Ternary MXene-loaded PLCL/collagen nanofibrous scaffolds that promote spontaneous osteogenic differentiation
Open accessAbstract
Conventional bioinert bone grafts often have led to failure in osseointegration due to low bioactivity, thus much effort has been made up to date to find alternatives. Recently, MXene nanoparticles (NPs) have shown prominent results as a rising material by possessing an osteogenic potential to facilitate the bioactivity of bone grafts or scaffolds, which can be attributed to the unique repeating atomic structure of two carbon layers existing between three titanium layers. In this study, we produced MXene NPs-integrated the ternary nanofibrous matrices of poly(L-lactide-co-ε-caprolactone, PLCL) and collagen (Col) decorated with MXene NPs (i.e., PLCL/Col/MXene), as novel scaffolds for bone tissue engineering, via electrospinning to explore the potential benefits for the spontaneous osteogenic differentiation of MC3T3-E1 preosteoblasts. The cultured cells on the physicochemical properties of the nanofibrous PLCL/Col/MXene-based materials revealed favorable interactions with the supportive matrices, highly suitable for the growth and survival of preosteoblasts. Furthermore, the combinatorial ternary material system of the PLCL/Col/MXene nanofibers obviously promoted spontaneous osteodifferentiation with positive cellular responses by providing effective microenvironments for osteogenesis. Therefore, our results suggest that the unprecedented biofunctional advantages of the MXene-integrated PLCL/Col nanofibrous matrices can be expanded to a wide range of strategies for the development of effective scaffolds in bone tissue regeneration. Graphical Abstract
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Doping MXene in PLCL enhances osteogenic differentiation induction ability of scaffold; collagen modification of scaffold surface enhances cell adhesion ability, promotes cell adhesion and growth, and promotes spontaneous ossification of MC3T3.
“Lee et al. doped MXene in PLCL to enhance the osteogenic differentiation induction ability of the scaffold (Fig. 11). Meanwhile, collagen was used to modify the scaffold surface to enhance the cell adhesion ability of the scaffold surface, promote the cell adhesion and growth on the scaffold surface, and promote the spontaneous ossification of MC3T3 [209].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [209]
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Fabrication of PLCL Block Polymer with Tunable Structure and Properties for Biomedical Application
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Self-citationAntimicrobial applications of MXenes
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MXene Chemistries for Biomedicine: On-Body, In-Body, and Beyond
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- Authors
- Lee, S. H., Jeon, S., Qu, X., Kang, M. S., Lee, J. H., Han, D.-W., & Hong, S. W.
- Affiliations
- Pusan National University (KR)
- Corresponding author
- Han, Dong-Wook
- Hong, Suck Won
- Venue
- Nano Convergence
- Published
- 2022-08-27
- Volume
- 9
- Issue
- 1
- Pages
- 38-38
- ISSN
- 2196-5404 (ISSN-L)
- PMC
- PMC9420163
- OpenAlex
- W4293332099
- Cited by
- 39
- References
- 98
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 15 · 2023: 8
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nano Convergence (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation of Korea (2021R1A2C2006013, 2021R1A5A1032937)
- Korea Medical Device Development Fund (NTIS Number: 9991006781, KMDF_PR_20200901_0108)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Materials Chemistry › MXene and MAX Phase Materials
- Keywords
- MXene nanoparticles, PLCL, collagen, nanofibrous scaffolds, bone tissue engineering, osteogenic differentiation, MC3T3-E1 preosteoblasts, electrospinning, bone graft substitutes, osseointegration, bone regeneration
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