Anxiety, Depression and Quality of Life—A Systematic Review of Evidence from Longitudinal Observational Studies

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Cognitive behavioral therapy for anxiety and related disorders: A meta-analysis of randomized placebo-controlled trials

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School-based depression and anxiety prevention programs for young people: A systematic review and meta-analysis

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Exercise for Mental Well-Being: Exploring Neurobiological Advances and Intervention Effects in Depression

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Intrinsic Capacity to Predict Future Adverse Health Outcomes in Older Adults: A Scoping Review

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Exploring the efficacy and safety of a novel standardized ashwagandha ( Withania somnifera ) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial

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Effect of Saffron Versus Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment of Depression and Anxiety: A Meta-analysis of Randomized Controlled Trials

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Fear of war and mental health in Germany

Hajek, A., Kretzler, B., & König, H. (2022) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-022-02394-9 · Cited by 49

Preclinical modeling in depression and anxiety: Current challenges and future research directions

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Personalised depression forecasting using mobile sensor data and ecological momentary assessment

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Mediating roles of sleep quality and resilience in the relationships between chronotypes and mental health symptoms

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Zero-Shot Strike: Testing the generalisation capabilities of out-of-the-box LLM models for depression detection

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Depression, anxiety and quality of life of Afghan women living in urban areas under the Taliban government: a cross-sectional study

Neyazi, A., Padhi, B. K., Mohammadi, A. Q., Ahmadi, M., Erfan, A., Bashiri, B., Neyazi, M., Ishaqzada, M., Noormohammadi, M., & Griffiths, M. D. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-071939 · Cited by 38

Psychometric properties of the ultra-brief self-report Patient Health Questionnaire-4 (PHQ-4) to assess anxiety and depression in Arabic-speaking adults

Obeïd, S., Hemade, A., Malaeb, D. N., Sakr, F., Dabbous, M., Xu, J., Ying, Y., Jiang, C., Meng, R., Fekih‐Romdhane, F., et al. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05978-8 · Cited by 42

Illness perceptions and health literacy are strongly associated with health-related quality of life, anxiety, and depression in patients with coronary heart disease: results from the EUROASPIRE V cross-sectional survey

Jennings, C. S., Astin, F., Prescott, E., Hansen, T., Gale, C. P., & Bacquer, D. D. (2022) · European Journal of Cardiovascular Nursing · doi:10.1093/eurjcn/zvac105 · Cited by 40

Longitudinal associations between family conflict, intergenerational transmission, and adolescents’ depressive symptoms: evidence from China Family Panel studies (2016–2020)

Jin, Y., Liu, J., Li, P., Yun-quan, H., Hong, X., Li, X., Teng, Y., Huang, M., & Wang, Y. (2025) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-025-00866-9 · Cited by 31

Global prevalence of anxiety symptoms and its associated factors in older adults: A systematic review and meta‐analysis

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Climate Anxiety and Mental Health in Germany

Hajek, A., & König, H.-H. (2023) · Climate · doi:10.3390/cli11080158 · Cited by 24

A systematic review and meta-analysis of the effectiveness of co-designed, in-person, mental health interventions for reducing anxiety and depression symptoms

Barker, T. G., O’Higgins, A., Fonagy, P., & Gardner, F. E. M. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.12.080 · Cited by 28

World Psychiatric Association-Asian Journal of Psychiatry Commission on Public Mental Health.

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Health survey on anxiety, depression, and stress in Afghanistan: A large-scale cross-sectional study amid ongoing challenges

Neyazi, A., Mohammadi, A. Q., Razaqi, N., Rahimi, B. A., Sifat, S., Rahimy, N., Tareen, Z., Mehmood, Q., Satapathy, P., & Griffiths, M. D. (2024) · Discover Mental Health · doi:10.1007/s44192-024-00090-5 · Cited by 27

The impact of fibroid treatments on quality of life and mental health: a systematic review

Neumann, B., Singh, B., Brennan, J. T., Blanck, J. F., & Segars, J. H. (2024) · Fertility and Sterility · doi:10.1016/j.fertnstert.2024.01.021 · Cited by 24

Financial assets and mental health over time

Ettman, C. K., Thornburg, B., Abdalla, S. M., Meiselbach, M. K., & Galea, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-76990-x · Cited by 31

The Impact of Mental Health and Sociodemographic Characteristics on Quality of Life and Life Satisfaction during the Second Year of the COVID-19 Pandemic—Results of a Population-Based Survey in Germany

Geprägs, A., Bürgin, D., Fegert, J., Brähler, E., & Clemens, V. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19148734 · Cited by 21

Psychological Distress, Resources, and Coping Strategies Among Evacuees and Non‐Evacuees From an Armed Conflict Zone: A Network Analysis

Hamama, L., Sarid, O., & Hamama‐Raz, Y. (2024) · Stress and Health · doi:10.1002/smi.3525 · Cited by 27

An open-label pilot trial assessing tolerability and feasibility of LSD microdosing in patients with major depressive disorder (LSDDEP1)

Donegan, C. J., Daldegan‐Bueno, D., Sumner, R. L., Menkes, D. B., Evans, W., Hoeh, N. R., Sundram, F., Reynolds, L., Ponton, R., Cavadino, A., et al. (2023) · Pilot and Feasibility Studies · doi:10.1186/s40814-023-01399-8 · Cited by 21

Adherence to the Mediterranean diet and mental health among university students in Lebanon

Mikkawi, H. E., Khoury, C. E., & Rizk, R. (2024) · Applied Food Research · doi:10.1016/j.afres.2024.100435 · Cited by 20

Building Emotional Awareness and Mental Health (BEAM): an open-pilot and feasibility study of a digital mental health and parenting intervention for mothers of infants

Xie, E. B., Freeman, M., Penner‐Goeke, L., Reynolds, K., Lebel, C. A., Giesbrecht, G. F., Rioux, C., MacKinnon, A., Sauer-Zavala, S. E., Roos, L. E., et al. (2023) · Pilot and Feasibility Studies · doi:10.1186/s40814-023-01245-x · Cited by 25

Empirical support for a model of risk and resilience in children and families during COVID-19: A systematic review & narrative synthesis

Shoychet, G., Kimber, M., Weiss, J. A., Honest, O., & Prime, H. (2023) · Development and Psychopathology · doi:10.1017/s0954579423000767 · Cited by 21

Is Mental Health Worse in Medical Students than in the General Population? A Cross-Sectional Study

Stirparò, G., Pireddu, R., D’Angelo, M., Bottignole, D., Mazzoli, R., & Gambolò, L. (2024) · Medicina · doi:10.3390/medicina60060863 · Cited by 18

Relationship between self-management of patients with anxiety disorders and their anxiety level and quality of life: A cross-sectional study

Cao, X., Feng, M., Ge, R., Wen, Y., Yang, J., & Li, X. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284121 · Cited by 19

A Narrative Review on REM Sleep Deprivation: A Promising Non-Pharmaceutical Alternative for Treating Endogenous Depression

Crișan, C. A., Milhem, Z., Stretea, R., Țața, I.-M., Cherecheș, R. M., & Micluția, I. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13020306 · Cited by 19

Efficacy of Intellect’s self-guided anxiety and worry mobile health programme: A randomized controlled trial with an active control and a 2-week follow-up

Kosasih, F. R., Yee, V. T. S., Toh, S. H. Y., & Sündermann, O. (2023) · PLOS Digital Health · doi:10.1371/journal.pdig.0000095 · Cited by 17

The effect of symptomatology and mental wellbeing on quality of life in people with acoustic neuroma

Nowacka, A., Barker-Collo, S. L., Miles, A., & Ben-Harosh, L. (2023) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2023.08.005 · Cited by 15

Early effects predict trajectories of response to esketamine in treatment-resistant depression

Estrade, I., Petit, A., Sylvestre, V., Danon, M., Leroy, S., Perrain, R., Vinckier, F., Mékaoui, L., Gaillard, R., Advenier-Iakovlev, E., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.09.030 · Cited by 16

Coping, meaning in life, and quality of life during ongoing conflict: insights from Israeli populations

Sarid, O., Hamama, L., & Hamama‐Raz, Y. (2025) · Israel Journal of Health Policy Research · doi:10.1186/s13584-024-00665-1 · Cited by 14

Investigation of the quality of life and influencing factors among perimenopausal women

Liu, X., Zhang, X., Wang, D., Zhou, J., & Li, Y. (2025) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-025-08116-1 · Cited by 23

From Weight Bias Internalization to Health-Related Quality of Life: Self-esteem and Psychopathology in Pre-bariatric Surgery Patients

Liu, X., Zhang, W., Yue, W., Sun, C., & Li, W. (2022) · Obesity Surgery · doi:10.1007/s11695-022-06261-z · Cited by 15

Evolution of Depression and Anxiety During the COVID-19 Pandemic and Across Demographic Groups in a Large Sample of U.S. Adults

Ettman, C. K., Badillo‐Goicoechea, E., & Stuart, E. A. (2023) · AJPM Focus · doi:10.1016/j.focus.2023.100140 · Cited by 15

Association of Fast-Food Intake with Depressive and Anxiety Symptoms among Young Adults: A Pilot Study

Tang, W.-K., & Lee, J. C. (2024) · Nutrients · doi:10.3390/nu16193317 · Cited by 14

Predicting antidepressant response via local-global graph neural network and neuroimaging biomarkers

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Depression is associated with worse health-related quality of life, lower physical activity levels, and inadequate sleep quality in a Greek elderly population

Christodoulou, E., Pavlidou, E., Mantzorou, M., Koutelidakis, A. Ε., Vadikolias, Κ., Psara, E., Vorvolakos, T., Antasouras, G., Serdari, A., Vasios, G. K., et al. (2023) · Psychology Health & Medicine · doi:10.1080/13548506.2023.2221446 · Cited by 13

Predictors of Changes in Quality of Life of Patients with Major Depressive Disorder—A Prospective Naturalistic 3-Month Follow-Up Study

Dionisie, V., Puiu, M. G., Manea, M., & Pacearcă, I. A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12144628 · Cited by 15

Psychometric properties of the Urdu version of the EORTC QLQ-H&N35 (European organization for research and treatment of cancer head and neck module) quality of life tool

Zahid, N., Martins, R. S., Zahid, W., Azam, I., Ikram, M., Hassan, A., Bhamani, S. S., Jabbar, A. A., Asad, N., Akhtar, S., et al. (2022) · BMC Psychology · doi:10.1186/s40359-022-00900-x · Cited by 13

Predicting Health-Related Quality of Life Using Social Determinants of Health: A Machine Learning Approach with the All of Us Cohort

Abegaz, T. M., Ahmed, M. B., Ali, A. A., & Bhagavathula, A. S. (2025) · Bioengineering · doi:10.3390/bioengineering12020166 · Cited by 15

Meshing Anxiety, Depression, Quality of Life, and Functionality in Chronic Disease

Costa, A. P., Brito, I. D. S., Mestre, T. D., Pires, A. M., & Lopes, M. J. (2025) · Healthcare · doi:10.3390/healthcare13050539 · Cited by 12

Profiles of risk factors for depressive and anxiety symptoms during the COVID-19 pandemic: A latent class analysis

Kenntemich, L., von Hülsen, L., Schäfer, I., Böttche, M., & Lotzin, A. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115150 · Cited by 11

Association between anxiety, depression and quality of life in male and female German students during the COVID-19 pandemic

Wilzer, E., Zeisel, A., Roessner, V., & Ring, M. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05611-8 · Cited by 11

Quality of Life and Functioning Impairments Across Psychiatric Disorders in Adults Presenting for Outpatient Psychiatric Evaluation and Treatment

IsHak, W. W., Mirocha, J., Dang, J., Vanle, B., Metrikin, B., Tessema, K. K., Steiner, A. J., & Danovitch, I. (2024) · Psychiatric Research and Clinical Practice · doi:10.1176/appi.prcp.20230064 · Cited by 11

Drug–Drug Interactions of Selective Serotonin Reuptake Inhibitors: A Pharmacovigilance Study on Real-World Evidence from the EudraVigilance Database

Dobrea, C. M., Frum, A., Butucă, A., Morgovan, C., Stoicescu, L., Chiş, A. A., Arseniu, A. M., Rus, L. L., Gligor, F. G., & Vonica-Țincu, A. L. (2024) · Pharmaceuticals · doi:10.3390/ph17101278 · Cited by 11

Quality of Life and Mental Health Status in Recovered COVID-19 Subjects at Two Years after Infection in Taizhou, China: A Longitudinal Cohort Study

Pan, J., Zhou, K., Wang, J., Zheng, Y., Yu, D., Kang, H., Zhang, Y., Peng, S., Tung, T., & Shen, B. (2022) · Brain Sciences · doi:10.3390/brainsci12070939 · Cited by 11

The correlation between OSA-related quality of life and two mental statuses in adolescent Chinese patients with cleft palate: A comprehensive study

Zong, Y., Cheng, X., Xia, W., Xie, Z., Yang, Y., Shi, B., Gong, C., & Huang, H. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.985375 · Cited by 11

Sleep Quality, Stress, and Mental Health in College Students: The Protective Role of Optimism and Critical Thinking

Fabio, R. A., Pietro, A. D., & Suriano, R. (2025) · Psychiatry International · doi:10.3390/psychiatryint7010005 · Cited by 13

Factors related to self-rated health of older adults in rural China: A study based on decision tree and logistic regression model

Zhang, M., Rong, J., Liu, S., Zhang, B., Zhao, Y., Wang, H., & Ding, H. S. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.952714 · Cited by 10

Serum BDNF levels are involved in the diagnosis and treatment response in patients with PD

Li, R., Li, J., Liu, Y., Li, D., Chu, L., Zhang, J., Luο, X., & Zhang, Y. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.01.107 · Cited by 10

A novel probe of attentional bias for threat in specific phobia: Application of the “MouseView.js” approach

Woronko, S. E., Jessup, S. C., Armstrong, T., Anwyl-Irvine, A. L., Dalmaijer, E. S., & Olatunji, B. O. (2023) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2023.102700 · Cited by 10

Constipation among workers with depression/anxiety: a retrospective study using a claims database and survey data in Japan

Karasawa, Y., Nozawa, K., Nomoto, K., & Fukudo, S. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-083668 · Cited by 10

Physical, Cognitive, Social, and Functional Health Correlates of Major Depressive Disorder Subtypes: A Systematic Review

McKeough, J. E., Sharpley, C. F., Vessey, K. A., Bitsika, V., Williams, R. J., Odierna, G. L., & Evans, I. D. (2025) · Brain Sciences · doi:10.3390/brainsci15050525 · Cited by 10

Cluster Analysis on the Mental Health States in a Community Sample of Young Women During Pre-Pregnancy, Pregnancy, or the Postpartum Period

Lim, H. J., Moon, E., Kim, K., Suh, H., Park, J., Kim, D.-R., Park, J., Shin, M., & Lee, Y.-H. (2023) · Psychiatry Investigation · doi:10.30773/pi.2023.0002 · Cited by 11

Development of a General Health Score Based on 12 Objective Metabolic and Lifestyle Items: The Lifestyle and Well-Being Index

Pano, O., Sayón-Orea, C., Hershey, M. S., Bes‐Rastrollo, M., Martínez‐González, M. Á., & Martínez, J. A. (2022) · Healthcare · doi:10.3390/healthcare10061088 · Cited by 10

New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol's antidepressant effect

Guldager, M. B., Biojone, C., da Silva, N. R., Godoy, L. D., & Joca, S. R. L. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111029 · Cited by 10

Coexisting frailty and depression associated with low physical activity and quality of life in Saudi community-dwelling older adults: a cross-sectional study

Alhwoaimel, N. A., Alqahtani, B. A., Alshehri, M. M., Alhowimel, A., & Alenazi, A. M. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1531101 · Cited by 9

Depressive symptoms and antidepressant use in relation to white blood cell count among postmenopausal women from the Women’s Health Initiative

Beydoun, H. A., Beydoun, M. A., Wassertheil-Smoller, S. W., Saquib, N., Manson, J. E., Snetselaar, L. G., Weiss, J., Zonderman, A. B., & Brunner, R. L. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02872-5 · Cited by 9

Is There a Change in Anxiety and Depression Following Total Knee Arthroplasty?

Tripuraneni, K. R., Anderson, M. B., Cholewa, J. M., Smith, K., VanAndel, D. C., Redfern, R. E., & Barnett, S. L. (2024) · The Journal of Arthroplasty · doi:10.1016/j.arth.2024.02.009 · Cited by 8

Metacognitive strategies mediate the association between metacognitive beliefs and perceived quality of life

Havnen, A., Anyan, F., & Nordahl, H. (2024) · Scandinavian Journal of Psychology · doi:10.1111/sjop.13015 · Cited by 9

Dietary diversity among women with depressive and generalized anxiety symptoms in Nepal

Pengpid, S., & Peltzer, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-68346-2 · Cited by 8

The self in depression and anxiety as a transdiagnostic and differential-diagnostic neural marker: A systematic review

Sabbah, S. G., & Northoff, G. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106034 · Cited by 10

Contributions of common and rare genetic variation to different measures of mood and anxiety disorder in the UK Biobank

Katzourou, I. K., Barroso, I., Benger, L., Ingason, A., Stow, D., Tsang, R. S. M., Wood, M. L., Kirov, G., Walters, J., Owen, M. J., et al. (2025) · BJPsych Open · doi:10.1192/bjo.2025.43 · Cited by 7

Impact of comorbid depression and anxiety on temporomandibular disorders related pain, sleep, function, behaviors, and quality of life

Yap, A. U., Zheng, Y., Liu, T., Li, Y., Wo, P., Du, S., & Xiong, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-19524-3 · Cited by 8

The impact of psychological factors on outcome after salvage surgery for wrist osteoarthritis

Swärd, E. M., Brodda-Jansen, G., Schriever, T., Andersson-Franko, M., & Wilcke, M. K. (2022) · Journal of Hand Surgery (European Volume) · doi:10.1177/17531934221104603 · Cited by 9

Quality of life in Female Users of Antiageing Cosmetic Products/Aesthetic Treatments

Evangelista, M., Vilaça, M., Almeida, I. F., & Pereira, M. G. (2022) · International Journal of Cosmetic Science · doi:10.1111/ics.12804 · Cited by 8

Depression and generalized anxiety and associated factors among adult women and men in Nepal: Results of a national cross-sectional survey in 2022

Suanrueang, P., & Peltzer, K. (2024) · Journal of Human Behavior in the Social Environment · doi:10.1080/10911359.2024.2316127 · Cited by 8

Factors related to depression in adults with oral health problems in Spain (2017 to 2020)

Cebrino, J., & de la Cruz, S. P. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1364119 · Cited by 8

Periodontitis and Depressive Disorders: The Effects of Antidepressant Drugs on the Periodontium in Clinical and Preclinical Models: A Narrative Review

Taccardi, D., Chiesa, A., Maiorani, C., Pardo, A., Lombardo, G., Scribante, A., Sabatini, S., & Butera, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13154524 · Cited by 8

Psychometric properties of the Generalised Anxiety Disorder Dimensional Scale in an Australian sample

Groves, D., Binasis, T., Wootton, B. M., & Moses, K. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286634 · Cited by 10

Bidirectional associations between maladaptive cognitions and emotional symptoms, and their mediating role on the quality of life in adults with ADHD: a mediation model

Pan, M.-R., Zhang, S., Chen, C.-L., Qiu, S.-W., Liu, L., Li, H.-M., Zhao, M.-J., Dong, M., Si, F.-F., Wang, Y.-F., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1200522 · Cited by 9

Evaluating the reliability and validity of the Questionnaire on Well-Being: a validation study for a clinically informed measurement of subjective well-being

Hlynsson, J. I., Sjöberg, A., Ström, L., & Carlbring, P. (2024) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2024.2402992 · Cited by 12

Meta‐analysis reveals low language capacity in childhood is associated with mental health problems in adulthood

Lim, S. W. Y., & Lum, J. A. G. (2024) · International Journal of Language & Communication Disorders · doi:10.1111/1460-6984.13125 · Cited by 7

Cognitive behavioural therapy for internalizing symptoms in LGBTQ+ people: a preliminary meta-analysis

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Microbiome modulation as a novel therapeutic modality for anxiety disorders: A review of clinical trials

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