A state-of-the-art review on the alternatives to animal testing for the safety assessment of cosmetics

Guidelines for snowballing in systematic literature studies and a replication in software engineering

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METHODS FOR THE STUDY OF IRRITATION AND TOXICITY OF SUBSTANCES APPLIED TOPICALLY TO THE SKIN AND MUCOUS MEMBRANES

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Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

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Alternatives to animal testing: a review

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Test No. 471: Bacterial Reverse Mutation Test

OECD (2009) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264071247-en · Cited by 442 · see citing works

Test No. 423: Acute Oral toxicity - Acute Toxic Class Method

OECD (2002) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264071001-en · Cited by 436 · see citing works

The relationship between knowledge and attitudes in the public understanding of science in Britain

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Perceived Risk, Real Risk: Social Science and the Art of Probabilistic Risk Assessment

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Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

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Test No. 487: In Vitro Mammalian Cell Micronucleus Test

OECD (2016) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264264861-en · Cited by 280 · see citing works

The US Federal Tox21 Program: A strategic and operational plan for continued leadership

Thomas, R. (2018) · ALTEX · doi:10.14573/altex.1803011 · Cited by 229 · see citing works

A Review of In Silico Tools as Alternatives to Animal Testing: Principles, Resources and Applications

Madden, J. C., Enoch, S. J., Paini, A., & Cronin, M. (2020) · Alternatives to Laboratory Animals · doi:10.1177/0261192920965977 · Cited by 215 · see citing works

A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom–Up and Top–Down approaches

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Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme

Eastmond, D. A., Hartwig, A., Anderson, D. C., Anwar, W. A., Cimino, M. C., Dobrev, I. D., Douglas, G. R., Nohmi, T., Phillips, D. H., & Vickers, C. (2009) · Mutagenesis · doi:10.1093/mutage/gep014 · Cited by 213 · see citing works

The ECVAM International Validation Study on In Vitro Tests for Skin Corrosivity. 2. Results and Evaluation by the Management Team

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Animal testing and its alternatives—the most important omics is economics

Meigs, L. (2018) · ALTEX · doi:10.14573/altex.1807041 · Cited by 184 · see citing works

Green Marketing: A Study of Consumer Perception and Preferences in India

Bhatia, M., & Jain, A. K. (2014) · Electronic Green Journal · doi:10.5070/g313618392 · Cited by 176 · see citing works

Public Attitudes toward Animal Research: A Review

Ormandy, E., & Schuppli, C. A. (2014) · Animals · doi:10.3390/ani4030391 · Cited by 170 · see citing works

Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method

OECD (2015) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264242845-en · Cited by 170 · see citing works

In silico toxicology: From structure–activity relationships towards deep learning and adverse outcome pathways

Hemmerich, J., & Ecker, G. F. (2020) · Wiley Interdisciplinary Reviews Computational Molecular Science · doi:10.1002/wcms.1475 · Cited by 169 · see citing works

In Silico Toxicology – Non-Testing Methods

Raunio, H. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00033 · Cited by 167 · see citing works

Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure

OECD (2002) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264070943-en · Cited by 165 · see citing works

Public Attitudes Toward Animal Research: Some International Comparisons

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The role of hazard- and risk-based approaches in ensuring food safety

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Phototoxicity: Its Mechanism and Animal Alternative Test Methods

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Skin Irritation and Sensitization: Mechanisms and New Approaches for Risk Assessment

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Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens

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Skin Irritation and Sensitization: Mechanisms and New Approaches for Risk Assessment

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Green Toxicology: a strategy for sustainable chemical and material development

Crawford, S. E., Härtung, T., Hollert, H., Mathes, B., van Ravenzwaay, B., Steger‐Hartmann, T., Studer, C., & Krug, H. F. (2017) · Environmental Sciences Europe · doi:10.1186/s12302-017-0115-z · Cited by 128 · see citing works

Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods

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Test No. 442D: In Vitro Skin Sensitisation

OECD (2015) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264229822-en · Cited by 123 · see citing works

Test No. 442E: In Vitro Skin Sensitisation

OECD (2016) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264264359-en · Cited by 123 · see citing works

Test No. 442C: In Chemico Skin Sensitisation

OECD (2015) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264229709-en · Cited by 122 · see citing works

Test No. 432: In Vitro 3T3 NRU Phototoxicity Test

OECD (2009) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264071162-en · Cited by 114 · see citing works

Extrapolation of animal toxicity to humans: Interspecies comparisons in drug development

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Development of a next generation risk assessment framework for the evaluation of skin sensitisation of cosmetic ingredients

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The Integrated Project ReProTect: A novel approach in reproductive toxicity hazard assessment

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Food for thought... on the economics of animal testing

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Quantitative In Vitro Assessment of Phototoxicity by a Fibroblast-Neutral Red Assay

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Test No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

OECD (2013) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264203846-en · Cited by 84 · see citing works

Photochemical genotoxicity: principles and test methods

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Stem cell-based retina models

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The way forward for assessing the human health safety of cosmetics in the EU - Workshop proceedings

Rogiers, V., Benfenati, E., Bernauer, U., Bodin, L., Carmichael, P. L., Chaudhry, Q., Coenraads, P. J., Cronin, M., Dent, M. P., Dušinská, M., et al. (2020) · Toxicology · doi:10.1016/j.tox.2020.152421 · Cited by 74 · see citing works

Safety Testing of Cosmetic Products: Overview of Established Methods and New Approach Methodologies (NAMs)

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A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States

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Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part IV:Recommendation of a Working Group of the Gesellschaft fuer Umwelt-Mutationsforschung (GUM) for a Simple and Straightforward Approach to Genotoxicity Testing

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Test No. 492: Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage

OECD (2015) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264242548-en · Cited by 71 · see citing works

From in vivo to in vitro: The medical device testing paradigm shift

Myers, D. (2017) · ALTEX · doi:10.14573/altex.1608081 · Cited by 66 · see citing works

International regulatory needs for development ofan IATA for non-genotoxic carcinogenic chemical substances

Jacobs, M. N. (2016) · ALTEX · doi:10.14573/altex.1601201 · Cited by 62 · see citing works

Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop

Corvi, R., Madia, F., Guyton, K. Z., Kasper, P., Rudel, R. A., Colacci, A., Kleinjans, J. C. S., & Jennings, P. (2017) · Toxicology in Vitro · doi:10.1016/j.tiv.2017.09.010 · Cited by 61 · see citing works

Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method

OECD (2016) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264264618-en · Cited by 59 · see citing works

Replacement of in vivo acute oral toxicity studies by in vitro cytotoxicity methods: Opportunities, limits and regulatory status

Ukelis, U., Kramer, P.-J., Olejniczak, K., & Mueller, S. O. (2008) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2008.02.002 · Cited by 57 · see citing works

Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments

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Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

OECD (2015) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264242432-en · Cited by 51 · see citing works

The Assessment of Repeated Dose Toxicity In Vitro : A Proposed Approach

Prieto, P., Baird, A. W., Blaauboer, B. J., Ripoll, J. V. C., Corvi, R., Dekant, W., Dietl, P., Gennari, A., Gribaldo, L., Griffin, J. L., et al. (2006) · Alternatives to Laboratory Animals · doi:10.1177/026119290603400307 · Cited by 50 · see citing works

Green cosmetics: perspectives and challenges in the context of green chemistry

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Ban of Cosmetic Testing on Animals: A Brief Overview

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Regulatory acceptance of in silico approaches for the safety assessment of cosmetic-related substances

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Test No. 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

OECD (2013) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264203860-en · Cited by 43 · see citing works

The Draize test—Motivations for change

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NAM-supported read-across: From case studies to regulatory guidance in safety assessment

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The transformics assay: first steps for the development of an integrated approach to investigate the malignant cell transformation in vitro

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A Systematic Review of Published Physiologically-based Kinetic Models and an Assessment of their Chemical Space Coverage

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Innovative non-animal testing strategies for reproductive toxicology: the contribution of Italian partners within the EU project ReProTect.

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What’s Cruel About Cruelty Free: An Exploration of Consumers, Moral Heuristics, and Public Policy

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Test No. 442B: Skin Sensitization

OECD (2010) · OECD guidelines for the testing of chemicals. Section 4: Health effects · doi:10.1787/9789264090996-en · Cited by 34 · see citing works

Attitudes towards the use of genetically modified animals in research

Schuppli, C. A., & Weary, D. M. (2010) · Public Understanding of Science · doi:10.1177/0963662510362834 · Cited by 31 · see citing works

Continuing animal tests on cosmetic ingredients for REACH in the EU

Knight, J. (2021) · ALTEX · doi:10.14573/altex.2104221 · Cited by 31 · see citing works

Let the people speak

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Public Attitudes toward the Use of Animals in Research: Effects of Invasiveness, Genetic Modification and Regulation

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Integration of data across toxicity endpoints for improved safety assessment of chemicals: the example of carcinogenicity assessment

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EURL ECVAM strategy for achieving 3Rs impact in the assessment of toxicokinetics and systemic toxicity

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Phototoxicity Evaluation of Pharmaceutical Substances with a Reactive Oxygen Species Assay Using Ultraviolet A

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A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity

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Extrapolation of Animal Research Data to Humans: An Analysis of the Evidence

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The Effects of Chemicals on Mammalian Fertility

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Impact of ‘Green’ Product Label Standards on Consumer Behaviour: A Systematic Review Analysis

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THE INFLUENCE OF CONSUMER PERCEPTION TOWARDS GREEN ADVERTISING ON GREEN PURCHASE INTENTIONPreprint

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History of the 3Rs in Toxicity Testing: From Russell and Burch to 21st Century Toxicology

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Cost-Effectiveness Analysis of Chemical Testing for Decision-Support: How to Include Animal Welfare?

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Openness about animal research increases public support

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A Tutorial for Analysing the Cost-effectiveness of Alternative Methods for Assessing Chemical Toxicity: The Case of Acute Oral Toxicity Prediction

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Institutional transparency improves public perception of lab animal technicians and support for animal research

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Hepatotoxicity Screening Taking a Mode-Of-Action Approach Using HepaRG Cells and HCA

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TG 494: Vitrigel-Eye Irritancy Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage

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Acute Systemic Toxicity: Oral, Dermal and Inhalation Exposures

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The current status of alternative methods for cosmetics safety assessment in China

Luo, F.-Y. (2018) · ALTEX · doi:10.14573/altex.1808021 · Cited by 5 · see citing works

Reproductive Toxicity and Endocrine Disruption

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European Centre for the Validation of Alternative Methods (ECVAM): its role and contribution

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History and Social Duties in Future of the AATEX: Alternatives to Animal Testing and Experimentation

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The dark side of beauty: an in-depth analysis of the health hazards and toxicological impact of synthetic cosmetics and personal care products

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Skin-on-a-chip technologies towards clinical translation and commercialization

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Glycolipid Biosurfactants in Skincare Applications: Challenges and Recommendations for Future Exploitation

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Exploitation of alternative skin models from academia to industry: proposed functional categories to answer needs and regulation demands

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AttentiveSkin: To Predict Skin Corrosion/Irritation Potentials of Chemicals via Explainable Machine Learning Methods

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In Vitro Skin Models as Non-Animal Methods for Dermal Drug Development and Safety Assessment

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Toxicity Tests for Chemical Pesticide Registration: Requirement Differences among the United States, the European Union, Japan, and China?

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Towards skin-on-a-chip for screening the dermal absorption of cosmetics

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In vitro hepatic 3D cell models and their application in genetic toxicology: A systematic review

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Application and Safety Research of Nanotechnology in Cosmetics: Current Status, Challenges, and Future Prospects

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A review on tailoring lignin derivatives for sunscreen formulations: Structural modification and antioxidant properties for enhanced UV protection

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Evaluation of the Safety of Cosmetic Ingredients and Their Skin Compatibility through In Silico and In Vivo Assessments of a Newly Developed Eye Serum

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Hydrodynamically generated multilayer skin spheroids enable in vitro screening of biologically active ingredients and toxicity tests

Chen, Z., Kalhori, D., Rakhshani, F., Baraka, O. E., Qu, L., Kolle, S. N., Andre, V., Deisenroth, T. W., & Kumacheva, E. (2025) · Science Advances · doi:10.1126/sciadv.adu1251 · Cited by 14 · see citing works

Multiscale modeling of molecule transport through skin’s deeper layers

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Organ‐on‐Chip: The Future of Nutrition Research in a One Health World

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Guidelines for Manufacturing and Application of Organoids: Skin

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New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches

Islas‐Robles, A., Ramani, M., Phillips, J., & Costin, G. (2025) · Toxics · doi:10.3390/toxics13080693 · Cited by 11 · see citing works

Transgenic Zebrafish Expressing Rat Cytochrome P450 2E1 (CYP2E1): Augmentation of Acetaminophen-Induced Toxicity in the Liver and Retina

Sato, Y., Dong, W., Nakamura, T., Mizoguchi, N., Nawaji, T., Nishikawa, M., Onaga, T., Ikushiro, S., Kobayashi, M., & Teraoka, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044013 · Cited by 11 · see citing works

Miniaturized method for the quantification of persistent organic pollutants and their metabolites in HepG2 cells: assessment of their biotransformation

Oro‐Carretero, P. D., & Sanz-Landaluze, J. (2023) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-023-04781-w · Cited by 11 · see citing works

Study of Elastin, Hydrolyzed Collagen and Collagen-like Products in a Tri-Layered Chitosan Membrane to Test Anti-Aging Skin Properties

Guerle-Cavero, R., & Balfagón-Costa, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311016 · Cited by 11 · see citing works

The TOXIN knowledge graph: supporting animal-free risk assessment of cosmetics

Sepehri, S., Heymans, A., Win, D. D., Maushagen, J., Sanctorum, A., Debruyne, C., Rodrigues, R. M., Kock, J. D., Rogiers, V., Troyer, O. D., et al. (2025) · Database · doi:10.1093/database/baae121 · Cited by 7 · see citing works

Overview of In Silico Tools to Evaluate Human Health Toxicity, Ecotoxicity, and Toxicokinetic Profiles in the Hazard Assessment of Chemicals Used in Cosmetics

Lancia, P., Louazzani, M., Gros, L., Ginestar, J., Fioravanzo, E., & Baleydier, A. (2025) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.4c00534 · Cited by 8 · see citing works

Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture

Piasek, A. M., Levkovych, I., Musolf, P., Chmielewska, H., Ścieżyńska, A., & Sobiepanek, A. (2023) · Journal of Visualized Experiments · doi:10.3791/65773 · Cited by 8 · see citing works

Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry

Lachance, G. P., Gauvreau, D., Boisselier, É., Boukadoum, M., & Miled, A. (2024) · Sensors · doi:10.3390/s24020647 · Cited by 8 · see citing works

Combining a microphysiological system of three organ equivalents and transcriptomics to assess toxicological endpoints for cosmetic ingredients

Indolfo, N. D. C., Ganzerla, M. D., Doratioto, T. R., Avelino, T. M., Tofani, L. B., Peroni, L. A., Rabelo, R. S., Arroteia, K. F., & Figueira, A. C. M. (2023) · Lab on a Chip · doi:10.1039/d3lc00546a · Cited by 7 · see citing works

Applying new approach methodologies to assess next-generation tobacco and nicotine products

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Lipid Biomimetic Models as Simple Yet Complex Tools to Predict Skin Permeation and Drug–Membrane Biophysical Interactions

Fernandes, E., Lopes, C. M., & Lúcio, M. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16060807 · Cited by 6 · see citing works

Tissue Engineering in Cosmetics and Dermatology: A New Era of Innovation and Application

Golchin, A., Rahnama, M., Chapani, M. S., Shams, F., Rekabgardan, M., Poursalehi, Z., & Ranjbarvan, P. (2025) · The Open Dermatology Journal · doi:10.2174/0118743722398355250709053244 · Cited by 6 · see citing works

Purified Acidic Sophorolipid Biosurfactants in Skincare Applications: An Assessment of Cytotoxic Effects in Comparison with Synthetic Surfactants Using a 3D In Vitro Human Skin Model

Adu, S. A., Twigg, M. S., NAUGHTON, P. J., Marchant, R., & Banat, I. M. (2023) · Fermentation · doi:10.3390/fermentation9110985 · Cited by 6 · see citing works

From animal testing to in Silico models: a systematic review and practical guide to cosmetic assessment

Vasiljev, T. G., Salvioni, L., Colombo, M., Galli, P., & Greselin, F. (2025) · Statistical Methods & Applications · doi:10.1007/s10260-025-00794-0 · Cited by 5 · see citing works

Assessing the Toxic Potential of New Entities: The Role of Cytotoxicity Assays

Çetin, Y. (2025) · Biochemistry · doi:10.5772/intechopen.1008309 · Cited by 5 · see citing works

Advances in skin-on-a-chip technology: Functional innovations and translational challenges

Zhang, J., Zhang, Q., Fang, X., Guo, G. S., & Wang, X. (2025) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2025.118500 · Cited by 5 · see citing works

The dawn of animal-free safety: A comprehensive review of new approach methodologies in 21st century toxicology

Jadhav, V., Gurgude, R., & Sawant, R. (2025) · Next research. · doi:10.1016/j.nexres.2025.100986 · Cited by 5 · see citing works

Mechanistic toxicity profiling of chemicals: A comparative study in 2D and 3D HepaRG models using high-content analysis

Saleh, M., Hogeveen, K. N., Fessard, V., & Hégarat, L. L. (2025) · Toxicology · doi:10.1016/j.tox.2025.154280 · Cited by 4 · see citing works

Responses of an In Vitro Coculture Alveolar Model for the Prediction of Respiratory Sensitizers (ALIsens®) Following Exposure to Skin Sensitizers and Non-Sensitizers

Burla, S., Chary, A., Serchi, T., Cambier, S., Sullivan, K. M., Baker, E. J., Sadekar, N., & Gutleb, A. C. (2024) · Toxics · doi:10.3390/toxics13010029 · Cited by 4 · see citing works

Responsible and Sustainable Beauty Consumption for Wellbeing of Older Adults

Daniels, G., & Gupta, S. (2025) · Journal of Macromarketing · doi:10.1177/02761467251331440 · Cited by 3 · see citing works

Assessment of Systemic Safety of Althaea rosea Flower Extract for Use in Cosmetics: Threshold of Toxicological Concern and History of Safe Consumption Approaches

Gil, S., & Lim, K. (2025) · Cosmetics · doi:10.3390/cosmetics12040133 · Cited by 3 · see citing works

New approach methodologies for next-generation risk assessment of nanomaterials and nano-enabled products

Lee, E., Chary, A., Gerelkhuu, Z., Weber, P., Virmani, I., Brugger, B. A., Ribeiro, I. R. S., Brun, E., Lacconi, V., Bang, H., et al. (2026) · Nano Convergence · doi:10.1186/s40580-026-00566-w · Cited by 5 · see citing works

Can next generation ecological risk assessment decisions be made today?―A case study of regulatory risk assessment in the United States

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Evaluation of chemical-mediated alterations in production of cytokines derived in vitro from THP-1 cell line

Lee, D., Acharya, M., Kim, S., Maharjan, A., Na, Y. R., Lee, G., Kim, C., Heo, Y., & Kim, H. (2025) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2025.2549556 · Cited by 2 · see citing works

Alternatives to animal testing in cosmetic products: A patent applications review and future perspectives

Cedrola, C. C., Cedrola, C. C., de Paula, A. C. C., da Costa, J. D. C., & Vilela, F. M. P. (2025) · Toxicology in Vitro · doi:10.1016/j.tiv.2025.106187 · Cited by 2 · see citing works

Decision matrix for integrating 3D printing technologies for biomanufacturing of alternative testing model

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الوعي المعرفي لدى المستهلك لاستخدام الحيوانات في التجارب المخبرية لإنتاج مستحضرات التجميل (رؤية جرافيكية)

Jokhrasha, A. H. A., Omar, M. K. A. E. S., Basyouni, N. S. E. S. E., & Ismal, D. A. S. (2024) · Dirasat Human and Social Sciences · doi:10.35516/hum.v51i5.4746 · Cited by 1 · see citing works

Let’s talk about “talking” dogs! Reviewing the science behind a bold idea

Lenkei, R., Fraga, P. P., Zsiros, L. R., Szigeti, B., & Faragó, T. (2025) · Biologia Futura · doi:10.1007/s42977-025-00276-0 · Cited by 1 · see citing works

Bridging the attitude–intention gap in vegan cosmetics consumption: an investigation with Brazilian consumers

Rauber, G. N., Bagatini, F. Z., & Fagundes, A. F. A. (2026) · Journal of Consumer Marketing · doi:10.1108/jcm-10-2024-7297 · Cited by 1 · see citing works

Strategic Developments for Pre-clinical Safety/Efficacy Studies of Hair Care Products

Srivastava, A., Srivastava, A. K., & Pant, A. B. (2024) · Springer eBooks · doi:10.1007/978-981-97-6740-3_14 · Cited by 1 · see citing works

Investigation of additional suitable positive controls in the human Cell Line Activation Test

Nakayama, K., Oeda, S., Mizumachi, H., Hirota, M., Tamura, A., & Miyazawa, M. (2025) · The Journal of Toxicological Sciences · doi:10.2131/jts.50.1 · Cited by 1 · see citing works

Artificial Skin Models for Animal-Free Testing: 3D Skin Reconstruct Approach, a Journey in the Past Two Decades

Pandey, R., & Poojan, S. (2023) · Springer eBooks · doi:10.1007/978-981-99-2804-0_1

JoVE Video Dataset

Piasek, A. M., Levkovych, I., Musolf, P., Chmielewska, H., Ścieżyńska, A., & Sobiepanek, A. (2023) · doi:10.3791/65773-v

Cell-based in vitro models for dermal permeability studies

Silva, A. M., Bessa, M. J., & Rodrigues, F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15510-9.00007-4

Developing an in vitro repeat-dose approach to detect non-genotoxic carcinogens (NGCs)

Pritchard, D. (2024) · doi:10.23889/suthesis.66287

Noninvasive Bioengineering Methods for the Evaluation of Cosmeceutical Efficacy

Yingngam, B. (2024) · Advances in chemical and materials engineering book series · doi:10.4018/979-8-3693-5473-5.ch015

Application of Nanochitosan as Food Additive and Preservatives

Oyegbade, S. A., Oni, G. J., Kolawole, A., Yetu, T. P., Oyewole, O. A., Adetunji, C. O., Eniola, K. I. T., & Yerima, M. B. (2025) · doi:10.1002/9781394214945.ch9

Anti-Aging Evaluation of Cosmetics on a Tri-Layered Chitosan Membrane: An Alternative to Animal Testing

Guerle-Cavero, R., & Balfagón-Costa, A. (2025) · Cosmetics · doi:10.3390/cosmetics12060277

Advances in the application of computational toxicology in cosmetic safety assessment

Zhou, Z., Guo, D., Liang, J., Li, Y., Wu, Q., & Fang, J. (2026) · Archives of Toxicology · doi:10.1007/s00204-025-04282-y

Regulatory aspects of cosmetic product testing and the role of alternative models in modern strategies

Katona, G., Vojvodić, S., & Stojiljković, D. (2026) · Pravo - teorija i praksa · doi:10.5937/ptp2601064k

Environmental considerations in skincare

Raza, M., & Nazir, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-41640-8.00011-8

Do halal certification and cruelty-free labeling affect purchase decisions for local cosmetic products?

Zahra, A., Hidayati, N., & Ruslan, M. (2026) · Halal Studies and Society · doi:10.29244/hass.3.1.10-13

Green Biosynthesis of Phycobiliprotein-Mediated TiO₂ Nanoparticles and Their Application in Nigella Sativa–Based Antioxidant and Antimicrobial Topical Gels

Dehghanizadeh, M., & Nowruzi, B. (2026) · BioNanoScience · doi:10.1007/s12668-026-02694-3

Next-Generation Risk Assessment for cosmetic ingredients: a critical evaluation of published case studies

Nepal, R. U., 권세옥, & Kim, K. (2026) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2026.2702958

Beliefs about animal emotions are associated with self-reported consumer behaviors related to animal use

Kisley, M. A. (2026) · PLoS ONE · doi:10.1371/journal.pone.0354794

Convergent design principles for functional sensory innervation in bioprinted and engineered skin constructs

Pandya, T. J., Shariatzadeh, F. J., Logsetty, S., Spiwak, R. P., & Liu, S. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.08.006

Toxicity and Safety Assessment of Heterocyclic Anticancer Agents

Kesharwani, G., Mishra, A., Mishra, P., & Dewangan, S. (2026) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898817084126010012

An evidence-informed commentary on animal experimentation regulation and the development of alternative methods in six Latin American countries

Concha, D. A. M., & Vilos, R. V. (2026) · Evidence-Based Toxicology · doi:10.1080/2833373x.2026.2706752

Safety Assessment of Cosmetic Ingredients

Kojima, H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802005-0.00051-3 · Cited by 3 · see citing works

Safety Testing of Cosmetic Products: Overview of Established Methods and New Approach Methodologies (NAMs)

Barthe, M., Bavoux, C., Finot, F., Mouche, I., Petrenci, C. C., Forreryd, A., Hansson, A. C., Johansson, H., Lemkine, G. F., Thénot, J., et al. (2021) · Cosmetics · doi:10.3390/cosmetics8020050 · Cited by 73 · see citing works

The way forward for assessing the human health safety of cosmetics in the EU: Proceedings of Workshop 2

Rogiers, V., Benfenati, E., Bernauer, U., Bodin, L., Browne, P., Cabaton, N. J., Chaudhry, Q., Coenraads, P. J., Corsini, E., Dent, M. P., et al. (2026) · Archives of Toxicology · doi:10.1007/s00204-025-04275-x · Cited by 9 · see citing works

Related Topic: Safety Evaluation and Alternatives to Animal Testing for Skin Toxicity

Kojima, H. (2017) · Springer eBooks · doi:10.1007/978-4-431-56526-0_27

Análise da utilização de testes alternativos para avaliação de segurança de produtos cosméticos

Paiva, D. D. S., Vitalli, J. R., Moreira, M. A. L., & Moraes, C. A. P. (2015) · Revista da Sociedade Brasileira de Ciência em Animais de Laboratório