Cited by 15Genetic and phenotypic traits in livestockGenetic Mapping and Diversity in Plants and AnimalsLivestock Farming and Management

Exploring and Identifying Candidate Genes and Genomic Regions Related to Economically Important Traits in Hanwoo Cattle

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Naserkheil, Masoumeh, Manzari, Zeinab, Dang, Chang Gwon, Lee, Seung Soo, Park, Mi Na·2022·Current Issues in Molecular Biology

Abstract

The purpose of the current review was to explore and summarize different studies concerning the detection and characterization of candidate genes and genomic regions associated with economically important traits in Hanwoo beef cattle. Hanwoo cattle, the indigenous premium beef cattle of Korea, were introduced for their marbled fat, tenderness, characteristic flavor, and juiciness. To date, there has been a strong emphasis on the genetic improvement of meat quality and yields, such as backfat thickness (BFT), marbling score (MS), carcass weight (CW), eye muscle area (EMA), and yearling weight (YW), as major selection criteria in Hanwoo breeding programs. Hence, an understanding of the genetics controlling these traits along with precise knowledge of the biological mechanisms underlying the traits would increase the ability of the industry to improve cattle to better meet consumer demands. With the development of high-throughput genotyping, genomewide association studies (GWAS) have allowed the detection of chromosomal regions and candidate genes linked to phenotypes of interest. This is an effective and useful tool for accelerating the efficiency of animal breeding and selection. The GWAS results obtained from the literature review showed that most positional genes associated with carcass and growth traits in Hanwoo are located on chromosomes 6 and 14, among which LCORL, NCAPG, PPARGC1A, ABCG2, FAM110B, FABP4, DGAT1, PLAG1, and TOX are well known. In conclusion, this review study attempted to provide comprehensive information on the identified candidate genes associated with the studied traits and genes enriched in the functional terms and pathways that could serve as a valuable resource for future research in Hanwoo breeding programs.

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  • In Hanwoo, genomic regions under selection for carcass and growth traits are mainly located on chromosomes 6 and 14, including candidate genes LCORL, NCAPG, PPARGC1A, etc.

    “In Hanwoo, genomic regions under selection for carcass and growth traits are mainly located on chromosomes 6 and 14, including candidate genes LCORL, NCAPG, PPARGC1A, ABCG2, FAM110B, FABP4, DGAT1, PLAG1, and TOX [170,171].”

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  1. [62]Shin S. Heo J. Chung K. Chung E. Validation of molecular diagnostic markers for carcass traits in commercial Hanwoo steers Proceedings of the 56th International Congress of Meat Science and Technology (56th ICoMST) Jeju, Korea 15–20 August 2010 15 20

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Authors
Naserkheil, M., Manzari, Z., Dang, C. G., Lee, S. S., & Park, M. N.
Affiliations
  • National Institute of Animal Science (KR)
  • Animal Genetics and Breeding Unit (AU)
Corresponding author
Park, Mi Na
Venue
Current Issues in Molecular Biology
Publisher
MDPI AG
Published
2022-12-04
Volume
44
Issue
12
Pages
6075-6092
ISSN
  • 1467-3037 (ISSN-L)
  • 1467-3045
OpenAlex
W4311624373
Cited by
15
References
167
Citations by year
2026: 6 · 2025: 5 · 2024: 3 · 2023: 1
FWCI
0.35
Type
journal article
Language
en
Open access
Locations
  • Current Issues in Molecular Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Rural Development Administration (PJ015987)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
  • Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Livestock Farming and Management
Keywords
Hanwoo cattle, candidate genes, genomic regions, meat quality traits, marbling, backfat thickness, carcass characteristics, growth traits, genome-wide association study, positional candidate genes, chromosome 6, chromosome 14, LCORL, NCAPG, PGC-1α, FABP4, TOX, PLAG1, DGAT1, ABCG2, beef cattle breeding

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