CoChat
Sign Up
Cited by 164Air Quality and Health ImpactsEnvironmental Justice and Health DisparitiesPreterm Birth and Chorioamnionitis

Intrauterine Inflammation and Maternal Exposure to Ambient PM2.5 during Preconception and Specific Periods of Pregnancy: The Boston Birth Cohort

Open access
Nachman, Rebecca Massa, Mao, Guangyun, Zhang, Xingyou, Hong, Xiumei, Chen, Zhu, Soria, Claire Sampankanpanich, He, Huan, Wang, Guoying +6 more·2016·Environmental Health Perspectives
DOI 10.1289/ehp243PMC PMC5047781
Open this paper in CoChat — free accountOpen PDF

Abstract

Background: Prenatal exposure to ambient PM2.5, (i.e., fine particulate matter, aerodynamic diameter ≤ 2.5 μm) has been associated with preterm birth and low birth weight. The association between prenatal PM2.5 exposure and intrauterine inflammation (IUI), an important risk factor for preterm birth and neurodevelopmental outcomes, has not been evaluated. Objectives: We aimed to investigate the association between maternal exposure to PM2.5 and IUI in the Boston Birth Cohort, a predominantly urban low-income minority population. Methods: This analysis included 5,059 mother–infant pairs in the Boston Birth Cohort. IUI was assessed based on intrapartum fever and placenta pathology. PM2.5 exposure was assigned using data from the U.S. EPA’s Air Quality System. Odds ratios (OR) and 95% confidence intervals (CI) quantified the association of maternal PM2.5 exposure during preconception and various periods of pregnancy with IUI. Results: Comparing the highest with the lowest PM2.5 exposure quartiles, the multi-adjusted association with IUI was significant for all exposure periods considered, including 3 months before conception (OR = 1.52; 95% CI: 1.22, 1.89), first trimester (OR = 1.93; 95% CI: 1.55, 2.40), second trimester (OR = 1.67; 95% CI: 1.35, 2.08), third trimester (OR = 1.53; 95% CI: 1.24, 1.90), and whole pregnancy (OR = 1.92; 95% CI: 1.55, 2.37). Conclusions: Despite relatively low exposures, our results suggest a monotonic positive relationship between PM2.5 exposure during preconception and pregnancy and IUI. IUI may be a sensitive biomarker for assessing early biological effect of PM2.5 exposure on the developing fetus. Citation: Nachman RM, Mao G, Zhang X, Hong X, Chen Z, Soria CS, He H, Wang G, Caruso D, Pearson C, Biswal S, Zuckerman B, Wills-Karp M, Wang X. 2016. Intrauterine inflammation and maternal exposure to ambient PM2.5 during preconception and specific periods of pregnancy: the Boston Birth Cohort. Environ Health Perspect 124:1608–1615; http://dx.doi.org/10.1289/EHP243

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1289/ehp243

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 38

  1. Astolfi P Zonta LA 1999 Risks of preterm delivery and association with maternal age, birth order and fetal gender. Hum Reprod 14 2891 2894 10548643
  2. Backes CH Nelin T Gorr MW Wold LE 2013 Early life exposure to air pollution: how bad is it? Toxicol Lett 216 1 47 53, doi: 10.1016/j.toxlet.2012.11.007 23164674 PMC3527658 · DOI
  3. Bell ML Ebisu K Belanger K 2007 Ambient air pollution and low birth weight in Connecticut and Massachusetts. Environ Health Perspect 115 1118 1124, doi: 10.1289/ehp.9759 17637932 PMC1913584 · DOI
  4. Benirschke KKP, Kaufmann P, Baergen R 2000 Pathology of the Human Placenta. New York Springer
  5. Brauer M Lencar C Tamburic L Koehoorn M Demers P Karr C 2008 A cohort study of traffic-related air pollution impacts on birth outcomes. Environ Health Perspect 116 680 686, doi: 10.1289/ehp.10952 18470315 PMC2367679 · DOI
  6. Dadvand P Basagaña X Figueras F Martinez D Beelen R Cirach M 2014 Air pollution and preterm premature rupture of membranes: a spatiotemporal analysis. Am J Epidemiol 179 2 200 207, doi: 10.1093/aje/kwt240 24125920 · DOI
  7. de Melo JO Soto SF Katayama IA Wenceslau CF Pires AG Veras MM 2015 Inhalation of fine particulate matter during pregnancy increased IL-4 cytokine levels in the fetal portion of the placenta. Toxicol Lett 232 2 475 480, doi: 10.1016/j.toxlet.2014.12.001 25481569 · DOI · Paper page
  8. Fleischer NL Merialdi M van Donkelaar A Vadillo-Ortega F Martin RV Betran AP 2014 Outdoor air pollution, preterm birth, and low birth weight: analysis of the World Health Organization global survey on maternal and perinatal health. Environ Health Perspect 122 425 430, doi: 10.1289/ehp.1306837 24508912 PMC3984219 · DOI
  9. Gehring U Wijga AH Fischer P de Jongste JC Kerkhof M Koppelman GH 2011 Traffic-related air pollution, preterm birth and term birth weight in the PIAMA birth cohort study. Environ Res 111 1 125 135, doi: 10.1016/j.envres.2010.10.004 21067713 · DOI
  10. Gibbs RS Blanco JD St Clair PJ Castaneda YS 1982 Quantitative bacteriology of amniotic fluid from women with clinical intraamniotic infection at term. J Infect Dis 145 1 1 8 7033397
  11. Goldenberg RL Culhane JF Iams JD Romero R 2008 Epidemiology and causes of preterm birth. Lancet 371 75 84, doi: 10.1016/S0140-6736(08)60074-4 18177778 PMC7134569 · DOI · Paper page
  12. Gupta M Mestan KK Martin CR Pearson C Ortiz K Fu L 2007 Impact of clinical and histologic correlates of maternal and fetal inflammatory response on gestational age in preterm births. J Matern Fetal Neonatal Med 20 1 39 46, doi: 10.1080/14767050601156861 17437198 · DOI
  13. Hajat A Allison M Diez-Roux AV Jenny NS Jorgensen NW Szpiro AA 2015 Long-term exposure to air pollution and markers of inflammation, coagulation, and endothelial activation: a repeat-measures analysis in the Multi-Ethnic Study of Atherosclerosis (MESA). Epidemiology 26 310 320 25710246 PMC4455899
  14. Incerpi MH 2010 Chorio-amnionitis and postpartum endometritis. In: Management of Common Problems in Obstetrics and Gynecology. (Goodwin TM, Montoro MN, Muderspach L, Paulson R, Roy S, eds) Oxford, UK Blackwell Publishing Ltd 48 51
  15. Institute of Medicine (U.S.) Committee on Understanding Premature Birth and Assuring Healthy Outcomes 2007 Preterm Birth: Causes, Consequences, and Prevention. Washington, DC National Academies Press
  16. Jalaludin B Mannes T Morgan G Lincoln D Sheppeard V Corbett S 2007 Impact of ambient air pollution on gestational age is modified by season in Sydney, Australia. Environ Health 6 16, doi: 10.1186/1476-069X-6-16 17553174 PMC1894960 · DOI
  17. Jones MR Diez-Roux AV Hajat A Kershaw KN O’Neill MS Guallar E 2014 Race/ethnicity, residential segregation, and exposure to ambient air pollution: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Public Health 104 11 2130 2137, doi: 10.2105/AJPH.2014.302135 25211756 PMC4202969 · DOI
  18. Kloog I Melly SJ Ridgway WL Coull BA Schwartz J 2012 Using new satellite based exposure methods to study the association between pregnancy PM2.5 exposure, premature birth and birth weight in Massachusetts. Environ Health 11 40, doi: 10.1186/1476-069X-11-40 22709681 PMC3464884 · DOI
  19. Kumar R Yu Y Story RE Pongracic JA Gupta R Pearson C 2008 Prematurity, chorioamnionitis, and the development of recurrent wheezing: a prospective birth cohort study. J Allergy Clin Immunol 121 4 878 84.e6, doi: 10.1016/j.jaci.2008.01.030 18313129 PMC2993062 · DOI
  20. Langston C Kaplan C Macpherson T Manci E Peevy K Clark B 1997 Practice guideline for examination of the placenta: developed by the Placental Pathology Practice Guideline Development Task Force of the College of American Pathologists. Arch Pathol Lab Med 121 5 449 476 9167599
  21. Le HQ Batterman SA Wirth JJ Wahl RL Hoggatt KJ Sadeghnejad A 2012 Air pollutant exposure and preterm and term small-for-gestational-age births in Detroit, Michigan: long-term trends and associations. Environ Int 44 7 17, doi: 10.1016/j.envint.2012.01.003 22314199 PMC4331339 · DOI
  22. Lee PC Roberts JM Catov JM Talbott EO Ritz B 2013 First trimester exposure to ambient air pollution, pregnancy complications and adverse birth outcomes in Allegheny County, PA. Matern Child Health J 17 3 545 555, doi: 10.1007/s10995-012-1028-5 22544506 PMC3636771 · DOI
  23. Malmqvist E Rignell-Hydbom A Tinnerberg H Björk J Stroh E Jakobsson K 2011 Maternal exposure to air pollution and birth outcomes. Environ Health Perspect 119 553 558, doi: 10.1289/ehp.1002564 21212043 PMC3080940 · DOI
  24. Masri S Kang CM Koutrakis P 2015 Composition and sources of fine and coarse particles collected during 2002–2010 in Boston, MA. J Air Waste Manag Assoc 65 3 287 297 25947125 PMC4740916
  25. Mestan K Yu Y Matoba N Cerda S Demmin B Pearson C 2010 Placental inflammatory response is associated with poor neonatal growth: preterm birth cohort study. Pediatrics 125 4 e891 e898, doi: 10.1542/peds.2009-0313 20308216 · DOI · Paper page
  26. Muglia LJ Katz M 2010 The enigma of spontaneous preterm birth. N Engl J Med 362 6 529 535, doi: 10.1056/NEJMra0904308 20147718 · DOI
  27. Pereira G Belanger K Ebisu K Bell ML 2014 Fine particulate matter and risk of preterm birth in Connecticut in 2000–2006: a longitudinal study. Am J Epidemiol 179 1 67 74, doi: 10.1093/aje/kwt216 24068199 PMC3864709 · DOI
  28. Rappazzo KM Daniels JL Messer LC Poole C Lobdell DT 2014 Exposure to fine particulate matter during pregnancy and risk of preterm birth among women in New Jersey, Ohio, and Pennsylvania, 2000–2005. Environ Health Perspect 122 992 997, doi: 10.1289/ehp.1307456 24879653 PMC4154214 · DOI
  29. Ritz B Wilhelm M Hoggatt KJ Ghosh JK 2007 Ambient air pollution and preterm birth in the environment and pregnancy outcomes study at the University of California, Los Angeles. Am J Epidemiol 166 9 1045 1052, doi: 10.1093/aje/kwm181 17675655 · DOI
  30. Ritz B Yu F Chapa G Fruin S 2000 Effect of air pollution on preterm birth among children born in Southern California between 1989 and 1993. Epidemiology 11 5 502 511 10955401
  31. Simmonds M Jeffery H Watson G Russell P 2004 Intraobserver and interobserver variability for the histologic diagnosis of chorioamnionitis. Am J Obstet Gynecol 190 1 152 155, doi: 10.1016/S0002-9378(03)00870-6 14749652 · DOI
  32. Slama R Darrow L Parker J Woodruff TJ Strickland M Nieuwenhuijsen M 2008 Meeting report: atmospheric pollution and human reproduction. Environ Health Perspect 116 791 798, doi: 10.1289/ehp.11074 18560536 PMC2430236 · DOI
  33. van den Hooven EH de Kluizenaar Y Pierik FH Hofman A van Ratingen SW Zandveld PY 2012a Chronic air pollution exposure during pregnancy and maternal and fetal C-reactive protein levels: the Generation R Study. Environ Health Perspect 120 746 751, doi: 10.1289/ehp.1104345 22306530 PMC3346784 · DOI
  34. van den Hooven EH Pierik FH de Kluizenaar Y Hofman A van Ratingen SW Zandveld PY 2012b Air pollution exposure and markers of placental growth and function: the Generation R Study. Environ Health Perspect 120 1753 1759, doi: 10.1289/ehp.1204918 22922820 PMC3548279 · DOI
  35. Wang X Ding H Ryan L Xu X 1997 Association between air pollution and low birth weight: a community-based study. Environ Health Perspect 105 514 520 9222137 PMC1469882
  36. Wang X Zuckerman B Pearson C Kaufman G Chen C Wang G 2002 Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight. JAMA 287 2 195 202, doi: 10.1001/jama.287.2.195 11779261 · DOI
  37. Wright RJ Brunst KJ 2013 Programming of respiratory health in childhood: influence of outdoor air pollution. Curr Opin Pediatr 25 2 232 239, doi: 10.1097/MOP.0b013e32835e78cc 23422354 · DOI
  38. Xu X Ding H Wang X 1995 Acute effects of total suspended particles and sulfur dioxides on preterm delivery: a community-based cohort study. Arch Environ Health 50 6 407 415, doi: 10.1080/00039896.1995.9935976 8572718 · DOI

Cited by

Sorted by citations

Authors
Nachman, R. M., Mao, G., Zhang, X., Hong, X., Chen, Z., Soria, C. S., He, H., Wang, G., Caruso, D., Pearson, C., Biswal, S., Zuckerman, B., Wills-Karp, M., & Wang, X.
Affiliations
  • Johns Hopkins University (US)
  • Lurie Children's Hospital (US)
  • Boston University (US)
Corresponding author
Wang, Xiaobin
ORCID
Venue
Environmental Health Perspectives
Publisher
American Chemical Society (ACS)
Published
2016-04-27
Volume
124
Issue
10
Pages
1608-1615
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
DOI
10.1289/ehp243
PMC
PMC5047781
OpenAlex
W2344260988
Cited by
164
References
3
Citations by year
2026: 17 · 2025: 16 · 2024: 13 · 2023: 17 · 2022: 21 · 2021: 18 · 2020: 12 · 2019: 14 · 2018: 15 · 2017: 15 · 2016: 6
FWCI
10.47
Type
journal article
Language
en
Open access
Licence
Locations
  • Environmental Health Perspectives (publishedVersion, public-domain)
  • PubMed Central (publishedVersion, public-domain)
  • PubMed (publishedVersion)
Funders
  • March of Dimes Foundation (#21-FY07-605, 20-FY02-56 and 21-FY07-605, 20-FY02-56)
  • School of Medicine, Boston University
  • Ludwig Family Foundation
  • National Institutes of Health
  • National Institute of Environmental Health Sciences (R21ES011666, R01ES006721, T32ES007141)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD066471, R01HD041702)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
  • Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
Keywords
PM2.5, maternal air pollution exposure, prenatal exposure, preconception exposure, pregnancy trimesters, intrapartum fever, preterm birth, low birth weight, neurodevelopmental outcomes, Boston Birth Cohort, air quality monitoring data

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review