Anti-Aging Effects of Monomethylsilanetriol and Maltodextrin-Stabilized Orthosilicic Acid on Nails, Skin and Hair
Open accessAbstract
Chemical form of silicon determines its absorption and bioavailability: particulate and polymerized forms exhibit minimal oral bioavailability, while monomers (maltodextrin-stabilized orthosilicic acid, M-OSA) and organic compounds (monomethylsilanetriol, MMST) may hypothetically be highly absorbed. This study aimed to investigate the dermatological effects of oral ingestion of silicon, either solid (M-OSA–SiliciuMax® Powder) or liquid (MMST, SiliciuMax® Liquid) on the skin, hair and nails of healthy volunteers, through a clinical trial (Registry number 2,032,724. Full protocol at Plataforma Brasil website). Patients were randomized to receive 5 mg of elemental Si, either M-OSA or MMST (group 1 and 2, n = 17 each) or placebo (group 3, n = 17) twice a day for 150 days. Clinical and patients’ subjective evaluations were conducted. Multispectral face imaging and hair mineral analysis were also performed. Use of M-OSA and MMST provided significant (p < 0.05) betterment of facial wrinkles and UV spots. Changes were also observed at the end of the study in skin texture and length of eyelashes. Hair aluminum levels decrease with the treatments. Self-reported questionnaire indicated good satisfaction with both M-OSA and MMST. Continuous use of both M-OSA and MMST can provide improvements on skin parameters, as well as act as a detox agent for aluminum.
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Silicon promotes the synthesis of elastin and GAGs, helps to preserve blood vessel elasticity, and increases the resistance and thickness of nail and hair fibers.
“Si also promotes the synthesis of elastin and GAGs, helps to preserve blood vessel elasticity, and increases the resistance and thickness of nail and hair fibers [135].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [135]
Oral intake of maltodextrin-stabilized orthosilicic acid and monomethylsilanetriol improves skin parameters, increases eyelash length, reduces facial wrinkles and UV spots, and acts as aluminum detoxification agents.
“Ferreira et al. investigated the oral intake of two forms of Si—maltodextrin-stabilized orthosilicic acid (M-OSA) and monomethylsilanetriol (MMST)—and their effects on the nails, skin and hair. They were found to improve skin parameters, increase eyelash length, reduce facial wrinkles and UV spots, and act as aluminum detoxification agents [135].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [135]
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“Complementing these findings, a study by Ferreira et al. (2018) showed that other forms of stabilized OSA, namely maltodextrin-stabilized OSA and MMST, also improved facial wrinkles and UV spots.”
- Authors
- Ferreira, A. O., Freire, É. S., Polonini, H. C., Da Silva, P. J. L. C., Brandão, M. A. F., & Raposo, N. R. B.
- Affiliations
- Universidade Federal de Juiz de Fora (BR)
- Núcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora 36036-900, MG, Brazil
- Corresponding author
- Polonini, Hudson Caetano
- ORCID
- Venue
- Cosmetics
- Publisher
- MDPI AG
- Published
- 2018-07-02
- Volume
- 5
- Issue
- 3
- Pages
- 41
- ISSN
- 2079-9284 (ISSN-L)
- OpenAlex
- W2810720834
- Cited by
- 13
- References
- 38
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 1
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Cosmetics (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Silicon Effects in Agriculture
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- silicon supplementation, anti-aging effects, skin aging, wrinkles, skin texture, eyelash length, hair, nails, hair mineral analysis
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