The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
DNA Methylation Biomarkers: Cancer and Beyond
Open accessAbstract
Biomarkers are naturally-occurring characteristics by which a particular pathological process or disease can be identified or monitored. They can reflect past environmental exposures, predict disease onset or course, or determine a patient’s response to therapy. Epigenetic changes are such characteristics, with most epigenetic biomarkers discovered to date based on the epigenetic mark of DNA methylation. Many tissue types are suitable for the discovery of DNA methylation biomarkers including cell-based samples such as blood and tumor material and cell-free DNA samples such as plasma. DNA methylation biomarkers with diagnostic, prognostic and predictive power are already in clinical trials or in a clinical setting for cancer. Outside cancer, strong evidence that complex disease originates in early life is opening up exciting new avenues for the detection of DNA methylation biomarkers for adverse early life environment and for estimation of future disease risk. However, there are a number of limitations to overcome before such biomarkers reach the clinic. Nevertheless, DNA methylation biomarkers have great potential to contribute to personalized medicine throughout life. We review the current state of play for DNA methylation biomarkers, discuss the barriers that must be crossed on the way to implementation in a clinical setting, and predict their future use for human disease.
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Citations
Cites
DNA methylation age of human tissues and cell types
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Effects of stress throughout the lifespan on the brain, behaviour and cognition
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Genome-wide methylation profiles reveal quantitative views of human aging rates
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Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
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DNA methylation arrays as surrogate measures of cell mixture distribution
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High density DNA methylation array with single CpG site resolution
Bibikova, M., Barnes, B., Tsan, C., Ho, V., Klotzle, B., Le, J. M., Delano, D., Zhang, L., Schroth, G. P., Gunderson, K. L., et al. (2011) · Genomics · doi:10.1016/j.ygeno.2011.07.007 · Cited by 1,727 · cited 1×
“As of June 2014, ten independent methylome-wide studies using Illumina Infinium HM450 arrays (containing probes for about 480,000 CpG dinucleotides located in functionally-relevant regions of the genome [206]) had all identified the same smoking-associated probe, cg05575921, located in a region of intermediate CpG den…”
Method
Cited by
Profiling genome-wide DNA methylation
Yong, W.-S., Hsu, F.-M., & Chen, P.-Y. (2016) · Epigenetics & Chromatin · doi:10.1186/s13072-016-0075-3 · Cited by 374
DNA methylation, early life environment, and health outcomes
Mitchell, C., Schneper, L. M., & Notterman, D. A. (2016) · Pediatric Research · doi:10.1038/pr.2015.193 · Cited by 146
Rutten, B. P. F., Vermetten, E., Vinkers, C. H., Ursini, G., Daskalakis, N. P., Pishva, E., de Nijs, L., Houtepen, L. C., Eijssen, L., Jaffe, A. E., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.120 · Cited by 142
The Value of Twins for Health and Medical Research: A Third of a Century of Progress
Craig, J. M., Calais-Ferreira, L., Umstad, M. P., & Buchwald, D. (2020) · Twin Research and Human Genetics · doi:10.1017/thg.2020.4 · Cited by 44
“Studies involving genome-wide analysis of DNA methylation have begun to identify causal mechanisms and diagnostic biomarkers for complex human diseases (Mikeska & Craig, 2014).”
Self-citationEpigenetics in the primary biliary cholangitis and primary sclerosing cholangitis
Cheung, A., LaRusso, N., Gores, G., & Lazaridis, K. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1603324 · Cited by 37
Jockmann, E., Subrizi, F., Mohr, M. K. F., Carter, E. M., Hebecker, P. M., Popadić, D., Hailes, H. C., & Andexer, J. N. (2023) · ChemCatChem · doi:10.1002/cctc.202300930 · Cited by 19
Salas-Pérez, F., Cuevas-Sierra, A., Cuervo, M., Goni, L., Milagro, F. I., Martínez, J. A., & Riezu-Boj, J. I. (2022) · Epigenetics · doi:10.1080/15592294.2021.1873629 · Cited by 16
Metadata
- Authors
- Mikeska, T., & Craig, J.
- Venue
- Genes
- Publisher
- MDPI AG
- Published
- 2014-09-16
- Volume
- 5
- Issue
- 3
- Pages
- 821-864
- ISSN
- 2073-4425 (ISSN-L)
- OpenAlex
- W2164229713
- Cited by
- 288
- References
- 37
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- gold
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