Evaluation of cutaneous rejuvenation associated with the use of ortho-silicic acid stabilized by hydrolyzed marine collagen
Abstract
BACKGROUND: Organic silicon plays an important role in dermal structure by promoting neocollagenesis. Thus, the supplementation of silicon in a highly bioavailable form can be used for skin rejuvenation. AIMS: This study aimed to evaluate skin changes associated with the use of ortho-silicic acid stabilized by hydrolyzed collagen. PATIENTS/METHODS: Patients were randomized to receive 600 mg of ortho-silicic acid stabilized by hydrolyzed collagen (group 1, n = 11) or placebo (group 2, n = 11) to be taken 15 minutes before breakfast for 90 days. Clinical, photographical, and patients' subjective evaluations were conducted. RESULTS: A total of 22 patients were included. Clinical evaluations demonstrated changes in skin texture, firmness, and hydration statistically superior in group 1. Brightness, firmness, and overall appearance showed trends for a difference favoring group 1 according to patients' subjective evaluations. Objective images showed no statistical differences. No side effects, hypersensitivity, or systemic symptoms were observed in group 1. Treatment satisfaction in group 1 reached 80%. CONCLUSIONS: Ortho-silicic acid stabilized by hydrolyzed collagen in a daily dose of 600 mg showed positive results in skin rejuvenation according to clinical evaluation in firmness, hydration, and skin texture. Further studies with larger and representative samples should be conducted to confirm our results.
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Orthosilicic acid stabilized with hydrolyzed marine collagen at 600 mg/day has a positive effect on skin texture, firmness and hydration.
“Kalil et al. described the positive effect of orthosilicic acid stabilized with hydrolyzed marine collagen at 600 mg/day on skin texture, firmness and hydration [141].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [141]
Supplementation with silicon in a highly bioavailable form can be used for skin rejuvenation.
“Supplementation with silicon in a highly bioavailable form can be used for skin rejuvenation [141].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [141]
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Bioactive Compounds for Skin Health: A Review
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“[18] affirm that one of the diverse Si supplem nts in the most r scribed oral product for skin rejuvenation in Brazil.”
BackgroundInfluentialNukaly, H. Y., Halawani, I. R., Irtaza, H. M., Alturkistani, T., Serafi, M. R., Alhawsawi, W., Bogari, H. O., Ahmed, F. A., Alhaddad, Y., Shadid, A., et al. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1618306 · Cited by 3 · see citing works
- Authors
- Petersen Vitello Kalil, C. L., Campos, V., Cignachi, S., Favaro Izidoro, J., Prieto Herman Reinehr, C., & Chaves, C.
- Affiliations
- Célia Kalil Dermatologic Clinic Porto Alegre—Rio Grande de Sul Brazil
- Valéria Campos Dermatologic Clinic Jundiaí—São Paulo Brazil
- Pharmaceutical Farmatec Pharmacy Porto Alegre Brazil
- Venue
- Journal of Cosmetic Dermatology
- Publisher
- Wiley
- Published
- 2017-09-20
- Volume
- 17
- Issue
- 5
- Pages
- 814-820
- ISSN
- 1473-2130 (ISSN-L)
- 1473-2165
- OpenAlex
- W2760359980
- Cited by
- 22
- References
- 23
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cosmetic Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- skin rejuvenation, silicon supplementation, skin firmness, skin hydration, skin texture, neocollagenesis, oral supplementation
- MeSH terms
- Administration, Oral, Adult, Collagen, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Prospective Studies, Rejuvenation, Silicic Acid, Skin Aging, Drug Delivery Systems, Treatment Outcome
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