Effect of Schisandra chinensis Extract Supplementation on Quadriceps Muscle Strength and Fatigue in Adult Women: A Randomized, Double-Blind, Placebo-Controlled Trial
Open accessAbstract
The fruit of Schisandra chinensis (SC) is a well-known traditional herb used for pharmacological purposes in Asian countries (e.g., Korea, China, and Japan). In animal studies, SC extract supplementation had beneficial effects on muscle strength and lactate level. However, the effect of SC extract supplementation on skeletal muscle strength and lactate at rest in humans remains unclear. The purpose of this study was to evaluate the effect of SC extract supplementation on quadriceps muscle strength (QMS) and lactate at rest in adult women. Forty five healthy post-menopausal middle-aged women (61.9 ± 8.4 years) were randomly divided into the SC (n = 24) or the placebo group (n = 21). The SC group consumed 1000 mg of SC extract per day, whereas the placebo group consumed 1000 mg of starch per day for 12 weeks. The difference in muscle mass, physical function, and biomarkers and the relative changes between baseline and 12 weeks were evaluated. We used two-factor repeated measures analysis of variance (ANOVA) to determine interaction (group × time) effects for variables. Statistical significance was accepted at p < 0.05. In ANOVA results, QMS (p = 0.001) and lactate level (p = 0.038) showed significant interactions. With paired t-tests, QMS was significantly increased (p < 0.001) and lactate level at rest was significantly decreased (p < 0.05) after 12 weeks in the SC group. However, no interactions were found between the other variables. Supplementation of SC extract may help to improve QMS as well as decrease lactate level at rest in adult women. We believe that SC extract is a health supplement that can support healthy life in this population.
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The intake of Schisandra chinensis is not associated with serious side effects.
“The intake of Schisandra chinensis is not associated with serious side effects [105,106,107,108,109,110,111,112,113,114,115,116].”
From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [105]
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- Authors
- Park, J., Han, S., & Park, H.
- Affiliations
- Department of Sport Rehabilitation, Dong Ju College, Busan 49318, Korea
- Dong-A University (KR)
- Corresponding author
- Park, Hyuntae
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2020-04-04
- Volume
- 17
- Issue
- 7
- Pages
- 2475
- ISSN
- 1660-4601 (ISSN-L)
- PMC
- PMC7177795
- OpenAlex
- W3014463044
- Cited by
- 33
- References
- 54
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 1 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 1
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-2018S1A5A2A03037691)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- Schisandra chinensis, quadriceps strength, muscle fatigue, postmenopausal women, herbal supplements, muscle mass, physical function
- MeSH terms
- Adult, Aged, Animals, Double-Blind Method, Fatigue, Female, Humans, Middle Aged, Plant Extracts, Muscle, Skeletal, Dietary Supplements, Schisandra, Quadriceps Muscle, Muscle Strength
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