Rheological considerations of pharmaceutical formulations: focus on viscoelasticity
Open accessAbstract
Controlling rheological properties offers the opportunity to gain insight into the physical characteristics, structure, stability and drug release rate of formulations. To better understand the physical properties of hydrogels, not only rotational but also oscillatory experiments should be performed. Viscoelastic properties, including elastic and viscous properties, are measured using oscillatory rheology. The gel strength and elasticity of hydrogels are of great importance for pharmaceutical development as the application of viscoelastic preparations has considerably expanded in recent decades. Viscosupplementation, ophthalmic surgery and tissue engineering are just a few examples from the wide range of possible applications of viscoelastic hydrogels. Hyaluronic acid, alginate, gellan gum, pectin and chitosan are remarkable representatives of gelling agents that attract great attention applied in biomedical fields. This review provides a brief summary of rheological properties, highlighting the viscoelasticity of hydrogels with great potential in biomedicine.
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The onset of a crossover at higher frequencies in the SFMA-UV sample can be attributed to the increased structural organization of the protein chains within the gel induced by the photopolymerization process.
“The onset of a crossover at higher frequencies in the SFMA-UV sample can be attributed to the increased structural organization of the protein chains within the gel induced by the photopolymerization process [25,58].”
From Montmorillonite-reinforced methacrylated collagen/methacrylated silk fibroin hydrogel-based inks: rheological and physicochemical characterization for bone scaffold applications (2026) · cites this paper as [58]
The Introduction describes what a frequency-sweep crossover indicates, and section 2.2 reports a crossover at higher frequencies when methylcellulose concentration increased. Neither passage addresses the SFMA-UV sample or attributes its crossover to photopolymerization-induced organization of protein chains. (LLM, conf=0.78)
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Cites
Alginate: Properties and biomedical applications
Lee, K. Y., & Mooney, D. J. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.06.003 · Cited by 8,218 · see citing works
Hydrogels for Tissue Engineering
Lee, K. Y., & Mooney, D. J. (2001) · Chemical Reviews · doi:10.1021/cr000108x · Cited by 5,295 · see citing works
Hydrogels in regenerative medicine
Slaughter, B. V., Khurshid, S. S., Fisher, O. Z., Khademhosseini, A., & Peppas, N. A. (2009) · Advanced Materials · doi:10.1002/adma.200802106 · Cited by 2,703 · see citing works
Functional and bioactive properties of collagen and gelatin from alternative sources: A review
Gómez-Guillén, M. C., Giménez, B., López-Caballero, M. E., & Montero, P. (2011) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2011.02.007 · Cited by 2,078 · see citing works
Hydrogel nanoparticles in drug delivery
Hamidi, M., Azadi, A., & Rafiei, P. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.08.002 · Cited by 2,077 · see citing works
Chitosan: An Overview of Its Properties and Applications
Aranaz, I., Alcántara, A. R., Civera, C., Arias, C., Elorza, B., Caballero, A. H., & Acosta, N. (2021) · Polymers · doi:10.3390/polym13193256 · Cited by 1,786 · see citing works
Chitosan: an update on potential biomedical and pharmaceutical applications.
Cheung, R., Ng, T., Wong, J., & Chan, W. (2015) · Marine Drugs · doi:10.3390/md13085156 · Cited by 1,297 · see citing works
Smart Hydrogels in Tissue Engineering and Regenerative Medicine
Mantha, S., Pillai, S., Khayambashi, P., Upadhyay, A., Zhang, Y., Tao, O., Pham, H. M., & Tran, S. D. (2019) · Materials · doi:10.3390/ma12203323 · Cited by 863 · see citing works
Chitosan: A Natural Biopolymer with a Wide and Varied Range of Applications
Jiménez-Gómez, C. P., & Cecilia, J. A. (2020) · Molecules · doi:10.3390/molecules25173981 · Cited by 817 · see citing works
Rheological properties of peptide-based hydrogels for biomedical and other applications
Yan, C., & Pochan, D. J. (2010) · Chemical Society Reviews · doi:10.1039/b919449p · Cited by 805 · see citing works
Morris, E. R., Nishinari, K., & Rinaudo, M. (2012) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2012.01.004 · Cited by 766 · see citing works
Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review
Hamedi, H., Moradi, S., Hudson, S. M., & Tonelli, A. E. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.06.114 · Cited by 761 · see citing works
A decade of progress in tissue engineering
Khademhosseini, A., & Langer, R. (2016) · Nature Protocols · doi:10.1038/nprot.2016.123 · Cited by 746 · see citing works
Prosthodontic Applications of Polymethyl Methacrylate (PMMA): An Update
Zafar, M. S. (2020) · Polymers · doi:10.3390/polym12102299 · Cited by 732 · see citing works
Relationship between Structure and Rheology of Hydrogels for Various Applications
Stojkov, G., Niyazov, Z., Picchioni, F., & Bose, R. K. (2021) · Gels · doi:10.3390/gels7040255 · Cited by 667 · see citing works
Alginates as a useful natural polymer for microencapsulation and therapeutic applications
Goh, C. H., Heng, P. W. S., & Chan, L. W. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.11.012 · Cited by 660 · see citing works
Alginate gel particles–A review of production techniques and physical properties
Ching, S. H., Bansal, N., & Bhandari, B. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.965773 · Cited by 654 · see citing works
Gupta, D., Tator, C. H., & Shoichet, M. S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.11.015 · Cited by 584 · see citing works
Pectin as a rheology modifier: Origin, structure, commercial production and rheology
Chan, S. Y., Choo, W. S., Young, D. J., & Loh, X. J. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.12.033 · Cited by 563 · see citing works
Fakhari, A., & Berkland, C. J. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.03.005 · Cited by 523 · see citing works
Current Advancements in Pectin: Extraction, Properties and Multifunctional Applications
Chandel, V., Biswas, D., Roy, S., Vaidya, D., Verma, A. K., & Gupta, A. K. S. (2022) · Foods · doi:10.3390/foods11172683 · Cited by 447 · see citing works
Application of gellan gum in pharmacy and medicine
Osmałek, T. Z., Froelich, A., & Tasarek, S. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.03.038 · Cited by 420 · see citing works
Thixotropic property in pharmaceutical formulations
Lee, C., Moturi, V., & Lee, Y. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.02.013 · Cited by 405 · see citing works
Typical Physicochemical Behaviors of Chitosan in Aqueous Solution
Schatz, C., Viton, C., Delair, T., et al. (2003) · Biomacromolecules · doi:10.1021/bm025724c · Cited by 397 · see citing works
A protocol for rheological characterization of hydrogels for tissue engineering strategies
Zuidema, J. M., Rivet, C. J., Gilbert, R. J., & Morrison, F. A. (2013) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33088 · Cited by 395 · see citing works
Hyaluronan and synovial joint: function, distribution and healing
Tamer, T. M. (2013) · Interdisciplinary Toxicology · doi:10.2478/intox-2013-0019 · Cited by 317 · see citing works
Biopolymers for hydrogels in cosmetics: review
Mitura, S., Sionkowska, A., & Jaiswal, A. K. (2020) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-020-06390-w · Cited by 316 · see citing works
Marine Origin Polysaccharides in Drug Delivery Systems
Cardoso, M., Costa, R. R., & Mano, J. F. (2016) · Marine Drugs · doi:10.3390/md14020034 · Cited by 298 · see citing works
Alginate drug delivery systems: application in context of pharmaceutical and biomedical research
Jain, D., & Bar‐Shalom, D. (2014) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2014.917657 · Cited by 277 · see citing works
Current Status of Alginate in Drug Delivery
Hariyadi, D. M., & Islam, N. (2020) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/2020/8886095 · Cited by 270 · see citing works
Injectable Hydrogels: From Laboratory to Industrialization
Alonso, J. M., del Olmo, J. A., González, R. P., et al. (2021) · Polymers · doi:10.3390/polym13040650 · Cited by 267 · see citing works
Viscoelastic microfluidics: progress and challenges
Zhou, J., & Papautsky, I. (2020) · Microsystems & Nanoengineering · doi:10.1038/s41378-020-00218-x · Cited by 235 · see citing works
Rheology of Biopolymer Solutions and Gels
Picout, D. R., & Ross‐Murphy, S. B. (2003) · The Scientific World JOURNAL · doi:10.1100/tsw.2003.15 · Cited by 234 · see citing works
Rheological properties of synovial fluids
Fam, H., Bryant, J. T., & Kontopoulou, M. (2007) · Biorheology · doi:10.1177/0006355x2007044002005 · Cited by 233 · see citing works
Gelatin-Based Hydrogels: Potential Biomaterials for Remediation
Andreazza, R., Morales, A., Pieniz, S., & Labidi, J. (2023) · Polymers · doi:10.3390/polym15041026 · Cited by 220 · see citing works
Tiffany, J. M. (1991) · International Ophthalmology · doi:10.1007/bf00137947 · Cited by 217 · see citing works
Thermogelation of methylcellulose: rheological considerations
Desbrières, J., Hirrien, M., & Ross-Murphy, S. B. (2000) · Polymer · doi:10.1016/s0032-3861(99)00413-9 · Cited by 212 · see citing works
Viscosupplementation: Therapeutic Mechanisms and Clinical Potential in Osteoarthritis of the Knee
Watterson, J. R., & Esdaile, J. M. (2000) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-200009000-00001 · Cited by 211 · see citing works
Alginate Particles as Platform for Drug Delivery by the Oral Route: State-of-the-Art
Sosnik, A. (2014) · ISRN Pharmaceutics · doi:10.1155/2014/926157 · Cited by 206 · see citing works
Sources, Extraction and Biomedical Properties of Polysaccharides
Ullah, S., Khalil, A. A., Shaukat, F., & Song, Y. (2019) · Foods · doi:10.3390/foods8080304 · Cited by 203 · see citing works
Polysaccharide-Based Hydrogels: The Key Role of Water in Affecting Mechanical Properties
Pasqui, D., Cagna, M. D., & Barbucci, R. (2012) · Polymers · doi:10.3390/polym4031517 · Cited by 199 · see citing works
Said, N. S., & Sarbon, N. M. (2022) · Membranes · doi:10.3390/membranes12050442 · Cited by 199 · see citing works
Role of hyaluronic acid in joint lubrication.
Swann, D. A., Radin, E. L., Nazimiec, M. E., Weisser, P. A., Curran, N., & LEWINNEK, G. E. (1974) · Annals of the Rheumatic Diseases · doi:10.1136/ard.33.4.318 · Cited by 194 · see citing works
Spatially and temporally controlled hydrogels for tissue engineering
Leijten, J., Seo, J., Yue, K., Santiago, G. T., Tamayol, A., Ruiz‐Esparza, G. U., Shin, S. R., Sharifi, R., Noshadi, I., Álvarez, M. M., et al. (2017) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2017.07.001 · Cited by 192 · see citing works
Seshadri, R., Weiß, J., HULBERT, G. J., et al. (2003) · Food Hydrocolloids · doi:10.1016/s0268-005x(02)00051-6 · Cited by 179 · see citing works
Advances and prospects in the food applications of pectin hydrogels
Ishwarya, S. P., Sandhya, R., & Nisha, P. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1875394 · Cited by 179 · see citing works
Smart materials: in situ gel-forming systems for nasal delivery
Karavasili, C., & Fatouros, D. G. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.10.016 · Cited by 175 · see citing works
Liang, H., Hong, M.-H., Ho, R., Chung, C.-K., Lin, Y.-H., Chen, C., & Sung, H. (2004) · Biomacromolecules · doi:10.1021/bm049813w · Cited by 173 · see citing works
Fan, Z., Cheng, P., Zhang, P., Zhang, G., & Han, J. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.10.082 · Cited by 172 · see citing works
Moslemi, M. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117324 · Cited by 165 · see citing works
Rheological Characterization of Hydrogels from Alginate-Based Nanodispersion
Cuomo, F., Cofelice, M., & Lopez, F. (2019) · Polymers · doi:10.3390/polym11020259 · Cited by 160 · see citing works
Bertolo, M. R. V., Martins, V. D. C. A., Horn, M. M., Brenelli, L. B., & Plepis, A. M. D. G. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115386 · Cited by 155 · see citing works
Chattopadhyay, D. P., & Inamdar, M. S. (2010) · International Journal of Polymer Science · doi:10.1155/2010/939536 · Cited by 154 · see citing works
Calcium and acid induced gelation of (amidated) low methoxyl pectin
Capel, F., Nicolai, T., Durand, D., Boulenguer, P., & Langendorff, V. (2006) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2005.09.004 · Cited by 152 · see citing works
Host Tissue Interaction, Fate, and Risks of Degradable and Nondegradable Gel Fillers
Christensen, L. H. (2009) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2009.01338.x · Cited by 149 · see citing works
Kwiatek, M. A., Roman, S., Fareeduddin, A., et al. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04678.x · Cited by 148 · see citing works
Sathaye, S., Mbi, A., Sönmez, C., Chen, Y., Blair, D. L., Schneider, J. P., & Pochan, D. J. (2014) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1299 · Cited by 145 · see citing works
Thirupathi, K., Raorane, C. J., Ramkumar, V., Ulagesan, S., Santhamoorthy, M., Raj, V., Krishnakumar, G. S., Phan, T. T. V., & Kim, S. (2022) · Gels · doi:10.3390/gels9010035 · Cited by 129 · see citing works
Hägerström, H., Paulsson, M., & Edsman, K. L. M. (2000) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(99)00070-6 · Cited by 124 · see citing works
Insights into the nanostructure of low-methoxyl pectin–calcium gels
Ventura, I., Jammal, J., & Bianco‐Peled, H. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.05.055 · Cited by 121 · see citing works
Wang, W., & Xu, D. (1994) · International Journal of Biological Macromolecules · doi:10.1016/0141-8130(94)90042-6 · Cited by 112 · see citing works
Chitosan as a Tool for Sustainable Development: A Mini Review
Maliki, S., Sharma, G., Kumar, A., Moral-Zamorano, M., Moradi, O., Baselga, J., Stadler, F. J., & García‐Peñas, A. (2022) · Polymers · doi:10.3390/polym14071475 · Cited by 112 · see citing works
Liu, Z., & Yao, P. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.06.013 · Cited by 111 · see citing works
Gelatin-Polyvinyl Alcohol Film for Tissue Engineering: A Concise Review
Zulkiflee, I., & Fauzi, M. B. (2021) · Biomedicines · doi:10.3390/biomedicines9080979 · Cited by 109 · see citing works
Ngouémazong, D. E., Jolie, R. P., Cardinaels, R., Fraeye, I., Loey, A. M. V., Moldenaers, P., & Hendrickx, M. (2011) · Carbohydrate Research · doi:10.1016/j.carres.2011.11.011 · Cited by 97 · see citing works
Sobral, P. J. D. A., Gebremariam, G., Drudi, F., et al. (2022) · Foods · doi:10.3390/foods11172692 · Cited by 97 · see citing works
Use of viscoelastic substance in ophthalmic surgery — focus on sodium hyaluronate
Higashide (2008) · Clinical ophthalmology · doi:10.2147/opth.s1439 · Cited by 88 · see citing works
Rheometric study of the gelation of chitosan in a hydroalcoholic medium
Montembault, A., Viton, C., & Domard, A. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.06.029 · Cited by 86 · see citing works
Microstructure and Kinetic Rheological Behavior of Amidated and Nonamidated LM Pectin Gels
Löfgren, C., Guillotin, S., & Hermansson, A. (2005) · Biomacromolecules · doi:10.1021/bm050459r · Cited by 84 · see citing works
Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update
Georgiev, G. A., Eftimov, P., & Yokoi, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246132 · Cited by 83 · see citing works
Medicated hydrogels of hyaluronic acid derivatives for use in orthopedic field
Pitarresi, G. L., Palumbo, F. S., Calascibetta, F., Fiorica, C., Stefano, M. D., & Giammona, G. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.03.059 · Cited by 82 · see citing works
Rebenda, D., Vrbka, M., Čípek, P., et al. (2020) · Materials · doi:10.3390/ma13112659 · Cited by 82 · see citing works
Structural aspects and phase behaviour in deacylated and high acyl gellan systems
Kasapis, S., Giannouli, P., Hember, M. W. N., et al. (1999) · Carbohydrate Polymers · doi:10.1016/s0144-8617(98)00116-7 · Cited by 76 · see citing works
Everett, J. S., & Sommers, M. S. (2012) · Biological Research For Nursing · doi:10.1177/1099800411434151 · Cited by 74 · see citing works
Mierczyńska, J., Cybulska, J., Sołowiej, B. G., et al. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.07.046 · Cited by 71 · see citing works
Molecular origin for rheological characteristics of native gellan gum
Tako, M., Teruya, T., Tamaki, Y., et al. (2009) · Colloid & Polymer Science · doi:10.1007/s00396-009-2112-2 · Cited by 68 · see citing works
The Usages and Potential Uses of Alginate for Healthcare Applications
Mollah, M. Z. I., Zahid, H. M., Mahal, Z., Faruque, M. R. I., & Khandaker, M. U. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.719972 · Cited by 66 · see citing works
Nondestructive Evaluation of Hydrogel Mechanical Properties Using Ultrasound
Walker, J. M., Myers, A. M., SCHLUCHTER, M. D., et al. (2011) · Annals of Biomedical Engineering · doi:10.1007/s10439-011-0351-0 · Cited by 63 · see citing works
Mirtič, J., Ilaš, J., & Kristl, J. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.10.040 · Cited by 63 · see citing works
Versatile Use of Chitosan and Hyaluronan in Medicine
Valachová, K., & Šoltés, L. (2021) · Molecules · doi:10.3390/molecules26041195 · Cited by 61 · see citing works
Ophthalmic Viscosurgical Devices (OVDs) in Challenging Cases: a Review
Borkenstein, A. F. M., Borkenstein, E.-M., & Malyugin, B. E. (2021) · Ophthalmology and Therapy · doi:10.1007/s40123-021-00403-9 · Cited by 59 · see citing works
Khunawattanakul, W., Puttipipatkhachorn, S., Rades, T., et al. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.09.038 · Cited by 58 · see citing works
New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering
Camponeschi, F., Atrei, A., Rocchigiani, G., et al. (2015) · Gels · doi:10.3390/gels1010003 · Cited by 56 · see citing works
Rheology in Pharmaceutical Formulations-A Perspective
Mastropietro, D. J. (2013) · Journal of Developing Drugs · doi:10.4172/2329-6631.1000108 · Cited by 53 · see citing works
pH mediated rheological modulation of chitosan hydrogels
Richa, R., & Choudhury, A. R. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.04.049 · Cited by 52 · see citing works
Hyaluronic acid as a treatment for ankle osteoarthritis
Sun, S., Chou, Y., Hsu, C., et al. (2009) · Current Reviews in Musculoskeletal Medicine · doi:10.1007/s12178-009-9048-5 · Cited by 48 · see citing works
Zerbinati, N., Sommatis, S., Maccario, C., et al. (2021) · Polymers · doi:10.3390/polym13060948 · Cited by 48 · see citing works
Alginate hydrogel: The influence of the hardening on the rheological behaviour
Liparoti, S., Speranza, V., & Marra, F. (2021) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2021.104341 · Cited by 46 · see citing works
Formation and rupture of Ca 2+ induced pectin biopolymer gels
Basak, R., & Bandyopadhyay, R. (2014) · Soft Matter · doi:10.1039/c4sm00748d · Cited by 45 · see citing works
Jin, Y., Yang, T. Z., Ju, S., Zhang, H., Choi, T.-Y., & Neogi, A. (2020) · Polymers · doi:10.3390/polym12071462 · Cited by 45 · see citing works
A new viscosupplement based on partially hydrophobic hyaluronic acid: A comparative study
Finelli, I., Chiessi, E., Galesso, D., et al. (2011) · Biorheology · doi:10.3233/bir-2011-0596 · Cited by 44 · see citing works
Mechanically-robust electrospun nanocomposite fiber membranes for oil and water separation
Nueraji, M., Toktarbay, Z., Ardakkyzy, A., et al. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115212 · Cited by 44 · see citing works
Nicholls, M. A., Manjoo, A., Shaw, P. M., et al. (2018) · Clinical Medicine Insights Arthritis and Musculoskeletal Disorders · doi:10.1177/1179544117751622 · Cited by 43 · see citing works
Sun, M., Sun, H., Wang, Y., et al. (2018) · Gels · doi:10.3390/gels4020033 · Cited by 43 · see citing works
VITHANAGE, C. R., GRIMSON, M. J., WILLS, P. R., HARRISON, P., & SMITH, B. G. (2010) · Journal of Texture Studies · doi:10.1111/j.1745-4603.2010.00261.x · Cited by 41 · see citing works
Rheological study of chitosan and its blends: An overview
El-hefian, E. A. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 40 · see citing works
Iglesias, N., Galbis, E., Valencia, C., de‐Paz, M. ‐., & Galbis, J. A. (2018) · Polymers · doi:10.3390/polym10040392 · Cited by 39 · see citing works
Contemporary denture base resins: part 1
Rickman, L. J., Padipatvuthikul, P., & Satterthwaite, J. D. (2012) · Dental Update · doi:10.12968/denu.2012.39.1.25 · Cited by 38 · see citing works
Viscoelastic properties of the human tear film
Recchioni, A., Mocciardini, E., Ponzini, E., et al. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109083 · Cited by 35 · see citing works
Rheological study of hyaluronic acid derivatives
Chernos, M., Grecov, D., Kwok, E., et al. (2017) · Biomedical Engineering Letters · doi:10.1007/s13534-017-0010-y · Cited by 34 · see citing works
Demir, Ö., & Ege, D. (2018) · Materials · doi:10.3390/ma11040604 · Cited by 34 · see citing works
Eskens, O. N., Villani, G., & Amin, S. (2020) · Cosmetics · doi:10.3390/cosmetics8010003 · Cited by 34 · see citing works
Intrinsic viscosity–molecular weight relationship and hydrodynamic volume for pullulan
Kasaai, M. R. (2006) · Journal of Applied Polymer Science · doi:10.1002/app.22324 · Cited by 33 · see citing works
Applied Rheology as Tool for the Assessment of Chitosan Hydrogels for Regenerative Medicine
Sánchez‐Cid, P., Jiménez‐Rosado, M., Alonso‐González, M., et al. (2021) · Polymers · doi:10.3390/polym13132189 · Cited by 33 · see citing works
Karim, M., Kohale, S. C., Indei, T., Schieber, J. D., & Khare, R. (2012) · Physical Review E · doi:10.1103/physreve.86.051501 · Cited by 31 · see citing works
Using Rheology to Understand Transient and Dynamic Gels
Bianco, S., Panja, S., & Adams, D. J. (2022) · Gels · doi:10.3390/gels8020132 · Cited by 31 · see citing works
Vo, T. M. T., Kobayashi, T., & Potiyaraj, P. (2022) · Gels · doi:10.3390/gels8120814 · Cited by 31 · see citing works
Dynamic Rheological Properties of Concentrated Chitosan Soltions
Ruvalcaba, A. M., Chornet, E., & Rodrigue, D. (2004) · Applied Rheology · doi:10.1515/arh-2004-0009 · Cited by 30 · see citing works
Jin, Y., Heo, H., Walker, E., et al. (2019) · Ultrasonics · doi:10.1016/j.ultras.2019.05.004 · Cited by 29 · see citing works
You, J., Zhou, J., Li, Q., et al. (2012) · Langmuir · doi:10.1021/la2046417 · Cited by 27 · see citing works
Engineering Gels with Time-Evolving Viscoelasticity
Mattei, G., Cacopardo, L., & Ahluwalia, A. D. (2020) · Materials · doi:10.3390/ma13020438 · Cited by 25 · see citing works
Osmałek, T. Z., Froelich, A., Jadach, B., et al. (2018) · Journal of Biomaterials Applications · doi:10.1177/0885328218762361 · Cited by 23 · see citing works
Gatta, A. L., Bedini, E., Aschettino, M., Finamore, R., & Schiraldi, C. (2022) · Polymers · doi:10.3390/polym14122402 · Cited by 22 · see citing works
Rheology Applied to Microgels: Brief (Revision of the) State of the Art
Echeverría, C., & Mijangos, C. (2022) · Polymers · doi:10.3390/polym14071279 · Cited by 19 · see citing works
Acoustic waves in hydrogels: A bi-phasic model for ultrasound tissue-mimicking phantom
Chiarelli, P., Lanatà, A., & Carbone, M. (2008) · Materials Science and Engineering C · doi:10.1016/j.msec.2008.07.036 · Cited by 18 · see citing works
Benoso, P., Bittante, A. M. Q. B., Moraes, I. C. F., et al. (2022) · International Journal of Food Science & Technology · doi:10.1111/ijfs.15592 · Cited by 18 · see citing works
Measurements of interfacial strength from the blister test
Wang, C. (1999) · Journal of Applied Polymer Science · doi:10.1002/(sici)1097-4628(19990906)73:10 · Cited by 15 · see citing works
Yang, T. Z., Jin, Y., & Neogi, A. (2022) · ACS Omega · doi:10.1021/acsomega.2c06750 · Cited by 15 · see citing works
Shimokawa, K., Saegusa, K., & Ishii, F. (2009) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2009.06.022 · Cited by 14 · see citing works
Walker, E., Reyes, D., Krokhin, A. A., et al. (2014) · Ultrasonics · doi:10.1016/j.ultras.2014.01.014 · Cited by 13 · see citing works
Ruland, A., Onofrillo, C., Duchi, S., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.05.037 · Cited by 11 · see citing works
Tazhibayeva, S. M., Tyussyupova, B., Yermagambetova, A., et al. (2020) · Eastern-European Journal of Enterprise Technologies · doi:10.15587/1729-4061.2020.213226 · Cited by 8 · see citing works
Rheological and mechanical properties of pharmaceutical gels. Part I: Non-medicated systems.
Ferrari, F., Rossi, S., Bonferoni, M. C., et al. (2001) · PubMed · Cited by 6 · see citing works
Demkin, V. P., Melnichuk, S. V., Удут, В. В., et al. (2020) · Russian Physics Journal · doi:10.1007/s11182-020-01969-w · Cited by 3 · see citing works
Study on the Viscoelastic Behaviors of PMMA
Cheng, D., Chen, T., & Cao, W. D. (2020) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1637/1/012120 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Antunes, B. S. L., Pedrini, F., Komatsu, D., Asami, J., Dicko, C., & Duek, E. A. R. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.154129
- Authors
- Budai, L., Budai, M., Fülöpné Pápay, Z. E., Vilimi, Z., & Antal, I.
- Affiliations
- Semmelweis University (HU)
- Department of Pharmaceutics, Semmelweis University, 1092 Budapest, Hungary
- Corresponding author
- Antal, István
- Venue
- Gels
- Publisher
- MDPI AG
- Published
- 2023-06-07
- Volume
- 9
- Issue
- 6
- Pages
- 469
- ISSN
- 2310-2861 (ISSN-L)
- PMC
- PMC10298452
- OpenAlex
- W4380052381
- Cited by
- 91
- References
- 125
- Citations by year
- 2026: 28 · 2025: 34 · 2024: 26 · 2023: 3
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Gels (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Physical Sciences › Chemical Engineering › Fluid Flow and Transfer Processes › Rheology and Fluid Dynamics Studies
- Keywords
- viscoelasticity, hydrogels, drug formulation, oscillatory rheology, gel strength, gelling agents, hyaluronic acid, alginate, gellan gum, pectin, chitosan, drug release, tissue engineering, ophthalmic surgery, viscosupplementation
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