The Influence of Quercetin on Maternal Immunity, Oxidative Stress, and Inflammation in Mice with Exposure of Fine Particulate Matter during Gestation
Open accessAbstract
The objective is to investigate the influence of PM2.5 exposure on peripheral blood lymphocyte subsets in pregnant mice and the antagonism of quercetin on adverse effects induced by PM2.5 exposure. Pregnant mice were randomly divided into control group, PM2.5 model group and 3 quercetin intervention groups. Dams in all groups except the control group were exposed to PM2.5 suspension by intratracheal instillation on gestational day (GD) 3, 6, 9, 12 and 15. Meanwhile, each dam was given 0.15% carboxymethylcellulose sodium (CMCS) (control group & PM2.5 model group) and different doses of quercetin (quercetin intervention groups) by gavage once a day from GD0 to GD17. The percentage of lymphocyte subsets, Biomarkers of systemic inflammation injuries (IL-2, IL-6, IL-8 & TNF-α) and oxidative stress indicators (CAT, GSH & HO-1) in peripheral blood of the dams were analyzed. The number of T cells increased, accompanied by increased level of IL-2, IL-6, IL-8 and HO-1 due to PM2.5 exposure. Less CD4+ and CD8+ T cells were counted in 100 mg/kg quercetin intervention group, compared with PM2.5 model group. Quercetin may inhibit cytokine production, especially in IL-6 and IL-8 and may upgrade the level of HO-1. Our findings indicate that PM2.5 could significantly influence the distribution of T-lymphocyte subsets, activate inflammatory reaction and elevate oxidative stress level in peripheral blood of pregnant mice. Certain dose of quercetin administration during pregnancy may protect the dams against the adverse effects through various ways.
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Biomarkers of systemic inflammation in an ICR mouse model employing gestational PM2.5 exposure indicated increased IL-2, IL-6, IL-8, and TNFα.
“Biomarkers of systemic inflammation measured in peripheral blood in an ICR mouse model employing gestational PM2.5 exposure indicated increased IL-2, IL-6, IL-8, and TNFα [170].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [170]
Methods §2.2 identifies the gestational PM2.5 model as ICR mice, and Methods §2.3 says the cytokines were measured in maternal blood serum. Results §3.6 reports increased IL-2, IL-6, and IL-8 in the PM2.5 group versus controls, but TNF-α was lower, not increased. (LLM, conf=0.94)
Experimental — accuracy not yet measuredHigher doses of quercetin supplementation protected the dams against these adverse effects.
“In the quercetin intervention groups, higher doses of supplementation protected the dams against these adverse effects.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [170]
The Results (§§3.5–3.7; page unavailable) show protective effects in the dams: the 100 mg/kg group had fewer elevated T-cell subsets, and the 200 mg/kg group had lower IL-6 and higher HO-1 than the PM2.5 model group. But the 200 mg/kg group did not show the reported T-cell improvement, and the Discussion (§4; page unavailable) says the medium dose had the most apparent effect. The claim overstates how consistently higher doses protected against the adverse effects. (LLM, conf=0.87)
Experimental — accuracy not yet measuredGestational PM2.5 exposure led to significantly altered T-lymphocyte subsets and increased markers of systemic inflammation and oxidative stress in peripheral blood of pregnant mice.
“In this model, gestational PM2.5 exposure led to significantly altered T-lymphocyte subsets and increased markers of systemic inflammation and oxidative stress in peripheral blood of pregnant mice.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [170]
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- Authors
- Liu, W., Zhang, M., Feng, J., Fan, A., Zhou, Y., & Xu, Y.
- Affiliations
- Peking University (CN)
- Corresponding author
- Xu, Yajun
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2017-06-02
- Volume
- 14
- Issue
- 6
- Pages
- 592
- ISSN
- 1660-4601 (ISSN-L)
- PMC
- PMC5486278
- OpenAlex
- W2620998393
- Cited by
- 63
- References
- 46
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 12 · 2021: 7 · 2020: 11 · 2019: 7 · 2018: 6 · 2017: 1
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- quercetin, PM2.5, prenatal exposure, maternal immunity, lymphocyte subsets, T cells, oxidative stress, inflammation, cytokines, interleukin-6, interleukin-8, TNF-α, interleukin-2, heme oxygenase-1, glutathione, catalase, air pollution, pregnancy protection
- MeSH terms
- Animals, Female, Gene Expression Regulation, Inflammation, Pregnancy, Quercetin, Random Allocation, Biomarkers, Lymphocyte Subsets, Cytokines, Oxidative Stress, Protective Agents, Mice, Particulate Matter
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