Epigenetics in the primary biliary cholangitis and primary sclerosing cholangitis

Finding the missing heritability of complex diseases

Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336 · see citing works

Functions of DNA methylation: islands, start sites, gene bodies and beyond

Jones, P. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3230 · Cited by 6,061 · see citing works

Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland

Lichtenstein, P., Holm, N. V., Verkasalo, P. K., Iliadou, A., Kaprio, J., Koskenvuo, M., Pukkala, E., Skytthe, A., & Hemminki, K. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007133430201 · Cited by 4,114 · see citing works

Epigenetics in Cancer

Esteller, M. (2008) · New England Journal of Medicine · doi:10.1056/nejmra072067 · Cited by 3,681 · see citing works

DNA methylation and human disease

Robertson, K. D. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1655 · Cited by 2,864 · see citing works

Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility

Anway, M. D., Cupp, A. S., Uzumcu, M., & Skinner, M. K. (2005) · Science · doi:10.1126/science.1108190 · Cited by 2,563 · see citing works

Environmental epigenomics and disease susceptibility

Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492 · see citing works

The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones

Cech, T. R., & Steitz, J. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.008 · Cited by 2,270 · see citing works

Histone methylation: a dynamic mark in health, disease and inheritance

Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3173 · Cited by 2,241 · see citing works

X-inactivation profile reveals extensive variability in X-linked gene expression in females

Carrel, L., & Willard, H. F. (2005) · Nature · doi:10.1038/nature03479 · Cited by 2,097 · see citing works

Function and information content of DNA methylation

Schübeler, D. (2015) · Nature · doi:10.1038/nature14192 · Cited by 2,060 · see citing works

Variations in the Prevalence of Obesity Among European Countries, and a Consideration of Possible Causes

Blundell, J. E., Baker, J. L., Boyland, E. J., Blaak, E. E., Charzewska, J., Henauw, S. D., Frühbeck, G., González‐Gross, M., Hebebrand, J., Holm, L., et al. (2017) · Obesity Facts · doi:10.1159/000455952 · Cited by 1,980 · see citing works

Genetic and epigenetic fine mapping of causal autoimmune disease variants

Farh, K. K.-H., Marson, A., Zhu, J., Kleinewietfeld, M., Housley, W. J., Beik, S., Shoresh, N., Whitton, H., Ryan, R. J. H., Shishkin, A. A., et al. (2015) · Nature · doi:10.1038/nature13835 · Cited by 1,956 · see citing works

Multitarget Stool DNA Testing for Colorectal-Cancer Screening

Imperiale, T. F., Ransohoff, D. F., Itzkowitz, S. H., Levin, T. R., Lavin, P., Lidgard, G. P., Ahlquist, D. A., & Berger, B. M. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1311194 · Cited by 1,900 · see citing works

An operational definition of epigenetics: Figure 1.Preprint

Berger, S. L., Kouzarides, T., Shiekhattar, R., & Shilatifard, A. (2009) · Genes & Development · doi:10.1101/gad.1787609 · Cited by 1,889 · see citing works

Mass-spectrometry-based draft of the human proteome

Wilhelm, M., Schlegl, J., Hahne, H., Gholami, A. M., Lieberenz, M., Savitski, M. M., Ziegler, E., Butzmann, L., Gessulat, S., Marx, H., et al. (2014) · Nature · doi:10.1038/nature13319 · Cited by 1,820 · see citing works

Conserved role of intragenic DNA methylation in regulating alternative promoters

Maunakea, A. K., Nagarajan, R. P., Bilenky, M., Ballinger, T. J., D’Souza, C., Fouse, S. D., Johnson, B. E., Hong, C., Nielsen, C., Zhao, Y., et al. (2010) · Nature · doi:10.1038/nature09165 · Cited by 1,743 · see citing works

EASL Clinical Practice Guidelines: management of cholestatic liver diseases

European Association for the Study of the Liver (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.04.009 · Cited by 1,729 · see citing works

Genomewide Association Studies and Assessment of the Risk of Disease

Manolio, T. A. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0905980 · Cited by 1,512 · see citing works

Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS

Nicolae, D. L., Gamazon, E., Zhang, W., Duan, S., Dolan, M. E., & Cox, N. J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000888 · Cited by 1,292 · see citing works

Primary Biliary Cirrhosis

Schwab, M. (2011) · Springer eBooks · doi:10.1007/978-3-642-16483-5_4730 · Cited by 1,241 · see citing works

Diagnosis and Management of Primary Sclerosing Cholangitis

Chapman, R. W., Fevery, J., Kalloo, A. N., Nagorney, D. M., Boberg, K. M., Shneider, B. L., & Gores, G. J. (2009) · Hepatology · doi:10.1002/hep.23294 · Cited by 1,217 · see citing works

Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies

Aune, D., Chan, D. S. M., Lau, R., Vieira, R., Greenwood, D. C., Kampman, E., & Norat, T. (2011) · BMJ · doi:10.1136/bmj.d6617 · Cited by 1,146 · see citing works

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

Nevens, F., Andreone, P., Mazzella, G., Strasser, S. I., Bowlus, C., Invernizzi, P., Drenth, J. P. H., Pockros, P. J., Regula, J., Beuers, U., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1509840 · Cited by 1,131 · see citing works

Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature

Hou, J. K., Abraham, B., & El-Serag, H. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.44 · Cited by 1,009 · see citing works

RNA-mediated epigenetic regulation of gene expression

Holoch, D., & Moazed, D. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3863 · Cited by 994 · see citing works

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

Donohoe, D. R., Collins, L. B., Wali, A., Bigler, R., Sun, W., & Bultman, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.033 · Cited by 993 · see citing works

CXCR3 in T cell function

Groom, J. R., & Luster, A. D. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.12.017 · Cited by 980 · see citing works

Histone exchange, chromatin structure and the regulation of transcription

Venkatesh, S., & Workman, J. L. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3941 · Cited by 940 · see citing works

Epigenetics and environmental chemicals

Baccarelli, A., & Bollati, V. (2009) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32832925cc · Cited by 935 · see citing works

Enhancer function: new insights into the regulation of tissue-specific gene expression

Ong, C.-T., & Corces, V. G. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2957 · Cited by 929 · see citing works

RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse

Rassoulzadegan, M., Grandjean, V., Gounon, P., Vincent, S. D., Gillot, I., & Cuzin, F. (2006) · Nature · doi:10.1038/nature04674 · Cited by 921 · see citing works

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

Pastor, W. A., Aravind, L., & Rao, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3589 · Cited by 897 · see citing works

CpG islands – ‘A rough guide’

Illingworth, R. S., & Bird, A. P. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.04.012 · Cited by 881 · see citing works

Balancing Life-Style and Genomics Research for Disease Prevention

Willett, W. C. (2002) · Science · doi:10.1126/science.1071055 · Cited by 871 · see citing works

PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis

Loftus, E. V., Harewood, G. C., Loftus, C. G., Tremaine, W. J., Harmsen, W. S., Zinsmeister, A. R., Jewell, D. A., & Sandborn, W. J. (2005) · Gut · doi:10.1136/gut.2004.046615 · Cited by 777 · see citing works

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

The International IBD Genetics Consortium (IIBDGC), Ellinghaus, D., International Genetics of Ankylosing Spondylitis Consortium (IGAS), International PSC Study Group (IPSCSG), Genetic Analysis of Psoriasis Consortium (GAPC), Psoriasis Association Genetics Extension (PAGE), Jostins, L., Spain, S. L., Cortes, A., Bethune, J., et al. (2016) · Nature Genetics · doi:10.1038/ng.3528 · Cited by 751 · see citing works

Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying Put

Simon, J. A., & Kingston, R. E. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.02.013 · Cited by 727 · see citing works

Hepatic and extrahepatic malignancies in primary sclerosing cholangitis

Bergquist, A., Ekbom, A., Olsson, R., Kornfeldt, D., Lööf, L., Danielsson, Å., Hultcrantz, R., Lindgren, S., Prytz, H., Sandberg-Gertzén, H., et al. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00288-4 · Cited by 717 · see citing works

Bile acid receptors as targets for drug development

Schaap, F. G., Trauner, M., & Jansen, P. L. M. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.151 · Cited by 696 · see citing works

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

Jackson-Grusby, L., Beard, C., Possemato, R., Tudor, M., Fambrough, D., Csankovszki, G., Dausman, J., Lee, P., Wilson, C., Lander, E., et al. (2001) · Nature Genetics · doi:10.1038/83730 · Cited by 694 · see citing works

Estimation of effect size distribution from genome-wide association studies and implications for future discoveries

Park, J.-H., Wacholder, S., Gail, M. H., Peters, U., Jacobs, K. B., Chanock, S. J., & Chatterjee, N. (2010) · Nature Genetics · doi:10.1038/ng.610 · Cited by 678 · see citing works

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

Önengüt-Gümüşcü, S., Chen, W., Burren, O. S., Cooper, N. J., Quinlan, A. R., Mychaleckyj, J. C., Farber, E., Bonnie, J. K., Szpak, M., Schofield, E. C., et al. (2015) · Nature Genetics · doi:10.1038/ng.3245 · Cited by 675 · see citing works

Insulators: exploiting transcriptional and epigenetic mechanisms

Gaszner, M., & Felsenfeld, G. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1925 · Cited by 649 · see citing works

Primary sclerosing cholangitis: Natural history, prognostic factors and survival analysis

Wiesner, R. H., Grambsch, P. M., Dickson, E. R., Ludwig, J., MacCarty, R. L., Hunter, E. B., Fleming, T. R., Fisher, L. D., Beaver, S. J., & LaRusso, N. F. (1989) · Hepatology · doi:10.1002/hep.1840100406 · Cited by 641 · see citing works

Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: A systematic review

Boonstra, K., Beuers, U., & Ponsioen, C. Y. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.10.025 · Cited by 632 · see citing works

Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview‐based study of 1032 patients

Gershwin, E. M., Selmi, C., Worman, H. J., Gold, E. B., Watnik, M., Utts, J., Lindor, K. D., Kaplan, M. M., & Vierling, J. M. (2005) · Hepatology · doi:10.1002/hep.20907 · Cited by 621 · see citing works

Targets and dynamics of promoter DNA methylation during early mouse development

Borgel, J., Guibert, S., Li, Y., Chiba, H., Schübeler, D., Sasaki, H., Forné, T., & Weber, M. (2010) · Nature Genetics · doi:10.1038/ng.708 · Cited by 602 · see citing works

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

O’Hagan, H. M., Wang, W., Sen, S., Shields, C. E. D., Lee, S. S., Zhang, Y. W., Clements, E. G., Cai, Y., Neste, L. V., Easwaran, H., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.09.012 · Cited by 569 · see citing works

Mapping Human Epigenomes

Rivera, C. M., & Ren, B. (2013) · Cell · doi:10.1016/j.cell.2013.09.011 · Cited by 550 · see citing works

Methyl-cpG-binding domain proteins: readers of the epigenome

Du, Q., Luu, P.-L., Stirzaker, C., & Clark, S. J. (2015) · Epigenomics · doi:10.2217/epi.15.39 · Cited by 544 · see citing works

Abundant Pleiotropy in Human Complex Diseases and Traits

Sivakumaran, S., Agakov, F. V., Τheodoratou, E., Prendergast, J. G. D., Zgaga, L., Manolio, T. A., Rudan, I., McKeigue, P., Wilson, J. F., & Campbell, H. J. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.10.004 · Cited by 534 · see citing works

SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS

WALKER, J. (1965) · The Lancet · doi:10.1016/s0140-6736(65)91372-3 · Cited by 507 · see citing works

[Primary biliary cirrhosis].

Celaya, F. B. (1989) · PubMed · Cited by 504 · see citing works

FDA Drug Approval Summary: Azacitidine (5-azacytidine, Vidaza™) for Injectable Suspension

Kaminskas, E., Farrell, A. T., Wang, Y.-C., Sridhara, R., & Pazdur, R. (2005) · The Oncologist · doi:10.1634/theoncologist.10-3-176 · Cited by 493 · see citing works

Primary biliary cirrhosis in monozygotic and dizygotic twins: Genetics, epigenetics, and environment

Selmi, C., Mayo, M. J., Bach, N., Ishibashi, H., Invernizzi, P., Gish, R. G., Gordon, S. C., Wright, H. I., Zweiban, B., Podda, M., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.005 · Cited by 480 · see citing works

Implications of the exposome for exposure science

Rappaport, S. M. (2010) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2010.50 · Cited by 450 · see citing works

CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation

Groom, J. R., Richmond, J. M., Murooka, T. T., Sorensen, E. W., Sung, J. H., Bankert, K., von Andrian, U. H., Moon, J. J., Mempel, T. R., & Luster, A. D. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.016 · Cited by 434 · see citing works

Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.

Mali, P., Chou, B.-K., Yen, J., Ye, Z., Zou, J., Dowey, S., Brodsky, R. A., Ohm, J. E., Yu, W., Baylin, S. B., et al. (2010) · Stem Cells · doi:10.1002/stem.402 · Cited by 417 · see citing works

Epigenetic Therapeutics: A New Weapon in the War Against Cancer

Ahuja, N., Sharma, A. R., & Baylin, S. B. (2016) · Annual Review of Medicine · doi:10.1146/annurev-med-111314-035900 · Cited by 364 · see citing works

Genome-wide association studies: potential next steps on a genetic journey

McCarthy, M. I., & Hirschhorn, J. N. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn289 · Cited by 354 · see citing works

Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells

Chen, T., Hevi, S., Gay, F., Tsujimoto, N., He, T., Zhang, B., Ueda, Y., & Li, E. (2007) · Nature Genetics · doi:10.1038/ng1982 · Cited by 353 · see citing works

From promises to practical strategies in epigenetic epidemiology

Mill, J. S., & Heijmans, B. T. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3405 · Cited by 347 · see citing works

Use of Epigenetic Drugs in Disease: An Overview

Heerboth, S., LAPINSKA, K., Snyder, N., Leary, M., Rollinson, S., & Sarkar, S. (2014) · Genetics & Epigenetics · doi:10.4137/geg.s12270 · Cited by 325 · see citing works

Epigenetic inheritance and the missing heritability

Trerotola, M., Relli, V., Simeone, P., & Alberti, S. (2015) · Human Genomics · doi:10.1186/s40246-015-0041-3 · Cited by 318 · see citing works

Following TRAIL’s path in the immune system

Falschlehner, C., Schaefer, U., & Walczak, H. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03058.x · Cited by 300 · see citing works

DNA Methylation Biomarkers: Cancer and Beyond

Mikeska, T., & Craig, J. M. (2014) · Genes · doi:10.3390/genes5030821 · Cited by 287 · see citing works

Co-evolution of X-chromosome inactivation and imprinting in mammals

Reik, W., & Lewis, A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1602 · Cited by 267 · see citing works

Natural history of primary sclerosing cholangitis and prognostic value of cholangiography in a Dutch population

Ponsioen, C. Y., Vrouenraets, S. M. E., Prawirodirdjo, W., Rajaram, R., Rauws, E. A., Mulder, C. J. J., Reitsma, J. B., Heisterkamp, S. H., & Tytgat, G. N. J. (2002) · Gut · doi:10.1136/gut.51.4.562 · Cited by 267 · see citing works

Primary Biliary Cirrhosis

Hirschfield, G. M., & Heathcote, E. J. (2010) · Wiley eBooks · doi:10.1002/9781444314403.ch32 · Cited by 260 · see citing works

MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancerPreprint

Olson, P., Lü, J., Zhang, H., Shai, A., Chun, M. G. H., Wang, Y., Libutti, S. K., Nakakura, E. K., Golub, T. R., & Hanahan, D. (2009) · Genes & Development · doi:10.1101/gad.1820109 · Cited by 259 · see citing works

Reading signals on the nucleosome with a new nomenclature for modified histones

Turner, B. M. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb0205-110 · Cited by 258 · see citing works

The regulation of T cell homeostasis and autoimmunity by T cell–derived LIGHT

Wang, J. H., Lo, J. C., Foster, A., Yu, P., Chen, H. M., Wang, Y., Tamada, K., Chen, L., & Fu, Y. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13827 · Cited by 249 · see citing works

Nongenetic inheritance and transgenerational epigenetics

Szyf, M. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.12.004 · Cited by 238 · see citing works

Risk factors for primary biliary cirrhosis in a cohort of patients from the United States

Parikh-Patel, A., Gold, E. B., Worman, H., Krivy, K. E., & Gershwin, E. M. (2001) · Hepatology · doi:10.1053/jhep.2001.21165 · Cited by 236 · see citing works

Demographic, lifestyle, medical and familial factors associated with primary biliary cirrhosis

Corpechot, C., Chrétien, Y., Chazouillères, O., & Poupon, R. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.02.019 · Cited by 235 · see citing works

Epigenetic reprogramming of host genes in viral and microbial pathogenesis

Paschos, K., & Allday, M. J. (2010) · Trends in Microbiology · doi:10.1016/j.tim.2010.07.003 · Cited by 229 · see citing works

DNA methylation pattern in human zygotes and developing embryos

Fulka, J., Mrazek, M., Tepla, O., & Fulka, J. (2004) · Reproduction · doi:10.1530/rep.1.00217 · Cited by 227 · see citing works

Apotopes and the biliary specificity of primary biliary cirrhosis†

Lleo, A., Selmi, C., Invernizzi, P., Podda, M., Coppel, R. L., Mackay, I. R., Gores, G. J., Ansari, A. A., Van de Water, J., & Gershwin, M. E. (2009) · Hepatology · doi:10.1002/hep.22736 · Cited by 222 · see citing works

Diverse Roles and Interactions of the SWI/SNF Chromatin Remodeling Complex Revealed Using Global Approaches

Euskirchen, G. M., Auerbach, R. K., Davidov, E., Gianoulis, T. A., Zhong, G., Rozowsky, J. S., Bhardwaj, N., Gerstein, M., & Snyder, M. P. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002008 · Cited by 219 · see citing works

IL-12/Th1 and IL-23/Th17 Biliary Microenvironment in Primary Biliary Cirrhosis: Implications for Therapy

Yang, C.-Y., Ma, X., Tsuneyama, K., Huang, S., Takahashi, T., Chalasani, N. P., Bowlus, C. L., Yang, G.-X., Leung, P. S. C., Ansari, A. A., et al. (2014) · Hepatology · doi:10.1002/hep.26979 · Cited by 213 · see citing works

Diet, the Gut Microbiome, and Epigenetics

Hullar, M. A. J., & Fu, B. C. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000053 · Cited by 205 · see citing works

Epigenetic Influence of Stress and the Social Environment

Gudsnuk, K. M., & Champagne, F. A. (2012) · ILAR Journal · doi:10.1093/ilar.53.3-4.279 · Cited by 185 · see citing works

Epigenetic transgenerational inheritance

Skinner, M. K. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.206 · Cited by 184 · see citing works

Periductal interleukin‐17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis

Harada, K., Shimoda, S., Sato, Y., Isse, K., Ikeda, H., & Nakanuma, Y. (2009) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2009.03947.x · Cited by 183 · see citing works

Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease†

Wakabayashi, K., Lian, Z., Leung, P. S. C., Moritoki, Y., Tsuneyama, K., Kurth, M. J., Lam, K. S., Yoshida, K., Yang, G., Hibi∥, T., et al. (2008) · Hepatology · doi:10.1002/hep.22390 · Cited by 180 · see citing works

Case‐control studies of risk factors for primary biliary cirrhosis in two United Kingdom populations

Prince, M. I., Ducker, S. J., & James, O. F. W. (2010) · Gut · doi:10.1136/gut.2009.184218 · Cited by 171 · see citing works

Increased DNA methylation variability in type 1 diabetes across three immune effector cell types

Paul, D. S., Teschendorff, A. E., Dang, M. N., Lowe, R., Hawa, M. I., Ecker, S., Beyan, H., Cunningham, S. L., Fouts, A., Ramelius, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms13555 · Cited by 170 · see citing works

Helicobacter pylori Infection, Oncogenic Pathways and Epigenetic Mechanisms in Gastric Carcinogenesis

Ding, S., Goldberg, J. B., & Hatakeyama, M. (2010) · Future Oncology · doi:10.2217/fon.10.37 · Cited by 169 · see citing works

Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population

Rong, G., Zhou, Y., Xiong, Y., Zhou, L., Geng, H., Jiang, T., Zhu, Y., Lu, H., Zhang, S., Wang, P., et al. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03898.x · Cited by 162 · see citing works

Immunoreactivity of Organic Mimeotopes of the E2 Component of Pyruvate Dehydrogenase: Connecting Xenobiotics with Primary Biliary Cirrhosis

Long, S. A., Quan, C., de Water, J. V., Nantz, M. H., Kurth, M. J., Barsky, D., Colvin, M. E., Lam, K. S., Coppel, R. L., Ansari, A. A., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.5.2956 · Cited by 161 · see citing works

The Genetics of Complex Cholestatic Disorders

Hirschfield, G. M., Chapman, R. W., Karlsen, T. H., Lammert, F., Lazaridis, K. N., & Mason, A. L. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.03.053 · Cited by 143 · see citing works

Preferential X chromosome loss but random inactivation characterize primary biliary cirrhosis†

Miozzo, M. R., Selmi, C. F., Gentilin, B., Grati, F. R., Sirchia, S. M., Oertelt‐Prigione, S., Zuin, M. G., Gershwin, M. E., Podda, M., & Invernizzi, P. (2007) · Hepatology · doi:10.1002/hep.21696 · Cited by 136 · see citing works

Immunoglobulin M levels inversely correlate with CD40 ligand promoter methylation in patients with primary biliary cirrhosis

Lleo, A., Liao, J., Invernizzi, P., Zhao, M., Bernuzzi, F., Ma, L., Lanzi, G., Ansari, A. A., Coppel, R. L., Zhang, P., et al. (2012) · Hepatology · doi:10.1002/hep.24630 · Cited by 133 · see citing works

An exploratory population-based case-control study of primary biliary cirrhosis

Howel, D., Fischbacher, C. M., Bhopal, R. S., Gray, J., Metcalf, J. V., & James, O. F. (2000) · Hepatology · doi:10.1053/he.2000.7050 · Cited by 131 · see citing works

Primary sclerosing cholangitis is associated with nonsmoking: A case- control study

Loftus, E. V., Sandborn, W., Tremaine, W., Mahoney, D., Zinsmeister, A., Offord, K., & Melton, L. J. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8613055 · Cited by 129 · see citing works

Immunization with a Xenobiotic 6-Bromohexanoate Bovine Serum Albumin Conjugate Induces Antimitochondrial Antibodies

Leung, P. S. C., Quan, C., Park, O., de Water, J. V., Kurth, M. J., Nantz, M. H., Ansari, A. A., Coppel, R. L., Lam, K. S., & Gershwin, M. E. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.5326 · Cited by 124 · see citing works

Chronic expression of interferon‐gamma leads to murine autoimmune cholangitis with a female predominance

Bae, H. R., Leung, P. S. C., Tsuneyama, K., Valencia, J. C., Hodge, D. L., Kim, S., Back, T., Karwan, M., Merchant, A. S., Baba, N., et al. (2016) · Hepatology · doi:10.1002/hep.28641 · Cited by 121 · see citing works

Cigarette smoking, appendectomy, and tonsillectomy as risk factors for the development of primary sclerosing cholangitis: a case control study

Mitchell, S. A. (2002) · Gut · doi:10.1136/gut.51.4.567 · Cited by 118 · see citing works

Ancestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs

Schuster, A. S., Skinner, M. K., & Yan, W. (2016) · Current Zoology · doi:10.1093/eep/dvw001 · Cited by 117 · see citing works

Epigenetics in autoimmune diseases: Pathogenesis and prospects for therapy.

Zhang, Z., & Zhang, R. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.05.008 · Cited by 116 · see citing works

Y chromosome loss in male patients with primary biliary cirrhosis

Lleò, A., Oertelt‐Prigione, S., Bianchi, I., Caliari, L., Finelli, P., Miozzo, M. R., Lazzari, R., Floreani, A., Donato, F., Colombo, M., et al. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.12.008 · Cited by 113 · see citing works

X-linked immunodeficiency with hyper-IgM (XHIM)

Notarangelo, L. D., & Hayward, A. R. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01142.x · Cited by 111 · see citing works

Novel insights into autoimmune liver diseases provided by genome-wide association studies

Mells, G. F., Kaser, A., & Karlsen, T. H. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.07.004 · Cited by 110 · see citing works

TNF ligands and receptors in autoimmunity: an update

Mackay, F., & Kalled, S. L. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00407-7 · Cited by 108 · see citing works

Risk of primary sclerosing cholangitis is associated with nonsmoking behavior

van Erpecum, K. J., Smits, S. R. J. G., van de Meeberg, P., Linn, F. H. H., Wolfhagen, F. H. J., Henegouwen, G. P. V. B., & Algra, A. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8613056 · Cited by 105 · see citing works

Genetic studies of Crohn's disease: Past, present and future

Liu, J. Z., & Anderson, C. A. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.04.009 · Cited by 104 · see citing works

DNA methylation profiling of the X chromosome reveals an aberrant demethylation on CXCR3 promoter in primary biliary cirrhosis

Lleò, A., Zhang, W., Zhao, M., Tan, Y., Bernuzzi, F., Zhu, B., Liu, Q., Tan, Q., Malinverno, F., Valenti, L. V. C., et al. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0098-9 · Cited by 90 · see citing works

Environmental epigenomics and disease susceptibility

Skinner, M. K. (2011) · EMBO Reports · doi:10.1038/embor.2011.125 · Cited by 90 · see citing works

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

Fu, W., Farache, J., Clardy, S. M., Hattori, K., Mander, P. K., Lee, K. C., Rioja, I., Weissleder, R., Prinjha, R. K., Benoist, C. O., et al. (2014) · eLife · doi:10.7554/elife.04631 · Cited by 83 · see citing works

Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis

Mitchell, M. M., Lleò, A., Zammataro, L. A., Mayo, M. J., Invernizzi, P., Bach, N., Shimoda, S., Gordon, S. C., Podda, M., Gershwin, M. E., et al. (2011) · Epigenetics · doi:10.4161/epi.6.1.13405 · Cited by 79 · see citing works

Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization

Wakabayashi, K., Yoshida, K., Leung, P. S. C., Moritoki, Y., Yang, G.-X., Tsuneyama, K., Lian, Z.-X., Hibi∥, T., Ansari, A. A., Wicker, L. S., et al. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03837.x · Cited by 78 · see citing works

Effects of Coffee Consumption, Smoking, and Hormones on Risk for Primary Sclerosing Cholangitis

Andersen, I. M., Tengesdal, G., Lie, B. A., Boberg, K. M., Karlsen, T. H., & Hov, J. R. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.09.024 · Cited by 75 · see citing works

Genome-Wide Analysis of DNA Methylation, Copy Number Variation, and Gene Expression in Monozygotic Twins Discordant for Primary Biliary Cirrhosis

Selmi, C. F., Cavaciocchi, F., Lleò, A., Cheroni, C., Francesco, R. D., Lombardi, S. A., Santis, M. D., Meda, F., Raimondo, M. G., Crotti, C., et al. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00128 · Cited by 71 · see citing works

Microbiome–Epigenome Interactions and the Environmental Origins of Inflammatory Bowel Diseases

Fofanova, T. Y., Petrosino, J. F., & Kellermayer, R. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000950 · Cited by 66 · see citing works

A comprehensive assessment of environmental exposures among 1000 North American patients with primary sclerosing cholangitis, with and without inflammatory bowel disease

Eaton, J. E., Juran, B. D., Atkinson, E. J., Schlicht, E. M., Xie, X., de Andrade, M., Lammert, C. S., Luketic, V. A., Odin, J. A., Koteish, A. A., et al. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13154 · Cited by 65 · see citing works

Predisease: When Does it Make Sense?

Viera, A. J. (2011) · Epidemiologic Reviews · doi:10.1093/epirev/mxr002 · Cited by 54 · see citing works

β-Arrestin 1 Modulates Functions of Autoimmune T Cells from Primary Biliary Cirrhosis Patients

Hu, Z., Huang, Y., Liu, Y., Sun, Y., Zhou, Y., Gu, M., Chen, Y., Xia, R., Chen, S., Deng, A., et al. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9492-4 · Cited by 50 · see citing works

Primary biliary cirrhosis

Nguyen, D. L., Juran, B. D., & Lazaridis, K. N. (2010) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2010.07.006 · Cited by 46 · see citing works

Farnesoid X receptor–induced lysine‐specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity

Kim, Y., Fang, S., Byun, S., Seok, S., KEMPER, B. W., & Kemper, J. K. (2014) · Hepatology · doi:10.1002/hep.27677 · Cited by 43 · see citing works

Questionnaire based assessment of risk factors for primary biliary cirrhosis

Lammert, C., Nguyen, D. L., Juran, B. D., Schlicht, E., Larson, J. J., Atkinson, E. J., & Lazaridis, K. N. (2013) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.01.028 · Cited by 40 · see citing works

Reduced Coffee Consumption Among Individuals With Primary Sclerosing Cholangitis but Not Primary Biliary Cirrhosis

Lammert, C. S., Juran, B. D., Schlicht, E. M., Xie, X., Atkinson, E. J., de Andrade, M., & Lazaridis, K. N. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.12.036 · Cited by 39 · see citing works

Immune Disease-Associated Variants in Gene Enhancers Point to BET Epigenetic Mechanisms for Therapeutic Intervention

Tough, D. F., & Prinjha, R. K. (2016) · Epigenomics · doi:10.2217/epi-2016-0144 · Cited by 37 · see citing works

Epigenetic Signatures of Obesity

Ozanne, S. E. (2015) · New England Journal of Medicine · doi:10.1056/nejmcibr1414707 · Cited by 36 · see citing works

Potential of epigenetic therapies in non-cancerous conditions

Mau, T., & Yung, R. L. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00438 · Cited by 35 · see citing works

Identification and function of enhancers in the human genome

Coppola, C. J., Ramaker, R. C., & Mendenhall, E. M. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw216 · Cited by 33 · see citing works

Insights into missing heritability

Koch, L. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3713 · Cited by 29 · see citing works

Characterisation of TNF-related apoptosis-inducing ligand in peripheral blood in patients with primary biliary cirrhosis

Liang, Y., Yang, Z., Li, C., Zhu, Y., Lingzhen, Z., & Zhong, R. (2008) · Clinical and Experimental Medicine · doi:10.1007/s10238-008-0149-z · Cited by 29 · see citing works

Topical agents for idiopathic distal colitis and proctitis

Lawrance, I. C. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06497.x · Cited by 24 · see citing works

Soluble apoptosis molecules in primary biliary cirrhosis: analysis and commitment of the Fas and tumour necrosis factor-related apoptosis-inducing ligand systems in comparison with chronic hepatitis C

Pelli, N., Floreani, A., Torre, F., Delfino, A., Baragiotta, A. M., Contini, P., Basso, M., & Picciotto, A. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03293.x · Cited by 22 · see citing works

The Microbiome and Primary Sclerosing Cholangitis

Ali, A. H., Carey, E. J., & Lindor, K. M. (2016) · Seminars in Liver Disease · doi:10.1055/s-0036-1594007 · Cited by 19 · see citing works

Role of epigenetic reprogramming of host genes in bacterial pathogenesis.

Alakeel, R. (2013) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2013.05.003 · Cited by 18 · see citing works

An epigenetic twist on the missing heritability of complex traits

Koch, L. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3698 · Cited by 17 · see citing works

Dual Roles of IFN-γ and IL-4 in the Natural History of Murine Autoimmune Cholangitis: IL-30 and Implications for Precision Medicine

Syu, B.-J., Loh, C.-E., Hsueh, Y.-H., Gershwin, M. E., & Chuang, Y. (2016) · Scientific Reports · doi:10.1038/srep34884 · Cited by 16 · see citing works

Therapy of Primary Biliary Cirrhosis: Novel Approaches for Patients with Suboptimal Response to Ursodeoxycholic Acid

Parés, A. R. (2015) · Digestive Diseases · doi:10.1159/000440761 · Cited by 9 · see citing works

Epitranscriptomics: mixed messages

Eisenstein, M. S. (2016) · Nature Methods · doi:10.1038/nmeth.4125 · Cited by 7 · see citing works

Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases

Lindor, K. D., Bowlus, C. L., Boyer, J., Levy, C., & Mayo, M. (2019) · Hepatology · doi:10.1002/hep.30145 · Cited by 913 · see citing works

Cholangiocarcinoma in Patients with Primary Sclerosing Cholangitis (PSC): a Comprehensive Review

Song, J., Li, Y., Bowlus, C. L., Yang, G., Leung, P. S. C., & Gershwin, M. E. (2019) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-019-08764-7 · Cited by 98 · see citing works

Clinical Updates in Primary Biliary Cholangitis: Trends, Epidemiology, Diagnostics, and New Therapeutic Approaches

Galoosian, A., Hanlon, C. L., Zhang, J., Holt, E. W., & Yimam, K. K. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2019.00049 · Cited by 57 · see citing works

Genetics and epigenetics in the pathogenesis of primary biliary cholangitis

Joshita, S., Umemura, T., Tanaka, E., & Ôta, M. (2017) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-017-0799-z · Cited by 51 · see citing works

Epigenetic changes and their implications in autoimmune hepatitis

Czaja, A. J. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12899 · Cited by 36 · see citing works

Support of precision medicine through risk-stratification in autoimmune liver diseases – histology, scoring systems, and non-invasive markers

Bossen, L., Gerussi, A., Lygoura, V., Mells, G. F., Carbone, M., & Invernizzi, P. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.02.013 · Cited by 33 · see citing works

Proteasomal Degradation of Enhancer of Zeste Homologue 2 in Cholangiocytes Promotes Biliary Fibrosis

Jalan‐Sakrikar, N., de Assuncao, T. M., Shi, G., Aseem, S. O., Chi, C., Shah, V. H., & Huebert, R. C. (2019) · Hepatology · doi:10.1002/hep.30706 · Cited by 31 · see citing works

Bile Acids and Biliary Fibrosis

Aseem, S. O., Hylemon, P. B., & Zhou, H. (2023) · Cells · doi:10.3390/cells12050792 · Cited by 24 · see citing works

Roles of Trained Immunity in the Pathogenesis of Cholangiopathies: A Therapeutic Target

Yan, C., Koda, S., Wu, J., Zhang, B., Yu, Q., Netea, M. G., Tang, R., & Zheng, K. (2020) · Hepatology · doi:10.1002/hep.31395 · Cited by 21 · see citing works

Cholangiocyte death in ductopenic cholestatic cholangiopathies: Mechanistic basis and emerging therapeutic strategies

Salas‐Silva, S., Nieves, A. S., López-Ramirez, J., Bucio, L., Gómez-Quiroz, L. E., Gutiérrez‐Ruíz, M. C., & Roma, M. G. (2019) · Life Sciences · doi:10.1016/j.lfs.2018.12.044 · Cited by 20 · see citing works

Panic at the Bile Duct

Hrncir, H. R., Hantelys, F., & Gracz, A. D. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.02.012 · Cited by 18 · see citing works

Epigenetic Aspects and Prospects in Autoimmune Hepatitis

Czaja, A. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.921765 · Cited by 17 · see citing works

A nationwide study of primary biliary cholangitis prevalence, geographic distribution, and health care providers

Levy, C., Buchanan-Peart, K.-A., MacEwan, J. P., Levine, A., Nair, R., Wheeler, D., Bessonova, L., Goel, A., Gish, R. G., & Bonder, A. (2025) · Hepatology Communications · doi:10.1097/hc9.0000000000000677 · Cited by 16 · see citing works

Epigenetics of Primary Biliary Cholangitis

Li, Y., Tang, R., & Ma, X. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-3449-2_10 · Cited by 14 · see citing works

Current and promising therapy for primary biliary cholangitis

Gossard, A. A., & Lindor, K. D. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1601701 · Cited by 15 · see citing works

Epigenetic Modifications in Generalized Autoimmune Epithelitis: Sjögren’s Syndrome and Primary Biliary Cholangitis

Arvaniti, P., Zachou, K., Lyberopoulou, A., Gatselis, N., Brooks, W. H., Dalekos, G. N., & Renaudineau, Y. (2019) · Epigenomes · doi:10.3390/epigenomes3030015 · Cited by 14 · see citing works

Cholestatic liver disease: Practice guidelines from the Saudi Association for the Study of Liver diseases and Transplantation

Mawardi, M., Alalwan, A. M., Fallatah, H. I., Abaalkhail, F. A., Hasosah, M. Y., Shagrani, M. A., Alghamdi, M., & Alghamdi, A. (2021) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_112_21 · Cited by 12 · see citing works

Cell-free DNA testing: future applications in gastroenterology and hepatology

Zandvakili, I., & Lazaridis, K. N. (2019) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284819841896 · Cited by 12 · see citing works

Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro

Nevi, L., Costantini, D., Safarikia, S., Matteo, S. D., Melandro, F., Berloco, P. B., & Cardinale, V. (2019) · Cells · doi:10.3390/cells8111443 · Cited by 10 · see citing works

Cholangiocarcinoma Surveillance Recommendations in Patients with Primary Sclerosing Cholangitis

Saca, D., & Flamm, S. L. (2023) · Clinics in Liver Disease · doi:10.1016/j.cld.2023.07.010 · Cited by 9 · see citing works

The Treatment of Primary Biliary Cholangitis: Time for Personalized Medicine

Men, X., Liu, Y., Zhao, H., Xie, B., Guo, C., Leung, P. S. C., Timilsina, S., Gershwin, M. E., Shang, Y., & Han, Y. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09074-x · Cited by 8 · see citing works

Epigenetic disease markers in primary sclerosing cholangitis and primary biliary cholangitis—methylomics of cholestatic liver disease

Juran, B. D., McCauley, B. M., Atkinson, E. J., Schlicht, E. M., Bianchi, J. K., Vollenweider, J. M., Ye, H., LaRusso, N. F., Gores, G. J., Sun, Z., et al. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000496 · Cited by 8 · see citing works

Investigational drugs in early phase development for primary biliary cholangitis

Gochanour, E. M., & Kowdley, K. V. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2021.1857364 · Cited by 8 · see citing works

Epigenetic Signatures Discriminate Patients With Primary Sclerosing Cholangitis and Ulcerative Colitis From Patients With Ulcerative Colitis

de Krijger, M., Hageman, I., Yim, A. Y. F. L., Verhoeff, J., García-Vallejo, J. J., van Hamersveld, P. H. P., Levin, E., Hakvoort, T. B. M., Wildenberg, M. E., Henneman, P., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.840935 · Cited by 7 · see citing works

DNA Methylation Profile of Liver Tissue in End-Stage Cholestatic Liver Disease

Cheung, A., Juran, B. D., Schlicht, E. M., McCauley, B. M., Atkinson, E. J., Moore, R. M., Heimbach, J. K., Watt, K. D. S., Wu, T., LaRusso, N. F., et al. (2022) · Epigenomics · doi:10.2217/epi-2021-0343 · Cited by 7 · see citing works

Investigational farnesoid X receptor agonists for the treatment of primary biliary cholangitis

Akepati, P. R., & Gochanour, E. M. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2348743 · Cited by 6 · see citing works

Genome-wide Resolution Peripheral Blood Methylome Profiling Reveals Signatures for Cholestatic Liver Disease

Moore, R. M., Sun, Z., Juran, B. D., & Lazaridis, K. N. (2020) · Epigenomics · doi:10.2217/epi-2020-0048 · Cited by 5 · see citing works

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Pan, W., Yong, Y., Li, Y., Shi, G., Zhang, M., Wan, L., Zhao, Y., Zhan, W., Lin, Y., Qin, Q., et al. (2025) · Advanced Science · doi:10.1002/advs.202512799 · Cited by 4 · see citing works

Epigenetics of autoimmune liver diseases: current progress and future directions

Liu, Q., Li, Y., Ma, X., & Tang, R. (2019) · Journal of Bio-X Research · doi:10.1097/jbr.0000000000000030 · Cited by 3 · see citing works

Adverse events associated with obeticholic acid: a real-world, pharmacovigilance study

Zhang, C., & Wang, J. (2025) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2025.2487144 · Cited by 2 · see citing works

The Pathogenesis of Autoimmune Liver Diseases

Kovalic, A. J., & Bonkovsky, H. L. (2020) · Springer eBooks · doi:10.1007/978-3-030-33628-8_2 · Cited by 2 · see citing works

Clinical Patterns of Primary Biliary Cholangitis: Comparison Between Two European Case Series

Abenavoli, L., Procopio, A. C., Cinaglia, P., Zanza, C., Grazie, C. D., Longhitano, Y., Libicherová, P., & Luzza, F. (2022) · Reviews on Recent Clinical Trials · doi:10.2174/1574887117666220617095856 · Cited by 2 · see citing works

Anticuerpos antimitocondriales y anticuerpos contra antígenos extraíbles del núcleo en pacientes con cirrosis biliar primaria

Menacho, J. E. O., & Candela, J. A. O. (2020) · Revista Médica Herediana · doi:10.20453/rmh.v31i2.3770

Caracterización de los efectos de protección hepática y renal del factor de crecimiento de hepatocitos en la colestasis intrahepática

Silva, E. S. S. (2020) · doi:10.24275/uami.7w62f834n

Integrative Analysis of Molecular Interactions and Repurposable Drugs in Primary Biliary Cholangitis

Sari, D., Helvacı, N., Çon, F., & Kural, A. (2026) · Pharmedicine journal. · doi:10.62482/pmj.40

Breaking the metabolo-immune cycle in primary biliary cholangitis for therapeutic benefit

Yan, S., Wang, H., Du, S., Li, Y., Yang, D., Xu, M., & Jin, Q. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1766177

Orchestrated cell death pathways in cholangiopathies

Guicciardi, M. E., Pistorio, V., Soret, P., Steunou, V., Gores, G. J., & Gautheron, J. (2026) · Gut · doi:10.1136/gutjnl-2026-339264

Epigenetics of Primary Biliary Cholangitis

Li, Y., Tang, R., & Ma, X. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-3449-2_10 · Cited by 14 · see citing works

Epigenetic disease markers in primary sclerosing cholangitis and primary biliary cholangitis—methylomics of cholestatic liver disease

Juran, B. D., McCauley, B. M., Atkinson, E. J., Schlicht, E. M., Bianchi, J. K., Vollenweider, J. M., Ye, H., LaRusso, N. F., Gores, G. J., Sun, Z., et al. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000496 · Cited by 8 · see citing works

The Epigenetics of Primary Biliary Cholangitis

Marzorati, S., Lleò, A., & Invernizzi, P. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809912-4.00013-1

Genetics and epigenetics in the pathogenesis of primary biliary cholangitis

Joshita, S., Umemura, T., Tanaka, E., & Ôta, M. (2017) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-017-0799-z · Cited by 51 · see citing works

The Role of Epigenetics in Primary Biliary Cholangitis

Gerussi, A., Paraboschi, E. M., Cappadona, C., Caime, C., Binatti, E., Cristoferi, L., Asselta, R., & Invernizzi, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094873 · Cited by 27 · see citing works