Skin Protective Activity of LactoSporin-the Extracellular Metabolite from Bacillus Coagulans MTCC 5856
Open accessAbstract
Background: Probiotics and their products are increasingly used in skincare in recent years. Postbiotics are defined as any substance derived through the metabolic activity of a probiotic microorganism, which exerts a direct or indirect beneficial effect on the host. The extracellular metabolites of probiotic bacteria have antimicrobial activities, protect against acne, and improve skin condition. We studied skin protective activities of the extracellular metabolite (LactoSporin) of a spore-forming probiotic Bacillus coagulans MTCC 5856 in vitro. Methods: LactoSporin was evaluated for antioxidant activity by free radical scavenging activity and reactive oxygen quenching activity in human dermal fibroblast cells. Protection of fibroblasts from UV-induced apoptosis and cell death was studied by flow cytometry and neutral red uptake assays. Enzyme inhibition assays were carried out for collagenase, Elastase, and Hyaluronidase. Gene expression studies were carried out using polymerase chain reaction. Results: LactoSporin showed antioxidant activity and was found to protect skin cells from UV-induced apoptosis and cell death. LactoSporin inhibited collagenase, elastase, and hyaluronidase activity and upregulated the expression of hyaluronan synthase, transforming growth factor and epidermal growth factor, which are associated with extracellular matrix integrity. Conclusions: These results suggest LactoSporin is a skin protective postbiotic with wide application in cosmetic formulations.
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Chaudhuri, J., Bains, Y., Guha, S., Kahn, A., Hall, D., Bose, N., Gugliucci, A., & Kapahi, P. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.014 · Cited by 669 · cited 2× · see citing works
“Glycation in skin due to the undesired cross-linking of collagen proteins with sugar molecules eventually impairs the function of collagen fibers, leading to skin hardening and aging [38].”
BackgroundCharacteristics of the Aging Skin
Farage, M. A., Miller, K. W., Elsner, P., & Maibach, H. I. (2013) · Advances in Wound Care · doi:10.1089/wound.2011.0356 · Cited by 535 · see citing works
Prescott, S. L., Larcombe, D.-L., Logan, A. C., West, C., Burks, W., Caraballo, L., Levin, M., Etten, E. V., Horwitz, P., Kozyrskyj, A., et al. (2017) · World Allergy Organization Journal · doi:10.1186/s40413-017-0160-5 · Cited by 347 · see citing works
Huang, Y. J., Marsland, B. J., Bunyavanich, S., O'Mahony, L., Leung, D. Y. M., Muraro, A., & Fleisher, T. A. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.02.007 · Cited by 330 · see citing works
Free Radicals and Extrinsic Skin Aging
Poljšak, B., & Dahmane, R. (2012) · Dermatology Research and Practice · doi:10.1155/2012/135206 · Cited by 316 · see citing works
De Marco, S., Sichetti, M., Muradyan, D., Piccioni, M., Traina, G., Pagiotti, R., & Pietrella, D. (2018) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2018/1756308 · Cited by 297 · see citing works
Göllner, I., Voss, W., von Hehn, U., & Kammerer, S. (2017) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/2156587217743640 · Cited by 54 · see citing works
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- Authors
- Majeed, M., Majeed, S., Nagabhushanam, K., Lawrence, L., Arumugam, S., & Mundkur, L.
- Affiliations
- Sami Labs (India) (IN)
- Sabinsa Corporation, 20 Lake Drive, East Windsor, NJ 08520, USA
- Corresponding author
- Mundkur, Lakshmi
- Venue
- Cosmetics
- Publisher
- MDPI AG
- Published
- 2020-09-27
- Volume
- 7
- Issue
- 4
- Pages
- 76
- ISSN
- 2079-9284 (ISSN-L)
- OpenAlex
- W3087929852
- Cited by
- 34
- References
- 7
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 6 · 2023: 10 · 2022: 4 · 2021: 1 · 2020: 1
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cosmetics (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Keywords
- Bacillus coagulans, postbiotics, extracellular metabolites, skin protection, antioxidant activity, free radical scavenging, UV-induced apoptosis, human dermal fibroblasts, collagenase inhibition, elastase inhibition, hyaluronidase inhibition, hyaluronan synthase, extracellular matrix, epidermal growth factor, transforming growth factor
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