Ingestion of an oral hyaluronan solution improves skin hydration, wrinkle reduction, elasticity, and skin roughness: Results of a clinical study
Open accessAbstract
Intake of oral supplements with the aim of a cutaneous antiaging effect are increasingly common. Hyaluronic acid (HA) is a promising candidate, as it is the key factor for preserving tissue hydration. In our practice study, we evaluated the effect of an oral HA preparation diluted in a cascade-fermented organic whole food concentrate supplemented with biotin, vitamin C, copper, and zinc (Regulatpro Hyaluron) on skin moisture content, elasticity, skin roughness, and wrinkle depths. Twenty female subjects with healthy skin in the age group of 45 to 60 years took the product once daily for 40 days. Different skin parameters were objectively assessed before the first intake, after 20 and after 40 days. Intake of the HA solution led to a significant increase in skin elasticity, skin hydration, and to a significant decrease in skin roughness and wrinkle depths. The supplement was well tolerated; no side effects were noted throughout the study.
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Clinical studies have proven that oral supplementation with HA could improve skin moisture and elasticity and relieve wrinkles and roughness in eye skin.
“Clinical studies have proven that oral supplementation with HA could improve skin moisture and elasticity and relieve wrinkles and roughness in eye skin [127].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [127]
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- Authors
- Göllner, I., Voss, W., von Hehn, U., & Kammerer, S.
- Affiliations
- Dermatest GmbH, Münster, Germany
- Medistat GmbH, Kronshagen, Germany
- Scriptamed GmbH, Kirchheim, Germany
- Venue
- Journal of Evidence-Based Complementary & Alternative Medicine
- Publisher
- SAGE Publications
- Published
- 2017-10
- Volume
- 22
- Issue
- 4
- Pages
- 816-823
- ISSN
- 1076-1675 (ISSN-L)
- 2156-5872
- 2156-5899
- PMC
- PMC5871318
- OpenAlex
- W2772006446
- Cited by
- 54
- References
- 44
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 2 · 2023: 9 · 2022: 10 · 2021: 9 · 2020: 7 · 2019: 3 · 2018: 2
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Evidence-Based Complementary & Alternative Medicine (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Dr. Niedermaier Pharma GmbH
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- hyaluronic acid, oral supplementation, skin hydration, skin elasticity, skin roughness, wrinkle depth, anti-aging, skin aging, biotin, vitamin C, copper, zinc
- MeSH terms
- Administration, Oral, Ascorbic Acid, Biotin, Copper, Drug Combinations, Female, Humans, Hyaluronic Acid, Middle Aged, Rejuvenation, Zinc, Skin Aging, Treatment Outcome, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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