miyazaki, I., Isooka, N., Imafuku, F., Sun, J. Y., Kikuoka, R., Furukawa, C., & Asanuma, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093254 · Cited by 100

Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease

Miranda, B. R. D., Rocha, E. M., Bai, Q., Ayadi, A. E., Hinkle, D., Burton, E. A., & Greenamyre, J. T. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.04.008 · Cited by 99

GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease

de Tassigny, X. D., Pascual, A., & López‐Barneo, J. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00010 · Cited by 99

Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity

Miyazaki, I., Asanuma, M., Kikkawa, Y., Takeshima, M., Murakami, S., Miyoshi, K., Sogawa, N., & Kita, T. (2010) · Glia · doi:10.1002/glia.21112 · Cited by 96

Aging-InducedNrf2-AREPathway Disruption in the Subventricular Zone Drives Neurogenic Impairment in Parkinsonian Mice viaPI3K-Wnt/β-CateninDysregulation

L’Episcopo, F., Tirolo, C., Testa, N., Caniglia, S., Morale, M. C., Impagnatiello, F., Pluchino, S., & Marchetti, B. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3206-12.2013 · Cited by 96

Basic Fibroblast Growth Factor Stimulation of Glial Cells Protects Dopamine Neurons from 6‐Hydroxydopamine Toxicity: Involvement of the Glutathione System

Hou, J. G., Cohen, G., & Mytilineou, C. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69010076.x · Cited by 95

Neuroglial transmitophagy and Parkinson's disease

Moráles, I., Sánchez, A., Puertas‐Avendaño, R., Rodriguez‐Sabate, C., Perez‐Barreto, A., & Rodrı́guez, M. (2020) · Glia · doi:10.1002/glia.23839 · Cited by 95

Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria

Schmidt, S., Linnartz‐Gerlach, B., Mendritzki, S., Sczepan, T., Lübbert, M., Stichel, C. C., & Lübbert, H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddq564 · Cited by 93

Oxidative Stress Induction of DJ‐1 Protein in Reactive Astrocytes Scavenges Free Radicals and Reduces Cell Injury

Yanagida, T., Tsushima, J., Kitamura, Y., Yanagisawa, D., Takata, K., Shibaike, T., Yamamoto, A., Taniguchi, T., Yasui, H., Taira, T., et al. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.1.7985 · Cited by 93

A role for extracellular metallothioneins in CNS injury and repair

Chung, R. S., & West, A. K. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.10.019 · Cited by 92

Pink1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced akt and increased p38 mapk activation, and downregulation of egfr

Choi, I., Kim, J., Jeong, H., Kim, B., Jou, I., Park, S. M., Chen, L.-N., Kang, U. J., Zhuang, X., & Joe, E.-H. (2013) · Glia · doi:10.1002/glia.22475 · Cited by 90

Glia in neurodegeneration: Drivers of disease or along for the ride?

Gleichman, A. J., & Carmichael, S. T. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104957 · Cited by 90

Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases

Guan, Y., & Han, F. (2020) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2020.00037 · Cited by 90

Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress

Ledesma, M. D., Galván, C. A., Hellias, B., Dotti, C. G., & Jensen, P. H. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01253.x · Cited by 89

Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death

Sun, L., Shen, R., Agnihotri, S. K., Chen, Y., Huang, Z., & Büeler, H. (2018) · Scientific Reports · doi:10.1038/s41598-017-18786-w · Cited by 88

Mechanism of copper(II)-induced misfolding of Parkinson's disease protein

Rose, F., Hodak, M., & Bernholc, J. (2011) · Scientific Reports · doi:10.1038/srep00011 · Cited by 88

DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression

Kim, J., Cha, S., Choi, Y. R., Jou, I., Joe, E.-H., & Park, S. M. (2016) · Scientific Reports · doi:10.1038/srep28823 · Cited by 88

CDNF Protein Therapy in Parkinson’s Disease

Huttunen, H. J., & Saarma, M. (2019) · Cell Transplantation · doi:10.1177/0963689719840290 · Cited by 88

Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy

Ubhi, K. K., Inglis, C. A., Mante, M., Patrick, C., Adame, A., Spencer, B. J., Rockenstein, E. M., May, V. E. L., Winkler, J., & Masliah, E. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.01.008 · Cited by 87

Astrocytes as a primary locus for the conversion MPTP into MPP+

Brooks, W. J., Jarvis, M. F., & Wagner, G. C. (1989) · Journal of Neural Transmission · doi:10.1007/bf01244987 · Cited by 85

Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation

Montoya, A., Elgueta, D., Campos, J., Chovar, O., Falcón, P., Matus, S., Alfaro, I. E., Bono, M. R., & Pacheco, R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1652-8 · Cited by 84

Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons

Chavarría, C., Rodríguez-Bottero, S., Quijano, C., Cassina, P., & Souza, J. M. (2018) · Biochemical Journal · doi:10.1042/bcj20180297 · Cited by 83

Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease

Voutilainen, M. H., Arumäe, U., Airavaara, M., & Saarma, M. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.09.031 · Cited by 83

Manganese disrupts astrocyte glutamine transporter expression and function

Sidoryk‐Wȩgrzynowicz, M., Lee, E.-S., Albrecht, J., & Aschner, M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06172.x · Cited by 83

DJ-1 knock-down impairs astrocyte mitochondrial function

Larsen, N. J., Ambrosi, G., Mullett, S. J., Berman, S. B., & Hinkle, D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.016 · Cited by 82

Up-regulation of metallothionein gene expression in Parkinsonian astrocytes

Michael, G. J., Esmailzadeh, S., Moran, L. B., Christian, L., Pearce, R. K. B., & Graeber, M. B. (2011) · Neurogenetics · doi:10.1007/s10048-011-0294-5 · Cited by 81

Targeting 5-HT1A receptors in astrocytes to protect dopaminergic neurons in parkinsonian models

Miyazaki, I., Asanuma, M., Murakami, S., Takeshima, M., Torigoe, N., Kitamura, Y., & Miyoshi, K. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.08.003 · Cited by 79

Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage

Bergström, P., Andersson, H. C., Gao, Y., Karlsson, J.-O., Nodin, C., Anderson, M. F., Nilsson, M., & Hammarsten, O. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.023 · Cited by 79

Ceftriaxone Ameliorates Motor Deficits and Protects Dopaminergic Neurons in 6-Hydroxydopamine-Lesioned Rats

Leung, T. C. H., Lui, C. N. P., Chen, L. W., Yung, W. H., Chan, Y. S., & Yung, K. K. L. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn200072h · Cited by 78

DJ-1 deficiency in astrocytes selectively enhances mitochondrial Complex I inhibitor-induced neurotoxicity

Mullett, S. J., & Hinkle, D. A. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07175.x · Cited by 78

Atp13a2 Deficiency Aggravates Astrocyte‐Mediated Neuroinflammation via NLRP 3 Inflammasome Activation

Qiao, C., Yin, N., Gu, H., Zhu, J., Ding, J., Lu, M., & Hu, G. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12514 · Cited by 77

A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson's disease

Aflaki, E., Stubblefield, B. K., McGlinchey, R. P., McMahon, B., Ory, D. S., & Sidransky, E. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104647 · Cited by 77

A2A‐D2 receptor–receptor interaction modulates gliotransmitter release from striatal astrocyte processes

Cervetto, C., Venturini, A., Passalacqua, M., Guidolin, D., Genedani, S., Fuxé, K., Borroto‐Esquela, D. O., Cortelli, P., Woods, A. S., Maura, G., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13885 · Cited by 76

PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila

Shiba‐Fukushima, K., Inoshita, T., Hattori, N., & Imai, Y. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004391 · Cited by 75

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies

Okita, Y., Rcom-H'cheo-Gauthier, A. N., Goulding, M., Chung, R. S., Faller, P., & Pountney, D. L. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00114 · Cited by 73

Apomorphine‐induced activation of dopamine receptors modulates FGF‐2 expression in astrocytic cultures and promotes survival of dopaminergic neurons

Li, A., Guo, H., Luo, X., Sheng, J., Yang, S., Yin, Y., Zhou, J., & Zhou, J. (2006) · The FASEB Journal · doi:10.1096/fj.05-5510fje · Cited by 73

The dopamine agonist cabergoline provides neuroprotection by activation of the glutathione system and scavenging free radicals

Yoshioka, M., Tanaka, K.-I., Miyazaki, I., Fujita, N., Higashi, Y., Asanuma, M., & Ogawa, N. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00040-8 · Cited by 71

Astrocyte Metallothioneins (MTs) and Their Neuroprotective Rolea

Aschner, M. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48445.x · Cited by 70

Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective

Clarke, B. E., Taha, D. M., Tyzack, G. E., & Patani, R. (2020) · Glia · doi:10.1002/glia.23877 · Cited by 69

DJ-1 Expression Modulates Astrocyte-Mediated Protection Against Neuronal Oxidative Stress

Mullett, S. J., Maio, R. D., Greenamyre, J. T., & Hinkle, D. A. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9904-4 · Cited by 68

Striatal Astrocytes Act as a Reservoir for L-DOPA

Asanuma, M., Miyazaki, I., Murakami, S., Diaz-Corrales, F. J. J., & Ogawa, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106362 · Cited by 67

TNF-α expressed in the brain of transgenic mice lowers central tyroxine hydroxylase immunoreactivity and alters grooming behavior

Aloe, L., & Fiore, M. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00850-1 · Cited by 66

What’s to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?

Dunning, C. J. R., George, S., & Brundin, P. (2013) · Prion · doi:10.4161/pri.23806 · Cited by 66

Beneficial effect of antidepressants against rotenone induced Parkinsonism like symptoms in rats

Sharma, N., Jamwal, S., & Kumar, P. (2016) · Pathophysiology · doi:10.1016/j.pathophys.2016.03.002 · Cited by 66

Trophic activities of endoplasmic reticulum proteins CDNF and MANF

Jäntti, M. H., & Harvey, B. K. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03263-0 · Cited by 65

Knocking Out DJ-1 Attenuates Astrocytes Neuroprotection Against 6-Hydroxydopamine Toxicity

Lev, N., Barhum, Y., Ben‐Zur, T., Melamed, E., Steiner, I., & Offen, D. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-9984-9 · Cited by 64

Overexpression of conserved dopamine neurotrophic factor (CDNF) in astrocytes alleviates endoplasmic reticulum stress-induced cell damage and inflammatory cytokine secretion

Cheng, L., Zhao, H., Zhang, W., Liu, B., Liu, Y., Guo, Y., & Nie, L. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.04.029 · Cited by 64

The astrocytic response to the dopaminergic denervation of the striatum

Moráles, I., Sánchez, A., Rodriguez‐Sabate, C., & Rodríguez, M. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13684 · Cited by 64

Ceftriaxone Prevents and Reverses Behavioral and Neuronal Deficits in an MPTP-Induced Animal Model of Parkinson’s Disease Dementia

Hsu, C.-Y., Hung, C.-S., Chang, H.-M., Liao, W.-C., Ho, S.-C., & Ho, Y.-J. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.023 · Cited by 63

Connexin 43 hemichannels and pannexin‐1 channels contribute to the α‐synuclein‐induced dysfunction and death of astrocytes

Díaz, E. F., Labra, V. C., Alvear, T. F., Mellado, L. A., Inostroza, C. A., Oyarzún, J. E., Salgado, N., Quintanilla, R. A., & Orellana, J. A. (2019) · Glia · doi:10.1002/glia.23631 · Cited by 63

Effects of dopamine agonists bromocriptine, pergolide, cabergoline, and SKF-38393 on GDNF, NGF, and BDNF synthesis in cultured mouse astrocytes

Ohta, K., Kuno, S., Mizuta, I., Fujinami, A., Matsui, H., & Ohta, M. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00321-7 · Cited by 61

The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes

Wang, J., Zheng, B., Tang, X., Tang, X., Wang, J., & Wei, D. (2020) · Inflammation Research · doi:10.1007/s00011-020-01355-9 · Cited by 60

PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes

Choi, I., Choi, D., Yang, H., Woo, J. H., Chang, M., Kim, J. Y., Sun, W., Park, S.-M., Jou, I., Lee, S., et al. (2016) · Molecular Brain · doi:10.1186/s13041-016-0186-6 · Cited by 58

Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson’s Disease

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Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation

Singh, K., Han, K., Tilve, S. M., Wu, K., Geller, H. M., & Sack, M. N. (2018) · Glia · doi:10.1002/glia.23482 · Cited by 58

DJ‐1 immunoreactivity in human brain astrocytes is dependent on infarct presence and infarct age

Mullett, S., Hamilton, R. L., & Hinkle, D. (2009) · Neuropathology (Kyoto. 1993) · doi:10.1111/j.1440-1789.2008.00955.x · Cited by 57

Metallothionein (MT) isoforms in the central nervous system (CNS): regional and cell-specific distribution and potential functions as an antioxidant.

Aschner, M. (1998) · PubMed · Cited by 57

Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells

Klegeris, A., Walker, D. G., & McGeer, P. L. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00094-5 · Cited by 56

Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson’s disease pathogenesis

Sheng, L., Stewart, T., Yang, D., Thorland, E., Soltys, D., Aro, P., Khrisat, T., Xie, Z., Li, N., Liu, Z., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00983-w · Cited by 56

NF-κB Signaling in Astrocytes Modulates Brain Inflammation and Neuronal Injury Following Sequential Exposure to Manganese and MPTP During Development and Aging

Hammond, S. L., Bantle, C. M., Popichak, K. A., Wright, K. A., Thompson, D., Forero, C., Kirkley, K. S., Damale, P. U., Chong, E. K. P., & Tjalkens, R. B. (2020) · Toxicological Sciences · doi:10.1093/toxsci/kfaa115 · Cited by 56

Neuroprotective effects of levetiracetam target xCT in astrocytes in parkinsonian mice

Miyazaki, I., Murakami, S., Torigoe, N., Kitamura, Y., & Asanuma, M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13405 · Cited by 54

Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders

Brandebura, A. N., Paumier, A., Onur, T. S., & Allen, N. J. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-022-00641-1 · Cited by 427

Microglia Mediated Neuroinflammation in Parkinson’s Disease

Işık, S., Yeman-Kıyak, B., Akbayır, R., Şeyhali-Abutayeh, R., & Arpaci, T. (2023) · Cells · doi:10.3390/cells12071012 · Cited by 419

Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis

Wu, A., & Zhang, J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02964-x · Cited by 354

Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside

Mishra, A., Bandopadhyay, R., Singh, P. K., Mishra, P. S., Sharma, N., & Khurana, N. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00806-4 · Cited by 134

Immune Response in Neurological Pathology: Emerging Role of Central and Peripheral Immune Crosstalk

Passaro, A. P., Lebos, A. L., Yao, Y., & Stice, S. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.676621 · Cited by 124

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Li, Y., Li, Q., Wang, Y., Wang, X., Di, G., Niu, M., Xu, Z., & Huang, Y. (2026) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-026-01218-7 · Cited by 1

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Prunell, G., & Olivera‐Bravo, S. (2022) · Biomolecules · doi:10.3390/biom12121745 · Cited by 27

Therapeutic Strategy of Targeting Astrocytes for Neuroprotection in Parkinson's Disease

Miyazaki, I., & Asanuma, M. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612823666170710163731 · Cited by 20

Understanding the role of astrocytes in a rare model of Parkinson's disease

Gray, L. (2024) · Otago University Research Archive (University of Otago)

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Wang, T., Sun, Y., & Dettmer, U. (2023) · Cells · doi:10.3390/cells12192336 · Cited by 48