Evaluation of subcortical structure volumes in patients with non-specific digestive diseases
Open accessAbstract
(1) Background: To evaluate volume of subcortical structures such as hippocampus, globus pallidus, putamen, thalamus, nucleus accumbens, amygdala, caudate in patients with non-specific digestive diseases (functional dyspepsia-FD, irritable bowel syndrome-IBS) and non-specific inflammatory bowel diseases-IBD (colitis ulcerosa and Crohn's disease) in comparison to healthy control group (CON). (2) Material: The analysis included data obtained from 57 patients (FD-18, IBS-20, IBD-19) and 19 persons in control group. Both groups underwent examination in a 3T scanner (Achieva TX Philips Healthcare). (3) Results: Significant differences between the IBD group and Control group in volume of left thalamus and IBD group vs Control group in volume of right thalamus. (4) Conclusions: The brain-gut axis hypothesis explains connection between biological behavior, emotions and cognitive functions in patients with gastrointestinal disease. We found that there is a difference between volume of thalamus in IBD patients in comparison to both IBS and control group and it occurred to be smaller. Excess inflammation can be linked with psychological disorders like depressive symptoms, sleep difficulties and/or fatigue. Therefore, there is a need for using treatment both for depressive symptoms and IBD to reduce the causes and effects of inflammation.
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In IBD, thalamic volume is smaller than in healthy controls, as found using 3T MRI.
“A study using 3T MRI technology found thalamic volume to be smaller in the IBD group, when compared to healthy controls (494).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [494]
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Cites
Fischl, B. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.021 · Cited by 9,526 · see citing works
Cortical Surface-Based Analysis
Fischl, B., Sereno, M. I., & Dale, A. M. (1999) · NeuroImage · doi:10.1006/nimg.1998.0396 · Cited by 6,147 · see citing works
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689 · see citing works
Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features, and Rome IV
Drossman, D. A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.032 · Cited by 2,444 · see citing works
Barberio, B., Zamani, M., Black, C. J., Savarino, E. V., & Ford, A. C. (2021) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(21)00014-5 · Cited by 758 · see citing works
Brain–Gut Interactions in Inflammatory Bowel Disease
Bonaz, B. L., & Bernstein, C. N. (2013) · Gastroenterology · doi:10.1053/j.gastro.2012.10.003 · Cited by 667 · see citing works
Functional anatomy of thalamus and basal ganglia
Herrero, M.-T., Barcia, C., & Navarro, J. (2002) · Child s Nervous System · doi:10.1007/s00381-002-0604-1 · Cited by 660 · see citing works
Psychological stress in IBD: new insights into pathogenic and therapeutic implications
Mawdsley, J. E., & Rampton, D. S. (2005) · Gut · doi:10.1136/gut.2005.064261 · Cited by 622 · see citing works
Van Oudenhove, L., Levy, R. L., Crowell, M. D., Drossman, D. A., Halpert, A. D., Keefer, L., Lackner, J. M., Murphy, T. B., & Naliboff, B. D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.027 · Cited by 512 · see citing works
Stress and the gastrointestinal tract
Bhatia, V., & Tandon, R. (2005) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03508.x · Cited by 486 · see citing works
Talley, N. J., & Ford, A. C. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1501505 · Cited by 481 · see citing works
Neuroimaging of the brain–gut axis: From basic understanding to treatment of functional GI disorders
Mayer, E. A., Naliboff, B. D., & Craig, A. D. B. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.026 · Cited by 366 · see citing works
Dysregulation of the hypothalamic‐pituitary‐adrenal (HPA) axis in irritable bowel syndrome
Chang, L., Sundaresh, S., Elliott, J. E., Anton, P. A., Baldi, P., Licudine, A., Mayer, M., Vuong, T., Hirano, M., Naliboff, B. D., et al. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01171.x · Cited by 250 · see citing works
Labanski, A., Langhorst, J., Engler, H., & Elsenbruch, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104501 · Cited by 200 · see citing works
Abautret-Daly, Á., Dempsey, E., Parra‐Blanco, A., Medina, C., & Harkin, A. (2017) · Acta Neuropsychiatrica · doi:10.1017/neu.2017.3 · Cited by 185 · see citing works
Brzozowski, B., Mazur-Biały, A., Pajdo, R., Kwiecień, S., Bilski, J., Zwolińska-Wcisło, M., Mach, T., & Brzozowski, T. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160404124127 · Cited by 168 · see citing works
CORTICAL THINNING IN IBS: IMPLICATIONS FOR HOMEOSTATIC, ATTENTION, AND PAIN PROCESSING
Davis, K. D., Pope, G., Chen, J.-I., Kwan, C. L., Crawley, A. P., & Diamant, N. E. (2007) · Neurology · doi:10.1212/01.wnl.0000295509.30630.10 · Cited by 146 · see citing works
Böhmelt, A. H., Nater, U. M., Franke, S., Hellhammer, D. H., & Ehlert, U. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000157064.72831.ba · Cited by 134 · see citing works
Inflammatory Bowel Disease: A Stressed “Gut/Feeling”
Oligschlaeger, Y., Yadati, T., Houben, T., Oliván, C. M. C., & Shiri‐Sverdlov, R. (2019) · Cells · doi:10.3390/cells8070659 · Cited by 116 · see citing works
Regional Cerebral Blood Flow During Gastric Balloon Distention in Functional Dyspepsia
Vandenberghe, J. U., Dupont, P. J., Oudenhove, L. V., Bormans, G. M., Demyttenaere, K., Fischler, B., Geeraerts, B., Janssens, J., & Tack, J. F. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.037 · Cited by 115 · see citing works
Agostini, A., Benuzzi, F., Filippini, N., Bertani, A., Scarcelli, A., Farinelli, V., Marchetta, C., Calabrese, C., Rizzello, F., Gionchetti, P., et al. (2012) · Neurogastroenterology & Motility · doi:10.1111/nmo.12017 · Cited by 112 · see citing works
Vandenbergh, J., Dupont, P. J., Fischler, B., Bormans, G. M., Persoons, P., Janssens, J., & Tack, J. F. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.054 · Cited by 111 · see citing works
Neuronal correlates of gastric pain induced by fundus distension: a 3T‐fMRI study
Lu, C., Wu, Y., Yeh, T.-C., Chen, L., Chang, F. Y., Lee, S., Ho, L. ‐., & Hsieh, J. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00562.x · Cited by 100 · see citing works
Bao, C., Liu, P., Liu, H. R., Wu, L. Y., Shi, Y., Chen, W. F., Qin, W., Lu, Y., Zhang, J. Y., Jin, X. M., et al. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv057 · Cited by 97 · see citing works
Brain imaging and functional gastrointestinal disorders: has it helped our understanding?
Hobson, A. R. (2004) · Gut · doi:10.1136/gut.2003.035642 · Cited by 91 · see citing works
Oudenhove, L. V., Vandenberghe, J. U., Dupont, P. J., Geeraerts, B., Vos, R. D., Dirix, S., Laere, K. V., Bormans, G. M., Vanderghinste, D., Demyttenaere, K., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.04.015 · Cited by 88 · see citing works
IsHak, W. W., Pan, D., Steiner, A. J., Feldman, E. J., Mann, A., Mirocha, J., Danovitch, I., & MELMED, G. Y. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001060 · Cited by 80 · see citing works
Ganci, M., Suleyman, E., Butt, H., & Ball, M. (2019) · Brain and Behavior · doi:10.1002/brb3.1408 · Cited by 71 · see citing works
Neuroimaging the brain-gut axis in patients with irritable bowel syndrome
Weaver, K. R., Sherwin, L. B., Walitt, B. T., Melkus, G. D., & Henderson, W. A. (2016) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v7.i2.320 · Cited by 66 · see citing works
Inflammatory bowel diseases: a dysfunction of brain-gut interactions?
Bonaz, B. L. (2013) · PubMed · Cited by 41 · see citing works
Structural Imaging Changes and Behavioral Correlates in Patients with Crohn’s Disease in Remission
Nair, V. A., Beniwal-Patel, P. M., Mbah, I., Young, B. M., Prabhakaran, V., & Saha, S. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00460 · Cited by 41 · see citing works
Multimodal Brain MRI of Deep Gray Matter Changes Associated With Inflammatory Bowel Disease
Goodyear, B. G., Heidari, F., Ingram, R. J. M., Cortese, F., Sharifi, N., Kaplan, G. G., Ma, C., Panaccione, R., Sharkey, K. A., & Swain, M. G. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac089 · Cited by 41 · see citing works
Altered functional connectivity of the amygdala in Crohn’s disease
Fan, Y., Bao, C., Wei, Y., Wu, J., Zhao, Y.-S., Zeng, X., Qin, W., Wu, H., & Liu, P. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00159-8 · Cited by 32 · see citing works
Lin, S., Gao, T., Sun, C., Jia, M., Liu, C., & Ma, A. (2019) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001451 · Cited by 28 · see citing works
Zhou, G., Liu, P., Zeng, F., Yuan, K., Yu, D., von Deneen, K. M., Liang, F., Qin, W., & Tian, J. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2878 · Cited by 25 · see citing works
Patient-reported healthcare expectations in inflammatory bowel diseases
Pittet, V. E. H., Vaucher, C., Froehlich, F., Maillard, M. H., Michetti, P., & on behalf of the Swiss IBD Cohort Study Group (2018) · PLoS ONE · doi:10.1371/journal.pone.0197351 · Cited by 19 · see citing works
Mavroudis, G., Simrén, M., Jonefjäll, B., Öhman, L., & Strid, H. (2019) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284819827689 · Cited by 13 · see citing works
Ford, A., Lacy, B., & Talley, N. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1607547 · Cited by 11 · see citing works
Mao, C., Chen, F. R., Sun, H. H., Shi, M. J., Yang, H. J., Li, X. H., & Ding, D. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00181-w · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [9]Bickston S.J. Bloomfeld R.S. Handbook of Inflammatory Bowel Disease 2009 Lippincott Wiliams & Wilkins Philadelphia, PA, USA 2009
Cited by
Sorted by citations
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
Xie, Y., Zhao, Y., Zhou, Y., Jiang, Y., Zhang, Y., Du, J., Cai, M., Fu, J., & Liu, H. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae099 · Cited by 8 · see citing works
Brain Morphometry and Cognitive Features in the Prediction of Irritable Bowel Syndrome
Lundervold, A., Bjørsvik, B., Billing, J., Berentsen, B., Lied, G. A., Steinsvik, E. K., Hausken, T., Pfabigan, D. M., & Lundervold, A. J. (2025) · Diagnostics · doi:10.3390/diagnostics15040470 · Cited by 3 · see citing works
Wang, Q., Zheng, W., Zhang, C., Lv, S., Peng, L., Chen, J., & Lu, A. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102315
- Authors
- Skrobisz, K., Piotrowicz, G., Rudnik, A., Naumczyk, P., Sabisz, A., Markiet, K., & Szurowska, E.
- Affiliations
- Gdańsk Medical University (PL)
- Department of Gastroenterology, Self-Dependent Health Care Unit of Ministry of Interior, 80-104 Gdansk, Poland
- University of Gdańsk (PL)
- Corresponding author
- Skrobisz, Katarzyna
- ORCID
- Venue
- Diagnostics
- Publisher
- MDPI AG
- Published
- 2022-09-09
- Volume
- 12
- Issue
- 9
- Pages
- 2199
- ISSN
- 2075-4418 (ISSN-L)
- PMC
- PMC9497680
- OpenAlex
- W4295592604
- Cited by
- 4
- References
- 39
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Diagnostics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- subcortical structures, brain volume, thalamus, functional dyspepsia, irritable bowel syndrome, inflammatory bowel disease, ulcerative colitis, Crohn's disease, gut-brain axis, hippocampus, amygdala, caudate nucleus, depressive symptoms
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